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What is Irbesartan And Hydrochlorothiazide
IrbesartanThe Generic name of this drug
Treatment SummaryHydrochlorothiazide is a medication used to reduce swelling and high blood pressure. It is the most commonly prescribed thiazide diuretic, but its use has been declining in favor of other drugs like angiotensin converting enzyme inhibitors and angiotensin II receptor blockers. There are a variety of combination products available which pair hydrochlorothiazide with other medications. Hydrochlorothiazide was approved by the FDA in 1959.
Avaprois the brand name
Irbesartan And Hydrochlorothiazide Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Avapro
Irbesartan
1997
246
Approved as Treatment by the FDA
Irbesartan, also called Avapro, is approved by the FDA for 5 uses such as Hypertensive disease and multiple antihypertensive drugs likely required .Hypertensive disease
Helps manage High Blood Pressure (Hypertension)
multiple antihypertensive drugs likely required
Used to treat multiple antihypertensive drugs likely required in combination with Hydrochlorothiazide
not adequately controlled with monotherapy
Used to treat not adequately controlled with monotherapy in combination with Hydrochlorothiazide
Treatment Naive
Used to treat Treatment Naive in combination with Hydrochlorothiazide
Diabetic Nephropathy
Helps manage Diabetic Nephropathy
Effectiveness
How Irbesartan And Hydrochlorothiazide Affects PatientsHydrochlorothiazide helps the body get rid of excess water by preventing the reabsorption of sodium and water in the kidneys. The dose of this drug can vary depending on the individual, but typically ranges from 25-100mg. Hydrochlorothiazide should be used with caution in people with kidney or liver problems.
How Irbesartan And Hydrochlorothiazide works in the bodyHydrochlorothiazide works by reducing the amount of sodium that gets reabsorbed from the distal convoluted tubule. It does this by blocking a protein, Solute Carrier Family 12 Member 3 (SLC12A3), that normally helps move sodium into the epithelial cells. When this protein is blocked, there is less sodium in the epithelial cells, which creates a smaller concentration gradient between the tubule and the cell, reducing the amount of water that is reabsorbed.
When to interrupt dosage
The recommended portion of Irbesartan And Hydrochlorothiazide is contingent upon the acknowledged circumstance, such as Antepartum magnesium sulfate prophylaxis, blood pressure inadequately managed with monotherapy and antihypertensives. The amount of dosage fluctuates, in accordance with the delivery approach (e.g. Tablet, coated - Oral or Oral) featured in the table beneath.Condition
Dosage
Administration
Diabetic Nephropathy
150.0 mg, 300.0 mg, , 75.0 mg, 1.5 mg/mg, 3.0 mg/mg, 7.5 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral
Hypertensive disease
150.0 mg, 300.0 mg, , 75.0 mg, 1.5 mg/mg, 3.0 mg/mg, 7.5 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral
not adequately controlled with monotherapy
150.0 mg, 300.0 mg, , 75.0 mg, 1.5 mg/mg, 3.0 mg/mg, 7.5 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral
Treatment Naive
150.0 mg, 300.0 mg, , 75.0 mg, 1.5 mg/mg, 3.0 mg/mg, 7.5 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral
multiple antihypertensive drugs likely required
150.0 mg, 300.0 mg, , 75.0 mg, 1.5 mg/mg, 3.0 mg/mg, 7.5 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral
Warnings
Irbesartan And Hydrochlorothiazide ContraindicationsCondition
Risk Level
Notes
Hypesthesia
Do Not Combine
Volume depletion
Do Not Combine
Chronic Kidney Disease
Do Not Combine
Renal Artery Stenosis
Do Not Combine
Type 2 Diabetes
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Irbesartan may interact with Pulse Frequency
Common Irbesartan And Hydrochlorothiazide Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Irbesartan.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Irbesartan.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Irbesartan.
Amifostine
Major
Irbesartan may increase the hypotensive activities of Amifostine.
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Irbesartan.
Irbesartan And Hydrochlorothiazide Toxicity & Overdose RiskThe lowest toxic dose of hydrochlorothiazide in mice and rats is greater than 10g/kg. If a person overdoses on this drug, they may experience low levels of potassium, chlorine, or sodium in the blood. Treatment involves providing fluids, electrolytes, and oxygen, as well as administering vasopressors to treat low blood pressure.
Irbesartan And Hydrochlorothiazide Novel Uses: Which Conditions Have a Clinical Trial Featuring Irbesartan And Hydrochlorothiazide?
