Marplan

Depression

Treatment

1 FDA approval

20 Active Studies for Marplan

Treatment for

Depression

What is Marplan

IsocarboxazidThe Generic name of this drug

Treatment SummaryIsocarboxazid is a medication used to treat depression, anxiety disorders, and panic disorders. It works by inhibiting the activity of an enzyme called monoamine oxidase. This drug was created by Roche Pharmaceuticals and first approved by the FDA in 1959.

Marplanis the brand name

image of different drug pills on a surface

Marplan Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Marplan

Isocarboxazid

1959

Approved as Treatment by the FDA

Isocarboxazid, also known as Marplan, is approved by the FDA for 1 uses which include Depression .

Depression

Effectiveness

How Marplan Affects PatientsIsocarboxazid works by blocking the activity of an enzyme (MAO) in the brain, heart, and liver. This increases the amount of certain hormones like serotonin, epinephrine, norepinephrine, and dopamine in the nervous system and sympathetic nervous system. This increase in hormones is thought to be the reason why isocarboxazid is used to treat depression.

How Marplan works in the bodyIsocarboxazid works by blocking the action of enzymes in your nervous system, known as monoamine oxidases. These enzymes help break down serotonin and other important neurotransmitters. Isocarboxazid stops this process from happening, which can have a positive effect on your mood and mental state.

When to interrupt dosage

The suggested dosage of Marplan is contingent upon the determined circumstance. The amount of dosage is subject to the approach of administration laid out in the table beneath.

Condition

Dosage

Administration

Depression

, 10.0 mg

, Oral, Tablet - Oral, Tablet

Warnings

There are 20 known major drug interactions with Marplan.

Common Marplan Drug Interactions

Drug Name

Risk Level

Description

2,5-Dimethoxy-4-ethylamphetamine

Major

Isocarboxazid may increase the hypertensive activities of 2,5-Dimethoxy-4-ethylamphetamine.

2,5-Dimethoxy-4-ethylthioamphetamine

Major

Isocarboxazid may increase the hypertensive activities of 2,5-Dimethoxy-4-ethylthioamphetamine.

4-Bromo-2,5-dimethoxyamphetamine

Major

Isocarboxazid may increase the hypertensive activities of 4-Bromo-2,5-dimethoxyamphetamine.

4-Methoxyamphetamine

Major

Isocarboxazid may increase the hypertensive activities of 4-Methoxyamphetamine.

5-methoxy-N,N-dimethyltryptamine

Major

The metabolism of 5-methoxy-N,N-dimethyltryptamine can be decreased when combined with Isocarboxazid.

Marplan Toxicity & Overdose RiskNo studies have been conducted to determine if long-term use of this drug could cause cancer, mutations, or fertility problems.

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Marplan Novel Uses: Which Conditions Have a Clinical Trial Featuring Marplan?

602 active clinical trials are investigating the potential of Marplan in alleviating the symptoms of Depression.

Condition

Clinical Trials

Trial Phases

Depression

693 Actively Recruiting

Phase 2, Not Applicable, Phase 3, Phase 1, Early Phase 1, Phase 4

Marplan Reviews: What are patients saying about Marplan?

4Patient Review

12/4/2009

Marplan for Depression

I'm currently taking a low dose of Marplan, only 10 mg twice a day. I wonder if upping my dosage would help with my mood swings. Another change I've noticed since starting this medication is that I'm sweating more and have gained weight; not sure if those are related though.

1Patient Review

7/3/2012

Marplan for Major Depressive Disorder

The high cost of this medication is really prohibitive. My daughter has been on two other MAOI's without a change in her depression and I just can't afford to keep paying for something that may or may not work. It's so hard to say no when she needs help, but I just can't keep doing this financially.

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Patient Q&A Section about marplan

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What kind of drug is Marplan?

"Other antidepressants haven't worked for your depression symptoms? You might be prescribed Marplan, an MAOI. MAOIs are a type of antidepressant known to help with symptoms that may include anxiety, panic, or phobias."

Answered by AI

What are the side effects of Marplan?

"The side effects of Marplan can be sudden and severe, including headaches, a rapid heartbeat, stiffness in your neck, nausea, vomiting, cold sweats, vision problems, and sensitivity to light. Additionally, you may experience chest pain, a fast or slow heart rate, swelling, or rapid weight gain. In some cases, people have also reported jaundice (yellowing of the skin or eyes)."

Answered by AI

Is Marplan still available?

"GOVERNMENT WARNING: (1) These fraudulent online pharmacies may attempt to sell an illegal generic version of Marplan. These medications may be counterfeit and potentially unsafe. (2) There is currently no therapeutically equivalent version (generic) of Marplan available in the United States.

Marplan is a medication that is used to treat depression. It is available in the United States, but there is no generic version of the medication available at this time. There have been reports of fraudulent online pharmacies selling counterfeit versions of Marplan, which may be unsafe."

Answered by AI