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What is Metaxalone
MetaxaloneThe Generic name of this drug
Treatment SummaryMetaxalone is a medication used to treat muscle pain and stiffness. It is sold under the brand name Skelaxin, and works by calming the central nervous system. Metaxalone usually comes in an 800 mg tablet and has few side effects.
Skelaxinis the brand name
Metaxalone Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Skelaxin
Metaxalone
1962
134
Approved as Treatment by the FDA
Metaxalone, otherwise called Skelaxin, is approved by the FDA for 4 uses which include Pain and Musculoskeletal Disorders .Pain
Helps manage Pain
Musculoskeletal Disorders
Helps manage Musculoskeletal Disorders
Chronic Pain
Helps manage Pain
Musculoskeletal Diseases
Helps manage Musculoskeletal Disorders
Effectiveness
How Metaxalone Affects PatientsMetaxalone is a drug that helps relieve pain from muscle injuries and conditions. It is usually taken at the same time as rest, physical therapy, and other treatments. It is not known exactly how this drug works, but it is thought to be due to its calming effects. Metaxalone does not directly make tense muscles relaxed.
How Metaxalone works in the bodyWe don't know exactly how metaxalone works, but it seems to cause a calming effect on the central nervous system.
When to interrupt dosage
The prescribed amount of Metaxalone is reliant on the identified disorder. The amount of dosage fluctuates, according to the method of delivery featured in the table below.Condition
Dosage
Administration
Musculoskeletal Diseases
800.0 mg, , 400.0 mg, 640.0 mg
, Oral, Tablet - Oral, Tablet, Kit
Chronic Pain
800.0 mg, , 400.0 mg, 640.0 mg
, Oral, Tablet - Oral, Tablet, Kit
Warnings
There are 20 known major drug interactions with Metaxalone.Common Metaxalone Drug Interactions
Drug Name
Risk Level
Description
Azelastine
Major
Metaxalone may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Ethanol
Major
Metaxalone may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Methylene blue
Major
Metaxalone may increase the serotonergic activities of Methylene blue.
Mirtazapine
Major
Metaxalone may increase the serotonergic activities of Mirtazapine.
Oliceridine
Major
The risk or severity of hypotension, sedation, death, somnolence, and respiratory depression can be increased when Metaxalone is combined with Oliceridine.
Metaxalone Toxicity & Overdose RiskThe toxic dose of the drug in rats is 775mg/kg when given orally, and 1690mg/kg when given orally to mice. As the dosage increases, the animals may become increasingly sedated and eventually stop breathing. Dogs may vomit after 15-30 minutes when given high doses of the drug. Some side effects of the drug in humans include nausea, vomiting, drowsiness, dizziness, headaches, and irritability.
Metaxalone Novel Uses: Which Conditions Have a Clinical Trial Featuring Metaxalone?
There are 177 active clinical trials examining the potential of Metaxalone in alleviating Musculoskeletal Diseases.Condition
Clinical Trials
Trial Phases
Musculoskeletal Diseases
2 Actively Recruiting
Not Applicable
Chronic Pain
143 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 4, Phase 3, Early Phase 1
Metaxalone Reviews: What are patients saying about Metaxalone?
5Patient Review
7/28/2020 I've been using this medication to relieve severe leg cramps for over a decade now. These cramps often come at night without warning and can be incredibly painful. This medication helps fairly quickly, which allows me to get some much-needed rest.
5Patient Review
6/3/20144Patient Review
1/29/2017 Though it made me nauseous, this medication was no more effective than Advil at reducing my back pain.
4Patient Review
2/10/2016 I'm not sure if it's the placebo effect or what, but I feel like this treatment is giving me mood swings.
3.3Patient Review
3/20/2016 I was told to take this medication three times a day, but I found that cutting the pills in half and only taking them at night worked better for me. The main side effect I experienced was fatigue, which was really disrupting my daily life. I'm hoping to find something else that will work better for me when I see my doctor next week.
Patient Q&A Section about metaxalone
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Does metaxalone help with anxiety?
"Metaxalone relaxes the central nervous system, which can help with anxiety, and has consequent side effects of dizziness, drowsiness, and sedation. The drug is only a short-term therapy."
Answered by AI
What is the side effects metaxalone?
"The following side effects may occur: drowsiness, dizziness, nausea, vomiting, and upset stomach. If any of these effects last or worsen, tell your doctor or pharmacist. Remember that this medication was prescribed because your doctor has determined that the benefit to you is greater than the risk of side effects."
Answered by AI
What is metaxalone used to treat?
"This medication is used to help relax the muscles in your body and relieve the discomfort caused by acute (short-term), painful muscle or bone conditions."
Answered by AI
Is metaxalone a strong muscle relaxer?
"Metaxalone is a muscle relaxant that can be used for treating sprains, strains, and other muscle-based pain. It is not as strong as some other muscle relaxers, but it causes fewer side effects. These side effects can include nausea, drowsiness, vomiting, dizziness, and irritability."
Answered by AI
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