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What is Fluoroplex
FluorouracilThe Generic name of this drug
Treatment SummaryFluorouracil is a medication used to treat cancer. It works by blocking the production of the molecules needed to make DNA, which stops cancer cells from dividing and growing.
Efudexis the brand name
Fluoroplex Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Efudex
Fluorouracil
1970
62
Approved as Treatment by the FDA
Fluorouracil, also known as Efudex, is approved by the FDA for 1 uses like Actinic keratosis .Actinic keratosis
Used to treat hyperkeratotic actinic keratosis in combination with Salicylic acid
Effectiveness
How Fluoroplex Affects PatientsFluorouracil is a drug used to fight cancer. It does this by blocking certain enzymes from forming the building blocks of DNA, which prevents cells from dividing. Fluorouracil also stops an enzyme from changing one type of DNA building block into its deoxy form, and prevents the incorporation of another type of DNA building block into the DNA strand.
How Fluoroplex works in the bodyFluorouracil targets an enzyme called thymidylate synthase. It binds to this enzyme and the folate cofactor, preventing the formation of thymidylate. This stops the DNA and RNA synthesis needed for cell growth, leading to cell death. Fluorouracil can also be incorporated into RNA in place of uridine triphosphate, disrupting the RNA processing and protein synthesis needed for cell growth.
When to interrupt dosage
The recommended dose of Fluoroplex is contingent upon the determined condition, for example Actinic Keratosis, Verruca (Warts) and non-immunocompromised. The extent of dosage depends on the delivery process (e.g. Solution - Topical or Injection, solution) as specified in the table beneath.Condition
Dosage
Administration
Rectal Cancer
, 50.0 mg/mL, 0.005 mg/mg, 0.05 mg/mg, 0.04 mg/mg, 20.0 mg/mL, 5.0 %, 1.0 %, 0.5 %, 250.0 mg/mL, 0.01 mg/mg, 0.2 mg/mg, 10.0 mg/mL, 5.0 mg/mg, 125.0 mg/mL, 4.0 %, 100.0 mg/mL
, Intravenous, Injection, solution - Intravenous, Injection, solution, Topical, Cream, Cream - Topical, Solution, Solution - Topical, Solution - Intravenous, Liquid, Liquid - Intravenous, Kit, Injection, Injection - Intravenous
Verruca (Warts)
, 50.0 mg/mL, 0.005 mg/mg, 0.05 mg/mg, 0.04 mg/mg, 20.0 mg/mL, 5.0 %, 1.0 %, 0.5 %, 250.0 mg/mL, 0.01 mg/mg, 0.2 mg/mg, 10.0 mg/mL, 5.0 mg/mg, 125.0 mg/mL, 4.0 %, 100.0 mg/mL
, Intravenous, Injection, solution - Intravenous, Injection, solution, Topical, Cream, Cream - Topical, Solution, Solution - Topical, Solution - Intravenous, Liquid, Liquid - Intravenous, Kit, Injection, Injection - Intravenous
Colon Cancer
, 50.0 mg/mL, 0.005 mg/mg, 0.05 mg/mg, 0.04 mg/mg, 20.0 mg/mL, 5.0 %, 1.0 %, 0.5 %, 250.0 mg/mL, 0.01 mg/mg, 0.2 mg/mg, 10.0 mg/mL, 5.0 mg/mg, 125.0 mg/mL, 4.0 %, 100.0 mg/mL
, Intravenous, Injection, solution - Intravenous, Injection, solution, Topical, Cream, Cream - Topical, Solution, Solution - Topical, Solution - Intravenous, Liquid, Liquid - Intravenous, Kit, Injection, Injection - Intravenous
