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What is Maxipime
CefepimeThe Generic name of this drug
Treatment SummaryCefepime is an antibiotic used to treat severe bacterial infections. It was developed in 1994 and works by killing bacteria that cause infections. Cefepime is more effective than third-generation antibiotics and can be used to treat pneumonia, infections caused by resistant bacteria, and low white blood cell counts.
Maxipimeis the brand name
Maxipime Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Maxipime
Cefepime
1996
53
Approved as Treatment by the FDA
Cefepime, also known as Maxipime, is approved by the FDA for 9 uses including Pneumonia and Pneumonia .Pneumonia
Pneumonia
Urinary tract infection
Urinary tract infection
Bacterial Infections
Febrile Neutropenia
Pyelonephritis
Urinary Tract Infection (UTI)
Abdominal Infection
Used to treat Complicated Intra-Abdominal Infections (cIAIs) in combination with Metronidazole
Effectiveness
How Maxipime Affects PatientsCefepime is an antibiotic that is used to treat certain types of bacterial infections. It is effective against both Gram-positive (e.g. Staphylococcus aureus) and Gram-negative (e.g. Escherichia coli and Pseudomonas aeruginosa) bacteria. It is not affected by certain enzymes that break down other antibiotics, giving it an advantage over other antibiotics. To be effective, the amount of cefepime in the patient's system needs to be higher than the amount of bacteria. Studies have shown that it can cross the blood-brain barrier and can also
How Maxipime works in the bodyCefepime kills bacteria by targeting proteins responsible for building bacterial cell walls. These proteins, known as penicillin-binding proteins, are disrupted by Cefepime, which causes the cell wall to weaken and the bacteria to die. Cefepime is effective against a wide range of Gram-positive and Gram-negative bacteria. It has a particularly strong affinity for three types of penicillin-binding proteins in Escherichia coli and Pseudomonas aeruginosa, as well as two types of proteins in Enterobacter cloacae.
When to interrupt dosage
The advised dosage of Maxipime is contingent upon the diagnosed condition, such as Urinary Tract Infection (UTI), Abdominal Infection and Urinary tract infection. The amount of dosage fluctuates as per the technique of delivery (e.g. Powder, for solution - Intravenous or Injection, powder, for solution - Intravenous) outlined in the table beneath.Condition
Dosage
Administration
Abdominal Infection
100.0 mg/mL, , 200.0 mg/mL, 1000.0 mg, 2000.0 mg, 500.0 mg, 100000.0 mg, 1.0 mg/mg, 2.0 mg/mg
, Intravenous, Injection, solution, Injection, solution - Intravenous, Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, Injection, powder, for solution - Intravenous, Injection, Injection - Intramuscular; Intravenous, Injection - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Powder, for solution - Intramuscular; Intravenous
Urinary tract infection
100.0 mg/mL, , 200.0 mg/mL, 1000.0 mg, 2000.0 mg, 500.0 mg, 100000.0 mg, 1.0 mg/mg, 2.0 mg/mg
, Intravenous, Injection, solution, Injection, solution - Intravenous, Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, Injection, powder, for solution - Intravenous, Injection, Injection - Intramuscular; Intravenous, Injection - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Powder, for solution - Intramuscular; Intravenous
Pyelonephritis
100.0 mg/mL, , 200.0 mg/mL, 1000.0 mg, 2000.0 mg, 500.0 mg, 100000.0 mg, 1.0 mg/mg, 2.0 mg/mg
, Intravenous, Injection, solution, Injection, solution - Intravenous, Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, Injection, powder, for solution - Intravenous, Injection, Injection - Intramuscular; Intravenous, Injection - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Powder, for solution - Intramuscular; Intravenous
Pneumonia
100.0 mg/mL, , 200.0 mg/mL, 1000.0 mg, 2000.0 mg, 500.0 mg, 100000.0 mg, 1.0 mg/mg, 2.0 mg/mg
, Intravenous, Injection, solution, Injection, solution - Intravenous, Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, Injection, powder, for solution - Intravenous, Injection, Injection - Intramuscular; Intravenous, Injection - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Powder, for solution - Intramuscular; Intravenous
Pneumonia
100.0 mg/mL, , 200.0 mg/mL, 1000.0 mg, 2000.0 mg, 500.0 mg, 100000.0 mg, 1.0 mg/mg, 2.0 mg/mg
, Intravenous, Injection, solution, Injection, solution - Intravenous, Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, Injection, powder, for solution - Intravenous, Injection, Injection - Intramuscular; Intravenous, Injection - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Powder, for solution - Intramuscular; Intravenous
Bacterial Infections
100.0 mg/mL, , 200.0 mg/mL, 1000.0 mg, 2000.0 mg, 500.0 mg, 100000.0 mg, 1.0 mg/mg, 2.0 mg/mg
, Intravenous, Injection, solution, Injection, solution - Intravenous, Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, Injection, powder, for solution - Intravenous, Injection, Injection - Intramuscular; Intravenous, Injection - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Powder, for solution - Intramuscular; Intravenous
Urinary Tract Infection (UTI)
100.0 mg/mL, , 200.0 mg/mL, 1000.0 mg, 2000.0 mg, 500.0 mg, 100000.0 mg, 1.0 mg/mg, 2.0 mg/mg
