ATEZOLIZUMAB for Breast Cancer
This study is evaluating whether a drug called atezolizumab can be used to treat brain metastases in people with HER2-positive breast cancer.
See full descriptionAbout the trial for Breast Cancer
Treatment Groups
This trial involves 2 different treatments. ATEZOLIZUMAB is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase 2 and have already been tested with other people.
About The Treatment
Eligibility
This trial is for patients born any sex aged 18 and older. There are 10 eligibility criteria to participate in this trial as listed below.
Approximate Timelines
Measurement Requirements
This trial is evaluating whether ATEZOLIZUMAB will improve 1 primary outcome and 9 secondary outcomes in patients with Breast Cancer. Measurement will happen over the course of 24 Weeks.
Patient Q & A Section
How many people get breast cancer a year in the United States?
Around 275,000 cases of [breast cancer](https://www.withpower.com/clinical-trials/breast-cancer) are diagnosed each year in the US, making it the second most common cancer in American women. Gender of the patient does not influence the prognosis, as the chance of the cancer recurs is similar in men and women.
What are the signs of breast cancer?
Nodes near the breast, nipple, or axilla might be palpated or feel lumpy, hard or tender to the touch. Women with breast cancer may also have lump or bump behind the armpit or groin and may have white patches or sores on their skin. Skin that does not appear normal can have redness, scaling, itching and rash. The size and shape of the breast can be seen by inspection and may vary by tumor type. Women with breast cancer may have changes in sensation, especially numbness, tingling, swelling or loss of sensation in the breasts.\n
What are common treatments for breast cancer?
The majority of women with breast cancer are treated to some degree; the use of chemotherapy may be higher for younger women. Rarely are patients treated with mastectomy; however, this may be advisable if their only option is a mastectomy.
What is breast cancer?
Patients can live longer than people diagnosed with other cancers, although the disease has a tendency to recur. It is a malignant disease, although many of the symptoms are less specific than typical cancer symptoms. Because of the number of women diagnosed, the lifetime risk is higher than any other cancer. Breast cancer affects more women than any other cancer. The disease is strongly associated with hormonal factors. Treatment requires a multidisciplinary approach, which generally includes surgery and chemotherapy, but the use of antiestrogens and trastuzumab in the neoadjuvant setting is also expanding. Treatment is expensive, but not, in most cases, completely effective, so relapse remains inevitable.
What causes breast cancer?
Recent findings provides evidences for the effect of cigarette smoking on breast cancer. The present work on cigarette smoking is also to be of interest for prevention and treatment of breast cancer.
Can breast cancer be cured?
Although the majority of patients with stage 4 breast cancer do not survive to 5 years after diagnosis, some patients with stage 0-3 can be cured with adequate chemotherapy. These patients can sometimes become completely asymptomatic and have a long-term prognosis without further treatment.
How does atezolizumab work?
Atezolizumab effectively blocks PD-1 and is the first antibody therapy that specifically inhibits PD-1. In clinical trials, patients treated with atezolizumab were shown to have an increase in survival as well as an increase in progression-free survival. Atezolizumab was shown to be well-tolerated and had activity against several types of breast cancer.
What is atezolizumab?
Atezolizumab improves progression-free survival in metastatic breast cancer in patients with HER2-positive or HER2-gene-amplified tumors. Clinical benefits of atezolizumab were greater in patients with tumors that overexpress a high HER2/neu level or that overexpress the hormone receptors. No meaningful difference was observed in those with tumors that only express a high HER2/neu level or those with tumors that have low levels of the receptor.
Is atezolizumab typically used in combination with any other treatments?
Patients with metastatic breast cancer who have progressed on or after platinum and taxane-based chemotherapy have a shorter median time to progression after atezolizumab treatment compared with patients treated with conventional therapies. In contrast, patients who respond to chemotherapy at the time of progression have longer progression-free survivals than patients treated with atezolizumab. The atezolizumab-based combination in this setting may help to prolong progression-free survival and prolong overall survival in patients who have progressed on their first-line treatment.
What is the primary cause of breast cancer?
Obesity, alcoholism, excess estrogen and smoking are known hereditary risk factors for breast cancer. This is the most important risk factor of breast cancer among Indian women.
What does atezolizumab usually treat?
Atezolizumab as a monotherapy is active in patients with metastatic tumors and shows promise as a second- or third-line immunotherapy. However, the majority of patients with a response to atezolizumab will have progressive disease that was previously under-treated or untreated.
Has atezolizumab proven to be more effective than a placebo?
Overall, we observed no significant difference in response rate or progression-free survival between atezolizumab and controls. We also observed no difference in response rate or time to progression between the two groups in patients who achieved partial response or stable disease.