Inqovi

Anemia, Refractory Anemia, Anemia + 6 more
Treatment
20 Active Studies for Inqovi

What is Inqovi

DecitabineThe Generic name of this drug
Treatment SummaryMyelodysplastic syndromes (MDS) are a group of blood disorders that can cause decreases in neutrophils and platelets. In some cases, MDS can lead to secondary acute myeloid leukemia which is difficult to treat. Decitabine is a medication used to treat MDS. It works by integrating into DNA and blocking the action of enzymes that cause cancerous cells to multiply. Decitabine was approved by the FDA in 2006 and is available as an oral combination product with the drug cedazuridine.
Dacogenis the brand name
Inqovi Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Dacogen
Decitabine
1996
36

Effectiveness

How Inqovi Affects PatientsDecitabine is a drug that is changed into a different form when it enters the body and affects how genes are expressed. Taking decitabine can lead to a decrease in white blood cells and platelets. It is also known to cause harm to unborn babies, so pregnant women should not take decitabine and those taking it should use effective birth control to avoid pregnancy.
How Inqovi works in the bodyDecitabine is a drug used to treat myelodysplastic syndromes. It works by trapping DNA methyltransferase enzymes, preventing them from carrying out their usual functions. This leads to a decrease in their levels and global hypomethylation of DNA, which can cause tumour suppressor genes to be expressed. Decitabine also causes double-stranded breaks in DNA, which can lead to cell death. In this way, it can reduce neoplastic cell growth while activating pathways involved in DNA damage response.

When to interrupt dosage

The proposed dosage of Inqovi is contingent upon the acknowledged condition, including Chronic Myelomonocytic Leukemia, Anemia and Refractory anemias. Dosage is also determined by the delivery technique (e.g. Intravenous or Injection, powder, for solution) specified in the table beneath.
Condition
Dosage
Administration
Myelodysplastic Syndrome
, 5.0 mg/mL, 50.0 mg, 35.0 mg
, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection, Injection - Intravenous, Powder - Intravenous, Powder, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral
Chronic Myelomonocytic Leukemia
, 5.0 mg/mL, 50.0 mg, 35.0 mg
, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection, Injection - Intravenous, Powder - Intravenous, Powder, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral
IPSS High Risk
, 5.0 mg/mL, 50.0 mg, 35.0 mg
, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection, Injection - Intravenous, Powder - Intravenous, Powder, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral
IPSS Risk Category Intermediate-1
, 5.0 mg/mL, 50.0 mg, 35.0 mg
, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection, Injection - Intravenous, Powder - Intravenous, Powder, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral
Anemia
, 5.0 mg/mL, 50.0 mg, 35.0 mg
, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection, Injection - Intravenous, Powder - Intravenous, Powder, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral
Anemia
, 5.0 mg/mL, 50.0 mg, 35.0 mg
, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection, Injection - Intravenous, Powder - Intravenous, Powder, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral
Refractory Anemia
, 5.0 mg/mL, 50.0 mg, 35.0 mg
, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection, Injection - Intravenous, Powder - Intravenous, Powder, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral
Anemia
, 5.0 mg/mL, 50.0 mg, 35.0 mg
, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection, Injection - Intravenous, Powder - Intravenous, Powder, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral
IPSS Risk Category Intermediate-2
, 5.0 mg/mL, 50.0 mg, 35.0 mg
, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection, Injection - Intravenous, Powder - Intravenous, Powder, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral

