Generlac

Constipation, Hepatic Encephalopathy, Hepatic Encephalopathy

Treatment

6 FDA approvals

16 Active Studies for Generlac

Treatment for

Constipation

What is Generlac

LactuloseThe Generic name of this drug

Treatment SummaryLactulose is a type of sugar used to treat constipation and portal-systemic encephalopathy (PSE). It was first created in 1929, but only began being used as a laxative in the 1960s. It was officially approved by the FDA in 1977 and is now a widely available generic and brand-name non-prescription medication. There is limited data on the effectiveness of lactulose for treating constipation and PSE, as it is usually only used when other dietary and lifestyle modifications have failed.

Lactuloseis the brand name

image of different drug pills on a surface

Generlac Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Lactulose

1966

Approved as Treatment by the FDA

Lactulose, also known as Lactulose, is approved by the FDA for 6 uses which include Hepatic Encephalopathy (HE) and Constipation .

Hepatic Encephalopathy (HE)

Constipation

prophylaxis of Hepatic encephalopathy

Constipation

Hepatic Encephalopathy

Effectiveness

How Generlac Affects PatientsLactulose is usually taken orally or rectally and stays in the gastrointestinal tract. It works by increasing the amount and softening of stool, which can cause more frequent bowel sounds, feeling bloated, belching, passing gas, and diarrhea.

How Generlac works in the bodyLactulose is a medication used to treat constipation and portal-systemic encephalopathy. It is broken down by bacteria in the large intestine, which produces acids that increase water content in the stool, making it softer and easier to pass. This process also results in an acidic environment in the colon which helps to trap and remove excess ammonia in the body that can be a cause of encephalopathy. Additionally, it also reduces the number of bacteria that produce ammonia in the colon. All of these effects work together to help improve bowel movements and reduce levels of ammonia in the body.

When to interrupt dosage

The suggested dosage of Generlac is contingent upon the determined affliction, including Hepatic Encephalopathy, Chronic Constipation and Hepatic Encephalopathy. The degree of dosage is subject to the approach of delivery (e.g. Oral or Solution) as described in the table below.

Condition

Dosage

Administration

Constipation

, 1000.0 mg/mL, 2000.0 mg/mL, 1.0 mg/mg, 2.0 mg/mg, 667.0 mg, 667.0 mg/mL, 3300.0 mg/mL, 0.95 mg/mg

, Oral, Solution, Solution - Oral, Oral; Rectal, Solution - Oral; Rectal, Powder, for solution - Oral, Powder, for solution, Liquid, Liquid - Oral, Syrup, Syrup - Oral, Powder, Powder - Oral, Syrup - Oral; Rectal, Liquid - Oral; Rectal

Hepatic Encephalopathy

, 1000.0 mg/mL, 2000.0 mg/mL, 1.0 mg/mg, 2.0 mg/mg, 667.0 mg, 667.0 mg/mL, 3300.0 mg/mL, 0.95 mg/mg

Hepatic Encephalopathy

, 1000.0 mg/mL, 2000.0 mg/mL, 1.0 mg/mg, 2.0 mg/mg, 667.0 mg, 667.0 mg/mL, 3300.0 mg/mL, 0.95 mg/mg

Warnings

Generlac has two counter-indications, so it should not be used when suffering from the conditions indicated in the following table.Generlac Contraindications

Condition

Risk Level

Notes

low galactose diet

Do Not Combine

Pulse Frequency

Do Not Combine

There are 20 known major drug interactions with Generlac.

Common Generlac Drug Interactions

Drug Name

Risk Level

Description

Alloin

Minor

The risk or severity of adverse effects can be increased when Lactulose is combined with Alloin.

Bisacodyl

Minor

The risk or severity of adverse effects can be increased when Lactulose is combined with Bisacodyl.

Bisoxatin

Minor

The risk or severity of adverse effects can be increased when Lactulose is combined with Bisoxatin.

Calcium polycarbophil

Minor

The risk or severity of adverse effects can be increased when Lactulose is combined with Calcium polycarbophil.

Carboxymethylcellulose

Minor

The risk or severity of adverse effects can be increased when Lactulose is combined with Carboxymethylcellulose.

Generlac Toxicity & Overdose RiskThe toxic dose of lactulose in mice is 48.8 mL/kg and more than 30 mL/kg in rats. Overdosing can cause stomach cramps and diarrhea, both of which should be treated with fluids and electrolytes. Because the safety of using lactulose during pregnancy and breastfeeding is unknown, it should only be used if absolutely necessary. Studies in animals have not shown any effects on fertility. The safety and effectiveness of lactulose in children is limited or not yet known. There is no information about the long-term effects of lactulose on animals or humans.

image of a doctor in a lab doing drug, clinical research

Generlac Novel Uses: Which Conditions Have a Clinical Trial Featuring Generlac?

25 active trials are examining the potential of Generlac to ameliorate Hepatic Encephalopathy, Chronic Constipation and other related conditions.

Condition

Clinical Trials

Trial Phases

Hepatic Encephalopathy

0 Actively Recruiting

Constipation

16 Actively Recruiting

Phase 2, Not Applicable, Phase 4, Phase 3

Hepatic Encephalopathy

0 Actively Recruiting

Generlac Reviews: What are patients saying about Generlac?

5Patient Review

9/6/2012

Generlac for High Amount of Ammonium in the Blood

I've been taking a combination of morphine, ms-contin, oxycodone for going on 20 years now. I take 1 tablespoon and in 24 hours or less it works. This treatment is wonderful and has allowed me to eat again without struggling.

5Patient Review

10/20/2010

Generlac for Incomplete or Infrequent Bowel Movements

I started taking this treatment three weeks ago as directed by my doctor. I have been constipated since starting it and called the doctor today. They told me to keep taking it for another day or two. I would not recommend this medication to anyone based on my experience so far.

5Patient Review

7/27/2009

Generlac for Impaired Brain Function due to Liver Disease

3.7Patient Review

8/22/2015

Generlac for Incomplete or Infrequent Bowel Movements

This medication helped to an extent with my stomach issues and bowel leakage. However, if I ever missed a dose, I would be up all night.

3.7Patient Review

7/14/2010

Generlac for Incomplete or Infrequent Bowel Movements

View All Reviews

Patient Q&A Section about generlac

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Generlac and lactulose the same?

"A brand-name drug called Generlac is used to treat or prevent certain brain or mental problems caused by liver disease. It may be taken orally or rectally. A generic version of Generlac called Lactulose has been approved by the FDA."

Answered by AI

What is the drug lactulose used for?

"Lactulose is a synthetic sugar that pulls water out of the body and into the colon, softening stools. It is used to treat constipation and reduce the amount of ammonia in the blood of patients with liver disease."

Answered by AI

What is Generlac solution 10g 15ml?

"This medication is a laxative used to treat constipation. It may help increase the number of bowel movements you have each day, as well as the number of days you have a bowel movement. Lactulose is a colonic acidifier that works by increasing stool water content and softening the stool. It is a man-made sugar solution."

Answered by AI

What is Generlac used for?

"This drug is taken orally or rectally to treat or prevent liver disease complications (hepatic encephalopathy). It does not cure the problem, but may help improve mental status. Lactulose is a colonic acidifier that works by decreasing the amount of ammonia in the bloodstream."

Answered by AI

Clinical Trials for Generlac

Have you considered Generlac clinical trials? We made a collection of clinical trials featuring Generlac, we think they might fit your search criteria.

Have you considered Generlac clinical trials? We made a collection of clinical trials featuring Generlac, we think they might fit your search criteria.