Actinic keratosis
, 50.0 mg/mL, 0.005 mg/mg, 0.05 mg/mg, 0.04 mg/mg, 20.0 mg/mL, 5.0 %, 1.0 %, 0.5 %, 250.0 mg/mL, 0.01 mg/mg, 0.2 mg/mg, 10.0 mg/mL, 5.0 mg/mg, 125.0 mg/mL, 4.0 %, 100.0 mg/mL
, Intravenous, Injection, solution - Intravenous, Injection, solution, Topical, Cream, Cream - Topical, Solution, Solution - Topical, Solution - Intravenous, Liquid, Liquid - Intravenous, Kit, Injection, Injection - Intravenous
Superficial Basal Cell Carcinoma
, 50.0 mg/mL, 0.005 mg/mg, 0.05 mg/mg, 0.04 mg/mg, 20.0 mg/mL, 5.0 %, 1.0 %, 0.5 %, 250.0 mg/mL, 0.01 mg/mg, 0.2 mg/mg, 10.0 mg/mL, 5.0 mg/mg, 125.0 mg/mL, 4.0 %, 100.0 mg/mL
, Intravenous, Injection, solution - Intravenous, Injection, solution, Topical, Cream, Cream - Topical, Solution, Solution - Topical, Solution - Intravenous, Liquid, Liquid - Intravenous, Kit, Injection, Injection - Intravenous
Breast Cancer
, 50.0 mg/mL, 0.005 mg/mg, 0.05 mg/mg, 0.04 mg/mg, 20.0 mg/mL, 5.0 %, 1.0 %, 0.5 %, 250.0 mg/mL, 0.01 mg/mg, 0.2 mg/mg, 10.0 mg/mL, 5.0 mg/mg, 125.0 mg/mL, 4.0 %, 100.0 mg/mL
, Intravenous, Injection, solution - Intravenous, Injection, solution, Topical, Cream, Cream - Topical, Solution, Solution - Topical, Solution - Intravenous, Liquid, Liquid - Intravenous, Kit, Injection, Injection - Intravenous
Pancreatic Cancer
, 50.0 mg/mL, 0.005 mg/mg, 0.05 mg/mg, 0.04 mg/mg, 20.0 mg/mL, 5.0 %, 1.0 %, 0.5 %, 250.0 mg/mL, 0.01 mg/mg, 0.2 mg/mg, 10.0 mg/mL, 5.0 mg/mg, 125.0 mg/mL, 4.0 %, 100.0 mg/mL
, Intravenous, Injection, solution - Intravenous, Injection, solution, Topical, Cream, Cream - Topical, Solution, Solution - Topical, Solution - Intravenous, Liquid, Liquid - Intravenous, Kit, Injection, Injection - Intravenous
Actinic Keratosis
, 50.0 mg/mL, 0.005 mg/mg, 0.05 mg/mg, 0.04 mg/mg, 20.0 mg/mL, 5.0 %, 1.0 %, 0.5 %, 250.0 mg/mL, 0.01 mg/mg, 0.2 mg/mg, 10.0 mg/mL, 5.0 mg/mg, 125.0 mg/mL, 4.0 %, 100.0 mg/mL
, Intravenous, Injection, solution - Intravenous, Injection, solution, Topical, Cream, Cream - Topical, Solution, Solution - Topical, Solution - Intravenous, Liquid, Liquid - Intravenous, Kit, Injection, Injection - Intravenous
Stomach Cancer
, 50.0 mg/mL, 0.005 mg/mg, 0.05 mg/mg, 0.04 mg/mg, 20.0 mg/mL, 5.0 %, 1.0 %, 0.5 %, 250.0 mg/mL, 0.01 mg/mg, 0.2 mg/mg, 10.0 mg/mL, 5.0 mg/mg, 125.0 mg/mL, 4.0 %, 100.0 mg/mL
, Intravenous, Injection, solution - Intravenous, Injection, solution, Topical, Cream, Cream - Topical, Solution, Solution - Topical, Solution - Intravenous, Liquid, Liquid - Intravenous, Kit, Injection, Injection - Intravenous
Warnings
Fluoroplex has one contraindication and should not be utilized while encountering any of the conditions stated in the following table.Fluoroplex ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Common Fluoroplex Drug Interactions
Drug Name
Risk Level
Description
2-Methoxyethanol
Major
The risk or severity of adverse effects can be increased when Fluorouracil is combined with 2-Methoxyethanol.
