Nitric Oxide Supplement for Prehypertension
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests whether a nitric oxide supplement can lower blood pressure in individuals with prehypertension (slightly high blood pressure). Participants will receive either the actual supplement or a placebo (a harmless pill with no active ingredient) to determine any differences in blood pressure changes. It suits adults with blood pressure readings at or above 135/80 mmHg who are not on any blood pressure medications. As a Phase 1 trial, the research focuses on understanding how the treatment works in people, offering participants a chance to be among the first to receive this new treatment.
Will I have to stop taking my current medications?
If you are currently taking any medication to lower blood pressure, you cannot participate in this trial.
Is there any evidence suggesting that this trial's treatments are likely to be safe?
Research has shown that nitric oxide supplements can lower blood pressure and improve blood vessel function. People taking these supplements have experienced reduced blood pressure and enhanced blood flow. In one study, a nitric oxide supplement improved blood pressure and blood vessel health in just 30 minutes. Another study found that these supplements helped individuals with slightly high blood pressure walk longer distances.
However, nitric oxide supplements might cause side effects, particularly for those with certain health issues like liver disease. These side effects are uncommon in healthy individuals. Overall, studies suggest that most people tolerate nitric oxide supplements well.12345Why do researchers think this study treatment might be promising?
Most treatments for prehypertension, like ACE inhibitors and beta-blockers, work by controlling blood pressure through different biological pathways. But the Nitric Oxide supplement works differently, targeting the improvement of blood vessel function directly. Nitric Oxide is a natural molecule in the body that helps relax and widen blood vessels, potentially offering a novel way to manage blood pressure. Researchers are excited because this supplement could provide a more natural and possibly safer alternative to traditional medications, with fewer side effects.
What evidence suggests that this trial's treatments could be effective for prehypertension?
Research has shown that nitric oxide supplements, which participants in this trial may receive, can help lower blood pressure. In one study, participants experienced a noticeable drop in blood pressure after taking these supplements. Another study found that nitric oxide, a natural substance in the body, helps relax blood vessels, which can also lower blood pressure. Early findings suggest that these supplements can improve blood flow and heart health. These results are promising for using nitric oxide supplements to manage slightly elevated blood pressure, known as prehypertension.13678
Who Is on the Research Team?
Ernst Schwarz, MD, PhD
Principal Investigator
California Medical Institute, Cedars Sinai Medical Center
Are You a Good Fit for This Trial?
This trial is for adults aged 18-80 with prehypertension, which means their blood pressure readings are at or above 135/80 mmHg. Participants must be able to give informed consent and follow the study's procedures. Those with serious internal or heart diseases, using blood pressure meds, or unable to consent are excluded.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive oral supplementation of Neo40(TM), a nitrate lozenge, to reduce blood pressure
Follow-up
Participants are monitored for safety and effectiveness after treatment, including blood pressure readings and functional capacity tests
What Are the Treatments Tested in This Trial?
Interventions
- Nitric Oxide supplement
- Placebo
Find a Clinic Near You
Who Is Running the Clinical Trial?
Neogenis Laboratories
Lead Sponsor