Jantoven

Atrial Fibrillation, cardiac valve replacement, mechanical heart valve + 10 more
Treatment
14 FDA approvals
20 Active Studies for Jantoven

What is Jantoven

WarfarinThe Generic name of this drug
Treatment SummaryWarfarin is an anticoagulant drug given to stop blood clots from forming and moving around in the body. It was originally used as a pesticide, but is now the most commonly prescribed oral anticoagulant in North America. Warfarin can cross the placental barrier during pregnancy which can cause fetal bleeding, miscarriage, premature birth or death of the baby. Other side effects include necrosis, purple toe syndrome, osteoporosis, and drug interactions. Warfarin does not actually change the thickness of the blood, instead it prevents the body from making certain clotting factors and other regulatory factors.
Coumadinis the brand name
image of different drug pills on a surface
Jantoven Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Coumadin
Warfarin
1995
557

Approved as Treatment by the FDA

Warfarin, otherwise known as Coumadin, is approved by the FDA for 14 uses which include Atrial Fibrillation and history of myocardial infarction .
Atrial Fibrillation
history of myocardial infarction
Venous Thrombosis (Disorder)
Deep Vein Thrombosis (DVT)
cardiac valve replacement
Atrial Fibrillation
Systemic Embolism
prophylaxis of Venous thrombosis
Disease
Pulmonary Embolism
Pulmonary Embolism
prophylaxis of Thromboembolic event
Stroke
Heart Attack

Effectiveness

How Jantoven Affects PatientsWarfarin is a medicine used to reduce the risk of blood clots in people with deep vein thrombosis, atrial fibrillation, or valve disease/replacement. It works by disrupting the clotting process, but this can also lead to adverse effects. In people with atherosclerosis, plaque rupture can cause cholesterol to escape and form small blockages in small vessels, leading to vision issues, acute/chronic kidney injury, central nervous system ischemia, and/or purple/blue toe syndrome. Warfarin-related nephropathy and calciphylaxis may also occur. Finally, it
How Jantoven works in the bodyWarfarin is a medication that stops the body from making vitamin K. Vitamin K is needed to create proteins that help blood clot. Without these proteins, the body is unable to form clots, which can lead to bleeding. Warfarin binds to an enzyme that helps turn vitamin K into its active form, preventing it from being recycled. This leads to a hypercoagulable state, where the body cannot form clots. To reverse this effect, vitamin K must be supplied from outside sources and the body must be given time to produce new clotting proteins. Antibiotics can also have an effect on warfarin,

