What is Hydrocodone Bitartrate
HydrocodoneThe Generic name of this drug
Treatment SummaryHydrocodone is a powerful opioid pain reliever used to treat moderate to severe pain. It is usually combined with the drug acetaminophen, and is sometimes prescribed instead of an alternative cough suppressant called dextromethorphan. Hydrocodone’s more potent derivative, hydromorphone, is also used as an analgesic for severe pain. Hydrocodone was first approved by the FDA in 1943 and is sold under the name Hycodan.
Hycodanis the brand name
Hydrocodone Bitartrate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Hycodan
Hydrocodone
1943
1122
Approved as Treatment by the FDA
Hydrocodone, otherwise called Hycodan, is approved by the FDA for 2 uses including Pain and Pain .Pain
Used to treat Severe Pain in combination with Acetaminophen
Pain
Helps manage moderate Pain
Effectiveness
How Hydrocodone Bitartrate Affects PatientsHydrocodone works by blocking pain signals between the brain and spinal cord. It can also produce feelings of euphoria, depression of breathing, and sleepiness.
How Hydrocodone Bitartrate works in the bodyHydrocodone works mainly by binding to the mu opioid receptors (MOR) in the body. This blocks pain signals from being sent to the brain, and also prevents neurons from activating which can reduce pain. In the brain, hydrocodone can also suppress the GABAergic tone in the periaquaductal gray area, allowing pain-suppressing neurons to activate. Hydrocodone can also activate reward pathways in the brain, leading to feelings of pleasure when taken. Hydrocodone may also work on delta opioid receptors (DOR), but this has not been studied closely.
When to interrupt dosage
The advised dosage of Hydrocodone Bitartrate relies upon the diagnosed circumstance, including Coughing, Coughing and Chronic Pain. The measure of dosage is contingent upon the mode of delivery (e.g. Tablet, extended release - Oral or Tablet - Oral) delineated in the table beneath.Condition
Dosage
Administration
Pain
5.0 mg/mL, , 1.0 mg/mL, 7.5 mg, 5.0 mg, 10.0 mg, 0.075 mg/mL, 2.5 mg, 2.5 mg/mL, 45.0 mg, 20.0 mg, 90.0 mg, 0.5 mg/mL, 0.33 mg/mL, 1.8 mg/mL, 1.65 mg/mL, 1.667 mg/mL, 1.7 mg/mL, 1.67 mg/mL, 0.75 mg/mL, 30.0 mg, 10.0 mg/mL, 15.0 mg, 40.0 mg, 50.0 mg, 60.0 mg, 100.0 mg, 120.0 mg, 80.0 mg, 3.0 mg/mL, 750.0 mg
Tablet, extended release - Oral, Tablet - Oral, Oral, , Liquid - Oral, Solution - Oral, Solution, Syrup, Tablet, Suspension, Syrup - Oral, Tablet, film coated, Capsule, extended release - Oral, Capsule, extended release, Tablet, extended release, Tablet, coated, Tablet, film coated - Oral, Elixir - Oral, Capsule, Suspension, extended release - Oral, Liquid, Elixir, Suspension - Oral, Tablet, coated - Oral, Kit, Capsule - Oral, Topical, Cream - Topical, Suspension, extended release, Cream
Rhinitis
5.0 mg/mL, , 1.0 mg/mL, 7.5 mg, 5.0 mg, 10.0 mg, 0.075 mg/mL, 2.5 mg, 2.5 mg/mL, 45.0 mg, 20.0 mg, 90.0 mg, 0.5 mg/mL, 0.33 mg/mL, 1.8 mg/mL, 1.65 mg/mL, 1.667 mg/mL, 1.7 mg/mL, 1.67 mg/mL, 0.75 mg/mL, 30.0 mg, 10.0 mg/mL, 15.0 mg, 40.0 mg, 50.0 mg, 60.0 mg, 100.0 mg, 120.0 mg, 80.0 mg, 3.0 mg/mL, 750.0 mg
