Migranal

Cluster Headache, Migraine Disorders
Treatment
4 Active Studies for Migranal

What is Migranal

DihydroergotamineThe Generic name of this drug
Treatment SummaryDihydroergotamine is a medication used to treat severe migraines. It is used less often than other medications in its class, such as triptans, because it has more side effects. Recently, a new type of intranasal delivery device has been developed that increases the effectiveness of dihydroergotamine. This device, called Precision Olfactory Delivery technology, has been proven to make the medication three times more effective than other intranasal delivery methods.
Migranalis the brand name
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Migranal Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Migranal
Dihydroergotamine
1997
21

Effectiveness

How Migranal Affects PatientsDHE is a medication used to treat migraine headaches with or without aura, as well as cluster headache episodes. It is thought to work by reducing glutamate levels in the brain, which can help reduce the pain of migraine headaches, and by tightening blood vessels, which can reduce the effects of the chemical (CGRP) that causes blood vessels to widen during a migraine.
How Migranal works in the bodyDHE works as an abortive therapy for migraines by acting on several receptor sites in the brain. It causes blood vessels in the head to constrict, reducing inflammation and pain. It also blocks signals sent to the trigeminal nerve, which helps reduce central sensitization. Lastly, it prevents the release of neuropeptides which can cause pain and inflammation. DHE is less potent than its predecessor, ergotamine, which helps reduce side effects. However, it takes some time for DHE to take effect, making it difficult to predict its effects.

When to interrupt dosage

The advised measure of Migranal is contingent upon the diagnosed disorder. The amount of dosage relies on the technique of administration (e.g. Intramuscular; Intravenous; Subcutaneous or Spray, metered) as demonstrated in the table below.
Condition
Dosage
Administration
Cluster Headache
, 1.0 mg/mL, 4.0 mg/mL, 2.5 mg, 0.5 mg/pump actuation
, Intramuscular; Intravenous; Subcutaneous, Injection, solution, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Nasal, Spray, Spray - Nasal, Liquid - Intramuscular; Intravenous; Subcutaneous, Liquid, Liquid - Nasal, Tablet - Oral, Oral, Tablet, Injection, Injection - Intramuscular; Intravenous; Subcutaneous, Spray, metered, Spray, metered - Nasal
Migraine Disorders
, 1.0 mg/mL, 4.0 mg/mL, 2.5 mg, 0.5 mg/pump actuation
, Intramuscular; Intravenous; Subcutaneous, Injection, solution, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Nasal, Spray, Spray - Nasal, Liquid - Intramuscular; Intravenous; Subcutaneous, Liquid, Liquid - Nasal, Tablet - Oral, Oral, Tablet, Injection, Injection - Intramuscular; Intravenous; Subcutaneous, Spray, metered, Spray, metered - Nasal

Warnings

Migranal Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Dihydroergotamine may interact with Pulse Frequency
Coronary Vasospasm
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Chest Pain
Do Not Combine
Pulse Frequency
Do Not Combine
Documented Silent Ischemia
Do Not Combine
Severe Hepatic Impairment
Do Not Combine
Renal Insufficiency
Do Not Combine
Migraine with Aura
Do Not Combine
Hypertensive disease
Do Not Combine
Liver Failure
Do Not Combine
Hemiplegic migraine
Do Not Combine
Vasospastic Angina
Do Not Combine
Women who are breast-feeding or pregnant
Do Not Combine
Vascular Surgery
Do Not Combine
Peripheral Arterial Disease
Do Not Combine
Pulse Frequency
Do Not Combine
Coronary Artery Disease
Do Not Combine
There are 20 known major drug interactions with Migranal.
Common Migranal Drug Interactions
Drug Name
Risk Level
Description
4-Bromo-2,5-dimethoxyphenethylamine
Major
Dihydroergotamine may increase the hypertensive and vasoconstricting activities of 4-Bromo-2,5-dimethoxyphenethylamine.
4-Methoxyamphetamine
Major
Dihydroergotamine may increase the hypertensive and vasoconstricting activities of 4-Methoxyamphetamine.
5-methoxy-N,N-dimethyltryptamine
Major
Dihydroergotamine may increase the vasoconstricting activities of 5-methoxy-N,N-dimethyltryptamine.
Abediterol
Major
Dihydroergotamine may increase the hypertensive and vasoconstricting activities of Abediterol.
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Dihydroergotamine.
Migranal Toxicity & Overdose RiskAn overdose of ergot can lead to numbness, tingling, and pain in the limbs, accompanied by a decrease or absence of blood flow. Other symptoms include difficulty breathing, changes in blood pressure, confusion, seizures, and nausea. Treatment involves warming the affected areas and providing vasodilators. Contact your local poison control centre for more information about how to handle an ergot overdose.
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Migranal Novel Uses: Which Conditions Have a Clinical Trial Featuring Migranal?

Presently, seven clinical trials are being conducted to assess the efficacy of Migranal in providing relief for Cluster Headache.
Condition
Clinical Trials
Trial Phases
Migraine Disorders
1 Actively Recruiting
Not Applicable
Cluster Headache
3 Actively Recruiting
Phase 1, Phase 2

Migranal Reviews: What are patients saying about Migranal?

5Patient Review
10/1/2022
Migranal for Migraine Headache
This treatment really helped ease my migraines. I'm so grateful that there's finally something that works for me.
5Patient Review
8/25/2022
Migranal for Migraine Headache
Nurtec was really effective for me and didn't have any of the side effects that imitrex does. So far, so good!
5Patient Review
4/15/2022
Migranal for Migraine Prevention
This medication has been an incredible help for me. Not only does it prevent migraines, but it also lessens their intensity and duration when I do get them. It's really changed my life for the better.
5Patient Review
4/15/2022
Migranal for Migraine Prevention
This medication has been fantastic for me. I take it every other day, and it has all but stopped my migraines. When I do get them, they're less severe and don't last as long. It's really improved my quality of life.
5Patient Review
8/25/2022
Migranal for Migraine Headache
I got a few samples of this from my doctor to try it out. I normally take imitrex, but it gives me some unpleasant side effects sometimes, so I'm trying different treatments right now. Nurtec worked within an hour for me and had no side effects! So far, so good!
View All Reviews
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Patient Q&A Section about migranal

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What class of drug is Migranal?

"Migranal is a medication used to treat the symptoms of migraine headaches. It may be used alone or with other medications. Migranal belongs to a class of drugs known as ergot derivatives."

Answered by AI

Is Migranal a triptan?

"Amerge is a type of migraine medication that is classified as a 5HT agonist, while Migranal is classified as an ergot alkaloid."

Answered by AI

How often can I take Migranal?

"Since Migranal is used only when needed, it is unlikely that a dose will be missed. Use no more than 6 sprays of dihydroergotamine nasal per day or more than 8 sprays per week."

Answered by AI

Clinical Trials for Migranal

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