Fragmin

Deep Vein Thrombosis (DVT), Unstable Angina Pectoris, Clotting + 14 more
Treatment
13 FDA approvals
20 Active Studies for Fragmin

What is Fragmin

DalteparinThe Generic name of this drug
Treatment SummaryDalteparin is a medication used to prevent blood clots, and it is made from porcine intestinal mucosa. It is part of the low molecular weight heparin (LMWH) family, which has a predictable response, higher absorption rate, and longer lasting effects than traditional heparin. Dalteparin is generally safe for pregnant women and is less effective at preventing clotting caused by factor IIa.
Fragminis the brand name
image of different drug pills on a surface
Fragmin Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Fragmin
Dalteparin
1994
19

Approved as Treatment by the FDA

Dalteparin, also known as Fragmin, is approved by the FDA for 13 uses including prophylaxis of Clotting and severe restricted mobility .
prophylaxis of Clotting
severe restricted mobility
Deep Vein Thrombosis (DVT)
Abdominal Surgeries
Prophylaxis of Venous Thromboembolic Events
General Surgery
Hemodialysis
Haemofiltration
Venous Thromboembolism
Clotting
Acute Coryza
Deep Vein Thrombosis
Arthroplasty

Effectiveness

How Fragmin Affects PatientsDalteparin works by binding to the protein antithrombin (ATIII) in the blood, which helps prevent clotting. Doctors use the anti-Xa activity of the plasma to decide how much of the drug should be given. People with a creatinine clearance of less than 20mL/min should not use this drug, and instead take unfractionated heparin. To make sure the drug is working, doctors can measure the anti-Xa activity, but will not need to measure the active partial thromboplastin time (aPTT).
How Fragmin works in the bodyDalteparin helps stop your blood from clotting, much like unfractionated heparin. However, dalteparin is more targeted, and only affects one aspect of the clotting process. This means that you don't need to monitor it as closely as you would with other anticoagulants, except to watch for signs of an overdose.