Warnings

There are 20 known major drug interactions with Inqovi.
Common Inqovi Drug Interactions
Drug Name
Risk Level
Description
2-Methoxyethanol
Major
The risk or severity of adverse effects can be increased when Decitabine is combined with 2-Methoxyethanol.
9-(N-methyl-L-isoleucine)-cyclosporin A
Major
The risk or severity of adverse effects can be increased when Decitabine is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
Abatacept
Major
The risk or severity of adverse effects can be increased when Decitabine is combined with Abatacept.
Abetimus
Major
The risk or severity of adverse effects can be increased when Decitabine is combined with Abetimus.
Acteoside
Major
The risk or severity of adverse effects can be increased when Decitabine is combined with Acteoside.
Inqovi Toxicity & Overdose RiskDecitabine has been linked to mutations in certain animal cells and DNA. When pregnant mice were given decitabine, their offspring were smaller and had reduced fertility. Adult male mice given decitabine for seven weeks had smaller testicles, fewer sperm, and decreased fertility. There is no known antidote for an overdose of decitabine, so the best way to treat it is to provide supportive care. Patients who overdose may be more likely to experience severe effects such as a decrease in white and red blood cells and platelets.

Inqovi Novel Uses: Which Conditions Have a Clinical Trial Featuring Inqovi?

183 active clinical trials are being conducted to assess the efficacy of Inqovi in alleviating Anemia, Refractory Anemia and Myelodysplastic Syndrome.
Condition
Clinical Trials
Trial Phases
Myelodysplastic Syndrome
116 Actively Recruiting
Phase 2, Phase 1, Phase 3, Not Applicable, Early Phase 1
Anemia
1 Actively Recruiting
Phase 2
Anemia
0 Actively Recruiting
IPSS Risk Category Intermediate-1
0 Actively Recruiting
IPSS Risk Category Intermediate-2
0 Actively Recruiting
Refractory Anemia
5 Actively Recruiting
Phase 2, Phase 1
Chronic Myelomonocytic Leukemia
49 Actively Recruiting
Phase 1, Phase 2, Phase 3
Anemia
0 Actively Recruiting
IPSS High Risk
0 Actively Recruiting

Inqovi Reviews: What are patients saying about Inqovi?

4.3Patient Review
4/11/2022
Inqovi for chronic myelomonocytic leukemia
I haven't experienced any serious side effects, though my energy levels have been a bit lower than usual.
4Patient Review
10/24/2021
Inqovi for Bone Marrow Disorders Occurring Before Leukemia
I've only been on this medication for a week, but the only side effect I've noticed is increased flatulence.
2.3Patient Review
5/6/2021
Inqovi for Bone Marrow Disorders Occurring Before Leukemia
The side effects were too intense for me to continue after just two months. My numbers bottomed out and I felt totally shredded.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about inqovi

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What kind of drug is Inqovi?

"Inqovi is a prescription medicine that is used to treat adults with myelodysplastic syndromes (MDS, including chronic myelomonocytic leukemia (CMML).Myelodysplastic syndromes are types of blood or bone marrow disorders."

Answered by AI

Is Inqovi chemotherapy?

"Inqovi is a new drug that pairs decitabine with cedazuridine. Decitabine is an established anti-cancer drug, but it is not effective when taken orally because it is broken down by an enzyme called cytidine deaminase. Cedazuridine inhibits this enzyme, making it possible for decitabine to be taken orally."

Answered by AI

How long does it take for Inqovi to work?

"You may not see the effects of INQOVI for 4 or more cycles. Your blood cell counts may change within the first 2 months. Your healthcare provider will take blood tests before you start treatment with INQOVI and again before each 28-day cycle to check how well the treatment is working."

Answered by AI

What is Inqovi used for?

"INQOVI is a medication used to treat adults with myelodysplastic syndromes, including chronic myelomonocytic leukemia. Myelodysplastic syndrome is a type of blood cancer in which blood cells in the bone marrow are defective, leading to a low number of one or more types of blood cells."

Answered by AI

Clinical Trials for Inqovi

Have you considered Inqovi clinical trials? We made a collection of clinical trials featuring Inqovi, we think they might fit your search criteria.
Have you considered Inqovi clinical trials? We made a collection of clinical trials featuring Inqovi, we think they might fit your search criteria.
Have you considered Inqovi clinical trials? We made a collection of clinical trials featuring Inqovi, we think they might fit your search criteria.