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What is Fenofibric Acid
Fenofibric acidThe Generic name of this drug
Treatment SummaryFenofibric acid is a medication that is used to lower levels of cholesterol and triglycerides in the blood. It works by lowering low-density lipoprotein cholesterol, total cholesterol, triglycerides, and apolipoprotein B, while increasing high-density lipoprotein cholesterol. Because the medication is not easily absorbed by the body, prodrugs and other compounds have been developed to improve its absorption and make it easier to take.
Fenofibric Acidis the brand name
Fenofibric Acid Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Fenofibric Acid
Fenofibric acid
2008
66
Effectiveness
How Fenofibric Acid Affects PatientsStudies have shown that high levels of cholesterol, LDL-C (low-density lipoprotein), and apolipoprotein B (which is part of an LDL membrane complex) are linked to atherosclerosis. At the same time, lower levels of HDL-C (high-density lipoprotein) and apolipoproteins apo AI and apo AII are linked to atherosclerosis. Research has also found that cardiovascular disease and death are related to the levels of total cholesterol, LDL-C, and triglycerides, but inversely related to the level of HDL-C. Taking fenof
How Fenofibric Acid works in the bodyFenofibric acid works by activating a receptor in the body called PPAR-alpha. This causes lipolysis, which breaks down fatty particles in the blood. It also makes bigger, cholesterol-absorbing particles which are quickly broken down and removed from the body. Fenofibric acid also increases the amount of beneficial proteins in the blood, such as apoproteins A-I and A-II, as well as high-density lipoproteins. Finally, it helps reduce uric acid levels in both regular and hyperuricemic individuals by increasing the amount of uric acid that is removed from the body
When to interrupt dosage
The recommended dosage of Fenofibric Acid is contingent upon the diagnosed affliction, including Hypertriglyceridemias, Primary Hypercholesterolemia and Diet. The quantity of dosage alters as per the presentation approach (e.g. Capsule, delayed release - Oral or Oral) noted in the table below.Condition
Dosage
Administration
Primary Hypercholesterolemia
, 45.0 mg, 135.0 mg, 35.0 mg, 105.0 mg
, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, Tablet - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral
Hypertriglyceridemias
, 45.0 mg, 135.0 mg, 35.0 mg, 105.0 mg
, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, Tablet - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral
Diet
, 45.0 mg, 135.0 mg, 35.0 mg, 105.0 mg
, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, Tablet - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral
Triglycerides
, 45.0 mg, 135.0 mg, 35.0 mg, 105.0 mg
, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, Tablet - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral
Dyslipidemias
, 45.0 mg, 135.0 mg, 35.0 mg, 105.0 mg
, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, Tablet - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral
Warnings
Fenofibric Acid has five contraindications and should not be taken concurrently with any of the conditions featured in the subsequent table.Fenofibric Acid ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Fenofibric Acid may interact with Pulse Frequency
active liver disease
Do Not Combine
severe renal dysfunction
Do Not Combine
Disease
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Fenofibric Acid may interact with Pulse Frequency
Common Fenofibric Acid Drug Interactions
Drug Name
Risk Level
Description
Albutrepenonacog alfa
Minor
Fenofibric acid may decrease the excretion rate of Albutrepenonacog alfa which could result in a higher serum level.
Bismuth subgallate
Minor
Fenofibric acid may decrease the excretion rate of Bismuth subgallate which could result in a higher serum level.
Choline salicylate
Minor
Fenofibric acid may decrease the excretion rate of Choline salicylate which could result in a higher serum level.
Chromic citrate
Minor
Fenofibric acid may decrease the excretion rate of Chromic citrate which could result in a higher serum level.
Chromic nitrate
Minor
Fenofibric acid may decrease the excretion rate of Chromic nitrate which could result in a higher serum level.
Fenofibric Acid Novel Uses: Which Conditions Have a Clinical Trial Featuring Fenofibric Acid?
14 active clinical trials are analyzing the potential of Fenofibric Acid in relation to Diet, Dyslipidemias and Triglyceride levels.Condition
Clinical Trials
Trial Phases
Dyslipidemias
1 Actively Recruiting
Phase 2
Diet
5 Actively Recruiting
Not Applicable
Primary Hypercholesterolemia
16 Actively Recruiting
Early Phase 1, Not Applicable, Phase 3, Phase 2
Triglycerides
0 Actively Recruiting
Hypertriglyceridemias
0 Actively Recruiting
Fenofibric Acid Reviews: What are patients saying about Fenofibric Acid?
5Patient Review
8/18/2010 This treatment really helped me. I'm grateful for modern medicine.
5Patient Review
11/29/2021 My triglyceride level was very high, over 900, and my total cholesterol was 350. However, after my doctor switched me to Fenofibric Acid and Pravastatin, combining the two dropped my triglycerides to 150 and my total cholesterol to just 200 in three months. I've been on the new drugs for six months now with no issues.
3Patient Review
4/14/2017 I was unaware that sleeplessness was a potential side effect of this medication. After taking it for approximately one month, I started having pretty severe insomnia. However, after doing some research I found out that while it is possible, it's not very common. Once I stopped the medication, the insomnia went away as well.
3Patient Review
3/16/2010 I didn't have a great experience with this medication. I felt like it made me retain water, which led to weight gain and dry skin. Once I stopped taking the medication, all of those symptoms went away.
2.3Patient Review
1/10/20101Patient Review
12/4/2016 I took this medicine for a month along with atorvastin and noticed increased nausea and hot flashes. It was like my hormones were messed up. I have been off for about a week and both side effects are gone.
1Patient Review
7/7/2014 I have become weak and tired since taking this medication.
Patient Q&A Section about fenofibric acid
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.When is the best time to take fenofibric acid?
"The dosage is based on your medical condition and response to treatment.
To use Fenofibric Acid, take it by mouth once a day with or without food, as directed by your doctor. The dosage is based on your medical condition and response to treatment."
Answered by AI
Does fenofibric acid have side effects?
"If you experience any muscle pain, tenderness, or weakness, call your doctor, as it could be a sign of a rare condition that causes the breakdown of skeletal muscle tissue, leading to kidney failure."
Answered by AI
What does fenofibric acid do for you?
"Fenofibric acid is a medication used to treat high cholesterol and triglyceride levels in the blood, often in conjunction with a healthy diet. This can help prevent the development of pancreatitis, which is caused by high levels of triglycerides in the blood."
Answered by AI
What is the difference between fenofibric acid and fenofibrate?
"Fenofibrate is a type of fenofibric acid, and after humans consume it orally, it is turned into its active metabolite with no trace of the original compound found in the bloodstream. Fenofibric acid is mostly combined with glucuronic acid before being excreted in urine."
Answered by AI