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What is Haldol
HaloperidolThe Generic name of this drug
Treatment SummaryHaloperidol is a medication used to treat psychotic disorders such as schizophrenia, Tourette syndrome, and severe behavioral states. It works by blocking dopamine receptors in the brain, which helps reduce symptoms of psychosis. Haloperidol is an effective and widely used drug, but it can cause side effects such as movement disorders, sedation, weight gain, and changes in prolactin levels. It can also interact with other drugs and has been found to be affected by a person's genetics. Haloperidol is a first-generation antipsychotic drug which has largely been replaced by newer, second- or third-generation antipsych
Haldolis the brand name
Haldol Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Haldol
Haloperidol
1971
300
Approved as Treatment by the FDA
Haloperidol, otherwise known as Haldol, is approved by the FDA for 1 uses which include Gilles de la Tourette's Syndrome .Gilles de la Tourette's Syndrome
Helps manage Gilles de la Tourette's Syndrome
Effectiveness
How Haldol Affects PatientsHaloperidol is an antipsychotic drug used to treat the positive symptoms of schizophrenia, such as hearing voices, aggression, and disorganized speech. However, it can also cause side effects like movement disorders, drowsiness, weight gain, and a change in the level of the hormone prolactin. Compared to other first-generation antipsychotics, haloperidol usually has fewer side effects. Taking haloperidol long-term can lead to a condition called tardive dyskinesia, which is characterized by involuntary, jerky movements. Haloperidol can also cause a serious syndrome called Neurole
How Haldol works in the bodyHaloperidol is an antipsychotic medication that helps decrease psychotic symptoms by blocking dopamine receptors in the brain, particularly in the limbic system. It works by competing with dopamine for its receptor, effectively preventing dopamine from stimulating the nerve cells and reducing the abnormal activity associated with psychosis. Haloperidol also blocks other types of receptors in the autonomic system, which helps reduce nausea and vomiting. It can cause unpleasant side effects, such as extrapyramidal symptoms, due to its tight binding to dopamine receptors. Therefore, newer antipsychotic medications with a lower affinity for dopamine receptors have been developed to reduce the risk of these symptoms
When to interrupt dosage
The advised measure of Haldol is contingent upon the designated state, such as Palliative Care, aggressive response and phencyclidine. Dosage shifts, in light of the technique of delivery featured in the table beneath.Condition
Dosage
Administration
Severe Disruptive Behaviour Disorders
5.0 mg/mL, , 2.0 mg/mL, 1.0 mg, 2.0 mg, 5.0 mg, 10.0 mg, 0.5 mg, 20.0 mg, 50.0 mg/mL, 100.0 mg/mL, 1.5 mg, 500.0 mg/mL, 70.52 mg/mL, 141.04 mg/mL
, Injection, solution, Injection, solution - Intramuscular, Intramuscular, Oral, Solution, concentrate, Solution, concentrate - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Injection - Intramuscular, Injection, Liquid - Intramuscular, Liquid, Solution - Intramuscular
Delirium
5.0 mg/mL, , 2.0 mg/mL, 1.0 mg, 2.0 mg, 5.0 mg, 10.0 mg, 0.5 mg, 20.0 mg, 50.0 mg/mL, 100.0 mg/mL, 1.5 mg, 500.0 mg/mL, 70.52 mg/mL, 141.04 mg/mL
, Injection, solution, Injection, solution - Intramuscular, Intramuscular, Oral, Solution, concentrate, Solution, concentrate - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Injection - Intramuscular, Injection, Liquid - Intramuscular, Liquid, Solution - Intramuscular
severe Hyperactivity
5.0 mg/mL, , 2.0 mg/mL, 1.0 mg, 2.0 mg, 5.0 mg, 10.0 mg, 0.5 mg, 20.0 mg, 50.0 mg/mL, 100.0 mg/mL, 1.5 mg, 500.0 mg/mL, 70.52 mg/mL, 141.04 mg/mL
, Injection, solution, Injection, solution - Intramuscular, Intramuscular, Oral, Solution, concentrate, Solution, concentrate - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Injection - Intramuscular, Injection, Liquid - Intramuscular, Liquid, Solution - Intramuscular
Obsessive-Compulsive Disorder
5.0 mg/mL, , 2.0 mg/mL, 1.0 mg, 2.0 mg, 5.0 mg, 10.0 mg, 0.5 mg, 20.0 mg, 50.0 mg/mL, 100.0 mg/mL, 1.5 mg, 500.0 mg/mL, 70.52 mg/mL, 141.04 mg/mL