Tablet, extended release - Oral, Tablet - Oral, Oral, , Liquid - Oral, Solution - Oral, Solution, Syrup, Tablet, Suspension, Syrup - Oral, Tablet, film coated, Capsule, extended release - Oral, Capsule, extended release, Tablet, extended release, Tablet, coated, Tablet, film coated - Oral, Elixir - Oral, Capsule, Suspension, extended release - Oral, Liquid, Elixir, Suspension - Oral, Tablet, coated - Oral, Kit, Capsule - Oral, Topical, Cream - Topical, Suspension, extended release, Cream
Nasal Congestion caused by Common Cold
5.0 mg/mL, , 1.0 mg/mL, 7.5 mg, 5.0 mg, 10.0 mg, 0.075 mg/mL, 2.5 mg, 2.5 mg/mL, 45.0 mg, 20.0 mg, 90.0 mg, 0.5 mg/mL, 0.33 mg/mL, 1.8 mg/mL, 1.65 mg/mL, 1.667 mg/mL, 1.7 mg/mL, 1.67 mg/mL, 0.75 mg/mL, 30.0 mg, 10.0 mg/mL, 15.0 mg, 40.0 mg, 50.0 mg, 60.0 mg, 100.0 mg, 120.0 mg, 80.0 mg, 3.0 mg/mL, 750.0 mg
Tablet, extended release - Oral, Tablet - Oral, Oral, , Liquid - Oral, Solution - Oral, Solution, Syrup, Tablet, Suspension, Syrup - Oral, Tablet, film coated, Capsule, extended release - Oral, Capsule, extended release, Tablet, extended release, Tablet, coated, Tablet, film coated - Oral, Elixir - Oral, Capsule, Suspension, extended release - Oral, Liquid, Elixir, Suspension - Oral, Tablet, coated - Oral, Kit, Capsule - Oral, Topical, Cream - Topical, Suspension, extended release, Cream
Acute Pain
5.0 mg/mL, , 1.0 mg/mL, 7.5 mg, 5.0 mg, 10.0 mg, 0.075 mg/mL, 2.5 mg, 2.5 mg/mL, 45.0 mg, 20.0 mg, 90.0 mg, 0.5 mg/mL, 0.33 mg/mL, 1.8 mg/mL, 1.65 mg/mL, 1.667 mg/mL, 1.7 mg/mL, 1.67 mg/mL, 0.75 mg/mL, 30.0 mg, 10.0 mg/mL, 15.0 mg, 40.0 mg, 50.0 mg, 60.0 mg, 100.0 mg, 120.0 mg, 80.0 mg, 3.0 mg/mL, 750.0 mg
Tablet, extended release - Oral, Tablet - Oral, Oral, , Liquid - Oral, Solution - Oral, Solution, Syrup, Tablet, Suspension, Syrup - Oral, Tablet, film coated, Capsule, extended release - Oral, Capsule, extended release, Tablet, extended release, Tablet, coated, Tablet, film coated - Oral, Elixir - Oral, Capsule, Suspension, extended release - Oral, Liquid, Elixir, Suspension - Oral, Tablet, coated - Oral, Kit, Capsule - Oral, Topical, Cream - Topical, Suspension, extended release, Cream
Chronic Pain
5.0 mg/mL, , 1.0 mg/mL, 7.5 mg, 5.0 mg, 10.0 mg, 0.075 mg/mL, 2.5 mg, 2.5 mg/mL, 45.0 mg, 20.0 mg, 90.0 mg, 0.5 mg/mL, 0.33 mg/mL, 1.8 mg/mL, 1.65 mg/mL, 1.667 mg/mL, 1.7 mg/mL, 1.67 mg/mL, 0.75 mg/mL, 30.0 mg, 10.0 mg/mL, 15.0 mg, 40.0 mg, 50.0 mg, 60.0 mg, 100.0 mg, 120.0 mg, 80.0 mg, 3.0 mg/mL, 750.0 mg
Tablet, extended release - Oral, Tablet - Oral, Oral, , Liquid - Oral, Solution - Oral, Solution, Syrup, Tablet, Suspension, Syrup - Oral, Tablet, film coated, Capsule, extended release - Oral, Capsule, extended release, Tablet, extended release, Tablet, coated, Tablet, film coated - Oral, Elixir - Oral, Capsule, Suspension, extended release - Oral, Liquid, Elixir, Suspension - Oral, Tablet, coated - Oral, Kit, Capsule - Oral, Topical, Cream - Topical, Suspension, extended release, Cream
Inflammation
5.0 mg/mL, , 1.0 mg/mL, 7.5 mg, 5.0 mg, 10.0 mg, 0.075 mg/mL, 2.5 mg, 2.5 mg/mL, 45.0 mg, 20.0 mg, 90.0 mg, 0.5 mg/mL, 0.33 mg/mL, 1.8 mg/mL, 1.65 mg/mL, 1.667 mg/mL, 1.7 mg/mL, 1.67 mg/mL, 0.75 mg/mL, 30.0 mg, 10.0 mg/mL, 15.0 mg, 40.0 mg, 50.0 mg, 60.0 mg, 100.0 mg, 120.0 mg, 80.0 mg, 3.0 mg/mL, 750.0 mg
