Extended Bupropion Treatment for Smoking Cessation
((KISV) Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This study will evaluate the efficacy of extended bupropion(6 months) versus standard bupropion treatment (7 weeks) among African American daily smokers.
Will I have to stop taking my current medications?
The trial requires that you stop using certain medications, especially psychoactive medications and specific drugs metabolized by the liver enzyme CYP2D6, like metoprolol and tamoxifen. You also need to avoid using stop smoking medications in the 30 days before joining the study.
Is bupropion safe for smoking cessation?
Bupropion, used for smoking cessation, has been associated with minimal side effects in trials, but there are reports of adverse reactions and a warning about potential suicidal behavior and depression. Most exposures to bupropion were unintentional, with some serious effects noted, especially in cases of overdose.12345
How is the drug bupropion unique for smoking cessation?
Bupropion is unique for smoking cessation because it is one of the first non-nicotine medications used for this purpose, and it works by affecting brain chemicals related to addiction. It is often used in combination with cognitive-behavioral therapy (CBT) to improve success rates, and it has been shown to have minimal side effects compared to other treatments.36789
What data supports the effectiveness of the drug Bupropion for smoking cessation?
Who Is on the Research Team?
Lisa Sanderson Cox, PhD
Principal Investigator
University of Kanas Medical Center
Are You a Good Fit for This Trial?
This trial is for African American adults who smoke daily, want to quit, and are willing to commit to a 6-month treatment plan. Participants must not be using any stop smoking medications recently, be pregnant or breastfeeding, have had a recent heart attack, or take certain drugs metabolized by the liver enzyme CYP2D6.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive bupropion treatment with culturally-relevant smoking cessation counseling
Follow-up
Participants are monitored for smoking abstinence and medication adherence
What Are the Treatments Tested in This Trial?
Interventions
- Bupropion
Bupropion is already approved in United States, European Union, Canada for the following indications:
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Kansas Medical Center
Lead Sponsor