Fluorescent Imaging for Premalignant Oral Lesions
Trial Summary
What is the purpose of this trial?
This clinical trial studies widefield fluorescence and reflectance imaging, fluorescence spectroscopy, and tissue samples in regularly examining (monitoring) participants at risk for developing oral cancer. All tissue and cells are made of tiny particles. Some of these particles give off small amounts of light. This light is called fluorescence. Fluorescent imaging use instruments that shine different wavelengths (colors) of light in the mouth taking fluorescence pictures through a portable head light or by taking fluorescent and reflectance pictures through a dental microscope using a digital camera. Fluorescent spectroscopy uses a small probe placed gently against the lining of the mouth and the tissue is exposed to small amounts of fluorescent light that is then collected with a special camera and a computer to be analyzed. Checking mouth tissue samples under a microscope may also help detect abnormal cells. Diagnostic procedures, such as fluorescence and reflectance imaging, fluorescence spectroscopy imaging, and tissue samples, may help doctors detect pre-cancer or early cancer when it may be easier to treat.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications.
What data supports the effectiveness of this treatment for premalignant oral lesions?
Research shows that using fluorescence imaging and spectroscopy can accurately diagnose precancerous and cancerous oral lesions in over 94% of cases. Additionally, multimodal imaging systems combining different types of optical imaging have been effective in identifying high-risk lesions and reducing unnecessary biopsies.12345
Is fluorescent imaging for premalignant oral lesions safe for humans?
The studies on fluorescent imaging techniques, such as multimodal optical imaging and laser confocal endomicroscopy, suggest that these methods are noninvasive and have been used safely in humans to detect oral lesions. They involve using light to create images of the mouth's tissues, which does not appear to pose significant safety risks.12456
How does fluorescent imaging differ from other treatments for premalignant oral lesions?
Fluorescent imaging for premalignant oral lesions is unique because it uses light to detect changes in tissue, allowing for real-time, noninvasive evaluation. This method can identify suspicious areas with high sensitivity and avoid unnecessary biopsies, unlike traditional methods that rely solely on visual inspection and biopsy.13457
Research Team
Ann M. Gillenwater
Principal Investigator
M.D. Anderson Cancer Center
Eligibility Criteria
This trial is for adults at high risk of developing oral cancer, including those with conditions like lichen planus, Fanconi anemia, heavy tobacco use, or premalignant lesions in the mouth. It's also open to patients with a history of head and neck cancer but currently show no signs of disease.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Diagnostic Imaging
Participants undergo oral mucosa examination using wide-field reflectance and fluorescence imaging, and/or fluorescence spectroscopy imaging. Standard oral brush biopsies are also performed and examined microscopically.
Follow-up
Participants may undergo repeated imaging procedures and biopsy during subsequent follow-up visits to monitor for carcinogenic progression.
Treatment Details
Interventions
- Cytology Specimen Collection Procedure
- Diagnostic Microscopy
- Fluorescence Imaging
- Fluorescence Spectroscopy
- Reflectance Imaging
Find a Clinic Near You
Who Is Running the Clinical Trial?
M.D. Anderson Cancer Center
Lead Sponsor
National Cancer Institute (NCI)
Collaborator