Isoptin

Cluster Headache, prophylaxis of Cluster headaches, Unstable Angina Pectoris + 7 more
Treatment
3 FDA approvals
20 Active Studies for Isoptin

What is Isoptin

VerapamilThe Generic name of this drug
Treatment SummaryVerapamil is a type of medication that blocks calcium from entering the cells in the body. It was first introduced in the 1960s and is used to treat high blood pressure, heart arrhythmias, and angina. Verapamil is a non-dihydropyridine calcium channel blocker, which means it is a different type of medicine than drugs like diltiazem and flunarizine. It is made up of two different components, called enantiomers, which work differently and are metabolized at different rates.
Calanis the brand name
image of different drug pills on a surface
Isoptin Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Calan
Verapamil
1984
357

Approved as Treatment by the FDA

Verapamil, also called Calan, is approved by the FDA for 3 uses which include Atrial Fibrillation or Flutter and Hypertensive disease .
Atrial Fibrillation or Flutter
Used to treat Atrial Fibrillation or Flutter in combination with Digitoxin
Hypertensive disease
Used to treat High Blood Pressure (Hypertension) in combination with Trandolapril
Heart Rate
Used to treat Heart Rate in combination with Digitoxin

Effectiveness

How Isoptin Affects PatientsVerapamil is a drug that helps regulate heart rhythm, reduce chest pain, and lower blood pressure. The regular form of this drug needs to be taken 3-4 times per day, but there is an extended-release version which can be taken once a day. Verapamil has a negative effect on the heart's ability to contract, so it should not be used by people with severe heart problems such as left ventricular dysfunction or hypertrophic cardiomyopathy.
How Isoptin works in the bodyVerapamil blocks the flow of calcium into certain cells, including those found in the heart and the blood vessels. This reduces how hard the heart needs to work and how much pressure the blood vessels need to endure, lowering both blood pressure and levels of angina. It also slows down the electrical activity of the heart, making it beat more slowly and helping to regulate an irregular heart rate. The exact way it works to treat cluster headaches is unknown, but it is thought to be related to blocking other types of calcium channels and potassium channels, as well as affecting adrenaline receptors.

When to interrupt dosage

The indicated dosage of Isoptin is contingent upon the diagnosed condition, such as Tachycardia, Ventricular, Unstable Angina Pectoris and Vasospastic Angina. The magnitude of dosage deviates as per the administration approach indicated in the table underneath.
Condition
Dosage
Administration
Heart Rate
180.0 mg, 240.0 mg, , 120.0 mg, 360.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 80.0 mg, 2.4 mg, 2.5 mg/mL, 40.0 mg, 160.0 mg, 5.0 mg/mL, 10.0 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Injection, Injection - Intravenous, Solution, Solution - Intravenous, Tablet, coated, Tablet, coated - Oral
Tachycardia, Ventricular
180.0 mg, 240.0 mg, , 120.0 mg, 360.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 80.0 mg, 2.4 mg, 2.5 mg/mL, 40.0 mg, 160.0 mg, 5.0 mg/mL, 10.0 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Injection, Injection - Intravenous, Solution, Solution - Intravenous, Tablet, coated, Tablet, coated - Oral
Paroxysmal Supraventricular Tachycardia (PSVT)
180.0 mg, 240.0 mg, , 120.0 mg, 360.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 80.0 mg, 2.4 mg, 2.5 mg/mL, 40.0 mg, 160.0 mg, 5.0 mg/mL, 10.0 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Injection, Injection - Intravenous, Solution, Solution - Intravenous, Tablet, coated, Tablet, coated - Oral
Atrial Fibrillation or Flutter
180.0 mg, 240.0 mg, , 120.0 mg, 360.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 80.0 mg, 2.4 mg, 2.5 mg/mL, 40.0 mg, 160.0 mg, 5.0 mg/mL, 10.0 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Injection, Injection - Intravenous, Solution, Solution - Intravenous, Tablet, coated, Tablet, coated - Oral
Cluster Headache
180.0 mg, 240.0 mg, , 120.0 mg, 360.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 80.0 mg, 2.4 mg, 2.5 mg/mL, 40.0 mg, 160.0 mg, 5.0 mg/mL, 10.0 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Injection, Injection - Intravenous, Solution, Solution - Intravenous, Tablet, coated, Tablet, coated - Oral
prophylaxis of Cluster headaches
180.0 mg, 240.0 mg, , 120.0 mg, 360.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 80.0 mg, 2.4 mg, 2.5 mg/mL, 40.0 mg, 160.0 mg, 5.0 mg/mL, 10.0 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Injection, Injection - Intravenous, Solution, Solution - Intravenous, Tablet, coated, Tablet, coated - Oral
Unstable Angina Pectoris
180.0 mg, 240.0 mg, , 120.0 mg, 360.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 80.0 mg, 2.4 mg, 2.5 mg/mL, 40.0 mg, 160.0 mg, 5.0 mg/mL, 10.0 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Injection, Injection - Intravenous, Solution, Solution - Intravenous, Tablet, coated, Tablet, coated - Oral
Vasospastic Angina
180.0 mg, 240.0 mg, , 120.0 mg, 360.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 80.0 mg, 2.4 mg, 2.5 mg/mL, 40.0 mg, 160.0 mg, 5.0 mg/mL, 10.0 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Injection, Injection - Intravenous, Solution, Solution - Intravenous, Tablet, coated, Tablet, coated - Oral
Chronic Stable Angina Pectoris
180.0 mg, 240.0 mg, , 120.0 mg, 360.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 80.0 mg, 2.4 mg, 2.5 mg/mL, 40.0 mg, 160.0 mg, 5.0 mg/mL, 10.0 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Injection, Injection - Intravenous, Solution, Solution - Intravenous, Tablet, coated, Tablet, coated - Oral
Hypertensive disease
180.0 mg, 240.0 mg, , 120.0 mg, 360.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 80.0 mg, 2.4 mg, 2.5 mg/mL, 40.0 mg, 160.0 mg, 5.0 mg/mL, 10.0 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Injection, Injection - Intravenous, Solution, Solution - Intravenous, Tablet, coated, Tablet, coated - Oral

