Fragmin

Deep Vein Thrombosis (DVT), Unstable Angina Pectoris, Clotting + 14 more

Treatment

13 FDA approvals

20 Active Studies for Fragmin

Treatment for

Deep Vein Thrombosis (DVT)

What is Fragmin

DalteparinThe Generic name of this drug

Treatment SummaryDalteparin is a medication used to prevent blood clots, and it is made from porcine intestinal mucosa. It is part of the low molecular weight heparin (LMWH) family, which has a predictable response, higher absorption rate, and longer lasting effects than traditional heparin. Dalteparin is generally safe for pregnant women and is less effective at preventing clotting caused by factor IIa.

Fragminis the brand name

image of different drug pills on a surface

Fragmin Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Fragmin

Dalteparin

1994

Approved as Treatment by the FDA

Dalteparin, also known as Fragmin, is approved by the FDA for 13 uses including Deep Vein Thrombosis (DVT) and Abdominal Surgeries .

Deep Vein Thrombosis (DVT)

Abdominal Surgeries

prophylaxis of Clotting

severe restricted mobility

Prophylaxis of Venous Thromboembolic Events

General Surgery

Hemodialysis

Haemofiltration

Venous Thromboembolism

Clotting

Acute Coryza

Deep Vein Thrombosis

Arthroplasty

Effectiveness

How Fragmin Affects PatientsDalteparin works by binding to the protein antithrombin (ATIII) in the blood, which helps prevent clotting. Doctors use the anti-Xa activity of the plasma to decide how much of the drug should be given. People with a creatinine clearance of less than 20mL/min should not use this drug, and instead take unfractionated heparin. To make sure the drug is working, doctors can measure the anti-Xa activity, but will not need to measure the active partial thromboplastin time (aPTT).

How Fragmin works in the bodyDalteparin helps stop your blood from clotting, much like unfractionated heparin. However, dalteparin is more targeted, and only affects one aspect of the clotting process. This means that you don't need to monitor it as closely as you would with other anticoagulants, except to watch for signs of an overdose.

When to interrupt dosage

The measure of Fragmin depends upon the determined situation, including Haemofiltration, Prophylaxis of Venous Thromboembolic Events and General Surgery. The amount furthermore shifts as per the technique of conveyance (e.g. Subcutaneous or Solution - Intravenous; Subcutaneous) specified in the accompanying table.

Condition

Dosage

Administration

prophylaxis of Clotting

100000.0 [iU]/mL, , 10000.0 [iU]/mL, 125000.0 [iU]/mL, 150000.0 [iU]/mL, 180000.0 [iU]/mL, 25000.0 [iU]/mL, 50000.0 [iU]/mL, 75000.0 [iU]/mL, 10000.0 units/mL, 25000.0 units/mL, 2500.0 units/mL, 180000.0 units/mL, 35000.0 units/mL, 100000.0 units/mL, 50000.0 units/mL, 125000.0 units/mL, 165000.0 units/mL, 150000.0 units/mL, 75000.0 units/mL

, Subcutaneous, Injection, Injection - Subcutaneous, Intravenous; Subcutaneous, Liquid, Liquid - Intravenous; Subcutaneous, Solution, Solution - Intravenous; Subcutaneous, Solution - Parenteral, Parenteral

Unstable Angina Pectoris

Abdominal Surgeries

non-q wave myocardial infarction

Prophylaxis of Venous Thromboembolic Events

Cardiovascular Events

Acute Coryza

General Surgery

Deep Vein Thrombosis (DVT)

Haemofiltration

prophylaxis of cardiovascular event

Arthroplasty

Deep Vein Thrombosis

Hemodialysis

severe restricted mobility

Clotting

Venous Thromboembolism

Warnings

Fragmin has seven prohibitions, so it should not be employed when experiencing any of the conditions present in the following table.Fragmin Contraindications

Condition

Risk Level

Notes

Hemorrhage

Do Not Combine

history of thrombocytopenia caused by Heparin

Do Not Combine

history of thrombocytopenia with thrombosis caused by Heparin

Do Not Combine

neuraxial anesthesia

Do Not Combine

lumbar epidural anesthesia therapy

Do Not Combine

Pulse Frequency

Do Not Combine

neuraxial anesthesia

Do Not Combine

There are 20 known major drug interactions with Fragmin.

Common Fragmin Drug Interactions

Drug Name

Risk Level

Description

Albutrepenonacog alfa

Major

The therapeutic efficacy of Albutrepenonacog alfa can be decreased when used in combination with Dalteparin.

Andexanet alfa

Major

The therapeutic efficacy of Andexanet alfa can be decreased when used in combination with Dalteparin.

