What is Jardiance
EmpagliflozinThe Generic name of this drug
Treatment SummaryEmpagliflozin is a prescription medication used to help manage type 2 diabetes. It works by blocking a protein in the kidney that helps absorb glucose. This helps the body get rid of excess sugar in the urine instead of storing it in the blood. Empagliflozin was developed from a substance found in apple tree bark and approved by the FDA in 2014. It is more selective for SGLT2 than other medications in its class, meaning it has fewer side effects.
Jardianceis the brand name
Jardiance Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Jardiance
Empagliflozin
2014
24
Approved as Treatment by the FDA
Empagliflozin, also called Jardiance, is approved by the FDA for 5 uses including Diet and Cardiovascular Mortality .Diet
Used to treat Diet in combination with Metformin
Cardiovascular Mortality
Physical Activity
Used to treat Exercise in combination with Metformin
Type 2 Diabetes
Used to treat Type 2 Diabetes Mellitus in combination with Metformin
Cardiovascular Diseases
Effectiveness
How Jardiance Affects PatientsEmpagliflozin helps to lower blood sugar levels by preventing the body from reabsorbing glucose in the kidneys and instead passing it out in the urine. It is taken once-daily, but patients should be monitored for signs of ketoacidosis, even if their blood sugar is within a normal range. If a patient has acute kidney injury or develops chronic renal disease, empagliflozin may need to be stopped. Additionally, passing out more glucose in the urine can lead to an increased risk of urogenital infections, so patients should be monitored for any signs of infection.
How Jardiance works in the bodyEmpagliflozin increases the amount of glucose that is eliminated from the body through urine. It does this by targeting a particular transporter protein (SGLT2) in the kidneys that is responsible for reabsorbing glucose from the filtrate. This leads to a decrease in blood glucose levels. Empagliflozin also appears to have an independent cardiovascular benefit, though the exact mechanism is not known. Potential mechanisms include inhibition of specific proteins in the heart and kidneys, reduction of pre-load and blood pressure, prevention of cardiac fibrosis, and reduction of pro-inflammatory molecules.
When to interrupt dosage
The suggested measure of Jardiance is contingent upon the diagnosed condition, including Adrenal gland hypofunction, Diet and Physical Activity. The quantity of dosage is contingent upon the procedure of administration featured in the table below.Condition
Dosage
Administration
Adrenal gland hypofunction
, 5.0 mg, 12.5 mg, 10.0 mg, 25.0 mg
, Tablet, film coated, Oral, Tablet - Oral, Tablet, extended release, Tablet, Tablet, extended release - Oral, Tablet, film coated - Oral
Diet
, 5.0 mg, 12.5 mg, 10.0 mg, 25.0 mg
, Tablet, film coated, Oral, Tablet - Oral, Tablet, extended release, Tablet, Tablet, extended release - Oral, Tablet, film coated - Oral
Physical Activity
, 5.0 mg, 12.5 mg, 10.0 mg, 25.0 mg
, Tablet, film coated, Oral, Tablet - Oral, Tablet, extended release, Tablet, Tablet, extended release - Oral, Tablet, film coated - Oral
Type 2 Diabetes
, 5.0 mg, 12.5 mg, 10.0 mg, 25.0 mg
, Tablet, film coated, Oral, Tablet - Oral, Tablet, extended release, Tablet, Tablet, extended release - Oral, Tablet, film coated - Oral
Cardiovascular Mortality
, 5.0 mg, 12.5 mg, 10.0 mg, 25.0 mg
, Tablet, film coated, Oral, Tablet - Oral, Tablet, extended release, Tablet, Tablet, extended release - Oral, Tablet, film coated - Oral
Congestive Heart Failure
, 5.0 mg, 12.5 mg, 10.0 mg, 25.0 mg
, Tablet, film coated, Oral, Tablet - Oral, Tablet, extended release, Tablet, Tablet, extended release - Oral, Tablet, film coated - Oral
Hospitalizations
, 5.0 mg, 12.5 mg, 10.0 mg, 25.0 mg
, Tablet, film coated, Oral, Tablet - Oral, Tablet, extended release, Tablet, Tablet, extended release - Oral, Tablet, film coated - Oral
Cardiovascular Diseases
, 5.0 mg, 12.5 mg, 10.0 mg, 25.0 mg
, Tablet, film coated, Oral, Tablet - Oral, Tablet, extended release, Tablet, Tablet, extended release - Oral, Tablet, film coated - Oral
Warnings
Jardiance ContraindicationsCondition
Risk Level
Notes
Renal Dialysis
Do Not Combine
Kidney Failure
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Empagliflozin may interact with Toxoplasma Infections
Common Jardiance Drug Interactions
Drug Name
Risk Level
Description
Acetazolamide
Minor
Empagliflozin may increase the diuretic activities of Acetazolamide.
