Accelerated Theta-Burst Stimulation for Obsessive-Compulsive Disorder
Trial Summary
What is the purpose of this trial?
This study evaluates an accelerated schedule of theta-burst stimulation using a Transcranial Magnetic Stimulation (TMS) device for treatment-resistant Obsessive Compulsive Disorder (OCD). In a randomized fashion, half the participants will receive accelerated theta-burst stimulation at the dorsomedial prefrontal cortex (DMPFC), while half will receive accelerated theta-burst stimulation at the right orbitofrontal (rOFC) site.
Will I have to stop taking my current medications?
The trial requires participants to be stable on Serotonin Re-uptake Inhibitor (SRI) medication for at least 8 weeks before and throughout the study. Other medications may be allowed after review by a TMS specialist.
What data supports the effectiveness of this treatment for obsessive-compulsive disorder?
Research shows that continuous theta burst stimulation (cTBS) targeting specific brain areas like the orbitofrontal cortex (OFC) and supplementary motor area (SMA) can help reduce symptoms of obsessive-compulsive disorder (OCD), especially in patients who haven't responded to other treatments. Studies found improvements in anxiety and overall severity of OCD symptoms, suggesting this treatment may be beneficial.12345
Is theta-burst stimulation (TBS) generally safe for humans?
Theta-burst stimulation (TBS), a type of transcranial magnetic stimulation, has been studied for various conditions like depression and addiction. Research shows it generally has mild side effects and no serious issues like seizures or mania have been reported, indicating it is generally safe for humans.678910
How does the treatment Accelerated Theta-Burst Stimulation for Obsessive-Compulsive Disorder differ from other treatments?
Accelerated Theta-Burst Stimulation (TBS) is a unique treatment for Obsessive-Compulsive Disorder (OCD) because it uses magnetic pulses to non-invasively target specific brain areas, like the orbitofrontal cortex and supplementary motor area, which are involved in OCD symptoms. This approach is different from traditional treatments like medication and psychotherapy, as it directly modulates brain activity and is particularly promising for patients who do not respond to standard treatments.12345
Research Team
Ian Kratter, MD, PhD
Principal Investigator
Stanford University
Eligibility Criteria
This trial is for adults with moderate to severe OCD who haven't responded well to standard treatments like SRIs or cognitive behavioral therapy. Participants must be stable on SRI medication for at least 8 weeks and able to undergo study procedures. Excluded are those with substance abuse issues, severe depression, bipolar disorder, eating disorders, certain medical conditions like seizures or brain injuries, pregnant or nursing women, and anyone planning CBT during the study.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive accelerated theta-burst stimulation using a TMS device targeting either the DMPFC or rOFC site
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- Active bilateral DMPFC
- Active right-sided OFC
Active bilateral DMPFC is already approved in United States for the following indications:
- Obsessive Compulsive Disorder (OCD)
- Obsessive Compulsive Disorder (OCD)
- Obsessive Compulsive Disorder (OCD)
Find a Clinic Near You
Who Is Running the Clinical Trial?
Stanford University
Lead Sponsor