Warnings

Isoptin Contraindications
Condition
Risk Level
Notes
third degree AV block
Do Not Combine
Ventricular Tachycardia
Do Not Combine
Atrial Fibrillation
Do Not Combine
Shock, Cardiogenic
Do Not Combine
accessory bypass tract
Do Not Combine
severe Left Ventricular Dysfunction
Do Not Combine
Pulse Frequency
Do Not Combine
Sick Sinus Syndrome
Do Not Combine
absence of a functioning ventricular pacemaker
Do Not Combine
Hypotension
Do Not Combine
Pulse Frequency
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Verapamil may interact with Pulse Frequency
There are 20 known major drug interactions with Isoptin.
Common Isoptin Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The serum concentration of Abemaciclib can be increased when it is combined with Verapamil.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Verapamil.
Acepromazine
Major
Verapamil may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Acepromazine.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Verapamil.
Alfuzosin
Major
Verapamil may increase the hypotensive activities of Alfuzosin.
Isoptin Toxicity & Overdose RiskThe lowest toxic dose of verapamil for women is 14.4 mg/kg and for men is 3.429 mg/kg. The lethal dose in rats is 150 mg/kg and in mice is 163 mg/kg. If someone overdoses on verapamil, there is no specific antidote. Treatment focuses on managing the symptoms such as low blood pressure, slow heartbeat, and irregular heart rhythm. Severe cases may require intravenous calcium, atropine, or other drugs to support the heart. If the overdose involved a sustained-release formulation, the person should be monitored closely for at least 48 hours.
image of a doctor in a lab doing drug, clinical research

Isoptin Novel Uses: Which Conditions Have a Clinical Trial Featuring Isoptin?

34 active clinical trials are currently evaluating the possibility of employing Isoptin as a treatment option for Chronic Stable Angina Pectoris, Tachycardia, Ventricular and Paroxysmal Supraventricular Tachycardia (PSVT).
Condition
Clinical Trials
Trial Phases
prophylaxis of Cluster headaches
0 Actively Recruiting
Tachycardia, Ventricular
0 Actively Recruiting
Atrial Fibrillation or Flutter
1 Actively Recruiting
Not Applicable
Unstable Angina Pectoris
0 Actively Recruiting
Vasospastic Angina
0 Actively Recruiting
Cluster Headache
4 Actively Recruiting
Phase 1, Phase 3, Phase 2
Hypertensive disease
19 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Heart Rate
1 Actively Recruiting
Not Applicable
Paroxysmal Supraventricular Tachycardia (PSVT)
2 Actively Recruiting
Phase 3, Phase 2
Chronic Stable Angina Pectoris
1 Actively Recruiting
Not Applicable

Isoptin Reviews: What are patients saying about Isoptin?

5Patient Review
7/11/2017
Isoptin for Cluster Headache Prevention
Isoptin really has helped to reduce the intensity of my cluster headaches. I still get them occasionally, but they're nowhere near as bad as they used to be.
5Patient Review
9/28/2008
Isoptin for High Blood Pressure
4Patient Review
3/17/2015
Isoptin for Type of Angina Where Chest Pain Occurs at Rest
For me, this medication caused some allergic reactions.
3.7Patient Review
3/2/2010
Isoptin for High Blood Pressure
I've been taking Verapamil for 15 years with no side effects. I take 240 mg daily to keep my blood pressure in check and it does a great job!
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about isoptin

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

When should you take isoptin?

"Take Isoptin tablets two or three times daily, or Isoptin SR tablets once or twice daily as directed by physician. Swallow tablets whole with a full glass of water."

Answered by AI

What is isoptin used for?

"The drugs Isoptin and Isoptin SR are used to treat high blood pressure and angina. Isoptin is also used to treat irregular heartbeats."

Answered by AI

Is isoptin a beta blocker?

"Isoptin SR is a type of calcium channel blocker that is used to treat hypertension (high blood pressure), angina (chest pain), and certain heart rhythm disorders. The brand name Isoptin SR is no longer available in the United States, but generic versions may be."

Answered by AI

What is the generic name of isoptin?

"This medication is a calcium channel blocker used to treat high blood pressure and angina. It may be used alone or with other medicines.

The name of this medication is Verapamil and it is taken orally. It is a calcium channel blocker used to treat high blood pressure and angina and can be used alone or with other medications."

Answered by AI

Clinical Trials for Isoptin

Have you considered Isoptin clinical trials? We made a collection of clinical trials featuring Isoptin, we think they might fit your search criteria.
Have you considered Isoptin clinical trials? We made a collection of clinical trials featuring Isoptin, we think they might fit your search criteria.
Have you considered Isoptin clinical trials? We made a collection of clinical trials featuring Isoptin, we think they might fit your search criteria.
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