158 active trials are being conducted to assess the potential of Irbesartan And Hydrochlorothiazide in treating Cirrhosis, Edema and Congestive Heart Failure.Condition
Clinical Trials
Trial Phases
Diabetic Nephropathy
1 Actively Recruiting
Phase 4
Treatment Naive
0 Actively Recruiting
multiple antihypertensive drugs likely required
0 Actively Recruiting
not adequately controlled with monotherapy
0 Actively Recruiting
Hypertensive disease
19 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Irbesartan And Hydrochlorothiazide Reviews: What are patients saying about Irbesartan And Hydrochlorothiazide?
5Patient Review
1/22/2016 This treatment has been great for lowering my blood pressure. I haven't noticed any serious negative side effects, which is wonderful. The only downside is that I need to be near a bathroom in the morning as I have to go every 45 minutes or so.
4.3Patient Review
6/5/2013 The medication is keeping my blood pressure in check, but it's giving me some seriously weird dreams. I don't think it's impacting my waking life, but my dreaming life is totally different now. It makes me wonder if the drug is affecting my mind in some way.
4Patient Review
4/8/2017 I was not made aware of the risks this drug posed to my kidneys, and now I am in stage three kidney failure as a result.
3.7Patient Review
5/20/2014 This medication does wonders for my blood pressure, though I experience some pretty severe side effects including hair loss and vivid dreams.
3.7Patient Review
6/18/2017 I experienced extreme hair thinning while on this medication. My doctor told me that hair loss was not a side effect, but it was the only medication I was using at the time. After 2 years, I stopped taking the ibesartan and my hair has stopped falling out. So far, the hair I lost has not returned.
3.7Patient Review
7/8/2022 I was on irbesartan/HCTZ for several years and my hair got very thin (I am female). I asked to switch, now on olmesartan but that makes me very tired and gives stomach cramping.
3.3Patient Review
4/6/2022 In the last three years, I've experienced significant hair loss that corresponds with the time I've been taking irbesartan-HCTZ. I'm bringing this up at my next doctor's appointment and requesting a different blood pressure medication.
3Patient Review
10/30/2019 I started losing a significant amount of hair after just three months of using this product.
2.7Patient Review
9/22/2018 I'm starting to see my scalp more because of how much hair I'm losing. Additionally, I feel more rested and alert when I don't take this medication. Ocular migraines are also a new development since starting this treatment regimen.
2Patient Review
8/22/2020 I've been using this medication for three months and have seen a significant uptick in the number of rashes on my body, as well as hair loss. Not sure if I can continue use.
1.3Patient Review
11/6/2019 I'm really disappointed with this treatment. My hair is falling out and it's not doing anything to help.
1Patient Review
12/18/2016 I was really hoping this medication would work out, but unfortunately it just didn't. Not only did I experience some pretty nasty side effects like vomiting and diarrhea, but it also stopped being effective after a while.
1Patient Review
11/18/2017 I've been on this medication for three months and it has caused my kidney function to decline rapidly. I've also lost a lot of hair and my legs and ankles are constantly swollen. My doctor doesn't believe the meds are to blame, but I'm changing doctors anyways.
1Patient Review
7/23/2016 This treatment caused me to feel incredibly weak, always on the verge of cramping. The dreams it gave me were vivid and frightening, leaving me very confused in the morning. I also experienced fatigue and a lack of energy or enthusiasm.
1Patient Review
10/15/2019 This medication gave me headaches and low back pain. It was also too strong for my needs and made my tremor worse.
Patient Q&A Section about irbesartan and hydrochlorothiazide
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is the difference between irbesartan and Irbesartan Hydrochlorothiazide?
"Irbesartan is a drug that prevents constriction of blood vessels, which makes it easier for blood to flow. Hydrochlorothiazide is a diuretic, which means it helps rid the body of excess water and salt."
Answered by AI
Can irbesartan and hydrochlorothiazide lower blood pressure?
"As irbesartan relaxes the blood vessels, hydrochlorothiazide helps to lower the blood pressure by reducing the amount of water in the body and increasing the flow of urine."
Answered by AI
What is hydrochlorothiazide irbesartan used for?
"The combination of irbesartan and hydrochlorothiazide is used to treat high blood pressure either alone or with other medications. High blood pressure puts extra strain on the heart and arteries. If it is not treated, it can lead to long-term damage to the heart and arteries."
Answered by AI
What are the side effects of Irbesartan Hydrochlorothiazide?
"Bloody or cloudy urine, difficulty breathing, fast or irregular heartbeat, nausea or vomiting, numbness or tingling in the hands, feet, or lips, stomach pain, swelling, or weakness in the legs."
Answered by AI