Fluoroplex

Breast Cancer, Carcinoma, Basal Cell, Rectal Cancer + 6 more
Treatment
1 FDA approval
20 Active Studies for Fluoroplex

What is Fluoroplex

FluorouracilThe Generic name of this drug
Treatment SummaryFluorouracil is a medication used to treat cancer. It works by blocking the production of the molecules needed to make DNA, which stops cancer cells from dividing and growing.
Efudexis the brand name
image of different drug pills on a surface
Fluoroplex Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Efudex
Fluorouracil
1970
62

Approved as Treatment by the FDA

Fluorouracil, also known as Efudex, is approved by the FDA for 1 uses like Actinic keratosis .
Actinic keratosis
Used to treat hyperkeratotic actinic keratosis in combination with Salicylic acid

Effectiveness

How Fluoroplex Affects PatientsFluorouracil is a drug used to fight cancer. It does this by blocking certain enzymes from forming the building blocks of DNA, which prevents cells from dividing. Fluorouracil also stops an enzyme from changing one type of DNA building block into its deoxy form, and prevents the incorporation of another type of DNA building block into the DNA strand.
How Fluoroplex works in the bodyFluorouracil targets an enzyme called thymidylate synthase. It binds to this enzyme and the folate cofactor, preventing the formation of thymidylate. This stops the DNA and RNA synthesis needed for cell growth, leading to cell death. Fluorouracil can also be incorporated into RNA in place of uridine triphosphate, disrupting the RNA processing and protein synthesis needed for cell growth.