Anti-inhibitor coagulant complex

Major

The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Dalteparin.

Antihemophilic factor (recombinant), PEGylated

Major

The therapeutic efficacy of Antihemophilic factor (recombinant), PEGylated can be decreased when used in combination with Dalteparin.

Antihemophilic factor human

Major

The therapeutic efficacy of Antihemophilic factor human can be decreased when used in combination with Dalteparin.

Fragmin Toxicity & Overdose RiskAn overdose of heparin can lead to bleeding complications. Common side effects with extended use include bone thinning, low platelet count, and mild liver enzyme elevation. Uncommon reactions include severe allergic reactions, skin rashes and necrosis, internal bleeding, and swelling.

image of a doctor in a lab doing drug, clinical research

Fragmin Novel Uses: Which Conditions Have a Clinical Trial Featuring Fragmin?

119 active studies are currently exploring the potential of Fragmin to treat Deep Vein Thrombosis, General Surgery and prevent Clotting.

Condition

Clinical Trials

Trial Phases

Haemofiltration

0 Actively Recruiting

Unstable Angina Pectoris

0 Actively Recruiting

Cardiovascular Events

3 Actively Recruiting

Not Applicable

Abdominal Surgeries

3 Actively Recruiting

Phase 3, Not Applicable

Acute Coryza

1 Actively Recruiting

Not Applicable

Deep Vein Thrombosis (DVT)

26 Actively Recruiting

Phase 4, Phase 3, Not Applicable, Early Phase 1, Phase 1, Phase 2

Deep Vein Thrombosis

17 Actively Recruiting

Phase 4, Phase 3, Not Applicable, Phase 1, Phase 2

prophylaxis of cardiovascular event

0 Actively Recruiting

Prophylaxis of Venous Thromboembolic Events

0 Actively Recruiting

Arthroplasty

10 Actively Recruiting

Not Applicable, Phase 4, Phase 2

non-q wave myocardial infarction

0 Actively Recruiting

General Surgery

1 Actively Recruiting

Not Applicable

Clotting

0 Actively Recruiting

prophylaxis of Clotting

0 Actively Recruiting

Hemodialysis

11 Actively Recruiting

Not Applicable, Phase 3, Phase 2, Phase 1

Venous Thromboembolism

0 Actively Recruiting

severe restricted mobility

0 Actively Recruiting

Fragmin Reviews: What are patients saying about Fragmin?

5Patient Review

5/1/2012

Fragmin for Prevention of Recurrent Vein Thrombosis in Cancer

Fragmin has worked great for me and I haven't had any side effects or problems with it.

4.3Patient Review

10/14/2009

Fragmin for Treatment to Prevent a Blood Clot in the Lung

I've been using Fragmin for 19 days to help with my ankle bone fracture and so far it's been going well. I haven't had any problems or negative reactions to the medication. As per my surgeon's instructions, I can't put any weight on the ankle until it heals a bit more which hopefully will be soon. He may recommend that I stop taking Fragmin when I see him next Tuesday but overall it's been a good experience.

3.7Patient Review

10/23/2010

Fragmin for Blood Clot in a Deep Vein

Fragmin has been very effective in precenting blood clots and strokes. The injection can be painful at times, but it is a small price to pay for the peace of mind it brings.

3.3Patient Review

11/14/2008

Fragmin for Blood Clot in a Deep Vein

I've been 27 since my motorcycle accident. I lost my left leg and severely damaged my right leg to the point where it's been in a cast for two months now. I've been getting regular shots of this medication, but recently noticed that my stomach is really bruised. Can I inject the medication into another area?

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Patient Q&A Section about fragmin

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Fragmin the same as heparin?

"Fragmin is an anticoagulant that prevents ischemic complications in unstable angina and non-Q-wave myocardial infarction."

Answered by AI

What is the medication Fragmin used for?

"Dalteparin is a medication used to treat and prevent harmful blood clots. Harmful blood clots can lead to a stroke or heart attack, so by preventing them, dalteparin reduces the risk of these happening. The medication does this by lowering the activity of clotting proteins in the blood, which helps to keep the blood flowing smoothly."

Answered by AI

Does Fragmin dissolve blood clots?

"This medication is an anticoagulant, belonging to a class of medications designed to prevent blood clots from forming or growing. It does not dissolve existing blood clots."

Answered by AI

What are the side effects of Fragmin?

"The side effects of Fragmin are: easy bruising or bleeding, pain, redness, irritation, bruising, or swelling where the medicine is injected. Fragmin can cause bleeding if it has too strong of an effect on your clotting proteins."

Answered by AI