, Intravenous, Injection, solution, Injection, solution - Intravenous, Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, Injection, powder, for solution - Intravenous, Injection, Injection - Intramuscular; Intravenous, Injection - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Powder, for solution - Intramuscular; Intravenous
Febrile Neutropenia
100.0 mg/mL, , 200.0 mg/mL, 1000.0 mg, 2000.0 mg, 500.0 mg, 100000.0 mg, 1.0 mg/mg, 2.0 mg/mg
, Intravenous, Injection, solution, Injection, solution - Intravenous, Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, Injection, powder, for solution - Intravenous, Injection, Injection - Intramuscular; Intravenous, Injection - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Powder, for solution - Intramuscular; Intravenous
Urinary tract infection
100.0 mg/mL, , 200.0 mg/mL, 1000.0 mg, 2000.0 mg, 500.0 mg, 100000.0 mg, 1.0 mg/mg, 2.0 mg/mg
, Intravenous, Injection, solution, Injection, solution - Intravenous, Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, Injection, powder, for solution - Intravenous, Injection, Injection - Intramuscular; Intravenous, Injection - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Powder, for solution - Intramuscular; Intravenous
Meningitis, Bacterial
100.0 mg/mL, , 200.0 mg/mL, 1000.0 mg, 2000.0 mg, 500.0 mg, 100000.0 mg, 1.0 mg/mg, 2.0 mg/mg
, Intravenous, Injection, solution, Injection, solution - Intravenous, Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, Injection, powder, for solution - Intravenous, Injection, Injection - Intramuscular; Intravenous, Injection - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Powder, for solution - Intramuscular; Intravenous
Warnings
Maxipime has two contraindications and should not be administered while suffering from any of the conditions listed in the below table.Maxipime ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Cefepime may interact with Pulse Frequency
Severe Hypersensitivity Reactions
Do Not Combine
Cefepime may interact with Pulse Frequency
Common Maxipime Drug Interactions
Drug Name
Risk Level
Description
Neomycin
Major
The risk or severity of nephrotoxicity can be increased when Cefepime is combined with Neomycin.
Tenofovir
Major
Cefepime may increase the nephrotoxic activities of Tenofovir.
Tenofovir alafenamide
Major
Cefepime may increase the nephrotoxic activities of Tenofovir alafenamide.
Tenofovir disoproxil
Major
Cefepime may increase the nephrotoxic activities of Tenofovir disoproxil.
Vibrio cholerae CVD 103-HgR strain live antigen
Major
The therapeutic efficacy of Vibrio cholerae CVD 103-HgR strain live antigen can be decreased when used in combination with Cefepime.
Maxipime Toxicity & Overdose RiskTaking too much cefepime may cause changes in consciousness, jerking muscle movements, seizures, and long-lasting seizures. If the patient has kidney problems, dialysis should be used instead of peritoneal dialysis to remove the drug from the body. Research has not shown cefepime to have any negative effects on fertility or be carcinogenic or genotoxic.
Maxipime Novel Uses: Which Conditions Have a Clinical Trial Featuring Maxipime?
33 active trials are being conducted to determine the efficacy of Maxipime in treating Abdominal Infections, Bacterial Infections and Pneumonia.Condition
Clinical Trials
Trial Phases
Urinary tract infection
0 Actively Recruiting
Pneumonia
0 Actively Recruiting
Bacterial Infections
0 Actively Recruiting
Pyelonephritis
4 Actively Recruiting
Not Applicable, Phase 3
Pneumonia
0 Actively Recruiting
Urinary Tract Infection (UTI)
24 Actively Recruiting
Phase 2, Phase 1, Phase 4, Phase 3, Not Applicable
Meningitis, Bacterial
0 Actively Recruiting
Urinary tract infection
2 Actively Recruiting
Phase 2, Phase 3
Abdominal Infection
0 Actively Recruiting
Febrile Neutropenia
2 Actively Recruiting
Phase 2, Phase 4
Maxipime Reviews: What are patients saying about Maxipime?
4.3Patient Review
9/9/2009 I noticed that my urine has a very strong smell. At first I dismissed it but then realized it was the urine. The smell is like sour or metal. Am I the only one with this symptom? Well, besides the nasua and upset stomach?
3.7Patient Review
9/22/2007 I'm so sick of being sick all the time.
3.7Patient Review
11/4/2008 My young patient had a very high fever after taking this medication.
3.3Patient Review
4/6/2011 The side effects of this medication were eye irritation, itchiness, and loose stools. The good news is that it was easy to administer through my PICC line.
2Patient Review
11/25/2012 I experienced extreme tiredness, lethargy, and depression while taking this medication. I was also unable to retain any information effectively due to the nature of the medication.
Patient Q&A Section about maxipime
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What type of drug is MAXIPIME?
"This drug belongs to a class of antibiotics called cephalosporins. It works by preventing the growth of bacteria."
Answered by AI
Is MAXIPIME a penicillin?
"Maxipime is an antibiotic used to treat many kinds of bacterial infections, including severe or life-threatening forms."
Answered by AI
What is MAXIPIME used for?
"Maxipime (cefepime hydrochloride) is a broad-spectrum cephalosporin antibiotic that can be used to treat many different kinds of bacterial infections, including severe or life-threatening forms."
Answered by AI
Is MAXIPIME and cefepime the same?
"The administration of MAXIPIME is a mixture of cefepime hydrochloride and L-arginine. It contains the equivalent of not less than 90 percent and not more than 115 percent of the labeled amount of cefepime."
Answered by AI