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What is Loxitane
LoxapineThe Generic name of this drug
Treatment SummaryAn antipsychotic medication used to treat schizophrenia.
Loxapineis the brand name
Loxitane Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Loxapine
Loxapine
1988
78
Effectiveness
How Loxitane Affects PatientsLoxapine is a type of tranquilizer used to treat psychological disorders. It works by blocking certain receptors in the brain, like those that affect dopamine and serotonin, which can help to reduce aggression and promote a calming effect. The exact way it works is unknown, but it is believed that it helps to inhibit activity in the brain.
How Loxitane works in the bodyLoxapine works to reduce excitability in the brain and calm people down. It does this by blocking the effects of dopamine and serotonin, two chemicals in the brain that can increase activity. The exact way it works is unknown, but it has been seen to reduce aggression and promote relaxation in animals.
When to interrupt dosage
The measure of Loxitane is contingent upon the diagnosed affliction, including Acute Agitation, Schizophrenia and Bipolar Disorder. The amount of dosage fluctuates as per the technique of delivery outlined in the following table.Condition
Dosage
Administration
Schizophrenia
, 5.0 mg, 10.0 mg, 50.0 mg, 25.0 mg, 2.5 mg, 13.6 mg, 34.0 mg, 6.8 mg, 68.0 mg, 4.5 mg, 9.1 mg, 50.0 mg/mL, 25.0 mg/mL
, Oral, Capsule, Capsule - Oral, Intramuscular, Liquid, Liquid - Intramuscular, Tablet, Tablet - Oral, Solution, Solution - Oral, Liquid - Oral, Respiratory (inhalation), Powder, metered, Powder, metered - Respiratory (inhalation), Aerosol, powder, Aerosol, powder - Respiratory (inhalation)
Bipolar Disorder
, 5.0 mg, 10.0 mg, 50.0 mg, 25.0 mg, 2.5 mg, 13.6 mg, 34.0 mg, 6.8 mg, 68.0 mg, 4.5 mg, 9.1 mg, 50.0 mg/mL, 25.0 mg/mL
, Oral, Capsule, Capsule - Oral, Intramuscular, Liquid, Liquid - Intramuscular, Tablet, Tablet - Oral, Solution, Solution - Oral, Liquid - Oral, Respiratory (inhalation), Powder, metered, Powder, metered - Respiratory (inhalation), Aerosol, powder, Aerosol, powder - Respiratory (inhalation)
Acute Agitation
, 5.0 mg, 10.0 mg, 50.0 mg, 25.0 mg, 2.5 mg, 13.6 mg, 34.0 mg, 6.8 mg, 68.0 mg, 4.5 mg, 9.1 mg, 50.0 mg/mL, 25.0 mg/mL
, Oral, Capsule, Capsule - Oral, Intramuscular, Liquid, Liquid - Intramuscular, Tablet, Tablet - Oral, Solution, Solution - Oral, Liquid - Oral, Respiratory (inhalation), Powder, metered, Powder, metered - Respiratory (inhalation), Aerosol, powder, Aerosol, powder - Respiratory (inhalation)
Warnings
Loxitane has twenty-one contraindications and must not be employed in cases of the disorders listed in the table below.Loxitane ContraindicationsCondition
Risk Level
Notes
Asthma
Do Not Combine
Lung Disorder
Do Not Combine
Brain Injuries, Traumatic
Do Not Combine
Shock
Do Not Combine
Disease
Do Not Combine
history of COPD
Do Not Combine
Comatose
Do Not Combine
Pulse Frequency
Do Not Combine
severe heart disorder
Do Not Combine
phoechromocytoma
Do Not Combine
Chronic Obstructive Pulmonary Disease
Do Not Combine
severe, drug-induced depressed states
Do Not Combine
Pulse Frequency
Do Not Combine
history of asthma
Do Not Combine
Impaired Renal Function
Do Not Combine
acute respiratory symptoms
Do Not Combine
Anesthesia, Cardiac Procedures
Do Not Combine
severe,drug-induced depressive states
Do Not Combine
Comatose
Do Not Combine
Disease
Do Not Combine
Pulse Frequency
Do Not Combine
Common Loxitane Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The serum concentration of Abemaciclib can be increased when it is combined with Loxapine.
Aclidinium
Major
The therapeutic efficacy of Aclidinium can be decreased when used in combination with Loxapine.
Amisulpride
Major
Loxapine may increase the antipsychotic activities of Amisulpride.
Arformoterol
Major
The therapeutic efficacy of Arformoterol can be decreased when used in combination with Loxapine.
Axitinib
Major
The serum concentration of Axitinib can be increased when it is combined with Loxapine.
Loxitane Toxicity & Overdose RiskThe lowest toxic dose of the drug in mice has been found to be 65mg/kg if taken orally.
Loxitane Novel Uses: Which Conditions Have a Clinical Trial Featuring Loxitane?
171 active studies are being conducted to analyze the potential of Loxitane in managing Schizophrenia, Bipolar Disorder and Acute Agitation.Condition
Clinical Trials
Trial Phases
Bipolar Disorder
1 Actively Recruiting
Phase 4
Schizophrenia
175 Actively Recruiting
Not Applicable, Phase 3, Phase 2, Early Phase 1, Phase 4, Phase 1
Acute Agitation
0 Actively Recruiting
Loxitane Reviews: What are patients saying about Loxitane?
4.3Patient Review
2/1/2008 I've only been on Loxitane for a short while, but I could tell it was helping me almost immediately. My thinking became clearer and I felt less anxious.
3.7Patient Review
10/26/2013 The patient has been taking the medication for just under six months and it has been helping. The morning dose is key, as that seems to be when the voices are most active. However, the patient still struggles with depression and often sleeps for 12-20 hours a day.
Patient Q&A Section about loxitane
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is loxapine used for depression?
"Loxapine is a drug used to treat agitation, schizophrenia, and depression. It increases levels of dopamine and serotonin in the brain, which helps to regulate these conditions."
Answered by AI
What are the side effects of loxitane?
"To minimize the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.
The following effects may occur: drowsiness, dizziness, lightheadedness, constipation, dry mouth, weight gain, or blurred vision. If you experience any of these effects, speak to your doctor or pharmacist. Dizziness and lightheadedness can make falls more likely. Rise slowly when moving from a sitting or lying position. To reduce the risk of dizziness and lightheadedness, rise slowly when moving from a sitting or lying position."
Answered by AI
What class of drug is loxitane?
"Loxitane is a prescription medicine that is used to treat the symptoms of schizophrenia. It is usually taken either alone or with other medications. Loxitane belongs to a class of drugs known as antipsychotics, 1st generation."
Answered by AI
What is loxitane used for?
"Loxapine is used to treat schizophrenia. It is a mental illness that causes disturbed or unusual thinking, loss of interest in life, and strong or inappropriate emotions. Loxapine is in a group of medications called conventional antipsychotics."
Answered by AI