Lodosyn

manganese intoxication, carbon monoxide intoxication, Parkinson's Disease + 3 more
Treatment
6 FDA approvals
20 Active Studies for Lodosyn

What is Lodosyn

CarbidopaThe Generic name of this drug
Treatment SummaryCarbidopa is a medication used to treat nausea in patients who are not responding to levodopa. It works by reducing the production of an enzyme called aromatic amino acid decarboxylase. It does not cross the blood-brain barrier and is always taken with levodopa. The first product containing only carbidopa was approved by the FDA in 2014 and the combination treatment of levodopa and carbidopa was approved by the FDA in 1992.
Sinemetis the brand name
image of different drug pills on a surface
Lodosyn Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Sinemet
Carbidopa
1975
299

Approved as Treatment by the FDA

Carbidopa, also called Sinemet, is approved by the FDA for 6 uses which include Symptomatic Parkinson Disease and levodopa-driven nausea and vomiting .
Symptomatic Parkinson Disease
Used to treat Symptomatic Parkinson Disease in combination with Levodopa
levodopa-driven nausea and vomiting
manganese intoxication
Used to treat manganese intoxication in combination with Levodopa
carbon monoxide intoxication
Used to treat carbon monoxide intoxication in combination with Levodopa
Parkinsonism post encephalitic
Used to treat Parkinsonism post encephalitic in combination with Levodopa
Parkinson's Disease
Used to treat Parkinson's Disease (PD) in combination with Levodopa

Effectiveness

How Lodosyn Affects PatientsCarbidopa, when taken with levodopa, stops levodopa from being converted to dopamine outside the brain and prevents oxitriptan from being changed to serotonin. This helps more levodopa get to the brain and be used by healthy dopamine neurons, which can reduce symptoms. Carbidopa also helps levodopa last longer in the body and less is needed for it to be effective, which in turn reduces the side effects like nausea.
How Lodosyn works in the bodyCarbidopa helps levodopa work better in the body by blocking an enzyme called DDC. This enzyme is found in the body's periphery and in the brain's blood barrier. Carbidopa stops DDC from breaking down levodopa, which keeps it active longer. It does not work in the brain, so it does not affect how dopamine is generated there.

When to interrupt dosage

The measure of Lodosyn is contingent upon the determined illness, including Symptomatic Parkinson Disease, carbon monoxide intoxication and Parkinson's Disease. The dosage also depends upon the method of administration specified in the table below.
Condition
Dosage
Administration
carbon monoxide intoxication
10.0 mg, 25.0 mg, , 50.0 mg, 31.25 mg, 37.5 mg, 12.5 mg, 18.75 mg, 23.75 mg, 48.75 mg, 61.25 mg, 36.25 mg, 4.63 mg/mL, 43.75 mg, 5.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Enteral, Gel, Gel - Enteral, Capsule, extended release, Capsule, extended release - Oral, Suspension, Suspension - Enteral
Parkinson's Disease
10.0 mg, 25.0 mg, , 50.0 mg, 31.25 mg, 37.5 mg, 12.5 mg, 18.75 mg, 23.75 mg, 48.75 mg, 61.25 mg, 36.25 mg, 4.63 mg/mL, 43.75 mg, 5.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Enteral, Gel, Gel - Enteral, Capsule, extended release, Capsule, extended release - Oral, Suspension, Suspension - Enteral
Symptomatic Parkinson Disease
10.0 mg, 25.0 mg, , 50.0 mg, 31.25 mg, 37.5 mg, 12.5 mg, 18.75 mg, 23.75 mg, 48.75 mg, 61.25 mg, 36.25 mg, 4.63 mg/mL, 43.75 mg, 5.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Enteral, Gel, Gel - Enteral, Capsule, extended release, Capsule, extended release - Oral, Suspension, Suspension - Enteral
levodopa-driven nausea and vomiting
10.0 mg, 25.0 mg, , 50.0 mg, 31.25 mg, 37.5 mg, 12.5 mg, 18.75 mg, 23.75 mg, 48.75 mg, 61.25 mg, 36.25 mg, 4.63 mg/mL, 43.75 mg, 5.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Enteral, Gel, Gel - Enteral, Capsule, extended release, Capsule, extended release - Oral, Suspension, Suspension - Enteral
Parkinsonism post encephalitic
10.0 mg, 25.0 mg, , 50.0 mg, 31.25 mg, 37.5 mg, 12.5 mg, 18.75 mg, 23.75 mg, 48.75 mg, 61.25 mg, 36.25 mg, 4.63 mg/mL, 43.75 mg, 5.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Enteral, Gel, Gel - Enteral, Capsule, extended release, Capsule, extended release - Oral, Suspension, Suspension - Enteral
manganese intoxication
10.0 mg, 25.0 mg, , 50.0 mg, 31.25 mg, 37.5 mg, 12.5 mg, 18.75 mg, 23.75 mg, 48.75 mg, 61.25 mg, 36.25 mg, 4.63 mg/mL, 43.75 mg, 5.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Enteral, Gel, Gel - Enteral, Capsule, extended release, Capsule, extended release - Oral, Suspension, Suspension - Enteral