9-(N-methyl-L-isoleucine)-cyclosporin A
Major
The risk or severity of adverse effects can be increased when Fluorouracil is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
Abetimus
Major
The risk or severity of adverse effects can be increased when Fluorouracil is combined with Abetimus.
Acenocoumarol
Major
The metabolism of Acenocoumarol can be decreased when combined with Fluorouracil.
Acteoside
Major
The risk or severity of adverse effects can be increased when Fluorouracil is combined with Acteoside.
Fluoroplex Toxicity & Overdose RiskThe lowest dose of drug needed to cause toxicity in mice is 230mg/kg when taken orally.
Fluoroplex Novel Uses: Which Conditions Have a Clinical Trial Featuring Fluoroplex?
1138 active trials are being conducted to assess the capacity of Fluoroplex to ameliorate Stomach Cancer, Colon Cancer and Rectal Cancer.Condition
Clinical Trials
Trial Phases
Breast Cancer
716 Actively Recruiting
Phase 1, Phase 2, Phase 3, Not Applicable, Early Phase 1, Phase 4
Colon Cancer
64 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Early Phase 1
Pancreatic Cancer
229 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Early Phase 1
Actinic keratosis
0 Actively Recruiting
Verruca (Warts)
0 Actively Recruiting
Actinic Keratosis
11 Actively Recruiting
Not Applicable, Phase 2, Phase 3, Phase 1
Stomach Cancer
125 Actively Recruiting
Phase 2, Phase 1, Phase 3, Not Applicable
Rectal Cancer
52 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1
Superficial Basal Cell Carcinoma
4 Actively Recruiting
Phase 3, Phase 2, Not Applicable
Fluoroplex Reviews: What are patients saying about Fluoroplex?
5Patient Review
1/14/2011 I've used Fluoroplex on both pre-cancerous and cancerous areas of my skin with great success. The lesions have all healed without any issues.
5Patient Review
12/6/2014 I don't understand why more dermatologists don't prescribe this. It's always been something I've had to ask for, but I really love it!
4Patient Review
2/8/2013 The area I applied this to became red and irritated pretty quickly, but it did seem to be working by the time I had to stop using it due to other side effects. Compared to other treatments I've tried, this one was much more effective with fewer negative consequences.
4Patient Review
2/1/2014 I was amazed at how well this worked, even though it was painful.
3Patient Review
3/16/2010 This treatment really helped me. I'm grateful for modern medicine.
2.3Patient Review
2/17/2017 I tried this on a few pimples and it didn't seem to do anything. However, my skin did feel softer after using it and one dry spot went away.
1Patient Review
1/30/2013 Your discount card is totally useless! I was rejected for use of the card due to having Medicare part d coverage along with supplemental coverage which was also rejected for use. Being over 65 and on Medicare apparently doesn't help us when we need this tube, which cost me $415 out of pocket.
Patient Q&A Section about fluoroplex
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is Fluoroplex cream used for?
"This medication is used on the skin to treat pre-cancerous and cancerous skin growths. Fluorouracil works by inhibiting cell growth, specifically abnormal cells that cause the skin condition."
Answered by AI
How long does it take for Fluoroplex to work?
"It usually takes 2-6 weeks for FLUOROPLEX® Cream to start working. For areas of the body other than the head and neck, it may take a longer time to start seeing results."
Answered by AI
What is fluorouracil used to treat?
"Fluorouracil topical cream is a medication used to treat actinic or solar keratoses and a type of skin cancer called superficial basal cell carcinoma. Fluorouracil topical cream is only available with a doctor's prescription and is available in cream form."
Answered by AI
Is there a generic for Fluoroplex?
"A cheaper alternative to Fluoroplex is Fluorouracil (Topical). It has the same active ingredients, but is much less expensive, costing only $1,092.96 per 1, 30GM of 1% Cream."
Answered by AI