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What is Isosorbide Mononitrate
Isosorbide mononitrateThe Generic name of this drug
Treatment SummaryIsosorbide mononitrate is a medication used to treat angina (chest pain) caused by coronary artery disease. It works by relaxing the smooth muscles of both arteries and veins, reducing the strain on the heart. Isosorbide mononitrate comes in oral tablets and extended-release forms and is available both generically and under the brand names ISMO, Monoket, and Imdur. It was approved by the FDA in 1991 and while it takes longer to start working than other medications, it lasts longer than nitroglycerin.
Monoketis the brand name
Isosorbide Mononitrate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Monoket
Isosorbide mononitrate
1993
188
Effectiveness
How Isosorbide Mononitrate Affects PatientsIsosorbide mononitrate is a drug used to prevent and manage angina, a chest pain caused by reduced blood flow to the heart. It works by producing nitric oxide, which relaxes the walls of your veins and arteries to reduce the amount of pressure on your heart. This can lead to reduced oxygen consumption in the heart, increased blood flow to blocked arteries, and relief from coronary spasms. The effects of the drug can be felt within 1-4 hours of taking it, and can last for up to 12 hours.
How Isosorbide Mononitrate works in the bodyIsosorbide mononitrate helps widen blood vessels in the body. When metabolized, it releases nitric oxide, which signals the walls of blood vessels to relax. This lets more blood and oxygen flow through the vessel, which helps reduce blood pressure and increase circulation. The relaxation of the vessel is caused by a decrease in the amount of calcium inside the cell, which allows it to loosen up and let more blood through.
When to interrupt dosage
The measure of Isosorbide Mononitrate is contingent upon the detected condition. The amount of dosage also fluctuates in agreement with the mode of administration (e.g. Tablet or Tablet, extended release) highlighted in the table underneath.Condition
Dosage
Administration
Coronary Artery Disease (CAD)
120.0 mg, , 30.0 mg, 60.0 mg, 20.0 mg, 10.0 mg
, Tablet, extended release, Oral, Tablet, extended release - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral
Chest Pain
120.0 mg, , 30.0 mg, 60.0 mg, 20.0 mg, 10.0 mg
, Tablet, extended release, Oral, Tablet, extended release - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral
Warnings
Isosorbide Mononitrate has three known contraindications, so it should not be ingested when confronting the conditions in the following table.Isosorbide Mononitrate ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Isosorbide Mononitrate may interact with Pulse Frequency
Common Isosorbide Mononitrate Drug Interactions
Drug Name
Risk Level
Description
Riociguat
Major
Isosorbide mononitrate may increase the hypotensive activities of Riociguat.
Sildenafil
Major
The risk or severity of hypotension can be increased when Isosorbide mononitrate is combined with Sildenafil.
Abacavir
Minor
Isosorbide mononitrate may decrease the excretion rate of Abacavir which could result in a higher serum level.
Acebutolol
Minor
The risk or severity of adverse effects can be increased when Isosorbide mononitrate is combined with Acebutolol.
Aclidinium
Minor
Isosorbide mononitrate may decrease the excretion rate of Aclidinium which could result in a higher serum level.
Isosorbide Mononitrate Toxicity & Overdose RiskThe lowest toxic dose of isosorbide mononitrate in rats is 2010mg/kg and 1771mg/kg in mice. Overdosing on this drug can cause a decrease in blood pressure, throbbing headache, confusion, vertigo, palpitations, visual disturbances, nausea and vomiting, difficulty breathing, clammy skin, slowed heart rate, paralysis, coma, seizures, and death. To treat an overdose, it is best to elevate the patient's legs and administer fluids intravenously. Dialysis may be used to remove the drug from the body. It is not recommended to use epinephrine or other medications
Isosorbide Mononitrate Novel Uses: Which Conditions Have a Clinical Trial Featuring Isosorbide Mononitrate?
