Metaxalone

Musculoskeletal Diseases, Chronic Pain
Treatment
2 FDA approvals
20 Active Studies for Metaxalone

What is Metaxalone

MetaxaloneThe Generic name of this drug
Treatment SummaryMetaxalone is a medication used to treat muscle pain and stiffness. It is sold under the brand name Skelaxin, and works by calming the central nervous system. Metaxalone usually comes in an 800 mg tablet and has few side effects.
Skelaxinis the brand name
Metaxalone Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Skelaxin
Metaxalone
1962
130

Approved as Treatment by the FDA

Metaxalone, also known as Skelaxin, is approved by the FDA for 2 uses such as Chronic Pain and Musculoskeletal Diseases .
Chronic Pain
Helps manage Pain
Musculoskeletal Diseases
Helps manage Musculoskeletal Disorders

Effectiveness

How Metaxalone Affects PatientsMetaxalone is a drug that helps relieve pain from muscle injuries and conditions. It is usually taken at the same time as rest, physical therapy, and other treatments. It is not known exactly how this drug works, but it is thought to be due to its calming effects. Metaxalone does not directly make tense muscles relaxed.
How Metaxalone works in the bodyWe don't know exactly how metaxalone works, but it seems to cause a calming effect on the central nervous system.

When to interrupt dosage

The prescribed amount of Metaxalone is reliant on the identified disorder. The amount of dosage fluctuates, according to the method of delivery featured in the table below.
Condition
Dosage
Administration
Chronic Pain
800.0 mg, , 640.0 mg, 400.0 mg
, Oral, Tablet, Kit, Tablet - Oral
Musculoskeletal Diseases
800.0 mg, , 640.0 mg, 400.0 mg
, Oral, Tablet, Kit, Tablet - Oral

Warnings

There are 20 known major drug interactions with Metaxalone.
Common Metaxalone Drug Interactions
Drug Name
Risk Level
Description
Azelastine
Major
Metaxalone may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Ethanol
Major
Metaxalone may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Methylene blue
Major
Metaxalone may increase the serotonergic activities of Methylene blue.
Oliceridine
Major
The risk or severity of hypotension, sedation, death, somnolence, and respiratory depression can be increased when Metaxalone is combined with Oliceridine.
Sodium oxybate
Major
Metaxalone may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
Metaxalone Toxicity & Overdose RiskThe toxic dose of the drug in rats is 775mg/kg when given orally, and 1690mg/kg when given orally to mice. As the dosage increases, the animals may become increasingly sedated and eventually stop breathing. Dogs may vomit after 15-30 minutes when given high doses of the drug. Some side effects of the drug in humans include nausea, vomiting, drowsiness, dizziness, headaches, and irritability.

Metaxalone Novel Uses: Which Conditions Have a Clinical Trial Featuring Metaxalone?

There are 177 active clinical trials examining the potential of Metaxalone in alleviating Musculoskeletal Diseases.
Condition
Clinical Trials
Trial Phases
Chronic Pain
176 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Phase 4, Early Phase 1
Musculoskeletal Diseases
5 Actively Recruiting
Phase 3, Not Applicable, Phase 1, Phase 2

Metaxalone Reviews: What are patients saying about Metaxalone?

