Phenazopyridine for Pain After Urodynamic Testing
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests whether phenazopyridine, commonly known as AZO, can reduce pain after urodynamic testing, a procedure that assesses how well the bladder and urethra store and release urine. Participants will either take the medication or not before the test to determine its effect on pain levels. Individuals who require urodynamic testing and can read and write in English or Spanish may be suitable candidates. As a Phase 4 trial, this research aims to understand how this FDA-approved and effective treatment can benefit more patients.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What is the safety track record for phenazopyridine?
Research has shown that the FDA approves phenazopyridine to alleviate symptoms like pain, burning, and urgency caused by urinary tract irritation, indicating its general safety for these uses. Studies have found that phenazopyridine may cause side effects such as an upset stomach, headache, or dizziness. However, these side effects are usually mild and resolve on their own. Phenazopyridine has been used successfully for many years to treat urinary discomfort, suggesting it is well-tolerated by most people. Always consult a healthcare provider to ensure it is suitable for individual needs.12345
Why are researchers enthusiastic about this study treatment?
Most treatments for pain after urodynamic testing typically don't involve medication beforehand, leaving patients to manage discomfort post-procedure. But phenazopyridine is unique because it's taken just before the test begins. This proactive approach aims to prevent discomfort right from the start, potentially offering immediate relief. Researchers are excited about phenazopyridine because it provides a new way to tackle pain by working as a local analgesic in the urinary tract, which is different from the usual reactive treatments. This could make a big difference for patients who undergo these tests, improving their overall experience and comfort.
What evidence suggests that phenazopyridine might be an effective treatment for pain after urodynamic testing?
Studies have shown that phenazopyridine reduces pain from urinary procedures. The FDA has approved it to relieve symptoms such as pain and burning during urination. Research indicates it provides quick pain relief after procedures similar to urodynamic testing. For example, one study found it effective for pain relief after cystoscopy, a similar urinary test. Phenazopyridine calms the lining of the urinary tract, lessening discomfort. In this trial, participants in the experimental arm will take phenazopyridine to evaluate its potential to reduce pain after urodynamic tests.12567
Who Is on the Research Team?
Elizabeth A Wilkinson, MD
Principal Investigator
University of South Florida
Are You a Good Fit for This Trial?
This trial is for individuals experiencing pain (dysuria) after urodynamic testing, which checks how well the bladder, sphincters, and urethra hold and release urine. Specific eligibility criteria are not provided.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo urodynamic testing with or without phenazopyridine administration
Follow-up
Participants are monitored for pain and anxiety levels after urodynamic testing
What Are the Treatments Tested in This Trial?
Interventions
- Phenazopyridine
Trial Overview
The study tests if Phenazopyridine Hydrochloride (99.5 MG), commonly known as AZO, can reduce pain following urodynamic studies compared to usual care without this medication.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Active Control
Patient to take two 99.5mg phenazopyridine hydrochloride (AZO) for a total of 199 mg by mouth once immediately prior to the start of urodynamic testing.
Patient to not receive any medication prior to the start of urodynamic testing.
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of South Florida
Lead Sponsor
Citations
NCT06577493 | Effectiveness of Phenazopyridine for Pain ...
The purpose of the study is to determine if taking phenazopyridine (AZO) at the time of urodynamic study testing will decrease pain experienced by patients ...
2.
trialx.com
trialx.com/clinical-trials/listings/319334/effectiveness-of-phenazopyridine-for-pain-following-urodynamics/Effectiveness of Phenazopyridine for Pain Following ...
The purpose of the study is to determine if taking phenazopyridine (AZO) at the time of urodynamic study testing will decrease pain experienced ...
Phenazopyridine for Pain After Urodynamic Testing
Phenazopyridine is generally used for short-term relief of urinary tract pain, but it can have side effects like orange urine, stomach issues, ...
Phenazopyridine - StatPearls - NCBI Bookshelf - NIH
Phenazopyridine is approved by the US Food and Drug Administration (FDA) to alleviate symptoms of dysuria, burning sensations, urgency, ...
A Randomized, Prospective, Placebo/Controlled Study for ...
We conclude that phenazopyridine HCl is effective for early acute pain relief following cystoscopy without side effects, and it is safe when used in combination ...
6.
mayoclinic.org
mayoclinic.org/drugs-supplements/phenazopyridine-oral-route/description/drg-20065473Phenazopyridine (oral route) - Side effects & dosage
Phenazopyridine is used to relieve the pain, burning, and discomfort caused by infection or irritation of the urinary tract.
Phenazopyridine (Azo, Pyridium, and others) – Uses, Side ...
Phenazopyridine is used to help reduce symptoms of a bladder infection, such as pain or burning. It does not help treat the infection.
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