Tablet, extended release - Oral, Tablet - Oral, Oral, , Liquid - Oral, Solution - Oral, Solution, Syrup, Tablet, Suspension, Syrup - Oral, Tablet, film coated, Capsule, extended release - Oral, Capsule, extended release, Tablet, extended release, Tablet, coated, Tablet, film coated - Oral, Elixir - Oral, Capsule, Suspension, extended release - Oral, Liquid, Elixir, Suspension - Oral, Tablet, coated - Oral, Kit, Capsule - Oral, Topical, Cream - Topical, Suspension, extended release, Cream
Nasal Congestion caused by Allergic Rhinitis
5.0 mg/mL, , 1.0 mg/mL, 7.5 mg, 5.0 mg, 10.0 mg, 0.075 mg/mL, 2.5 mg, 2.5 mg/mL, 45.0 mg, 20.0 mg, 90.0 mg, 0.5 mg/mL, 0.33 mg/mL, 1.8 mg/mL, 1.65 mg/mL, 1.667 mg/mL, 1.7 mg/mL, 1.67 mg/mL, 0.75 mg/mL, 30.0 mg, 10.0 mg/mL, 15.0 mg, 40.0 mg, 50.0 mg, 60.0 mg, 100.0 mg, 120.0 mg, 80.0 mg, 3.0 mg/mL, 750.0 mg
Tablet, extended release - Oral, Tablet - Oral, Oral, , Liquid - Oral, Solution - Oral, Solution, Syrup, Tablet, Suspension, Syrup - Oral, Tablet, film coated, Capsule, extended release - Oral, Capsule, extended release, Tablet, extended release, Tablet, coated, Tablet, film coated - Oral, Elixir - Oral, Capsule, Suspension, extended release - Oral, Liquid, Elixir, Suspension - Oral, Tablet, coated - Oral, Kit, Capsule - Oral, Topical, Cream - Topical, Suspension, extended release, Cream
Acute Bronchitis
5.0 mg/mL, , 1.0 mg/mL, 7.5 mg, 5.0 mg, 10.0 mg, 0.075 mg/mL, 2.5 mg, 2.5 mg/mL, 45.0 mg, 20.0 mg, 90.0 mg, 0.5 mg/mL, 0.33 mg/mL, 1.8 mg/mL, 1.65 mg/mL, 1.667 mg/mL, 1.7 mg/mL, 1.67 mg/mL, 0.75 mg/mL, 30.0 mg, 10.0 mg/mL, 15.0 mg, 40.0 mg, 50.0 mg, 60.0 mg, 100.0 mg, 120.0 mg, 80.0 mg, 3.0 mg/mL, 750.0 mg
Tablet, extended release - Oral, Tablet - Oral, Oral, , Liquid - Oral, Solution - Oral, Solution, Syrup, Tablet, Suspension, Syrup - Oral, Tablet, film coated, Capsule, extended release - Oral, Capsule, extended release, Tablet, extended release, Tablet, coated, Tablet, film coated - Oral, Elixir - Oral, Capsule, Suspension, extended release - Oral, Liquid, Elixir, Suspension - Oral, Tablet, coated - Oral, Kit, Capsule - Oral, Topical, Cream - Topical, Suspension, extended release, Cream
upper respiratory symptoms caused by Common Cold
5.0 mg/mL, , 1.0 mg/mL, 7.5 mg, 5.0 mg, 10.0 mg, 0.075 mg/mL, 2.5 mg, 2.5 mg/mL, 45.0 mg, 20.0 mg, 90.0 mg, 0.5 mg/mL, 0.33 mg/mL, 1.8 mg/mL, 1.65 mg/mL, 1.667 mg/mL, 1.7 mg/mL, 1.67 mg/mL, 0.75 mg/mL, 30.0 mg, 10.0 mg/mL, 15.0 mg, 40.0 mg, 50.0 mg, 60.0 mg, 100.0 mg, 120.0 mg, 80.0 mg, 3.0 mg/mL, 750.0 mg
Tablet, extended release - Oral, Tablet - Oral, Oral, , Liquid - Oral, Solution - Oral, Solution, Syrup, Tablet, Suspension, Syrup - Oral, Tablet, film coated, Capsule, extended release - Oral, Capsule, extended release, Tablet, extended release, Tablet, coated, Tablet, film coated - Oral, Elixir - Oral, Capsule, Suspension, extended release - Oral, Liquid, Elixir, Suspension - Oral, Tablet, coated - Oral, Kit, Capsule - Oral, Topical, Cream - Topical, Suspension, extended release, Cream
Coughing
5.0 mg/mL, , 1.0 mg/mL, 7.5 mg, 5.0 mg, 10.0 mg, 0.075 mg/mL, 2.5 mg, 2.5 mg/mL, 45.0 mg, 20.0 mg, 90.0 mg, 0.5 mg/mL, 0.33 mg/mL, 1.8 mg/mL, 1.65 mg/mL, 1.667 mg/mL, 1.7 mg/mL, 1.67 mg/mL, 0.75 mg/mL, 30.0 mg, 10.0 mg/mL, 15.0 mg, 40.0 mg, 50.0 mg, 60.0 mg, 100.0 mg, 120.0 mg, 80.0 mg, 3.0 mg/mL, 750.0 mg
