Metaxalone

Chronic Pain, Musculoskeletal Diseases
Treatment
2 FDA approvals
20 Active Studies for Metaxalone

What is Metaxalone

MetaxaloneThe Generic name of this drug
Treatment SummaryMetaxalone is a medication used to treat muscle pain and stiffness. It is sold under the brand name Skelaxin, and works by calming the central nervous system. Metaxalone usually comes in an 800 mg tablet and has few side effects.
Skelaxinis the brand name
image of different drug pills on a surface
Metaxalone Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Skelaxin
Metaxalone
1962
134

Approved as Treatment by the FDA

Metaxalone, otherwise called Skelaxin, is approved by the FDA for 2 uses which include Chronic Pain and Musculoskeletal Diseases .
Chronic Pain
Helps manage Pain
Musculoskeletal Diseases
Helps manage Musculoskeletal Disorders

Effectiveness

How Metaxalone Affects PatientsMetaxalone is a drug that helps relieve pain from muscle injuries and conditions. It is usually taken at the same time as rest, physical therapy, and other treatments. It is not known exactly how this drug works, but it is thought to be due to its calming effects. Metaxalone does not directly make tense muscles relaxed.
How Metaxalone works in the bodyWe don't know exactly how metaxalone works, but it seems to cause a calming effect on the central nervous system.

When to interrupt dosage

The prescribed amount of Metaxalone is reliant on the identified disorder. The amount of dosage fluctuates, according to the method of delivery featured in the table below.
Condition
Dosage
Administration
Chronic Pain
800.0 mg, , 400.0 mg, 640.0 mg
, Oral, Tablet - Oral, Tablet, Kit
Musculoskeletal Diseases
800.0 mg, , 400.0 mg, 640.0 mg
, Oral, Tablet - Oral, Tablet, Kit

Warnings

There are 20 known major drug interactions with Metaxalone.
Common Metaxalone Drug Interactions
Drug Name
Risk Level
Description
Azelastine
Major
Metaxalone may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Ethanol
Major
Metaxalone may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Methylene blue
Major
Metaxalone may increase the serotonergic activities of Methylene blue.
Mirtazapine
Major
Metaxalone may increase the serotonergic activities of Mirtazapine.
Oliceridine
Major
The risk or severity of hypotension, sedation, death, somnolence, and respiratory depression can be increased when Metaxalone is combined with Oliceridine.
Metaxalone Toxicity & Overdose RiskThe toxic dose of the drug in rats is 775mg/kg when given orally, and 1690mg/kg when given orally to mice. As the dosage increases, the animals may become increasingly sedated and eventually stop breathing. Dogs may vomit after 15-30 minutes when given high doses of the drug. Some side effects of the drug in humans include nausea, vomiting, drowsiness, dizziness, headaches, and irritability.
image of a doctor in a lab doing drug, clinical research

Metaxalone Novel Uses: Which Conditions Have a Clinical Trial Featuring Metaxalone?

There are 177 active clinical trials examining the potential of Metaxalone in alleviating Musculoskeletal Diseases.
Condition
Clinical Trials
Trial Phases
Musculoskeletal Diseases
5 Actively Recruiting
Phase 1, Phase 2, Not Applicable
Chronic Pain
177 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Phase 4, Early Phase 1

Metaxalone Reviews: What are patients saying about Metaxalone?

5Patient Review
7/28/2020
Metaxalone for Muscle Spasm
I've been using this medication to relieve severe leg cramps for over a decade now. These cramps often come at night without warning and can be incredibly painful. This medication helps fairly quickly, which allows me to get some much-needed rest.
5Patient Review
6/3/2014
Metaxalone for Muscle Spasm
4Patient Review
1/29/2017
Metaxalone for Muscle Spasm
Though it made me nauseous, this medication was no more effective than Advil at reducing my back pain.
4Patient Review
2/10/2016
Metaxalone for Muscle Spasm
I'm not sure if it's the placebo effect or what, but I feel like this treatment is giving me mood swings.
3.3Patient Review
3/20/2016
Metaxalone for Muscle Spasm
I was told to take this medication three times a day, but I found that cutting the pills in half and only taking them at night worked better for me. The main side effect I experienced was fatigue, which was really disrupting my daily life. I'm hoping to find something else that will work better for me when I see my doctor next week.
3.3Patient Review
7/2/2014
Metaxalone for Muscle Spasm
2.3Patient Review
9/23/2016
Metaxalone for Muscle Spasm
I've been taking this medication since my work-related back injury, but I have yet to feel any relief.
2.3Patient Review
1/14/2022
Metaxalone for Muscle Spasm
I didn't find this to be any more effective than Flexeril for my tendonitis, but I did feel a bit less forgetful. However, the other side effects were really bad - stomach issues, fatigue, and general malaise. I actually wondered if I had a virus it was so bad.
2Patient Review
5/17/2016
Metaxalone for Muscle Spasm
This medicine didn't help me and the side effects were really bad.
1.7Patient Review
4/14/2022
Metaxalone for Muscle Spasm
I didn't feel any different after taking these.
1.7Patient Review
10/9/2014
Metaxalone for Muscle Spasm
1.3Patient Review
4/24/2021
Metaxalone for Muscle Spasm
I didn't find this treatment effective at all. I still experienced cramps and nausea.
1Patient Review
7/22/2020
Metaxalone for Muscle Spasm
I have a herniated disc in my neck and back, and this treatment did nothing to ease the pain or spasms.
1Patient Review
7/30/2022
Metaxalone for Muscle Spasm
Unfortunately, this medication did not relieve any of the pain I was experiencing in my back. The spasms actually got worse while I was taking it. I had to stop and ask my doctor for something stronger.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about metaxalone

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does metaxalone help with anxiety?

"Metaxalone relaxes the central nervous system, which can help with anxiety, and has consequent side effects of dizziness, drowsiness, and sedation. The drug is only a short-term therapy."

Answered by AI

What is the side effects metaxalone?

"The following side effects may occur: drowsiness, dizziness, nausea, vomiting, and upset stomach. If any of these effects last or worsen, tell your doctor or pharmacist. Remember that this medication was prescribed because your doctor has determined that the benefit to you is greater than the risk of side effects."

Answered by AI

What is metaxalone used to treat?

"This medication is used to help relax the muscles in your body and relieve the discomfort caused by acute (short-term), painful muscle or bone conditions."

Answered by AI

Is metaxalone a strong muscle relaxer?

"Metaxalone is a muscle relaxant that can be used for treating sprains, strains, and other muscle-based pain. It is not as strong as some other muscle relaxers, but it causes fewer side effects. These side effects can include nausea, drowsiness, vomiting, dizziness, and irritability."

Answered by AI

Clinical Trials for Metaxalone

Have you considered Metaxalone clinical trials? We made a collection of clinical trials featuring Metaxalone, we think they might fit your search criteria.
Have you considered Metaxalone clinical trials? We made a collection of clinical trials featuring Metaxalone, we think they might fit your search criteria.
Have you considered Metaxalone clinical trials? We made a collection of clinical trials featuring Metaxalone, we think they might fit your search criteria.