Ambrisentan
Minor
Empagliflozin may increase the hypotensive activities of Ambrisentan.
Amiloride
Minor
Empagliflozin may increase the diuretic activities of Amiloride.
Angiotensin 1-7
Minor
Empagliflozin may increase the hypotensive activities of Angiotensin 1-7.
Azosemide
Minor
Empagliflozin may increase the diuretic activities of Azosemide.
Jardiance Toxicity & Overdose RiskThere is little information on empagliflozin overdoses, so it is best to treat any overdose with supportive care and, if appropriate, decontamination of the stomach. Hemodialysis has not been studied in empagliflozin overdose, but it is unlikely to be beneficial since the drug binds strongly to proteins.
Jardiance Novel Uses: Which Conditions Have a Clinical Trial Featuring Jardiance?
526 active trials are currently being conducted to investigate the potential of Jardiance to improve Physical Activity, Adrenal Hypofunction and reduce Cardiovascular Mortality.Condition
Clinical Trials
Trial Phases
Adrenal gland hypofunction
20 Actively Recruiting
Early Phase 1, Not Applicable, Phase 1, Phase 2, Phase 4
Physical Activity
34 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Early Phase 1
Cardiovascular Mortality
0 Actively Recruiting
Cardiovascular Diseases
0 Actively Recruiting
Diet
3 Actively Recruiting
Not Applicable
Hospitalizations
6 Actively Recruiting
Phase 4, Not Applicable
Type 2 Diabetes
175 Actively Recruiting
Phase 2, Not Applicable, Phase 4, Early Phase 1, Phase 1, Phase 3
Congestive Heart Failure
317 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Early Phase 1, Phase 4
Jardiance Reviews: What are patients saying about Jardiance?
5Patient Review
12/9/2021 If you're considering this medication, I urge you to speak with your doctor first. Low doses twice a day have been working great for me in combination with diet and exercise. My sugar levels are the best they've been in years! Just be sure to drink plenty of water while taking it.
5Patient Review
6/4/2022 Jardiance has been a life-changing medication for me. In the short time that I have been taking it, my A1C levels have decreased significantly and I have lost over 100 pounds.
5Patient Review
6/13/2021 I contacted my doctor but he has failed to respon.
4Patient Review
6/13/2022 I've been taking Jardiance for eight months and my A1C has decreased from 8.7 to 5.3. I'm really happy with the results and haven't experienced any negative side effects yet.
2.7Patient Review
8/3/2021 I discontinued usage of Jardiance due to the adverse effects I experienced. These included but were not limited to dizziness, lightheadedness, and nausea. Furthermore, this medication is very costly; a three-month supply cost me over $300 dollars. If anyone knows where I could get a refund, please let me know at the email provided above.
2Patient Review
10/11/2022 I used Jardiance for almost a year, but it had no impact on my blood sugar levels. I also found myself going to the toilet more often, which is not an encouraging side effect.
2Patient Review
9/12/2022 I started experiencing problems after only two weeks of taking this medication. These included dizziness, an upset stomach, fatigue, and a rash. I also began having chest pain.
1.7Patient Review
11/5/2021 I stopped taking Jardiance because it was too expensive with Medicare and my PPO. Glimepiride does the job just as well, so I could have saved a lot of money.
1.7Patient Review
3/16/2022 I was placed on jardiance and found myself at the local ER fighting for my life. I was in active DKA and was placed in the ICU for 4 days. The ER doctor stated if I would not have came in when I did, I would have died within hours.
1Patient Review
9/18/2022 Jardiance caused me extreme allergic reactions: a raised rash that felt like mosquito bites all over my body; the itching was unbearable, major yeast infection, the palms of my hand and feet were red and tinder, not able to hold on to anything without major pain, stomach pain that is outragous, nausea. I had to use my Epi Pen and go to the ER. That medicine has been dumped.
Patient Q&A Section about jardiance
What are the side effect of Jardiance?
"Symptoms of dehydration can include dizziness, lightheadedness, weakness, yeast infection, low blood sugar, nausea, and upper respiratory tract infection." - Anonymous Online Contributor
Unverified Answer
Is Jardiance the same as metformin?
"Both metformin and Jardiance help to control blood sugar and lower hemoglobin A1C, though they work in slightly different ways." - Anonymous Online Contributor
Unverified Answer
Do you lose weight on Jardiance?
"The bottom line is that Jardiance can lead to moderate weight loss in patients when taken alone or when combined with other medications. Overall, patients could lose 2% to 3% of their weight, although this is variable and can be affected by many factors, such as diet and exercise." - Anonymous Online Contributor
Unverified Answer
What is Jardiance used for?
"JARDIANCE is a prescription medicine used to: lower blood sugar in adults with type 2 diabetes when used with diet and exercise. reduce the risk of cardiovascular death in adults with type 2 diabetes and known cardiovascular disease." - Anonymous Online Contributor
Unverified Answer