, Injection, solution, Injection, solution - Intramuscular, Intramuscular, Oral, Solution, concentrate, Solution, concentrate - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Injection - Intramuscular, Injection, Liquid - Intramuscular, Liquid, Solution - Intramuscular
Nausea
5.0 mg/mL, , 2.0 mg/mL, 1.0 mg, 2.0 mg, 5.0 mg, 10.0 mg, 0.5 mg, 20.0 mg, 50.0 mg/mL, 100.0 mg/mL, 1.5 mg, 500.0 mg/mL, 70.52 mg/mL, 141.04 mg/mL
, Injection, solution, Injection, solution - Intramuscular, Intramuscular, Oral, Solution, concentrate, Solution, concentrate - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Injection - Intramuscular, Injection, Liquid - Intramuscular, Liquid, Solution - Intramuscular
Palliative Treatment
5.0 mg/mL, , 2.0 mg/mL, 1.0 mg, 2.0 mg, 5.0 mg, 10.0 mg, 0.5 mg, 20.0 mg, 50.0 mg/mL, 100.0 mg/mL, 1.5 mg, 500.0 mg/mL, 70.52 mg/mL, 141.04 mg/mL
, Injection, solution, Injection, solution - Intramuscular, Intramuscular, Oral, Solution, concentrate, Solution, concentrate - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Injection - Intramuscular, Injection, Liquid - Intramuscular, Liquid, Solution - Intramuscular
Schizophrenia
5.0 mg/mL, , 2.0 mg/mL, 1.0 mg, 2.0 mg, 5.0 mg, 10.0 mg, 0.5 mg, 20.0 mg, 50.0 mg/mL, 100.0 mg/mL, 1.5 mg, 500.0 mg/mL, 70.52 mg/mL, 141.04 mg/mL
, Injection, solution, Injection, solution - Intramuscular, Intramuscular, Oral, Solution, concentrate, Solution, concentrate - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Injection - Intramuscular, Injection, Liquid - Intramuscular, Liquid, Solution - Intramuscular
Schizophrenia
5.0 mg/mL, , 2.0 mg/mL, 1.0 mg, 2.0 mg, 5.0 mg, 10.0 mg, 0.5 mg, 20.0 mg, 50.0 mg/mL, 100.0 mg/mL, 1.5 mg, 500.0 mg/mL, 70.52 mg/mL, 141.04 mg/mL
, Injection, solution, Injection, solution - Intramuscular, Intramuscular, Oral, Solution, concentrate, Solution, concentrate - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Injection - Intramuscular, Injection, Liquid - Intramuscular, Liquid, Solution - Intramuscular
Gilles de la Tourette's Syndrome
5.0 mg/mL, , 2.0 mg/mL, 1.0 mg, 2.0 mg, 5.0 mg, 10.0 mg, 0.5 mg, 20.0 mg, 50.0 mg/mL, 100.0 mg/mL, 1.5 mg, 500.0 mg/mL, 70.52 mg/mL, 141.04 mg/mL
, Injection, solution, Injection, solution - Intramuscular, Intramuscular, Oral, Solution, concentrate, Solution, concentrate - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Injection - Intramuscular, Injection, Liquid - Intramuscular, Liquid, Solution - Intramuscular
phencyclidine
5.0 mg/mL, , 2.0 mg/mL, 1.0 mg, 2.0 mg, 5.0 mg, 10.0 mg, 0.5 mg, 20.0 mg, 50.0 mg/mL, 100.0 mg/mL, 1.5 mg, 500.0 mg/mL, 70.52 mg/mL, 141.04 mg/mL
, Injection, solution, Injection, solution - Intramuscular, Intramuscular, Oral, Solution, concentrate, Solution, concentrate - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Injection - Intramuscular, Injection, Liquid - Intramuscular, Liquid, Solution - Intramuscular
Huntington Disease
5.0 mg/mL, , 2.0 mg/mL, 1.0 mg, 2.0 mg, 5.0 mg, 10.0 mg, 0.5 mg, 20.0 mg, 50.0 mg/mL, 100.0 mg/mL, 1.5 mg, 500.0 mg/mL, 70.52 mg/mL, 141.04 mg/mL
, Injection, solution, Injection, solution - Intramuscular, Intramuscular, Oral, Solution, concentrate, Solution, concentrate - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Injection - Intramuscular, Injection, Liquid - Intramuscular, Liquid, Solution - Intramuscular
aggressive reaction
5.0 mg/mL, , 2.0 mg/mL, 1.0 mg, 2.0 mg, 5.0 mg, 10.0 mg, 0.5 mg, 20.0 mg, 50.0 mg/mL, 100.0 mg/mL, 1.5 mg, 500.0 mg/mL, 70.52 mg/mL, 141.04 mg/mL
, Injection, solution, Injection, solution - Intramuscular, Intramuscular, Oral, Solution, concentrate, Solution, concentrate - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Injection - Intramuscular, Injection, Liquid - Intramuscular, Liquid, Solution - Intramuscular
Warnings
Haldol ContraindicationsCondition
Risk Level
Notes
Comatose
Do Not Combine
Asthma
Do Not Combine
Parkinson's Disease
Do Not Combine
Mental Depression
Do Not Combine
Basal Ganglia Lesions
Do Not Combine
Mental Depression
Do Not Combine
Common Haldol Drug Interactions
Drug Name
Risk Level
Description
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Haloperidol.