When to interrupt dosage

The measure of Fragmin depends upon the determined situation, including Haemofiltration, Prophylaxis of Venous Thromboembolic Events and General Surgery. The amount furthermore shifts as per the technique of conveyance (e.g. Subcutaneous or Solution - Intravenous; Subcutaneous) specified in the accompanying table.
Condition
Dosage
Administration
non-q wave myocardial infarction
100000.0 [iU]/mL, , 10000.0 [iU]/mL, 125000.0 [iU]/mL, 150000.0 [iU]/mL, 180000.0 [iU]/mL, 25000.0 [iU]/mL, 50000.0 [iU]/mL, 75000.0 [iU]/mL, 10000.0 units/mL, 25000.0 units/mL, 2500.0 units/mL, 180000.0 units/mL, 35000.0 units/mL, 100000.0 units/mL, 50000.0 units/mL, 125000.0 units/mL, 165000.0 units/mL, 150000.0 units/mL, 75000.0 units/mL
, Subcutaneous, Injection, Injection - Subcutaneous, Intravenous; Subcutaneous, Liquid, Liquid - Intravenous; Subcutaneous, Solution, Solution - Intravenous; Subcutaneous, Solution - Parenteral, Parenteral
Deep Vein Thrombosis
100000.0 [iU]/mL, , 10000.0 [iU]/mL, 125000.0 [iU]/mL, 150000.0 [iU]/mL, 180000.0 [iU]/mL, 25000.0 [iU]/mL, 50000.0 [iU]/mL, 75000.0 [iU]/mL, 10000.0 units/mL, 25000.0 units/mL, 2500.0 units/mL, 180000.0 units/mL, 35000.0 units/mL, 100000.0 units/mL, 50000.0 units/mL, 125000.0 units/mL, 165000.0 units/mL, 150000.0 units/mL, 75000.0 units/mL
, Subcutaneous, Injection, Injection - Subcutaneous, Intravenous; Subcutaneous, Liquid, Liquid - Intravenous; Subcutaneous, Solution, Solution - Intravenous; Subcutaneous, Solution - Parenteral, Parenteral
Hemodialysis
100000.0 [iU]/mL, , 10000.0 [iU]/mL, 125000.0 [iU]/mL, 150000.0 [iU]/mL, 180000.0 [iU]/mL, 25000.0 [iU]/mL, 50000.0 [iU]/mL, 75000.0 [iU]/mL, 10000.0 units/mL, 25000.0 units/mL, 2500.0 units/mL, 180000.0 units/mL, 35000.0 units/mL, 100000.0 units/mL, 50000.0 units/mL, 125000.0 units/mL, 165000.0 units/mL, 150000.0 units/mL, 75000.0 units/mL
, Subcutaneous, Injection, Injection - Subcutaneous, Intravenous; Subcutaneous, Liquid, Liquid - Intravenous; Subcutaneous, Solution, Solution - Intravenous; Subcutaneous, Solution - Parenteral, Parenteral
Cardiovascular Events
100000.0 [iU]/mL, , 10000.0 [iU]/mL, 125000.0 [iU]/mL, 150000.0 [iU]/mL, 180000.0 [iU]/mL, 25000.0 [iU]/mL, 50000.0 [iU]/mL, 75000.0 [iU]/mL, 10000.0 units/mL, 25000.0 units/mL, 2500.0 units/mL, 180000.0 units/mL, 35000.0 units/mL, 100000.0 units/mL, 50000.0 units/mL, 125000.0 units/mL, 165000.0 units/mL, 150000.0 units/mL, 75000.0 units/mL
, Subcutaneous, Injection, Injection - Subcutaneous, Intravenous; Subcutaneous, Liquid, Liquid - Intravenous; Subcutaneous, Solution, Solution - Intravenous; Subcutaneous, Solution - Parenteral, Parenteral
Unstable Angina Pectoris
100000.0 [iU]/mL, , 10000.0 [iU]/mL, 125000.0 [iU]/mL, 150000.0 [iU]/mL, 180000.0 [iU]/mL, 25000.0 [iU]/mL, 50000.0 [iU]/mL, 75000.0 [iU]/mL, 10000.0 units/mL, 25000.0 units/mL, 2500.0 units/mL, 180000.0 units/mL, 35000.0 units/mL, 100000.0 units/mL, 50000.0 units/mL, 125000.0 units/mL, 165000.0 units/mL, 150000.0 units/mL, 75000.0 units/mL
, Subcutaneous, Injection, Injection - Subcutaneous, Intravenous; Subcutaneous, Liquid, Liquid - Intravenous; Subcutaneous, Solution, Solution - Intravenous; Subcutaneous, Solution - Parenteral, Parenteral
Abdominal Surgeries
100000.0 [iU]/mL, , 10000.0 [iU]/mL, 125000.0 [iU]/mL, 150000.0 [iU]/mL, 180000.0 [iU]/mL, 25000.0 [iU]/mL, 50000.0 [iU]/mL, 75000.0 [iU]/mL, 10000.0 units/mL, 25000.0 units/mL, 2500.0 units/mL, 180000.0 units/mL, 35000.0 units/mL, 100000.0 units/mL, 50000.0 units/mL, 125000.0 units/mL, 165000.0 units/mL, 150000.0 units/mL, 75000.0 units/mL
, Subcutaneous, Injection, Injection - Subcutaneous, Intravenous; Subcutaneous, Liquid, Liquid - Intravenous; Subcutaneous, Solution, Solution - Intravenous; Subcutaneous, Solution - Parenteral, Parenteral
Prophylaxis of Venous Thromboembolic Events
100000.0 [iU]/mL, , 10000.0 [iU]/mL, 125000.0 [iU]/mL, 150000.0 [iU]/mL, 180000.0 [iU]/mL, 25000.0 [iU]/mL, 50000.0 [iU]/mL, 75000.0 [iU]/mL, 10000.0 units/mL, 25000.0 units/mL, 2500.0 units/mL, 180000.0 units/mL, 35000.0 units/mL, 100000.0 units/mL, 50000.0 units/mL, 125000.0 units/mL, 165000.0 units/mL, 150000.0 units/mL, 75000.0 units/mL
, Subcutaneous, Injection, Injection - Subcutaneous, Intravenous; Subcutaneous, Liquid, Liquid - Intravenous; Subcutaneous, Solution, Solution - Intravenous; Subcutaneous, Solution - Parenteral, Parenteral
Deep Vein Thrombosis (DVT)
100000.0 [iU]/mL, , 10000.0 [iU]/mL, 125000.0 [iU]/mL, 150000.0 [iU]/mL, 180000.0 [iU]/mL, 25000.0 [iU]/mL, 50000.0 [iU]/mL, 75000.0 [iU]/mL, 10000.0 units/mL, 25000.0 units/mL, 2500.0 units/mL, 180000.0 units/mL, 35000.0 units/mL, 100000.0 units/mL, 50000.0 units/mL, 125000.0 units/mL, 165000.0 units/mL, 150000.0 units/mL, 75000.0 units/mL
, Subcutaneous, Injection, Injection - Subcutaneous, Intravenous; Subcutaneous, Liquid, Liquid - Intravenous; Subcutaneous, Solution, Solution - Intravenous; Subcutaneous, Solution - Parenteral, Parenteral
Clotting
