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What is Jardiance
EmpagliflozinThe Generic name of this drug
Treatment SummaryEmpagliflozin is a prescription medication used to help manage type 2 diabetes. It works by blocking a protein in the kidney that helps absorb glucose. This helps the body get rid of excess sugar in the urine instead of storing it in the blood. Empagliflozin was developed from a substance found in apple tree bark and approved by the FDA in 2014. It is more selective for SGLT2 than other medications in its class, meaning it has fewer side effects.
Jardianceis the brand name
Jardiance Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Jardiance
Empagliflozin
2014
24
Approved as Treatment by the FDA
Empagliflozin, also called Jardiance, is approved by the FDA for 6 uses including Type 2 Diabetes Mellitus and Physical Activity .Type 2 Diabetes Mellitus
Used to treat Type 2 Diabetes Mellitus in combination with Metformin
Physical Activity
Used to treat Exercise in combination with Metformin
Type 2 Diabetes
Used to treat Type 2 Diabetes Mellitus in combination with Metformin
Diet
Used to treat Diet in combination with Metformin
Cardiovascular Diseases
Cardiovascular Mortality
Effectiveness
How Jardiance Affects PatientsEmpagliflozin helps to lower blood sugar levels by preventing the body from reabsorbing glucose in the kidneys and instead passing it out in the urine. It is taken once-daily, but patients should be monitored for signs of ketoacidosis, even if their blood sugar is within a normal range. If a patient has acute kidney injury or develops chronic renal disease, empagliflozin may need to be stopped. Additionally, passing out more glucose in the urine can lead to an increased risk of urogenital infections, so patients should be monitored for any signs of infection.
How Jardiance works in the bodyEmpagliflozin increases the amount of glucose that is eliminated from the body through urine. It does this by targeting a particular transporter protein (SGLT2) in the kidneys that is responsible for reabsorbing glucose from the filtrate. This leads to a decrease in blood glucose levels. Empagliflozin also appears to have an independent cardiovascular benefit, though the exact mechanism is not known. Potential mechanisms include inhibition of specific proteins in the heart and kidneys, reduction of pre-load and blood pressure, prevention of cardiac fibrosis, and reduction of pro-inflammatory molecules.
When to interrupt dosage
The suggested measure of Jardiance is contingent upon the diagnosed condition, including Adrenal gland hypofunction, Diet and Physical Activity. The quantity of dosage is contingent upon the procedure of administration featured in the table below.Condition
Dosage
Administration
Cardiovascular Diseases
10.0 mg, 25.0 mg, , 5.0 mg, 12.5 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, extended release, Tablet, extended release - Oral
Type 2 Diabetes
10.0 mg, 25.0 mg, , 5.0 mg, 12.5 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, extended release, Tablet, extended release - Oral
Diet
10.0 mg, 25.0 mg, , 5.0 mg, 12.5 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, extended release, Tablet, extended release - Oral
Cardiovascular Mortality
10.0 mg, 25.0 mg, , 5.0 mg, 12.5 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, extended release, Tablet, extended release - Oral
Heart Failure
10.0 mg, 25.0 mg, , 5.0 mg, 12.5 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, extended release, Tablet, extended release - Oral
Therapeutic procedure
10.0 mg, 25.0 mg, , 5.0 mg, 12.5 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, extended release, Tablet, extended release - Oral
Ejection fraction decreased
10.0 mg, 25.0 mg, , 5.0 mg, 12.5 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, extended release, Tablet, extended release - Oral
Hospitalizations
10.0 mg, 25.0 mg, , 5.0 mg, 12.5 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, extended release, Tablet, extended release - Oral
Congestive Heart Failure
10.0 mg, 25.0 mg, , 5.0 mg, 12.5 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, extended release, Tablet, extended release - Oral
Physical Activity
10.0 mg, 25.0 mg, , 5.0 mg, 12.5 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, extended release, Tablet, extended release - Oral
Monotherapy
10.0 mg, 25.0 mg, , 5.0 mg, 12.5 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, extended release, Tablet, extended release - Oral
Warnings
Jardiance ContraindicationsCondition
Risk Level
Notes
Kidney Failure
Do Not Combine
Renal Dialysis
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Empagliflozin may interact with Pulse Frequency
Common Jardiance Drug Interactions
Drug Name
Risk Level
Description
Acetazolamide
Minor
Empagliflozin may increase the diuretic activities of Acetazolamide.