5Patient Review
7/28/2020
Metaxalone for Muscle Spasm
I've been using this medication to relieve severe leg cramps for over a decade now. These cramps often come at night without warning and can be incredibly painful. This medication helps fairly quickly, which allows me to get some much-needed rest.
5Patient Review
6/3/2014
Metaxalone for Muscle Spasm
4Patient Review
1/29/2017
Metaxalone for Muscle Spasm
Though it made me nauseous, this medication was no more effective than Advil at reducing my back pain.
4Patient Review
2/10/2016
Metaxalone for Muscle Spasm
I'm not sure if it's the placebo effect or what, but I feel like this treatment is giving me mood swings.
3.3Patient Review
3/20/2016
Metaxalone for Muscle Spasm
I was told to take this medication three times a day, but I found that cutting the pills in half and only taking them at night worked better for me. The main side effect I experienced was fatigue, which was really disrupting my daily life. I'm hoping to find something else that will work better for me when I see my doctor next week.
3.3Patient Review
7/2/2014
Metaxalone for Muscle Spasm
2.3Patient Review
9/23/2016
Metaxalone for Muscle Spasm
I've been taking this medication since my work-related back injury, but I have yet to feel any relief.
2.3Patient Review
1/14/2022
Metaxalone for Muscle Spasm
I didn't find this to be any more effective than Flexeril for my tendonitis, but I did feel a bit less forgetful. However, the other side effects were really bad - stomach issues, fatigue, and general malaise. I actually wondered if I had a virus it was so bad.
2Patient Review
5/17/2016
Metaxalone for Muscle Spasm
This medicine didn't help me and the side effects were really bad.
1.7Patient Review
4/14/2022
Metaxalone for Muscle Spasm
I didn't feel any different after taking these.
1.7Patient Review
10/9/2014
Metaxalone for Muscle Spasm
1.3Patient Review
4/24/2021
Metaxalone for Muscle Spasm
I didn't find this treatment effective at all. I still experienced cramps and nausea.
1Patient Review
7/22/2020
Metaxalone for Muscle Spasm
I have a herniated disc in my neck and back, and this treatment did nothing to ease the pain or spasms.
1Patient Review
7/30/2022
Metaxalone for Muscle Spasm
Unfortunately, this medication did not relieve any of the pain I was experiencing in my back. The spasms actually got worse while I was taking it. I had to stop and ask my doctor for something stronger.

Patient Q&A Section about metaxalone

Does metaxalone help with anxiety?

"Metaxalone relaxes the central nervous system, which can help with anxiety, and has consequent side effects of dizziness, drowsiness, and sedation. The drug is only a short-term therapy." - Anonymous Online Contributor

Unverified Answer

What is the side effects metaxalone?

"The following side effects may occur: drowsiness, dizziness, nausea, vomiting, and upset stomach. If any of these effects last or worsen, tell your doctor or pharmacist. Remember that this medication was prescribed because your doctor has determined that the benefit to you is greater than the risk of side effects." - Anonymous Online Contributor

Unverified Answer

What is metaxalone used to treat?

"This medication is used to help relax the muscles in your body and relieve the discomfort caused by acute (short-term), painful muscle or bone conditions." - Anonymous Online Contributor

Unverified Answer

Is metaxalone a strong muscle relaxer?

"Metaxalone is a muscle relaxant that can be used for treating sprains, strains, and other muscle-based pain. It is not as strong as some other muscle relaxers, but it causes fewer side effects. These side effects can include nausea, drowsiness, vomiting, dizziness, and irritability." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Clinical Trials for Metaxalone

Image of McMaster Children's Hospital in Hamilton, Canada.
Phase-Based Progress Estimates
3
Effectiveness
3
Safety

Comparatorfor Postoperative Pain

Hamilton, Canada
< 18
All Sexes
The goal of this pilot randomized clinical trial is to determine the effect of the addition of IV acetaminophen to opioid-based pain regimes for infants admitted to the neonatal intensive care unit (NICU) after surgery. This is a pilot trial; the main goals are to make sure our study methods work before performing a larger study. The main clinical aims are: Determine if adding IV acetaminophen reduces pain Determine if adding IV acetaminophen reduces opioid use Determine if adding IV acetaminophen reduces complications Participants will be randomized to two groups: Comparator: Fentanyl and IV acetaminophen Control: Fentanyl and placebo Patients will receive either IV acetaminophen or placebo at regular intervals for seven days after surgery. Patients will be followed daily during that period. Charts will be reviewed at 90-days for final outcomes.
Phase 4
Waitlist Available
McMaster Children's HospitalMark Walton, MD
Image of Massachusetts General Hospital Cancer Center in Boston, United States.
Phase-Based Progress Estimates
1
Effectiveness
1
Safety

