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What is Generlac
LactuloseThe Generic name of this drug
Treatment SummaryLactulose is a type of sugar used to treat constipation and portal-systemic encephalopathy (PSE). It was first created in 1929, but only began being used as a laxative in the 1960s. It was officially approved by the FDA in 1977 and is now a widely available generic and brand-name non-prescription medication. There is limited data on the effectiveness of lactulose for treating constipation and PSE, as it is usually only used when other dietary and lifestyle modifications have failed.
Lactuloseis the brand name
Generlac Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Lactulose
Lactulose
1966
63
Approved as Treatment by the FDA
Lactulose, also known as Lactulose, is approved by the FDA for 3 uses which include Hepatic Encephalopathy and Hepatic Encephalopathy .Hepatic Encephalopathy
Hepatic Encephalopathy
Constipation
Effectiveness
How Generlac Affects PatientsLactulose is usually taken orally or rectally and stays in the gastrointestinal tract. It works by increasing the amount and softening of stool, which can cause more frequent bowel sounds, feeling bloated, belching, passing gas, and diarrhea.
How Generlac works in the bodyLactulose is a medication used to treat constipation and portal-systemic encephalopathy. It is broken down by bacteria in the large intestine, which produces acids that increase water content in the stool, making it softer and easier to pass. This process also results in an acidic environment in the colon which helps to trap and remove excess ammonia in the body that can be a cause of encephalopathy. Additionally, it also reduces the number of bacteria that produce ammonia in the colon. All of these effects work together to help improve bowel movements and reduce levels of ammonia in the body.
When to interrupt dosage
The suggested dosage of Generlac is contingent upon the determined affliction, including Hepatic Encephalopathy, Chronic Constipation and Hepatic Encephalopathy. The degree of dosage is subject to the approach of delivery (e.g. Oral or Solution) as described in the table below.Condition
Dosage
Administration
Hepatic Encephalopathy
, 1000.0 mg/mL, 2000.0 mg/mL, 1.0 mg/mg, 2.0 mg/mg, 667.0 mg, 667.0 mg/mL, 3300.0 mg/mL, 0.95 mg/mg
, Oral, Solution, Solution - Oral, Oral; Rectal, Solution - Oral; Rectal, Powder, for solution - Oral, Powder, for solution, Liquid, Liquid - Oral, Syrup, Syrup - Oral, Powder, Powder - Oral, Syrup - Oral; Rectal, Liquid - Oral; Rectal
Constipation
, 1000.0 mg/mL, 2000.0 mg/mL, 1.0 mg/mg, 2.0 mg/mg, 667.0 mg, 667.0 mg/mL, 3300.0 mg/mL, 0.95 mg/mg
, Oral, Solution, Solution - Oral, Oral; Rectal, Solution - Oral; Rectal, Powder, for solution - Oral, Powder, for solution, Liquid, Liquid - Oral, Syrup, Syrup - Oral, Powder, Powder - Oral, Syrup - Oral; Rectal, Liquid - Oral; Rectal
Hepatic Encephalopathy
, 1000.0 mg/mL, 2000.0 mg/mL, 1.0 mg/mg, 2.0 mg/mg, 667.0 mg, 667.0 mg/mL, 3300.0 mg/mL, 0.95 mg/mg
, Oral, Solution, Solution - Oral, Oral; Rectal, Solution - Oral; Rectal, Powder, for solution - Oral, Powder, for solution, Liquid, Liquid - Oral, Syrup, Syrup - Oral, Powder, Powder - Oral, Syrup - Oral; Rectal, Liquid - Oral; Rectal
Warnings
Generlac has two counter-indications, so it should not be used when suffering from the conditions indicated in the following table.Generlac ContraindicationsCondition
Risk Level
Notes
low galactose diet
Do Not Combine
Pulse Frequency
Do Not Combine
Common Generlac Drug Interactions
Drug Name
Risk Level
Description
Alloin
Minor
The risk or severity of adverse effects can be increased when Lactulose is combined with Alloin.
Bisacodyl
Minor
The risk or severity of adverse effects can be increased when Lactulose is combined with Bisacodyl.
