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HFB200603 + Tislelizumab for Advanced Cancers
Study Summary
This trial tests the safety and effectiveness of two cancer treatments, HFB200603 and tislelizumab, in patients with advanced cancers.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
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- I am fully active or restricted in physically strenuous activity but can do light work.I do not have severe diabetes, bleeding disorders, or uncontrolled mental health conditions.My side effects from previous cancer treatments have mostly gone away or stabilized, except for things like hair loss or numbness.You have a current autoimmune disease or a history of an autoimmune disease that could come back.I haven't had any cancer other than the one being studied in the last 5 years.I have a history of serious lung conditions or currently need extra oxygen.I can have a biopsy before and during treatment.You have a tumor that can be measured using specific guidelines called RECIST 1.1.You have previously participated in a study using tislelizumab until certain important results from that study are known.I have not had radiation therapy in the last 2 weeks.I have a specific cancer type and have received the required number of treatments for it.I have not had major surgery in the last 4 weeks.I haven't had cancer treatment in the last 2-6 weeks, depending on the type.I haven't taken high-dose steroids or immune suppressants in the last 2 weeks.You have had allergic reactions or immune-related reactions to drugs similar to monoclonal antibodies or the study drugs HFB200603 or tislelizumab.
- Group 1: Dose Escalation - HFB200603 monotherapy
- Group 2: Dose Escalation - HFB200603 in combination with tislelizumab
- Group 3: Dose Expansion - HFB200603 monotherapy (optional)
- Group 4: Dose Expansion - HFB200603 in combination with tislelizumab
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Has Dose Expansion - HFB200603 monotherapy (optional) obtained clearance from the FDA?
"Due to the limited clinical data concerning Dose Expansion - HFB200603 monotherapy (optional), our team at Power rated its safety a 1 out of 3."
Is enrollment currently available for this research project?
"As seen on clinicaltrials.gov, this medical trial has commenced participant recruitment since April 1st 2023 and was last modified a little over three weeks ago."
To what extent has the trial been populated with participants?
"Affirmative. Information posted to clinicaltrials.gov confirms that the recruitment for this trial is ongoing, beginning April 1st 2023 and last edited on 4/25/2023. The aim is to enrol 83 individuals from a single medical centre."
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