Tablet, extended release - Oral, Tablet - Oral, Oral, , Liquid - Oral, Solution - Oral, Solution, Syrup, Tablet, Suspension, Syrup - Oral, Tablet, film coated, Capsule, extended release - Oral, Capsule, extended release, Tablet, extended release, Tablet, coated, Tablet, film coated - Oral, Elixir - Oral, Capsule, Suspension, extended release - Oral, Liquid, Elixir, Suspension - Oral, Tablet, coated - Oral, Kit, Capsule - Oral, Topical, Cream - Topical, Suspension, extended release, Cream
Pain
5.0 mg/mL, , 1.0 mg/mL, 7.5 mg, 5.0 mg, 10.0 mg, 0.075 mg/mL, 2.5 mg, 2.5 mg/mL, 45.0 mg, 20.0 mg, 90.0 mg, 0.5 mg/mL, 0.33 mg/mL, 1.8 mg/mL, 1.65 mg/mL, 1.667 mg/mL, 1.7 mg/mL, 1.67 mg/mL, 0.75 mg/mL, 30.0 mg, 10.0 mg/mL, 15.0 mg, 40.0 mg, 50.0 mg, 60.0 mg, 100.0 mg, 120.0 mg, 80.0 mg, 3.0 mg/mL, 750.0 mg
Tablet, extended release - Oral, Tablet - Oral, Oral, , Liquid - Oral, Solution - Oral, Solution, Syrup, Tablet, Suspension, Syrup - Oral, Tablet, film coated, Capsule, extended release - Oral, Capsule, extended release, Tablet, extended release, Tablet, coated, Tablet, film coated - Oral, Elixir - Oral, Capsule, Suspension, extended release - Oral, Liquid, Elixir, Suspension - Oral, Tablet, coated - Oral, Kit, Capsule - Oral, Topical, Cream - Topical, Suspension, extended release, Cream
Coughing
5.0 mg/mL, , 1.0 mg/mL, 7.5 mg, 5.0 mg, 10.0 mg, 0.075 mg/mL, 2.5 mg, 2.5 mg/mL, 45.0 mg, 20.0 mg, 90.0 mg, 0.5 mg/mL, 0.33 mg/mL, 1.8 mg/mL, 1.65 mg/mL, 1.667 mg/mL, 1.7 mg/mL, 1.67 mg/mL, 0.75 mg/mL, 30.0 mg, 10.0 mg/mL, 15.0 mg, 40.0 mg, 50.0 mg, 60.0 mg, 100.0 mg, 120.0 mg, 80.0 mg, 3.0 mg/mL, 750.0 mg
Tablet, extended release - Oral, Tablet - Oral, Oral, , Liquid - Oral, Solution - Oral, Solution, Syrup, Tablet, Suspension, Syrup - Oral, Tablet, film coated, Capsule, extended release - Oral, Capsule, extended release, Tablet, extended release, Tablet, coated, Tablet, film coated - Oral, Elixir - Oral, Capsule, Suspension, extended release - Oral, Liquid, Elixir, Suspension - Oral, Tablet, coated - Oral, Kit, Capsule - Oral, Topical, Cream - Topical, Suspension, extended release, Cream
Allergic rhinitis (disorder)
5.0 mg/mL, , 1.0 mg/mL, 7.5 mg, 5.0 mg, 10.0 mg, 0.075 mg/mL, 2.5 mg, 2.5 mg/mL, 45.0 mg, 20.0 mg, 90.0 mg, 0.5 mg/mL, 0.33 mg/mL, 1.8 mg/mL, 1.65 mg/mL, 1.667 mg/mL, 1.7 mg/mL, 1.67 mg/mL, 0.75 mg/mL, 30.0 mg, 10.0 mg/mL, 15.0 mg, 40.0 mg, 50.0 mg, 60.0 mg, 100.0 mg, 120.0 mg, 80.0 mg, 3.0 mg/mL, 750.0 mg
Tablet, extended release - Oral, Tablet - Oral, Oral, , Liquid - Oral, Solution - Oral, Solution, Syrup, Tablet, Suspension, Syrup - Oral, Tablet, film coated, Capsule, extended release - Oral, Capsule, extended release, Tablet, extended release, Tablet, coated, Tablet, film coated - Oral, Elixir - Oral, Capsule, Suspension, extended release - Oral, Liquid, Elixir, Suspension - Oral, Tablet, coated - Oral, Kit, Capsule - Oral, Topical, Cream - Topical, Suspension, extended release, Cream
Warnings
Hydrocodone Bitartrate ContraindicationsCondition
Risk Level
Notes
severe CNS depression
Do Not Combine
Abdomen
Do Not Combine
Cor Pulmonale
Do Not Combine
in the absence of resuscitative equipment acute bronchial asthma
Do Not Combine
Intracranial Hypertension
Do Not Combine
chronic obstructive airway
Do Not Combine
Mental Depression
Do Not Combine
Toxoplasma Infections
Do Not Combine
increased cerebrospinal pressure
Do Not Combine
Asthma
Do Not Combine
Alcohol Withdrawal Delirium
Do Not Combine
Hypercarbia