Bisoxatin
Minor
The risk or severity of adverse effects can be increased when Lactulose is combined with Bisoxatin.
Calcium polycarbophil
Minor
The risk or severity of adverse effects can be increased when Lactulose is combined with Calcium polycarbophil.
Carboxymethylcellulose
Minor
The risk or severity of adverse effects can be increased when Lactulose is combined with Carboxymethylcellulose.
Generlac Toxicity & Overdose RiskThe toxic dose of lactulose in mice is 48.8 mL/kg and more than 30 mL/kg in rats. Overdosing can cause stomach cramps and diarrhea, both of which should be treated with fluids and electrolytes. Because the safety of using lactulose during pregnancy and breastfeeding is unknown, it should only be used if absolutely necessary. Studies in animals have not shown any effects on fertility. The safety and effectiveness of lactulose in children is limited or not yet known. There is no information about the long-term effects of lactulose on animals or humans.
Generlac Novel Uses: Which Conditions Have a Clinical Trial Featuring Generlac?
25 active trials are examining the potential of Generlac to ameliorate Hepatic Encephalopathy, Chronic Constipation and other related conditions.Condition
Clinical Trials
Trial Phases
Constipation
38 Actively Recruiting
Phase 3, Phase 2, Not Applicable, Phase 4, Early Phase 1
Hepatic Encephalopathy
0 Actively Recruiting
Hepatic Encephalopathy
0 Actively Recruiting
Generlac Reviews: What are patients saying about Generlac?
5Patient Review
9/6/2012 I've been taking a combination of morphine, ms-contin, oxycodone for going on 20 years now. I take 1 tablespoon and in 24 hours or less it works. This treatment is wonderful and has allowed me to eat again without struggling.
5Patient Review
10/20/2010 I started taking this treatment three weeks ago as directed by my doctor. I have been constipated since starting it and called the doctor today. They told me to keep taking it for another day or two. I would not recommend this medication to anyone based on my experience so far.
5Patient Review
7/27/20093.7Patient Review
8/22/2015 This medication helped to an extent with my stomach issues and bowel leakage. However, if I ever missed a dose, I would be up all night.
3.7Patient Review
7/14/20102.7Patient Review
5/2/2011 My mom, who is 87, started having shortness of breath and weakness in her arms and legs. We began giving her this medication to lower her ammonium levels; they were at 128, but have lowered to 77 and then 66. However, she still needs to get them down to 32.
2.7Patient Review
11/6/2012 I tried this for a few weeks in early March, but the gas and bloating it caused was too much. It only worked sometimes, so I decided to go back to my fiber-filled food instead.
2.7Patient Review
9/17/2010 This medication caused a lot of gas and bloating. I had several bowel movements each time I took it, but they were large and quick. The upside is that it helped remove ammonia from my brain.
1.3Patient Review
8/15/2016 I've had bloating and stomach pain since taking this, with no significant relief.
1Patient Review
11/12/20081Patient Review
2/14/2016 After taking just two doses of this drug as prescribed by my doctor, I had an incredibly unpleasant experience last night. This medication is essentially a hyper-osmotic laxative, and should be avoided if at all possible.
Patient Q&A Section about generlac
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is Generlac and lactulose the same?
"A brand-name drug called Generlac is used to treat or prevent certain brain or mental problems caused by liver disease. It may be taken orally or rectally. A generic version of Generlac called Lactulose has been approved by the FDA."
Answered by AI
What is the drug lactulose used for?
"Lactulose is a synthetic sugar that pulls water out of the body and into the colon, softening stools. It is used to treat constipation and reduce the amount of ammonia in the blood of patients with liver disease."
Answered by AI
What is Generlac solution 10g 15ml?
"This medication is a laxative used to treat constipation. It may help increase the number of bowel movements you have each day, as well as the number of days you have a bowel movement. Lactulose is a colonic acidifier that works by increasing stool water content and softening the stool. It is a man-made sugar solution."
Answered by AI
What is Generlac used for?
"This drug is taken orally or rectally to treat or prevent liver disease complications (hepatic encephalopathy). It does not cure the problem, but may help improve mental status. Lactulose is a colonic acidifier that works by decreasing the amount of ammonia in the bloodstream."
Answered by AI