When to interrupt dosage

The recommended dose of Fluoroplex is contingent upon the determined condition, for example Actinic Keratosis, Verruca (Warts) and non-immunocompromised. The extent of dosage depends on the delivery process (e.g. Solution - Topical or Injection, solution) as specified in the table beneath.
Condition
Dosage
Administration
Actinic keratosis
, 50.0 mg/mL, 0.005 mg/mg, 0.05 mg/mg, 0.04 mg/mg, 20.0 mg/mL, 5.0 %, 1.0 %, 0.5 %, 250.0 mg/mL, 0.01 mg/mg, 0.2 mg/mg, 10.0 mg/mL, 5.0 mg/mg, 125.0 mg/mL, 4.0 %, 100.0 mg/mL
, Intravenous, Injection, solution - Intravenous, Injection, solution, Topical, Cream, Cream - Topical, Solution, Solution - Topical, Solution - Intravenous, Liquid, Liquid - Intravenous, Kit, Injection, Injection - Intravenous
Breast Cancer
, 50.0 mg/mL, 0.005 mg/mg, 0.05 mg/mg, 0.04 mg/mg, 20.0 mg/mL, 5.0 %, 1.0 %, 0.5 %, 250.0 mg/mL, 0.01 mg/mg, 0.2 mg/mg, 10.0 mg/mL, 5.0 mg/mg, 125.0 mg/mL, 4.0 %, 100.0 mg/mL
, Intravenous, Injection, solution - Intravenous, Injection, solution, Topical, Cream, Cream - Topical, Solution, Solution - Topical, Solution - Intravenous, Liquid, Liquid - Intravenous, Kit, Injection, Injection - Intravenous
Warts
, 50.0 mg/mL, 0.005 mg/mg, 0.05 mg/mg, 0.04 mg/mg, 20.0 mg/mL, 5.0 %, 1.0 %, 0.5 %, 250.0 mg/mL, 0.01 mg/mg, 0.2 mg/mg, 10.0 mg/mL, 5.0 mg/mg, 125.0 mg/mL, 4.0 %, 100.0 mg/mL
, Intravenous, Injection, solution - Intravenous, Injection, solution, Topical, Cream, Cream - Topical, Solution, Solution - Topical, Solution - Intravenous, Liquid, Liquid - Intravenous, Kit, Injection, Injection - Intravenous
Actinic Keratosis
, 50.0 mg/mL, 0.005 mg/mg, 0.05 mg/mg, 0.04 mg/mg, 20.0 mg/mL, 5.0 %, 1.0 %, 0.5 %, 250.0 mg/mL, 0.01 mg/mg, 0.2 mg/mg, 10.0 mg/mL, 5.0 mg/mg, 125.0 mg/mL, 4.0 %, 100.0 mg/mL
, Intravenous, Injection, solution - Intravenous, Injection, solution, Topical, Cream, Cream - Topical, Solution, Solution - Topical, Solution - Intravenous, Liquid, Liquid - Intravenous, Kit, Injection, Injection - Intravenous
Carcinoma, Basal Cell
, 50.0 mg/mL, 0.005 mg/mg, 0.05 mg/mg, 0.04 mg/mg, 20.0 mg/mL, 5.0 %, 1.0 %, 0.5 %, 250.0 mg/mL, 0.01 mg/mg, 0.2 mg/mg, 10.0 mg/mL, 5.0 mg/mg, 125.0 mg/mL, 4.0 %, 100.0 mg/mL
, Intravenous, Injection, solution - Intravenous, Injection, solution, Topical, Cream, Cream - Topical, Solution, Solution - Topical, Solution - Intravenous, Liquid, Liquid - Intravenous, Kit, Injection, Injection - Intravenous
Stomach Cancer
, 50.0 mg/mL, 0.005 mg/mg, 0.05 mg/mg, 0.04 mg/mg, 20.0 mg/mL, 5.0 %, 1.0 %, 0.5 %, 250.0 mg/mL, 0.01 mg/mg, 0.2 mg/mg, 10.0 mg/mL, 5.0 mg/mg, 125.0 mg/mL, 4.0 %, 100.0 mg/mL
, Intravenous, Injection, solution - Intravenous, Injection, solution, Topical, Cream, Cream - Topical, Solution, Solution - Topical, Solution - Intravenous, Liquid, Liquid - Intravenous, Kit, Injection, Injection - Intravenous
Rectal Cancer
, 50.0 mg/mL, 0.005 mg/mg, 0.05 mg/mg, 0.04 mg/mg, 20.0 mg/mL, 5.0 %, 1.0 %, 0.5 %, 250.0 mg/mL, 0.01 mg/mg, 0.2 mg/mg, 10.0 mg/mL, 5.0 mg/mg, 125.0 mg/mL, 4.0 %, 100.0 mg/mL
, Intravenous, Injection, solution - Intravenous, Injection, solution, Topical, Cream, Cream - Topical, Solution, Solution - Topical, Solution - Intravenous, Liquid, Liquid - Intravenous, Kit, Injection, Injection - Intravenous
Colon Cancer
, 50.0 mg/mL, 0.005 mg/mg, 0.05 mg/mg, 0.04 mg/mg, 20.0 mg/mL, 5.0 %, 1.0 %, 0.5 %, 250.0 mg/mL, 0.01 mg/mg, 0.2 mg/mg, 10.0 mg/mL, 5.0 mg/mg, 125.0 mg/mL, 4.0 %, 100.0 mg/mL
, Intravenous, Injection, solution - Intravenous, Injection, solution, Topical, Cream, Cream - Topical, Solution, Solution - Topical, Solution - Intravenous, Liquid, Liquid - Intravenous, Kit, Injection, Injection - Intravenous
Pancreatic Cancer
, 50.0 mg/mL, 0.005 mg/mg, 0.05 mg/mg, 0.04 mg/mg, 20.0 mg/mL, 5.0 %, 1.0 %, 0.5 %, 250.0 mg/mL, 0.01 mg/mg, 0.2 mg/mg, 10.0 mg/mL, 5.0 mg/mg, 125.0 mg/mL, 4.0 %, 100.0 mg/mL
, Intravenous, Injection, solution - Intravenous, Injection, solution, Topical, Cream, Cream - Topical, Solution, Solution - Topical, Solution - Intravenous, Liquid, Liquid - Intravenous, Kit, Injection, Injection - Intravenous