Do Not Combine
ethanol
Do Not Combine
Asthma
Do Not Combine
Paralytic Ileus
Do Not Combine
Status Asthmaticus
Do Not Combine
Toxoplasma Infections
Do Not Combine
Gastrointestinal obstruction
Do Not Combine
Asthma
Do Not Combine
convulsive disorders
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Hydrocodone may interact with Toxoplasma Infections
Common Hydrocodone Bitartrate Drug Interactions
Drug Name
Risk Level
Description
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Hydrocodone.
Azelastine
Major
Hydrocodone may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Cyclophosphamide
Major
The metabolism of Cyclophosphamide can be decreased when combined with Hydrocodone.
Eluxadoline
Major
The risk or severity of constipation can be increased when Hydrocodone is combined with Eluxadoline.
Enasidenib
Major
The metabolism of Enasidenib can be decreased when combined with Hydrocodone.
Hydrocodone Bitartrate Toxicity & Overdose RiskTaking too much hydrocodone can lead to symptoms of opioid intoxication, such as difficulty breathing, drowsiness, coma, weak muscles, pale and clammy skin, constricted pupils, fluid in the lungs, slow heartbeat, low blood pressure, and even death. If someone overdoses on hydrocodone, medical professionals should focus on maintaining an open airway and providing oxygen and fluids if needed. In some cases, additional treatments such as IV fluids, supplemental oxygen, and vasopressors may be used to treat circulatory shock. Naloxone is an opioid antagonist that can be used to reverse the respiratory and circ
Hydrocodone Bitartrate Novel Uses: Which Conditions Have a Clinical Trial Featuring Hydrocodone Bitartrate?
50 clinical trials are presently assessing Hydrocodone Bitartrate's capacity to reduce Chronic Pain, Nasal Congestion due to the Common Cold and Acute Bronchitis.Condition
Clinical Trials
Trial Phases
upper respiratory symptoms caused by Common Cold
0 Actively Recruiting
Nasal Congestion caused by Common Cold
0 Actively Recruiting
Coughing
0 Actively Recruiting
Chronic Pain
30 Actively Recruiting
Phase 3, Not Applicable, Phase 2
Inflammation
0 Actively Recruiting
Pain
0 Actively Recruiting
Acute Bronchitis
10 Actively Recruiting
Phase 4, Not Applicable, Phase 2, Phase 3
Coughing
0 Actively Recruiting
Pain
0 Actively Recruiting
Nasal Congestion caused by Allergic Rhinitis
0 Actively Recruiting
Acute Pain
20 Actively Recruiting
Phase 4, Early Phase 1, Not Applicable, Phase 2, Phase 3
Rhinitis
0 Actively Recruiting
Allergic rhinitis (disorder)
0 Actively Recruiting
Patient Q&A Section about hydrocodone bitartrate
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.How long does it take for hydrocodone bitartrate to work?
"It will take around an hour for you to start feeling the effects of hydrocodone. According to the package insert, a 10-mg oral dose of the medication will reach its peak concentration in the bloodstream in 1.3 hours after taking it."
Answered by AI
What is the difference between oxycodone hydrochloride and hydrocodone bitartrate?
"Oxycodone is more likely than hydrocodone to cause side effects like dizziness, drowsiness, and fatigue, as well as headaches and feelings of euphoria. The more severe, though less common, side effect of seizures is more likely with oxycodone."
Answered by AI