When to interrupt dosage

The proposed measure of Jantoven is contingent upon the diagnosed condition, such as Pulmonary Embolism, Atrial Fibrillation and Heart Attack. The dosage relies on the technique of delivery as presented in the table below.
Condition
Dosage
Administration
prophylaxis of Thromboembolic event
, 3.0 mg, 4.0 mg, 10.0 mg, 1.0 mg, 2.5 mg, 5.0 mg, 2.0 mg, 6.0 mg, 7.5 mg, 2.0 mg/mL, 0.0075 mg
, Oral, Tablet, Tablet - Oral, Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
cardiac valve replacement
, 3.0 mg, 4.0 mg, 10.0 mg, 1.0 mg, 2.5 mg, 5.0 mg, 2.0 mg, 6.0 mg, 7.5 mg, 2.0 mg/mL, 0.0075 mg
, Oral, Tablet, Tablet - Oral, Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
prophylaxis of Venous thrombosis
, 3.0 mg, 4.0 mg, 10.0 mg, 1.0 mg, 2.5 mg, 5.0 mg, 2.0 mg, 6.0 mg, 7.5 mg, 2.0 mg/mL, 0.0075 mg
, Oral, Tablet, Tablet - Oral, Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Deep Vein Thrombosis (DVT)
, 3.0 mg, 4.0 mg, 10.0 mg, 1.0 mg, 2.5 mg, 5.0 mg, 2.0 mg, 6.0 mg, 7.5 mg, 2.0 mg/mL, 0.0075 mg
, Oral, Tablet, Tablet - Oral, Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Disease
, 3.0 mg, 4.0 mg, 10.0 mg, 1.0 mg, 2.5 mg, 5.0 mg, 2.0 mg, 6.0 mg, 7.5 mg, 2.0 mg/mL, 0.0075 mg
, Oral, Tablet, Tablet - Oral, Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Atrial Fibrillation
, 3.0 mg, 4.0 mg, 10.0 mg, 1.0 mg, 2.5 mg, 5.0 mg, 2.0 mg, 6.0 mg, 7.5 mg, 2.0 mg/mL, 0.0075 mg
, Oral, Tablet, Tablet - Oral, Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Pulmonary Embolism
, 3.0 mg, 4.0 mg, 10.0 mg, 1.0 mg, 2.5 mg, 5.0 mg, 2.0 mg, 6.0 mg, 7.5 mg, 2.0 mg/mL, 0.0075 mg
, Oral, Tablet, Tablet - Oral, Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Stroke
, 3.0 mg, 4.0 mg, 10.0 mg, 1.0 mg, 2.5 mg, 5.0 mg, 2.0 mg, 6.0 mg, 7.5 mg, 2.0 mg/mL, 0.0075 mg
, Oral, Tablet, Tablet - Oral, Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
mechanical heart valve
, 3.0 mg, 4.0 mg, 10.0 mg, 1.0 mg, 2.5 mg, 5.0 mg, 2.0 mg, 6.0 mg, 7.5 mg, 2.0 mg/mL, 0.0075 mg
, Oral, Tablet, Tablet - Oral, Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Transient Ischemic Attack (TIA)
, 3.0 mg, 4.0 mg, 10.0 mg, 1.0 mg, 2.5 mg, 5.0 mg, 2.0 mg, 6.0 mg, 7.5 mg, 2.0 mg/mL, 0.0075 mg
, Oral, Tablet, Tablet - Oral, Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Pulmonary Embolism
, 3.0 mg, 4.0 mg, 10.0 mg, 1.0 mg, 2.5 mg, 5.0 mg, 2.0 mg, 6.0 mg, 7.5 mg, 2.0 mg/mL, 0.0075 mg
, Oral, Tablet, Tablet - Oral, Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Heart Attack
, 3.0 mg, 4.0 mg, 10.0 mg, 1.0 mg, 2.5 mg, 5.0 mg, 2.0 mg, 6.0 mg, 7.5 mg, 2.0 mg/mL, 0.0075 mg
, Oral, Tablet, Tablet - Oral, Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Systemic Embolism
, 3.0 mg, 4.0 mg, 10.0 mg, 1.0 mg, 2.5 mg, 5.0 mg, 2.0 mg, 6.0 mg, 7.5 mg, 2.0 mg/mL, 0.0075 mg
, Oral, Tablet, Tablet - Oral, Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous

Warnings

Jantoven has twenty-seven contraindications, so it must not be used if you have any of the conditions in the following table.Jantoven Contraindications
Condition
Risk Level
Notes
Hypertension, Malignant
Do Not Combine
Hemorrhagic tendencies
Do Not Combine
Pericardial effusion
Do Not Combine
Anesthesia procedures
Do Not Combine
Hemorrhage
Do Not Combine
Eclampsia
Do Not Combine
high risk Patient Non-Compliance
Do Not Combine
Aorta
Do Not Combine
Lumbar Punctures
Do Not Combine
Disease
Do Not Combine
Stomach Ulcer
Do Not Combine
Endocarditis, Bacterial
Do Not Combine
Ulcer
Do Not Combine
inadequate access to laboratory facilities
Do Not Combine
Spontaneous abortion
Do Not Combine
Gastrointestinal Hemorrhage
Do Not Combine
Cerebral Aneurysm
Do Not Combine
Antepartum magnesium sulfate prophylaxis
Do Not Combine
Pericarditis
Do Not Combine
Hemorrhage
Do Not Combine
Heart Valve Prosthesis
Do Not Combine
Nervous system surgery
Do Not Combine
eye surgery
Do Not Combine
large open surfaces
Do Not Combine
Anesthesia procedures
Do Not Combine
Choroid Hemorrhage
Do Not Combine
Ulcer
Do Not Combine
Hemorrhage
Do Not Combine
There are 20 known major drug interactions with Jantoven.
Common Jantoven Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be increased when combined with Warfarin.
Albutrepenonacog alfa
Major
The therapeutic efficacy of Albutrepenonacog alfa can be decreased when used in combination with Warfarin.
Alectinib
Major
The metabolism of Alectinib can be increased when combined with Warfarin.
Aminophylline
Major
The metabolism of Aminophylline can be increased when combined with Warfarin.
Andexanet alfa
Major
The therapeutic efficacy of Andexanet alfa can be decreased when used in combination with Warfarin.
Jantoven Toxicity & Overdose RiskThe toxic dose (LD50) of warfarin varies by species. For mice, it is 3 mg/kg orally, 165 mg/kg intravenously, and 750 mg/kg by injection. For rats, it is 1.6 mg/kg orally, 320 mg/kg through inhalation, and 1400 mg/kg through skin contact. In rabbits, it is 800 mg/kg orally, and in dogs and cats it is 3 mg/kg and 6 mg/kg orally, respectively. In chickens, it is 942 mg/kg orally, and in guinea pigs, it is 180 mg/kg
image of a doctor in a lab doing drug, clinical research

Jantoven Novel Uses: Which Conditions Have a Clinical Trial Featuring Jantoven?