Ambrisentan
Minor
Empagliflozin may increase the hypotensive activities of Ambrisentan.
Amiloride
Minor
Empagliflozin may increase the diuretic activities of Amiloride.
Angiotensin 1-7
Minor
Empagliflozin may increase the hypotensive activities of Angiotensin 1-7.
Azosemide
Minor
Empagliflozin may increase the diuretic activities of Azosemide.
Jardiance Toxicity & Overdose RiskThere is little information on empagliflozin overdoses, so it is best to treat any overdose with supportive care and, if appropriate, decontamination of the stomach. Hemodialysis has not been studied in empagliflozin overdose, but it is unlikely to be beneficial since the drug binds strongly to proteins.
Jardiance Novel Uses: Which Conditions Have a Clinical Trial Featuring Jardiance?
526 active trials are currently being conducted to investigate the potential of Jardiance to improve Physical Activity, Adrenal Hypofunction and reduce Cardiovascular Mortality.Condition
Clinical Trials
Trial Phases
Cardiovascular Diseases
0 Actively Recruiting
Congestive Heart Failure
176 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 4, Phase 3, Early Phase 1
Type 2 Diabetes
177 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4, Early Phase 1
Hospitalizations
2 Actively Recruiting
Not Applicable
Monotherapy
1 Actively Recruiting
Phase 1, Phase 2
Heart Failure
0 Actively Recruiting
Diet
5 Actively Recruiting
Not Applicable, Phase 1
Therapeutic procedure
0 Actively Recruiting
Ejection fraction decreased
0 Actively Recruiting
Physical Activity
35 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Early Phase 1
Cardiovascular Mortality
0 Actively Recruiting
Jardiance Reviews: What are patients saying about Jardiance?
5Patient Review
12/9/2021 If you're considering this medication, I urge you to speak with your doctor first. Low doses twice a day have been working great for me in combination with diet and exercise. My sugar levels are the best they've been in years! Just be sure to drink plenty of water while taking it.
5Patient Review
6/4/2022 Jardiance has been a life-changing medication for me. In the short time that I have been taking it, my A1C levels have decreased significantly and I have lost over 100 pounds.
5Patient Review
6/13/2021 I contacted my doctor but he has failed to respon.
4Patient Review
6/13/2022 I've been taking Jardiance for eight months and my A1C has decreased from 8.7 to 5.3. I'm really happy with the results and haven't experienced any negative side effects yet.
2.7Patient Review
8/3/2021 I discontinued usage of Jardiance due to the adverse effects I experienced. These included but were not limited to dizziness, lightheadedness, and nausea. Furthermore, this medication is very costly; a three-month supply cost me over $300 dollars. If anyone knows where I could get a refund, please let me know at the email provided above.
Patient Q&A Section about jardiance
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What are the side effect of Jardiance?
"Symptoms of dehydration can include dizziness, lightheadedness, weakness, yeast infection, low blood sugar, nausea, and upper respiratory tract infection."
Answered by AI
Is Jardiance the same as metformin?
"Both metformin and Jardiance help to control blood sugar and lower hemoglobin A1C, though they work in slightly different ways."
Answered by AI
Do you lose weight on Jardiance?
"The bottom line is that Jardiance can lead to moderate weight loss in patients when taken alone or when combined with other medications. Overall, patients could lose 2% to 3% of their weight, although this is variable and can be affected by many factors, such as diet and exercise."
Answered by AI
What is Jardiance used for?
"JARDIANCE is a prescription medicine used to: lower blood sugar in adults with type 2 diabetes when used with diet and exercise. reduce the risk of cardiovascular death in adults with type 2 diabetes and known cardiovascular disease."
Answered by AI
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