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What is Merrem
MeropenemThe Generic name of this drug
Treatment SummaryMeropenem is an antibiotic that can fight both gram-positive and gram-negative bacteria. It works by entering bacteria cells and disrupting the production of vital cell wall components, which leads to the death of the bacteria. In 2017, a combination of meropenem and another antibiotic was approved under the name vabomere and is used to treat complicated urinary tract infections in adults. The goal of this treatment is to reduce symptoms and clear the infection, if it is caused by susceptible bacteria.
Merrem IVis the brand name
Merrem Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Merrem IV
Meropenem
1996
52
Approved as Treatment by the FDA
Meropenem, commonly known as Merrem IV, is approved by the FDA for 4 uses like Abdominal Infection and Meningitis, Bacterial .Abdominal Infection
Meningitis, Bacterial
Communicable Diseases
Urinary Tract Infection (UTI)
Effectiveness
How Merrem Affects PatientsMeropenem is an antibiotic that works against a wide variety of bacteria, including both Gram-positive and Gram-negative. This drug works by entering bacterial cells and preventing them from making the components needed for their cell walls, eventually leading to death of the cells.
How Merrem works in the bodyMeropenem is an antibiotic that works by preventing bacteria from forming their cell walls. It easily passes through the cell walls of both Gram-positive and Gram-negative bacteria to reach its targets. It is particularly effective against PBPs 2, 3 and 4 found in Escherichia coli and Pseudomonas aeruginosa, and PBPs 1, 2 and 4 in Staphylococcus aureus.
When to interrupt dosage
The measure of Merrem relies upon the determined condition, such as Urinary Tract Infection (UTI), complicated Bacterial Urinary Tract Infections and Meningitis, Bacterial. The quantity of dosage fluctuates in accordance with the delivery mode described in the table below.Condition
Dosage
Administration
complicated Bacterial Urinary Tract Infections
, 100.0 mg/mL, 50.0 mg/mL, 500.0 mg, 1000.0 mg, 1.0 mg/mg
, Intravenous, Injection, Injection - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, solution - Intravenous, Injection, solution
Urinary Tract Infection (UTI)
, 100.0 mg/mL, 50.0 mg/mL, 500.0 mg, 1000.0 mg, 1.0 mg/mg
, Intravenous, Injection, Injection - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, solution - Intravenous, Injection, solution
Communicable Diseases
, 100.0 mg/mL, 50.0 mg/mL, 500.0 mg, 1000.0 mg, 1.0 mg/mg
, Intravenous, Injection, Injection - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, solution - Intravenous, Injection, solution
Meningitis, Bacterial
, 100.0 mg/mL, 50.0 mg/mL, 500.0 mg, 1000.0 mg, 1.0 mg/mg
, Intravenous, Injection, Injection - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, solution - Intravenous, Injection, solution
Abdominal Infection
, 100.0 mg/mL, 50.0 mg/mL, 500.0 mg, 1000.0 mg, 1.0 mg/mg
, Intravenous, Injection, Injection - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, solution - Intravenous, Injection, solution
Warnings
Merrem has a single contraindication. It should not be taken when exhibiting any of the conditions given in the following table.Merrem ContraindicationsCondition
Risk Level
Notes
Anaphylactic shock
Do Not Combine
Common Merrem Drug Interactions
Drug Name
Risk Level
Description
Vibrio cholerae CVD 103-HgR strain live antigen
Major
The therapeutic efficacy of Vibrio cholerae CVD 103-HgR strain live antigen can be decreased when used in combination with Meropenem.
Abacavir
Minor
Meropenem may decrease the excretion rate of Abacavir which could result in a higher serum level.
Aclidinium
Minor
Meropenem may decrease the excretion rate of Aclidinium which could result in a higher serum level.
Acrivastine
Minor
Meropenem may decrease the excretion rate of Acrivastine which could result in a higher serum level.
Albutrepenonacog alfa
Minor
Meropenem may decrease the excretion rate of Albutrepenonacog alfa which could result in a higher serum level.
Merrem Toxicity & Overdose RiskIn mice and rats, high doses of meropenem (2200-4000 mg/kg) intravenously can cause unsteady movement, difficulty breathing, seizures, and even death.
Merrem Novel Uses: Which Conditions Have a Clinical Trial Featuring Merrem?
27 active studies are currently assessing the potential of Merrem to mitigate Meningitis, Bacterial Abdominal Infections and Urinary Tract Infections (UTIs).Condition
Clinical Trials
Trial Phases
Communicable Diseases
0 Actively Recruiting
Urinary Tract Infection (UTI)
24 Actively Recruiting
Phase 2, Phase 1, Phase 4, Phase 3, Not Applicable
Meningitis, Bacterial
0 Actively Recruiting
complicated Bacterial Urinary Tract Infections
0 Actively Recruiting
Abdominal Infection
0 Actively Recruiting
Merrem Reviews: What are patients saying about Merrem?
5Patient Review
11/22/2015 I have anaphylactic reactions to most antibiotics, but Merrem is different. It's helped me a lot and I haven't had any major side effects.
5Patient Review
11/25/20074.3Patient Review
10/18/2011 Merrem has been working well for my daughter. The process of mixing and administering is easy, which is great. My only issue is how expensive it is; we're lucky to have good health care coverage!
4.3Patient Review
4/21/2013 This drug was completely effective and saved my life. I had bacterial meningitis for the second time and this medication healed me completely.
3.7Patient Review
11/5/2008 I was in the hospital for six days and they finally determined what was wrong with me. They started giving me Merrem IV every six hours, and I'm already feeling better. Up until now, nothing else had worked.
3.7Patient Review
10/31/2009 I'm allergic to most antibiotics, but this new IV form didn't bother me at all. I would love to find a pill form of it so I can recommend it to my doctor in the future. As for side effects, I didn't notice any.
1Patient Review
5/13/2013 This medication is unsuitable for bariatric patients and is very ineffective as a result. I have taken it for 10 days 3 x day and all it has done is make me sicker instead of better.
Patient Q&A Section about merrem
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is Merrem a strong antibiotic?
"Meropenem is considered a stronger antibiotic compared to other antibiotics. It is effective against many types of bacteria and can be used to treat severe or complicated infections when other antibiotics are not effective."
Answered by AI
What class of antibiotic is Merrem?
"It works by stopping the growth of bacteria.
Meropenem is an antibiotic that is used to treat a wide variety of bacterial infections. This medication stops the growth of bacteria by preventing them from creating the proteins they need to survive."
Answered by AI
Is Merrem a penicillin?
"Meropenem is an antibiotic that is effective against many of the same infections as penicillin. It may be an option for patients who are allergic to penicillin. However, because meropenem and penicillins have similar chemical structures, doctors often avoid using meropenem in patients who are allergic to penicillin."
Answered by AI
What is Merrem used for?
"Meropenem is an injection used to treat bacterial infections. It works by either killing the bacteria or preventing their growth. It will not work for infections caused by viruses, such as colds or the flu. This medicine must be given by a doctor or under their direct supervision."
Answered by AI