Ibandronate Sodium

Q: What are the side effects of ibandronate sodium?

<p>The symptoms of this illness include nausea, stomach <a href="https://www.withpower.com/clinical-trials/pain">pain</a>, diarrhea, constipation, weakness, dizziness, headache, fever, sore throat, chills, cough, and other signs of infection.</p>

Osteoporosis, Malignant Neoplasms, Bone Metastases + 1 more

Treatment

2 FDA approvals

20 Active Studies for Ibandronate Sodium

Treatment for

Osteoporosis

What is Ibandronate Sodium

IbandronateThe Generic name of this drug

Treatment SummaryIbandronate (also known as BM 21.0955) is a type of drug commonly used to help prevent and treat osteoporosis in postmenopausal women. It was first developed in 1993 as a treatment for bone loss in dogs and was approved by the FDA in 2003. Ibandronate is a third-generation bisphosphonate, which is similar to other drugs such as zoledronic acid, minodronic acid, and risedronic acid.

Bonivais the brand name

image of different drug pills on a surface

Ibandronate Sodium Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Boniva

Ibandronate

2005

Approved as Treatment by the FDA

Ibandronate, otherwise known as Boniva, is approved by the FDA for 2 uses which include Osteoporosis and Osteoporosis .

Osteoporosis

Helps manage Osteoporosis

Osteoporosis

Helps manage Osteoporosis

Effectiveness

How Ibandronate Sodium Affects PatientsIbandronate is a drug used to both treat and prevent weak bones in postmenopausal women. It is generally considered safe, with effects lasting up to 157 hours. However, it can have some side effects, including upper gastrointestinal problems, low calcium levels, muscle pain, jawbone death, unusual fractures of the thigh bone, and serious issues with the kidneys.

How Ibandronate Sodium works in the bodyBisphosphonates are taken into the bone and bind to hydroxyapatite. This helps to stop osteoclasts from breaking down the bone. Ibandronate, a nitrogen-based bisphosphonate, stops tumor cells from reproducing by blocking certain molecules from the mevalonate pathway. This stops GTP-binding proteins like Rap1 from functioning, resulting in cell death. Ibandronate also activates caspase-3, which also contributes to cell death.

When to interrupt dosage

The proposed measure of Ibandronate Sodium is contingent upon the determined circumstance, for example Bone Metastases, Malignant Neoplasms and Osteoporosis. Dosage additionally depends on the mode of delivery, as demonstrated in the table below.

Condition

Dosage

Administration

Malignant Neoplasms

, 3.0 mg/mL, 150.0 mg, 1.0 mg, 3.0 mg, 50.0 mg, 2.0 mg, 6.0 mg, 2.5 mg, 1.0 mg/mL

, Intravenous, Injection, solution, Injection, solution - Intravenous, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Injection, Injection - Intravenous

Breast Cancer

, 3.0 mg/mL, 150.0 mg, 1.0 mg, 3.0 mg, 50.0 mg, 2.0 mg, 6.0 mg, 2.5 mg, 1.0 mg/mL

Bone Metastases

, 3.0 mg/mL, 150.0 mg, 1.0 mg, 3.0 mg, 50.0 mg, 2.0 mg, 6.0 mg, 2.5 mg, 1.0 mg/mL

Osteoporosis

, 3.0 mg/mL, 150.0 mg, 1.0 mg, 3.0 mg, 50.0 mg, 2.0 mg, 6.0 mg, 2.5 mg, 1.0 mg/mL

Warnings

Ibandronate Sodium Contraindications

Condition

Risk Level

Notes

Esophageal Strictures

Do Not Combine

Hypocalcemia

Do Not Combine

Esophagus

Do Not Combine

Esophageal Achalasia

Do Not Combine

Orthostatic Intolerance

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Ibandronate may interact with Pulse Frequency

There are 20 known major drug interactions with Ibandronate Sodium.

Common Ibandronate Sodium Drug Interactions

Drug Name

Risk Level

Description

Hydroxyzine

Major

The risk or severity of QTc prolongation can be increased when Ibandronate is combined with Hydroxyzine.

Mobocertinib

Major

The risk or severity of QTc prolongation can be increased when Ibandronate is combined with Mobocertinib.