Amisulpride
Major
Haloperidol may increase the antipsychotic activities of Amisulpride.
Azelastine
Major
Haloperidol may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Cariprazine
Major
The metabolism of Cariprazine can be decreased when combined with Haloperidol.
Eliglustat
Major
The metabolism of Eliglustat can be decreased when combined with Haloperidol.
Haldol Toxicity & Overdose RiskTests have found that the toxic dose of this drug for rats is 71mg/kg.
Haldol Novel Uses: Which Conditions Have a Clinical Trial Featuring Haldol?
285 active trials are underway assessing the potential of Haldol to alleviate Obsessive-Compulsive Disorder, provide Palliative Care and counter phencyclidine toxicity.Condition
Clinical Trials
Trial Phases
Nausea
0 Actively Recruiting
Palliative Treatment
0 Actively Recruiting
Huntington Disease
4 Actively Recruiting
Phase 1, Phase 2, Phase 3
Schizophrenia
174 Actively Recruiting
Not Applicable, Phase 3, Phase 2, Early Phase 1, Phase 4, Phase 1
Schizophrenia
34 Actively Recruiting
Early Phase 1, Not Applicable, Phase 4
Delirium
51 Actively Recruiting
Phase 2, Not Applicable, Phase 3, Phase 4, Phase 1, Early Phase 1
severe Hyperactivity
0 Actively Recruiting
aggressive reaction
0 Actively Recruiting
Severe Disruptive Behaviour Disorders
0 Actively Recruiting
phencyclidine
0 Actively Recruiting
Obsessive-Compulsive Disorder
17 Actively Recruiting
Not Applicable, Phase 3, Phase 2
Gilles de la Tourette's Syndrome
0 Actively Recruiting
Haldol Reviews: What are patients saying about Haldol?
4.7Patient Review
12/21/2016 Haldol has been a much better fit for me than other atypical medications I've tried, namely Abilify, Risperdal, and Geodon. It's made a big difference in my quality of life. There are some mild side effects that come with it (tremors, pacing, etc.) but nothing that I can't handle. If you're struggling with similar issues, I say give Haldol a shot.
4.3Patient Review
12/16/2016 I've been using this medication to great success for intrusive thoughts. The only downside is that it makes me really drowsy and my mouth is always dry.
4Patient Review
3/21/2016 I have to take a monthly injection of this medication, since I've been deemed non-compliant in the past. It's effective for my mood but unfortunately comes with the side effect of weight gain. My doctor tried to dismiss it but it happens to everyone I know on this medicine.
4Patient Review
5/9/2020 I appreciate that Haldol doesn't cause me to gain a lot of weight.
2.7Patient Review
12/7/2018 The tics I was experiencing slowed down, but the sedation effects were so strong that it interfered with my life more than the tics did. It got to the point where I would rather deal with the tics than take this medication.
2.3Patient Review
5/7/2021 Haldol was terrible for me. I only experienced negative side effects and no benefits while taking it.
1Patient Review
8/7/2017 About six months ago, I started experiencing tremors in my left arm and hand. My doctor took me off the pill immediately, but the damage was already done. I now have difficulty talking and swallowing, and my life is ruined.
1Patient Review
1/27/2021 I really dislike having to take this medication, and I resent the people who created it.
Patient Q&A Section about haldol
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What class of drug is Haldol?
"Haloperidol is a type of medication known as a conventional antipsychotic."
Answered by AI
Is Haldol a narcotic?
"Haloperidol is a psychoactive drug that has been widely used to treat schizophrenia, mania, neuroses, stuttering, and phobic states. It was developed by Janssen et al3 during experiments with synthetic narcotic agents."
Answered by AI
Is Haldol a strong sedative?
"and alprazolam (Xanax)
Haldol can cause sedation, which may be increased if it is combined with alcohol or other drugs that have sedative effects, such as benzodiazepines ( drugs used to treat anxiety, such as diazepam [Valium], lorazepam [Ativan], and alprazolam [Xanax])."
Answered by AI
What are the side effects for Haldol?
"To minimize dizziness, get up slowly from a lying down position
You may experience dizziness, lightheadedness, drowsiness, difficulty urinating, sleep disturbances, headache, and anxiety. If these effects persist or worsen, notify your doctor or pharmacist promptly. Dizziness and lightheadedness can increase your risk of falling. To avoid dizziness, get up slowly when rising from a sitting or lying position."
Answered by AI