Individualized Evidence-Based Therapy In Cancer (Patients)for Emotional Distress

Boston, MA
18+
All Sexes
The goal of this research study is to train psychotherapists to administer individualized evidence-based psychotherapies in a cancer care setting to participants with elevated levels of distress due to their illness and/or treatment. The intervention will mirror clinical care in psycho-oncology in which the therapist, collaboratively with their supervisor, will choose specific components of the following evidence-based treatments to administer based on the clinical presentation of the patient and referring problem. Cognitive Behavioral Therapy (CBT) Acceptance Commitment Therapy (ACT) Mindfulness-Based Cognitive Therapy (MBCT) Mindfulness-Based Stress Reduction (MBSR) Meaning-Centered Psychotherapy (MCP) Cognitive Behavioral Therapy for Insomnia (CBT-I) CBT for other cancer-related physical symptoms like pain, fatigue, and nausea. Participation in this research study is expected to last about 26 weeks. It is expected that about 100 people and 15 therapists will take part in this research study.
Waitlist Available
Has No Placebo
Massachusetts General Hospital Cancer CenterJamie Jacobs, Ph.D
Have you considered Metaxalone clinical trials? We made a collection of clinical trials featuring Metaxalone, we think they might fit your search criteria.
Image of National Institutes of Health Clinical Center in Bethesda, United States.
Phase-Based Progress Estimates
1
Effectiveness
1
Safety

1for Pain

Bethesda, MD
18 - 55
All Sexes
Background: Negative emotional states can affect a person s behavior as they make decisions. For example, hunger may make people more impatient; they may then make riskier choices. Other negative emotional states that can change behavior include stress, pain, and sadness. By learning more about how emotions affect thinking and behavior in healthy people, researchers hope to better understand how to identify and treat people with mental disorders. Objective: To learn how negative emotions affect the brain and decision-making behavior. Eligibility: Healthy people aged 18 to 55 years. Design: Participants will have 3 clinic visits in 3 weeks. Participants will fill out questionnaires. They will be asked about their personal history, their personality, and state of mind. For 2 visits, participants will be assigned to different groups. Each group will experience 1 type of emotional stressor: Some participants will watch a video. Some will have to do arithmetic problems. Some will have heat applied to an arm or leg. Some will experience cold by immersing their hand in ice water. For a snack craving test, some will be tempted by food after a 4-hour fast. During these tests, participants will have sensors attached to their bodies. They will be videotaped. Saliva samples will be collected. After the stressors, participants will do tasks on a computer. They will need to make choices. Some participants will perform these decision-making tasks while lying in a brain scanner for functional magnetic resonance imaging. The brain scan involves lying on a table that slides into a cylinder that takes images of the brain.
Waitlist Available
Has No Placebo
National Institutes of Health Clinical CenterSilvia Lopez Guzman, M.D.
Image of Lake side spine & pain in Lake Havasu City, United States.
Phase-Based Progress Estimates
1
Effectiveness
1
Safety

Interventional Armfor Pain

Lake Havasu City, AZ
18+
All Sexes
This project will investigate the efficacy of a Stimfix Trail lead anchor system (StimfixTM) in patients undergoing dorsal column stimulator trial. In dorsal column stimulator trails, two leads are placed in the epidural space and various frequencies, pulse widths, and amplitudes are run to reduce pain perception. This therapy has been in use for the last 70 years and today there are about 100,000 implants done annually for various pain indications. The process of obtaining the therapy requires a trial period of seven days with percutaneous epidural leads connected to an external pulse generator (EPG). During this trial phase there has been incidence of lead migration in about 5-10% of patients resulting in trial failure. The function of StimfixTM is to standardize the lead anchoring procedure and to reduce the incidences of lead migration during the spinal cord stimulation trial phase.
Recruiting
Has No Placebo
Lake side spine & pain (+2 Sites)Dipan Patel, MD
Have you considered Metaxalone clinical trials? We made a collection of clinical trials featuring Metaxalone, we think they might fit your search criteria.
Have you considered Metaxalone clinical trials? We made a collection of clinical trials featuring Metaxalone, we think they might fit your search criteria.