100000.0 [iU]/mL, , 10000.0 [iU]/mL, 125000.0 [iU]/mL, 150000.0 [iU]/mL, 180000.0 [iU]/mL, 25000.0 [iU]/mL, 50000.0 [iU]/mL, 75000.0 [iU]/mL, 10000.0 units/mL, 25000.0 units/mL, 2500.0 units/mL, 180000.0 units/mL, 35000.0 units/mL, 100000.0 units/mL, 50000.0 units/mL, 125000.0 units/mL, 165000.0 units/mL, 150000.0 units/mL, 75000.0 units/mL
, Subcutaneous, Injection, Injection - Subcutaneous, Intravenous; Subcutaneous, Liquid, Liquid - Intravenous; Subcutaneous, Solution, Solution - Intravenous; Subcutaneous, Solution - Parenteral, Parenteral
severe restricted mobility
100000.0 [iU]/mL, , 10000.0 [iU]/mL, 125000.0 [iU]/mL, 150000.0 [iU]/mL, 180000.0 [iU]/mL, 25000.0 [iU]/mL, 50000.0 [iU]/mL, 75000.0 [iU]/mL, 10000.0 units/mL, 25000.0 units/mL, 2500.0 units/mL, 180000.0 units/mL, 35000.0 units/mL, 100000.0 units/mL, 50000.0 units/mL, 125000.0 units/mL, 165000.0 units/mL, 150000.0 units/mL, 75000.0 units/mL
, Subcutaneous, Injection, Injection - Subcutaneous, Intravenous; Subcutaneous, Liquid, Liquid - Intravenous; Subcutaneous, Solution, Solution - Intravenous; Subcutaneous, Solution - Parenteral, Parenteral
prophylaxis of cardiovascular event
100000.0 [iU]/mL, , 10000.0 [iU]/mL, 125000.0 [iU]/mL, 150000.0 [iU]/mL, 180000.0 [iU]/mL, 25000.0 [iU]/mL, 50000.0 [iU]/mL, 75000.0 [iU]/mL, 10000.0 units/mL, 25000.0 units/mL, 2500.0 units/mL, 180000.0 units/mL, 35000.0 units/mL, 100000.0 units/mL, 50000.0 units/mL, 125000.0 units/mL, 165000.0 units/mL, 150000.0 units/mL, 75000.0 units/mL
, Subcutaneous, Injection, Injection - Subcutaneous, Intravenous; Subcutaneous, Liquid, Liquid - Intravenous; Subcutaneous, Solution, Solution - Intravenous; Subcutaneous, Solution - Parenteral, Parenteral
Haemofiltration
100000.0 [iU]/mL, , 10000.0 [iU]/mL, 125000.0 [iU]/mL, 150000.0 [iU]/mL, 180000.0 [iU]/mL, 25000.0 [iU]/mL, 50000.0 [iU]/mL, 75000.0 [iU]/mL, 10000.0 units/mL, 25000.0 units/mL, 2500.0 units/mL, 180000.0 units/mL, 35000.0 units/mL, 100000.0 units/mL, 50000.0 units/mL, 125000.0 units/mL, 165000.0 units/mL, 150000.0 units/mL, 75000.0 units/mL
, Subcutaneous, Injection, Injection - Subcutaneous, Intravenous; Subcutaneous, Liquid, Liquid - Intravenous; Subcutaneous, Solution, Solution - Intravenous; Subcutaneous, Solution - Parenteral, Parenteral
Acute Coryza
100000.0 [iU]/mL, , 10000.0 [iU]/mL, 125000.0 [iU]/mL, 150000.0 [iU]/mL, 180000.0 [iU]/mL, 25000.0 [iU]/mL, 50000.0 [iU]/mL, 75000.0 [iU]/mL, 10000.0 units/mL, 25000.0 units/mL, 2500.0 units/mL, 180000.0 units/mL, 35000.0 units/mL, 100000.0 units/mL, 50000.0 units/mL, 125000.0 units/mL, 165000.0 units/mL, 150000.0 units/mL, 75000.0 units/mL
, Subcutaneous, Injection, Injection - Subcutaneous, Intravenous; Subcutaneous, Liquid, Liquid - Intravenous; Subcutaneous, Solution, Solution - Intravenous; Subcutaneous, Solution - Parenteral, Parenteral
General Surgery
100000.0 [iU]/mL, , 10000.0 [iU]/mL, 125000.0 [iU]/mL, 150000.0 [iU]/mL, 180000.0 [iU]/mL, 25000.0 [iU]/mL, 50000.0 [iU]/mL, 75000.0 [iU]/mL, 10000.0 units/mL, 25000.0 units/mL, 2500.0 units/mL, 180000.0 units/mL, 35000.0 units/mL, 100000.0 units/mL, 50000.0 units/mL, 125000.0 units/mL, 165000.0 units/mL, 150000.0 units/mL, 75000.0 units/mL
, Subcutaneous, Injection, Injection - Subcutaneous, Intravenous; Subcutaneous, Liquid, Liquid - Intravenous; Subcutaneous, Solution, Solution - Intravenous; Subcutaneous, Solution - Parenteral, Parenteral
Venous Thromboembolism
100000.0 [iU]/mL, , 10000.0 [iU]/mL, 125000.0 [iU]/mL, 150000.0 [iU]/mL, 180000.0 [iU]/mL, 25000.0 [iU]/mL, 50000.0 [iU]/mL, 75000.0 [iU]/mL, 10000.0 units/mL, 25000.0 units/mL, 2500.0 units/mL, 180000.0 units/mL, 35000.0 units/mL, 100000.0 units/mL, 50000.0 units/mL, 125000.0 units/mL, 165000.0 units/mL, 150000.0 units/mL, 75000.0 units/mL
, Subcutaneous, Injection, Injection - Subcutaneous, Intravenous; Subcutaneous, Liquid, Liquid - Intravenous; Subcutaneous, Solution, Solution - Intravenous; Subcutaneous, Solution - Parenteral, Parenteral
prophylaxis of Clotting
100000.0 [iU]/mL, , 10000.0 [iU]/mL, 125000.0 [iU]/mL, 150000.0 [iU]/mL, 180000.0 [iU]/mL, 25000.0 [iU]/mL, 50000.0 [iU]/mL, 75000.0 [iU]/mL, 10000.0 units/mL, 25000.0 units/mL, 2500.0 units/mL, 180000.0 units/mL, 35000.0 units/mL, 100000.0 units/mL, 50000.0 units/mL, 125000.0 units/mL, 165000.0 units/mL, 150000.0 units/mL, 75000.0 units/mL
, Subcutaneous, Injection, Injection - Subcutaneous, Intravenous; Subcutaneous, Liquid, Liquid - Intravenous; Subcutaneous, Solution, Solution - Intravenous; Subcutaneous, Solution - Parenteral, Parenteral
Arthroplasty
100000.0 [iU]/mL, , 10000.0 [iU]/mL, 125000.0 [iU]/mL, 150000.0 [iU]/mL, 180000.0 [iU]/mL, 25000.0 [iU]/mL, 50000.0 [iU]/mL, 75000.0 [iU]/mL, 10000.0 units/mL, 25000.0 units/mL, 2500.0 units/mL, 180000.0 units/mL, 35000.0 units/mL, 100000.0 units/mL, 50000.0 units/mL, 125000.0 units/mL, 165000.0 units/mL, 150000.0 units/mL, 75000.0 units/mL
, Subcutaneous, Injection, Injection - Subcutaneous, Intravenous; Subcutaneous, Liquid, Liquid - Intravenous; Subcutaneous, Solution, Solution - Intravenous; Subcutaneous, Solution - Parenteral, Parenteral