Warnings

Fluoroplex has one contraindication and should not be utilized while encountering any of the conditions stated in the following table.Fluoroplex Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
There are 20 known major drug interactions with Fluoroplex.
Common Fluoroplex Drug Interactions
Drug Name
Risk Level
Description
2-Methoxyethanol
Major
The risk or severity of adverse effects can be increased when Fluorouracil is combined with 2-Methoxyethanol.
9-(N-methyl-L-isoleucine)-cyclosporin A
Major
The risk or severity of adverse effects can be increased when Fluorouracil is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
Abetimus
Major
The risk or severity of adverse effects can be increased when Fluorouracil is combined with Abetimus.
Acenocoumarol
Major
The metabolism of Acenocoumarol can be decreased when combined with Fluorouracil.
Acteoside
Major
The risk or severity of adverse effects can be increased when Fluorouracil is combined with Acteoside.
Fluoroplex Toxicity & Overdose RiskThe lowest dose of drug needed to cause toxicity in mice is 230mg/kg when taken orally.

Fluoroplex Novel Uses: Which Conditions Have a Clinical Trial Featuring Fluoroplex?

1138 active trials are being conducted to assess the capacity of Fluoroplex to ameliorate Stomach Cancer, Colon Cancer and Rectal Cancer.
Condition
Clinical Trials
Trial Phases
Stomach Cancer
110 Actively Recruiting
Phase 2, Phase 3, Phase 1, Not Applicable, Phase 4
Pancreatic Cancer
167 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Early Phase 1, Phase 4
Rectal Cancer
43 Actively Recruiting
Phase 3, Phase 2, Not Applicable, Phase 1
Colon Cancer
55 Actively Recruiting
Not Applicable, Phase 1, Phase 2
Breast Cancer
21 Actively Recruiting
Phase 2, Phase 1, Not Applicable
Actinic keratosis
0 Actively Recruiting
Carcinoma, Basal Cell
0 Actively Recruiting
Warts
0 Actively Recruiting
Actinic Keratosis
10 Actively Recruiting
Not Applicable, Phase 2, Phase 3, Phase 1, Phase 4

Fluoroplex Reviews: What are patients saying about Fluoroplex?

5Patient Review
1/14/2011
Fluoroplex for Roughened Red Patches of Skin due to Sun Exposure
I've used Fluoroplex on both pre-cancerous and cancerous areas of my skin with great success. The lesions have all healed without any issues.
5Patient Review
12/6/2014
Fluoroplex for Roughened Red Patches of Skin due to Sun Exposure
I don't understand why more dermatologists don't prescribe this. It's always been something I've had to ask for, but I really love it!
4Patient Review
2/8/2013
Fluoroplex for Roughened Red Patches of Skin due to Sun Exposure
The area I applied this to became red and irritated pretty quickly, but it did seem to be working by the time I had to stop using it due to other side effects. Compared to other treatments I've tried, this one was much more effective with fewer negative consequences.
4Patient Review
2/1/2014
Fluoroplex for Superficial Basal Cell Carcinoma of the Skin
I was amazed at how well this worked, even though it was painful.
3Patient Review
3/16/2010
Fluoroplex for Osteoporosis
This treatment really helped me. I'm grateful for modern medicine.
2.3Patient Review
2/17/2017
Fluoroplex for Roughened Red Patches of Skin due to Sun Exposure
I tried this on a few pimples and it didn't seem to do anything. However, my skin did feel softer after using it and one dry spot went away.
1Patient Review
1/30/2013
Fluoroplex for Roughened Red Patches of Skin due to Sun Exposure
Your discount card is totally useless! I was rejected for use of the card due to having Medicare part d coverage along with supplemental coverage which was also rejected for use. Being over 65 and on Medicare apparently doesn't help us when we need this tube, which cost me $415 out of pocket.