11 active studies are examining the potential of Isosorbide Mononitrate to relieve Chest Pain symptoms.Condition
Clinical Trials
Trial Phases
Coronary Artery Disease (CAD)
1 Actively Recruiting
Not Applicable
Chest Pain
6 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 4
Isosorbide Mononitrate Reviews: What are patients saying about Isosorbide Mononitrate?
5Patient Review
8/4/2017 I've been taking this medication for a year now and have had bad diarrhea 5 times a day. I'm wondering if this is the cause or if it's my brilinta. Has anyone else had this problem on this drug?
5Patient Review
2/8/2021 I'm alive today because of this medication. I have to take it twice per day, but it's worth it.
5Patient Review
5/14/2020 I had a severe headache after taking this medication on the third day. However, my doctor told me to drink lots of water and that alleviated the problem.
5Patient Review
4/12/2018 I occasionally feel drowsy from this medication, but it's a small price to pay for the lack of headaches or other negative side effects. I take 20mg once daily, early in the morning.
5Patient Review
9/21/2017 I've been taking this medication for three weeks now with no negative side effects or problems whatsoever.
4.3Patient Review
10/22/2016 I was dealing with a really terrible headache accompanied by pain and numbness in my eye socket. I was also exhausted all the time, weak, and having trouble talking and walking.
4Patient Review
7/8/2017 Though I experience headaches as a side effect, this drug completely alleviates my angina pectoris.
4Patient Review
11/21/2021 I've only been taking this medication for a short while, but I already feel better. At first, I felt unsteady on my feet, but that went away pretty quickly. I also had a headache and chest pains, but those have both subsided partially. With continued use, I'm hoping all the side effects will go away completely.
3.7Patient Review
12/9/2015 I've been taking this for three months to manage my chest pain. It's effective, but I have fainted a few times and generally feel pretty tired all the time.
3.7Patient Review
2/28/2021 I'm pretty certain that these tablets are the cause of my recent issues with chest and throat pain, as well as shortness of breath. All the tests came back negative, but I've seen other reviews mentioning similar side effects.
3Patient Review
6/22/2015 I had a really tough time after taking this medication. I developed an excruciating headache that only got worse as the day went on, and then ended up vomiting all night long. It took two days for the pain to subside, and even now I still feel some residual effects. Overall, I would much rather deal with chest pain than go through that again.
1.7Patient Review
10/5/2016 At first, I had horrible headaches after taking this medication. However, I read a suggestion that said to take it an hour before bed. This has helped me immensely as now I only get headaches while sleeping and they're not nearly as bad.
1Patient Review
6/14/2021 This was a terrible experience. I fainted multiple times while taking this medication and only stopped after doing some research and discovering that fainting was a common side effect. It was also hard to get in touch with my doctor. Surely there's something better out there than this.
1Patient Review
4/25/2015Patient Q&A Section about isosorbide mononitrate
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is isosorbide mononitrate a blood pressure medication?
"Isosorbide mononitrate is an effective short-term treatment for reducing systolic blood pressure, pulse pressure, and pulse wave reflection in patients with systolic hypertension."
Answered by AI
What drug must not be prescribed when a patient is on isosorbide mononitrate?
"You should not take riociguat, sildenafil, tadalafil, or vardenafil while you are taking this medicine. Taking these medicines together can lower your blood pressure and cause blurred vision, dizziness, lightheadedness, or fainting."
Answered by AI
What isosorbide mononitrate is used for?
"Isosorbide mononitrate is used to prevent chest pain caused by coronary artery disease. It doesn't work quickly enough to relieve pain from an angina attack that has already started."
Answered by AI
What are side effects of isosorbide mononitrate?
"The following are potential symptoms of a heart problem: an abnormal heart sound, a decrease or absence of body movement, pain in the arm, back, or jaw, black or tarry stools, bladder pain, bleeding after defecation, blood in the urine or stools, or general body aches or pain."
Answered by AI