Warnings

Fragmin has seven prohibitions, so it should not be employed when experiencing any of the conditions present in the following table.Fragmin Contraindications
Condition
Risk Level
Notes
Hemorrhage
Do Not Combine
history of thrombocytopenia caused by Heparin
Do Not Combine
history of thrombocytopenia with thrombosis caused by Heparin
Do Not Combine
neuraxial anesthesia
Do Not Combine
lumbar epidural anesthesia therapy
Do Not Combine
Pulse Frequency
Do Not Combine
neuraxial anesthesia
Do Not Combine
There are 20 known major drug interactions with Fragmin.
Common Fragmin Drug Interactions
Drug Name
Risk Level
Description
Albutrepenonacog alfa
Major
The therapeutic efficacy of Albutrepenonacog alfa can be decreased when used in combination with Dalteparin.
Andexanet alfa
Major
The therapeutic efficacy of Andexanet alfa can be decreased when used in combination with Dalteparin.
Anti-inhibitor coagulant complex
Major
The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Dalteparin.
Antihemophilic factor (recombinant), PEGylated
Major
The therapeutic efficacy of Antihemophilic factor (recombinant), PEGylated can be decreased when used in combination with Dalteparin.
Antihemophilic factor human
Major
The therapeutic efficacy of Antihemophilic factor human can be decreased when used in combination with Dalteparin.
Fragmin Toxicity & Overdose RiskAn overdose of heparin can lead to bleeding complications. Common side effects with extended use include bone thinning, low platelet count, and mild liver enzyme elevation. Uncommon reactions include severe allergic reactions, skin rashes and necrosis, internal bleeding, and swelling.
image of a doctor in a lab doing drug, clinical research

Fragmin Novel Uses: Which Conditions Have a Clinical Trial Featuring Fragmin?

