Melphalan

Q: What are the side effects of melphalan?

<p>Certain <a href="https://www.withpower.com/clinical-trials/cancer">cancer</a> treatments can cause bone marrow <a href="https://www.withpower.com/clinical-trials/depression">depression</a>, which may lead to a decrease in white blood cells, red blood cells, and platelets. This can cause a variety of symptoms, such as nausea and vomiting, soreness of the mouth and throat, hair loss, and loose bowel movements.</p>

conditioning regimens for allogeneic stem cell transplantation therapy, Bone Marrow Transplant, Multiple Myeloma

Treatment

20 Active Studies for Melphalan

Treatment for

conditioning regimens for allogeneic stem cell transplantation therapy

What is Melphalan

MelphalanThe Generic name of this drug

Treatment SummaryMelphalan is an antineoplastic drug that is used to treat certain types of cancer. It is composed of the levo isomer, racemic mixture, and dextro isomer. This drug is toxic to bone marrow, but does not cause much damage to other tissues. It is also considered a potential carcinogen.

Alkeranis the brand name

image of different drug pills on a surface

Melphalan Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Alkeran

Melphalan

1984

Effectiveness

How Melphalan Affects PatientsMelphalan is an anti-cancer medication that belongs to a group of drugs called alkylating agents. These drugs work by changing the structure of DNA strands and making it impossible for the cells to replicate. They also add substances to molecules which prevents them from being used correctly. Alkylating agents can cause cell death and stop tumor growth, but they affect cells regardless of what stage of the cell cycle they are in.

How Melphalan works in the bodyMelphalan damages DNA by attaching to individual DNA strands and preventing them from separating. It may also cause mutations in the DNA, leading to errors in replication or transcription. The damage is caused when repair enzymes try to correct the errors that have been introduced by melphalan.

When to interrupt dosage

The prescribed dosage of Melphalan is contingent upon the established condition, including Multiple Myeloma, Stem cell transplant and Epithelial Ovarian Cancer. The quantity of dosage is contingent upon the mode of delivery listed in the table below.

Condition

Dosage

Administration

Multiple Myeloma

, 5.0 mg/mL, 2.0 mg, 5.0 mg, 50.0 mg, 5.0 mg/mg, 200.0 mg

, Kit, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Kit - Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet, Kit; Powder, for solution; Solution, Intra-arterial; Intravenous, Kit; Powder, for solution; Solution - Intra-arterial; Intravenous, Kit; Powder, for solution; Solution - Intravenous, Kit; Powder, for solution - Intra-arterial; Intravenous, Kit; Powder, for solution, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Kit; Powder, for solution - Intravenous

conditioning regimens for allogeneic stem cell transplantation therapy

, 5.0 mg/mL, 2.0 mg, 5.0 mg, 50.0 mg, 5.0 mg/mg, 200.0 mg

Bone Marrow Transplant

, 5.0 mg/mL, 2.0 mg, 5.0 mg, 50.0 mg, 5.0 mg/mg, 200.0 mg

Warnings

Melphalan has a single contraindication, and combining it with the conditions listed in the table below should be avoided.Melphalan Contraindications

Condition

Risk Level

Notes

prior resistance to drug

Do Not Combine

There are 20 known major drug interactions with Melphalan.

Common Melphalan Drug Interactions

Drug Name

Risk Level

Description

2-Methoxyethanol

Major

The risk or severity of adverse effects can be increased when Melphalan is combined with 2-Methoxyethanol.

9-(N-methyl-L-isoleucine)-cyclosporin A

Major

The risk or severity of adverse effects can be increased when Melphalan is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.

Abatacept

Major

The risk or severity of adverse effects can be increased when Melphalan is combined with Abatacept.

Abetimus

Major

The risk or severity of adverse effects can be increased when Melphalan is combined with Abetimus.

Acteoside

Major

The risk or severity of adverse effects can be increased when Melphalan is combined with Acteoside.

Melphalan Toxicity & Overdose RiskOverdosing on Mitomycin C can lead to vomiting, sores in the mouth, diarrhea, and internal bleeding. The most common side effect is a decrease in bone marrow activity. The toxic dose in rats has been measured at 11.2mg/kg when taken orally.

image of a doctor in a lab doing drug, clinical research

Melphalan Novel Uses: Which Conditions Have a Clinical Trial Featuring Melphalan?

120 active clinical trials are presently exploring the potential of Melphalan for Bone Marrow Transplantation, Epithelial Ovarian Cancer and conditioning regimens for allogeneic stem cell transplantation therapy.

Condition

Clinical Trials

Trial Phases

Multiple Myeloma

6 Actively Recruiting

Phase 1, Phase 2

conditioning regimens for allogeneic stem cell transplantation therapy

0 Actively Recruiting

Bone Marrow Transplant

28 Actively Recruiting

Not Applicable, Phase 2, Early Phase 1, Phase 1

Melphalan Reviews: What are patients saying about Melphalan?

5Patient Review

10/17/2007

Melphalan for Cancer of the Ovary

I began this treatment on 5/27/07 and my CA number (a measure of the cancer cells in my body) went from 2000 to 48.5 in just a few months. My doctor and NP were both very impressed with the results. I would definitely recommend this treatment to others facing similar situations.

5Patient Review

1/2/2021

Melphalan for Multiple Myeloma

This drug has been working really well for my father. He's 75 years old and we tried two other treatments before this one, but neither of them worked as well as this one has.

5Patient Review

1/2/2021

Melphalan for Multiple Myeloma

This was the third treatment my father tried, and it finally worked. He's 75 years old.

5Patient Review

10/17/2007

Melphalan for Cancer of the Ovary

I started this drug on 5/27/07 and my CA number went down from 2000 to 48.5 in just a few months. This is an inexpensive and easy treatment that can be done at home, but you will need to get your blood levels checked regularly. I feel great right now, but I know that the cancer may come back in the future.

3.3Patient Review

6/4/2009

Melphalan for Multiple Myeloma

I started feeling sick two days after the treatment, and now it's been four days. I really don't like this feeling.

View All Reviews

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Patient Q&A Section about melphalan

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does melphalan cause hair loss?

"Melphalan treatment may cause hair loss. You may see thinning or loss of hair within two to four weeks of taking the first dose of Melphalan. Loss of hair may happen on eyebrows, eyelashes, and pubic areas."

Answered by AI

What type of chemotherapy is melphalan?

"Melphalan is a chemotherapy drug used to treat multiple myeloma. It works by inhibiting DNA and RNA synthesis, causing the death of both dividing and non-dividing tumor cells. It has been used to treat MM since the 1960s."

Answered by AI

Is melphalan a chemotherapy?

"Melphalan is a chemotherapy treatment that is used to treat a number of different cancer types. It can also be used as a part of a stem cell or bone marrow transplant. Melphalan is also known as Alkeran."

Answered by AI

What are the side effects of melphalan?

"Certain cancer treatments can cause bone marrow depression, which may lead to a decrease in white blood cells, red blood cells, and platelets. This can cause a variety of symptoms, such as nausea and vomiting, soreness of the mouth and throat, hair loss, and loose bowel movements."

Answered by AI

Clinical Trials for Melphalan

Have you considered Melphalan clinical trials? We made a collection of clinical trials featuring Melphalan, we think they might fit your search criteria.

Have you considered Melphalan clinical trials? We made a collection of clinical trials featuring Melphalan, we think they might fit your search criteria.