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What is Methylergonovine Maleate
MethylergometrineThe Generic name of this drug
Treatment SummaryMethylergonovine is a drug related to ergonovine, but with an extra carbon-hydrogen (CH2) group added.
Methergineis the brand name
Methylergonovine Maleate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Methergine
Methylergometrine
1946
32
Effectiveness
How Methylergonovine Maleate Affects PatientsMethylergometrine is a drug derived from ergonovine, used to prevent heavy bleeding after childbirth or an abortion. It works by affecting certain receptors in the body. This drug increases the activity of the uterus, and as the dose increases, the contractions become more forceful and longer-lasting, with a greater resting tone.
How Methylergonovine Maleate works in the bodyMethylergometrine helps the uterus contract more strongly, quickly, and with more force. This tightens the uterus and helps the third stage of labor progress faster, reducing blood loss. It does this by blocking dopamine receptors in the uterus and making the muscles contract more powerfully.
When to interrupt dosage
The endorsed measure of Methylergonovine Maleate is contingent upon the diagnosed disorder, including Uterine Atony, Vaginal Bleeding and Postpartum Haemorrhage (PPH). The measure of dosage differs, in accordance with the technique of delivery (e.g. Oral or Tablet, coated) documented in the table beneath.Condition
Dosage
Administration
Spasm provocation test
0.2 mg, , 0.2 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Intravenous, Injection - Intravenous
Angina Pectoris, Variant
0.2 mg, , 0.2 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Intravenous, Injection - Intravenous
Postpartum Haemorrhage (PPH)
0.2 mg, , 0.2 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Intravenous, Injection - Intravenous
Vaginal Bleeding
0.2 mg, , 0.2 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Intravenous, Injection - Intravenous
Postpartum uterine subinvolution
0.2 mg, , 0.2 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Intravenous, Injection - Intravenous
Uterine Atony
0.2 mg, , 0.2 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Intravenous, Injection - Intravenous
Warnings
Methylergonovine Maleate has two contraindications, and it should not be ingested while having any of the conditions enumerated in the table below.Methylergonovine Maleate ContraindicationsCondition
Risk Level
Notes
Pre-eclampsia
Do Not Combine
Hypertensive disease
Do Not Combine
Common Methylergonovine Maleate Drug Interactions
Drug Name
Risk Level
Description
4-Bromo-2,5-dimethoxyphenethylamine
Major
Methylergometrine may increase the hypertensive and vasoconstricting activities of 4-Bromo-2,5-dimethoxyphenethylamine.
4-Methoxyamphetamine
Major
Methylergometrine may increase the hypertensive and vasoconstricting activities of 4-Methoxyamphetamine.
5-methoxy-N,N-dimethyltryptamine
Major
Methylergometrine may increase the vasoconstricting activities of 5-methoxy-N,N-dimethyltryptamine.
Abediterol
Major
Methylergometrine may increase the hypertensive and vasoconstricting activities of Abediterol.
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Methylergometrine.
Methylergonovine Maleate Toxicity & Overdose RiskSigns of taking too much of this drug may include high blood pressure, seizures, headaches, low blood pressure, nausea, and vomiting.
Methylergonovine Maleate Novel Uses: Which Conditions Have a Clinical Trial Featuring Methylergonovine Maleate?
8 active trials are currently underway to investigate the viability of Methylergonovine Maleate as a treatment for Uterine Atony, Postpartum Uterine Subinvolution and Variant Angina Pectoris.Condition
Clinical Trials
Trial Phases
Postpartum uterine subinvolution
0 Actively Recruiting
Spasm provocation test
0 Actively Recruiting
Uterine Atony
0 Actively Recruiting
Angina Pectoris, Variant
0 Actively Recruiting
Postpartum Haemorrhage (PPH)
3 Actively Recruiting
Phase 2, Not Applicable
Vaginal Bleeding
6 Actively Recruiting
Phase 4, Phase 3, Phase 2, Not Applicable
Methylergonovine Maleate Reviews: What are patients saying about Methylergonovine Maleate?
5Patient Review
8/21/2019 I had a c-section and was in a lot of pain afterwards. The ER prescribed this to me and it really helped. I didn't have any bad cramping like they said I might, just some diarrhea. But by the time I finished the medication, I felt way better.
5Patient Review
8/24/2011 I was flooding heavily after giving birth to my son, and Methergine really helped slow down the flow within 24 hours. The bleeding stopped completely within one week, which was a huge relief.
3.7Patient Review
4/10/2019 This medication was prescribed to me post-partum. I took as directed, three pills per day for five days. It helped with the bleeding and most of the pain, but unfortunately caused some pretty intense headaches.
2.3Patient Review
8/29/2014 I began feeling dizzy about an hour after each pill, and by the end of the three-day course, I was also experiencing cramping in my upper legs. The jury is still out on whether or not this treatment was effective for me, as there hasn't been a change in my post-op bleeding.
2.3Patient Review
9/20/2012 Though this medication was successful in stemming the bleeding from my miscarrying, the leg cramps I experience 30 minutes afterwards are unbearable. I can barely walk or stand for hours at a time as a result.
Patient Q&A Section about methylergonovine maleate
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is the adverse effect of methylergonovine?
"Among the most frequently reported adverse reactions are high blood pressure, seizures, and headaches. Other reactions include abdominal pain, nausea, and vomiting."
Answered by AI
When should Methergine not be given?
"Use of methylergonovine is not recommended for patients with high blood pressure. Injecting methylergonovine intravenously should not be done routinely because it could cause a sudden increase in blood pressure that could lead to a stroke."
Answered by AI
Is methylergonovine used for miscarriage?
"The medication Methergine®, which causes uterine contractions, is often used together with another medication, misoprostol, to treat heavy bleeding during early pregnancy loss. Methergine® begins working within 5-10 minutes, making it a good choice to use initially to manage early pregnancy loss hemorrhage."
Answered by AI
What is methylergonovine maleate used for?
"This medicine is used to prevent and control bleeding from the uterus that can happen after childbirth. It belongs to the class of medicines called ergot alkaloids. This medicine works by acting directly on the smooth muscles of the uterus and prevents bleeding after giving birth."
Answered by AI