There are 301 active trials assessing the potential of Jantoven in providing relief for Atrial Fibrillation, Disease and Pulmonary Embolism.
Condition
Clinical Trials
Trial Phases
Atrial Fibrillation
96 Actively Recruiting
Not Applicable, Phase 2, Phase 4, Phase 1, Phase 3, Early Phase 1
Heart Attack
26 Actively Recruiting
Not Applicable, Phase 4, Phase 1, Phase 2, Early Phase 1, Phase 3
prophylaxis of Venous thrombosis
0 Actively Recruiting
cardiac valve replacement
0 Actively Recruiting
mechanical heart valve
0 Actively Recruiting
Transient Ischemic Attack (TIA)
2 Actively Recruiting
Phase 4, Not Applicable
Deep Vein Thrombosis (DVT)
4 Actively Recruiting
Not Applicable, Phase 2
Pulmonary Embolism
25 Actively Recruiting
Phase 4, Phase 3, Early Phase 1, Not Applicable
Stroke
9 Actively Recruiting
Phase 4, Phase 1, Not Applicable
Pulmonary Embolism
0 Actively Recruiting
Disease
0 Actively Recruiting
Systemic Embolism
3 Actively Recruiting
Not Applicable
prophylaxis of Thromboembolic event
0 Actively Recruiting

Jantoven Reviews: What are patients saying about Jantoven?

5Patient Review
5/21/2008
Jantoven for Abnormal Increase in Ability of Blood to Clot
I've been on this medication for four years without any issues. It's the first blood thinner that hasn't caused me problems.
5Patient Review
11/19/2010
Jantoven for Blood Clot in Lung
I was experiencing incredibly loud noises in my ears, like blood pumping through my veins. I switched to a new brand and have been on it for two days now with much better results.
5Patient Review
7/20/2011
Jantoven for Heart Failure with Paroxysmal Atrial Fibrillation
Jantoven is taken to prevent the possibility of stroke from AFIB. The only side effect for me is bruising on my arms from leaking capillaries. My INR readings are stable even though I drink alcohol and take cranberry extract. I don't understand the connection with cranberry which I've been taking along with many other supplements for years, but it's worth mentioning nonetheless.
3.3Patient Review
2/16/2016
Jantoven for Treatment to Prevent Blood Clots in Chronic Atrial Fibrillation
It seems like it's hard to keep my INR in the acceptable range.
3.3Patient Review
3/29/2012
Jantoven for Blood Clot in a Deep Vein
I have experienced dizziness, weight gain, and increased blood flow during my periods since starting this medication.
View All Reviews

Patient Q&A Section about jantoven

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How is Jantoven different from Coumadin?

"UPSHER-SMITH Laboratories supplies generic warfarin under the brand name Jantoven in the United States. warfarin is a registered trademark of UPSHER-SMITH. Jantoven is a generic form of warfarin, not a brand name like Coumadin. You can compare prices for Jantoven and other generic warfarin drugs and see the cost savings."

Answered by AI

Do you need INR for Jantoven?

"A PT/INR blood test will be taken while you use this medicine to monitor how well your blood is clotting. Your doctor will use the test results to determine if the medicine is effective."

Answered by AI

Is Jantoven better than warfarin?

"62% of reviewers reported a positive effect, while 8% reported a negative effect.

Jantoven has a positive rating on Drugs.com with an average of 9.0 out of 10 from a total of 2 reviewers. 100% of reviewers reported a positive effect, while 0% reported a negative effect. Warfarin has a positive rating on Drugs.com with an average of 8.3 out of 10 from a total of 53 reviewers. 62% of reviewers reported a positive effect, while 8% reported a negative effect."

Answered by AI

Is Jantoven same as warfarin?

"Warfarin is a drug that helps prevent blood clotting. It is also known as a blood thinner. This drug may be important if you have already had blood clots, or if your doctor is worried that you may form a blood clot."

Answered by AI

Clinical Trials for Jantoven

Have you considered Jantoven clinical trials? We made a collection of clinical trials featuring Jantoven, we think they might fit your search criteria.
Have you considered Jantoven clinical trials? We made a collection of clinical trials featuring Jantoven, we think they might fit your search criteria.
Have you considered Jantoven clinical trials? We made a collection of clinical trials featuring Jantoven, we think they might fit your search criteria.
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