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What is Fulvestrant
FulvestrantThe Generic name of this drug
Treatment SummaryFulvestrant is a type of hormone therapy used to treat breast cancer in post-menopausal women whose cancer has progressed despite taking anti-estrogen medications. It works by blocking and destroying the estrogen receptor, which helps slow the growth of the cancer. It is most often used as a single drug treatment but may also be combined with alpelisib for certain types of breast cancer.
Faslodexis the brand name
Fulvestrant Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Faslodex
Fulvestrant
2010
29
Approved as Treatment by the FDA
Fulvestrant, commonly known as Faslodex, is approved by the FDA for 6 uses which include prior endocrine therapy and Progression, Disease .prior endocrine therapy
Used to treat prior endocrine therapy in combination with Abemaciclib
Progression, Disease
Used to treat Progression, Disease in combination with Abemaciclib
Disease
Used to treat disease progression after endocrine based therapy in combination with Alpelisib
Malignant Neoplasms
Used to treat Advanced or Metastatic Breast Cancer in combination with Abemaciclib
PI3K Gene Mutation
Used to treat PI3K Gene Mutation in combination with Alpelisib
PIK3CA Gene Mutation
Used to treat PIK3CA Gene Mutation in combination with Alpelisib
Effectiveness
How Fulvestrant Affects PatientsFulvestrant is a type of medicine given by injection that blocks the action of the hormone estrogen. It does not have any known effects that imitate estrogen.
How Fulvestrant works in the bodyFulvestrant is used to treat estrogen-sensitive breast cancer. It works by blocking the estrogen receptors in cancer cells. This prevents estrogen from binding to these receptors, and also causes them to break down. This helps stop the growth of cancers that are resistant to tamoxifen, as well as those that are sensitive to estrogen.
When to interrupt dosage
The proposed dosage of Fulvestrant is contingent upon the identified condition, including Progression, Disease, Breast and PIK3CA Gene Mutation. The volume of dosage is contingent upon the mode of delivery (e.g. Solution or Injection), which has been defined in the table below.Condition
Dosage
Administration
prior endocrine therapy
, 250.0 mg/mL, 50.0 mg/mL, 250.0 mg
, Intramuscular, Solution, Solution - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Injection, Injection - Intramuscular
Malignant Neoplasms
, 250.0 mg/mL, 50.0 mg/mL, 250.0 mg
, Intramuscular, Solution, Solution - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Injection, Injection - Intramuscular
PI3K Gene Mutation
, 250.0 mg/mL, 50.0 mg/mL, 250.0 mg
, Intramuscular, Solution, Solution - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Injection, Injection - Intramuscular
Breast
, 250.0 mg/mL, 50.0 mg/mL, 250.0 mg
, Intramuscular, Solution, Solution - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Injection, Injection - Intramuscular
PIK3CA Gene Mutation
, 250.0 mg/mL, 50.0 mg/mL, 250.0 mg
, Intramuscular, Solution, Solution - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Injection, Injection - Intramuscular
Progression, Disease
, 250.0 mg/mL, 50.0 mg/mL, 250.0 mg
, Intramuscular, Solution, Solution - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Injection, Injection - Intramuscular
Disease
, 250.0 mg/mL, 50.0 mg/mL, 250.0 mg
, Intramuscular, Solution, Solution - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Injection, Injection - Intramuscular
Warnings
There are 2 known major drug interactions with Fulvestrant.Common Fulvestrant Drug Interactions
Drug Name
Risk Level
Description
Ospemifene
Major
The risk or severity of adverse effects can be increased when Fulvestrant is combined with Ospemifene.
Fluoroestradiol F-18
Moderate
Fulvestrant may decrease effectiveness of Fluoroestradiol F-18 as a diagnostic agent.
Fulvestrant Toxicity & Overdose RiskThere is no known experience of overdosing on this drug in humans.
Fulvestrant Novel Uses: Which Conditions Have a Clinical Trial Featuring Fulvestrant?
At present, 20 clinical trials are assessing the potential of Fulvestrant to inhibit Progression of Disease, Breast Cancer and Malignant Neoplasms.Condition
Clinical Trials
Trial Phases
Progression, Disease
0 Actively Recruiting
PIK3CA Gene Mutation
0 Actively Recruiting
prior endocrine therapy
0 Actively Recruiting
Malignant Neoplasms
4 Actively Recruiting
Phase 1, Phase 3
Disease
0 Actively Recruiting
PI3K Gene Mutation
1 Actively Recruiting
Phase 2
Breast
18 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 3
Fulvestrant Reviews: What are patients saying about Fulvestrant?
4Patient Review
10/25/2013 So far, I've had two rounds of injections with only minor side effects like insomnia and a sore throat. Fingers crossed that this continues to be an effective treatment for me with no major complications.
4Patient Review
10/30/2017 I am currently on my sixth cycle of this protocol (Fluvestrant with Taselisib) and, so far, it is working well. My doctors tell me that the cancer is 'stable,' which is good news. I am hopeful that the tumors will disappear completely soon. In the meantime, I have learned to relax during treatment and Visualize the tumors disappearing, which has helped reduce the pain significantly.
3.7Patient Review
6/5/2013 I've been taking this for a couple years now. It's less painful if you heat it up first and administer it slowly. Over time, it became less painful for me in general. Additionally, it halted the growth of my tumor and helped me feel overall healthier--I'm really glad I use this treatment! That said, I do wish it came in pill form.
1.7Patient Review
9/25/2009 I just started this last week and had my first treatment.
Patient Q&A Section about fulvestrant
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.How long can you take fulvestrant?
"Fulvestrant is most commonly given to patients in hospitals every two weeks for the first three doses, and then once a month. Fulvestrant is often given to patients for as long as it is successful in controlling their breast cancer and any side effects can be managed."
Answered by AI
Is fulvestrant a chemotherapy?
"Faslodex is a hormonal therapy that blocks estrogen receptors in the body, which may help to treat breast cancer. Faslodex can be used alone or in combination with other medications."
Answered by AI
What are the side effects of fulvestrant?
"If you experience any of the following symptoms, you should see a doctor as soon as possible: black or tarry stools, bloating or swelling of the face, arms, hands, lower legs, or feet, blood in the urine or stools, chest pain or tightness, cloudy urine, difficulty breathing, hoarseness, or irregular heartbeat."
Answered by AI