Ziprasidone

Major

The risk or severity of QTc prolongation can be increased when Ibandronate is combined with Ziprasidone.

Abexinostat

Minor

The risk or severity of QTc prolongation can be increased when Ibandronate is combined with Abexinostat.

Aceprometazine

Minor

The risk or severity of QTc prolongation can be increased when Ibandronate is combined with Aceprometazine.

Ibandronate Sodium Toxicity & Overdose RiskThose who take too much ibandronate may experience low calcium or phosphate levels, upset stomach, heartburn, esophagitis, and ulcers. To reduce absorption, patients can be given milk or antacids. Intravenous electrolytes may also be administered to help manage the overdose and dialysis is not expected to help remove the drug from the blood.

image of a doctor in a lab doing drug, clinical research

Ibandronate Sodium Novel Uses: Which Conditions Have a Clinical Trial Featuring Ibandronate Sodium?

729 active trials are currently underway to assess the potential of Ibandronate Sodium to manage Bone Metastases, Malignant Neoplasms and Osteoporosis.

Condition

Clinical Trials

Trial Phases

Osteoporosis

34 Actively Recruiting

Not Applicable, Phase 2, Phase 4, Phase 1, Phase 3

Breast Cancer

26 Actively Recruiting

Phase 2, Phase 1, Not Applicable

Bone Metastases

7 Actively Recruiting

Not Applicable, Phase 4, Phase 2, Phase 3

Malignant Neoplasms

0 Actively Recruiting

Ibandronate Sodium Reviews: What are patients saying about Ibandronate Sodium?

3Patient Review

10/3/2015

Ibandronate Sodium for Decreased Bone Mass Following Menopause

I'm waiting for a test to see the efficacy of this treatment, which won't be until next year.

2.3Patient Review

5/2/2013

Ibandronate Sodium for Decreased Bone Mass Following Menopause

I unfortunately experience a red rash as a side effect of this medication. It's most visible behind my knees and inner thighs, but I have also noticed it on my calves and outer thighs. The rash doesn't itch, but it is very unsightly. Usually the rash goes away after a few days; however, I am considering discontinuing the medication because of this issue.

2Patient Review

5/3/2017

Ibandronate Sodium for Post-Menopausal Osteoporosis Prevention

I had pain in my hip, thigh, and shoulder 2-3 days after taking the pill. I also felt really tired and achy. The second month I had the same side effects plus indigestion. I hope I don't have to keep dealing with this every month.

1.7Patient Review

7/11/2016

Ibandronate Sodium for Post-Menopausal Osteoporosis Prevention

I had such intense and debilitating side effects from this treatment that I would rather take my chances with bone loss than use it again.

1Patient Review

7/5/2016

Ibandronate Sodium for Decreased Bone Mass Following Menopause

I started taking this medicine on 7/2/16 and immediately began feeling flu-like symptoms. My arms and legs felt heavy and rubbery, and I was exhausted all the time. I was previously taking Fosamax, which had left me crippled, so I thought I would try this new medication. Unfortunately, it seems to be just as bad, if not worse.

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Patient Q&A Section about ibandronate sodium

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the drug ibandronate sodium used for?

"Ibandronate is a medication used to treat and prevent osteoporosis in postmenopausal women. A prescription is required in order to obtain this medication."

Answered by AI

What are the side effects of ibandronate sodium?

"The symptoms of this illness include nausea, stomach pain, diarrhea, constipation, weakness, dizziness, headache, fever, sore throat, chills, cough, and other signs of infection."

Answered by AI

When should you take ibandronate sodium?

"Adults should take 2.5mg once a day in the morning, or 150mg once a month on the same date, at least 60 minutes before the first food or drink of the day (apart from water). Children's doses must be determined by a doctor."

Answered by AI

How long should you take ibandronate sodium?

"After taking bisphosphonates for at least 3 to 5 years, your doctor will consider your risk factors in determining whether you should continue to take these or other osteoporosis medications."

Answered by AI

Clinical Trials for Ibandronate Sodium

Have you considered Ibandronate Sodium clinical trials? We made a collection of clinical trials featuring Ibandronate Sodium, we think they might fit your search criteria.

Have you considered Ibandronate Sodium clinical trials? We made a collection of clinical trials featuring Ibandronate Sodium, we think they might fit your search criteria.