Warnings

Lodosyn has two prohibitions and should be avoided in cases of the conditions set forth in the following table.Lodosyn Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Carbidopa may interact with Pulse Frequency
There are 20 known major drug interactions with Lodosyn.
Common Lodosyn Drug Interactions
Drug Name
Risk Level
Description
Abacavir
Minor
Carbidopa may decrease the excretion rate of Abacavir which could result in a higher serum level.
Acetaminophen
Minor
Carbidopa may decrease the excretion rate of Acetaminophen which could result in a higher serum level.
Aclidinium
Minor
Carbidopa may decrease the excretion rate of Aclidinium which could result in a higher serum level.
Acrivastine
Minor
Carbidopa may decrease the excretion rate of Acrivastine which could result in a higher serum level.
Albutrepenonacog alfa
Minor
Carbidopa may decrease the excretion rate of Albutrepenonacog alfa which could result in a higher serum level.
Lodosyn Toxicity & Overdose RiskThe most toxic dose of carbidopa found in rats was 4810 mg/kg. Animal studies showed that carbidopa had no effect on fertility or the development of cancer. If someone overdoses on carbidopa, they should be given a stomach pump and an intravenous fluid. An electrocardiogram should also be taken to track the heart rate.

Lodosyn Novel Uses: Which Conditions Have a Clinical Trial Featuring Lodosyn?

Currently, 49 active studies are investigating the potential of Lodosyn to reduce the symptoms of Parkinsonism post encephalitic, levodopa-driven nausea and vomiting and manganese intoxication.
Condition
Clinical Trials
Trial Phases
Parkinson's Disease
46 Actively Recruiting
Phase 3, Not Applicable, Phase 1, Phase 2, Early Phase 1
carbon monoxide intoxication
0 Actively Recruiting
levodopa-driven nausea and vomiting
0 Actively Recruiting
manganese intoxication
0 Actively Recruiting
Parkinsonism post encephalitic
0 Actively Recruiting
Symptomatic Parkinson Disease
4 Actively Recruiting
Phase 2

Lodosyn Reviews: What are patients saying about Lodosyn?

5Patient Review
1/3/2010
Lodosyn for Parkinson's Disease
In 2008, I was diagnosed with Parkinson's Disease. My doctor put me on Sinemet, which made me very sick within 2 days. She then had me start taking Lodosyn every time I took a dose of Sinemet (3 times daily), and this combination has worked very well for me.
5Patient Review
12/31/2008
Lodosyn for Parkinson's Disease
I was pleased to find that LODOSYN didn't make my stomach upset like some of the other drugs I've tried. The dosage is 1-3 times a day, and it doesn't have the same nasty side effects as other medications, so that's great.
5Patient Review
4/30/2010
Lodosyn for Parkinson's Disease
I had excellent results with this treatment and didn't experience any negative side effects.

Patient Q&A Section about lodosyn

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is carbidopa for?

"Carbidopa and levodopa combination is used to treat Parkinson's disease, which is a disorder of the central nervous system."

Answered by AI

Who makes LODOSYN?

"The tablets known as Lodosyn are a registered trademark of Aton Pharma, Inc."

Answered by AI

What is Lodosyn used for?

"Lodosyn (carbidopa) is a drug used in combination with levodopa to treat the symptoms of Parkinson's disease, such as stiffness, tremors, spasms, and poor muscle control."

Answered by AI

How much does Lodosyn cost?

"99

Lodosyn is used to treat the symptoms of Parkinson's disease. The generic version of Lodosyn is carbidopa. On average, a supply of 100, 25 mg Lodosyn oral tablets cost about $2,757.99"

Answered by AI

Clinical Trials for Lodosyn

Have you considered Lodosyn clinical trials? We made a collection of clinical trials featuring Lodosyn, we think they might fit your search criteria.
Have you considered Lodosyn clinical trials? We made a collection of clinical trials featuring Lodosyn, we think they might fit your search criteria.
Have you considered Lodosyn clinical trials? We made a collection of clinical trials featuring Lodosyn, we think they might fit your search criteria.
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