119 active studies are currently exploring the potential of Fragmin to treat Deep Vein Thrombosis, General Surgery and prevent Clotting.
Condition
Clinical Trials
Trial Phases
Haemofiltration
0 Actively Recruiting
Abdominal Surgeries
3 Actively Recruiting
Phase 3, Not Applicable
Acute Coryza
0 Actively Recruiting
Deep Vein Thrombosis
18 Actively Recruiting
Phase 4, Phase 3, Not Applicable, Phase 1, Phase 2
Deep Vein Thrombosis (DVT)
28 Actively Recruiting
Phase 4, Phase 3, Not Applicable, Early Phase 1, Phase 1, Phase 2
Unstable Angina Pectoris
2 Actively Recruiting
Not Applicable
prophylaxis of cardiovascular event
0 Actively Recruiting
Cardiovascular Events
3 Actively Recruiting
Not Applicable
Prophylaxis of Venous Thromboembolic Events
0 Actively Recruiting
Arthroplasty
10 Actively Recruiting
Not Applicable, Phase 4, Phase 2
non-q wave myocardial infarction
0 Actively Recruiting
General Surgery
1 Actively Recruiting
Not Applicable
Clotting
0 Actively Recruiting
prophylaxis of Clotting
0 Actively Recruiting
Hemodialysis
12 Actively Recruiting
Not Applicable, Phase 3, Phase 2, Phase 1
Venous Thromboembolism
0 Actively Recruiting
severe restricted mobility
0 Actively Recruiting

Fragmin Reviews: What are patients saying about Fragmin?

5Patient Review
5/1/2012
Fragmin for Prevention of Recurrent Vein Thrombosis in Cancer
Fragmin has worked great for me and I haven't had any side effects or problems with it.
4.3Patient Review
10/14/2009
Fragmin for Treatment to Prevent a Blood Clot in the Lung
I've been using Fragmin for 19 days to help with my ankle bone fracture and so far it's been going well. I haven't had any problems or negative reactions to the medication. As per my surgeon's instructions, I can't put any weight on the ankle until it heals a bit more which hopefully will be soon. He may recommend that I stop taking Fragmin when I see him next Tuesday but overall it's been a good experience.
3.7Patient Review
10/23/2010
Fragmin for Blood Clot in a Deep Vein
Fragmin has been very effective in precenting blood clots and strokes. The injection can be painful at times, but it is a small price to pay for the peace of mind it brings.
3.3Patient Review
11/14/2008
Fragmin for Blood Clot in a Deep Vein
I've been 27 since my motorcycle accident. I lost my left leg and severely damaged my right leg to the point where it's been in a cast for two months now. I've been getting regular shots of this medication, but recently noticed that my stomach is really bruised. Can I inject the medication into another area?
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about fragmin

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Fragmin the same as heparin?

"Fragmin is an anticoagulant that prevents ischemic complications in unstable angina and non-Q-wave myocardial infarction."

Answered by AI

What is the medication Fragmin used for?

"Dalteparin is a medication used to treat and prevent harmful blood clots. Harmful blood clots can lead to a stroke or heart attack, so by preventing them, dalteparin reduces the risk of these happening. The medication does this by lowering the activity of clotting proteins in the blood, which helps to keep the blood flowing smoothly."

Answered by AI

Does Fragmin dissolve blood clots?

"This medication is an anticoagulant, belonging to a class of medications designed to prevent blood clots from forming or growing. It does not dissolve existing blood clots."

Answered by AI

What are the side effects of Fragmin?

"The side effects of Fragmin are: easy bruising or bleeding, pain, redness, irritation, bruising, or swelling where the medicine is injected. Fragmin can cause bleeding if it has too strong of an effect on your clotting proteins."

Answered by AI

Clinical Trials for Fragmin

Have you considered Fragmin clinical trials? We made a collection of clinical trials featuring Fragmin, we think they might fit your search criteria.
Have you considered Fragmin clinical trials? We made a collection of clinical trials featuring Fragmin, we think they might fit your search criteria.
Have you considered Fragmin clinical trials? We made a collection of clinical trials featuring Fragmin, we think they might fit your search criteria.