Patient Q&A Section about fluoroplex

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Fluoroplex cream used for?

"This medication is used on the skin to treat pre-cancerous and cancerous skin growths. Fluorouracil works by inhibiting cell growth, specifically abnormal cells that cause the skin condition."

Answered by AI

How long does it take for Fluoroplex to work?

"It usually takes 2-6 weeks for FLUOROPLEX® Cream to start working. For areas of the body other than the head and neck, it may take a longer time to start seeing results."

Answered by AI

What is fluorouracil used to treat?

"Fluorouracil topical cream is a medication used to treat actinic or solar keratoses and a type of skin cancer called superficial basal cell carcinoma. Fluorouracil topical cream is only available with a doctor's prescription and is available in cream form."

Answered by AI

Is there a generic for Fluoroplex?

"A cheaper alternative to Fluoroplex is Fluorouracil (Topical). It has the same active ingredients, but is much less expensive, costing only $1,092.96 per 1, 30GM of 1% Cream."

Answered by AI

Clinical Trials for Fluoroplex

Have you considered Fluoroplex clinical trials? We made a collection of clinical trials featuring Fluoroplex, we think they might fit your search criteria.Go to Trials
Image of Carolina Biooncology in Huntersville, United States.

RNDO-564 + Pembrolizumab for Bladder Cancer

18+
All Sexes
Huntersville, NC
The main goal of this study is to evaluate how safe and tolerable RNDO-564 is and to identify the best dose of RNDO-564 as a single agent and in combination with pembrolizumab. The study is focused on participants with certain solid tumors that are in an advanced stage and have certain tumor makers. This will be done by measuring the side effects that participants experience and how severe they are. Additionally, the study will evaluate how RNDO-564 moves into, through, and out of the body and how the treatment affects the body. The second goal of this study is to evaluate how well RNDO-564 works by itself or in combination with pembrolizumab at treating participants' cancer. This will be done by measuring the number of participants who respond to the treatment. The length of time where the tumor does not grow or spread will also be measured. Participants will take RNDO-564 weekly on Days 1, 8 and 15 of a 21 day cycle. Participants in the combination arms will take RNDO-564 as described with pembrolizumab every 3 weeks.
Phase 1
Recruiting
Carolina Biooncology (+1 Sites)Thomas Manley, MDRondo Therapeutics
Have you considered Fluoroplex clinical trials? We made a collection of clinical trials featuring Fluoroplex, we think they might fit your search criteria.Go to Trials
Image of University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center in Cleveland, United States.

Stereotactic Body Radiotherapy for Pancreatic Cancer Pain

18+
All Sexes
Cleveland, OH
Participants who are experiencing abdominal pain due to having cancer in their pancreas may be eligible for this research study. For this type of pain, doctors often recommend radiation therapy to help with the pain. This radiation therapy is called stereotactic body radiotherapy (SBRT). Preparing for SBRT typically takes a week or longer. In this research study, doctors want to test a new workflow in order to shorten the time it takes for participants to receive SBRT to help with their pain. Doctors typically determine how to administer the SBRT by doing a simulation, which requires a CT (Computerized Tomography) scan. The CT scan is used to create a treatment plan. It can take time to schedule this CT scan and then it takes 5-10 days to create a treatment plan. A way to reduce the planning time for SBRT is to use the CT scan that participants had when their cancer was diagnosed to plan the SBRT. This new workflow can cut down the time it takes to schedule another CT scan and plan for and deliver SBRT. The workflow where doctors use a pre-existing CT scan is called CTsim-free treatment planning. CTsim-free treatment planning is what is being tested in this research study.
Phase 1
Waitlist Available
University Hospitals Seidman Cancer Center, Case Comprehensive Cancer CenterLauren Henke, MD, MSCI
Have you considered Fluoroplex clinical trials? We made a collection of clinical trials featuring Fluoroplex, we think they might fit your search criteria.Go to Trials
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