MAAT for Chemotherapy-Related Cognitive Impairment
(TAMS Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests if a therapy called MAAT can help breast cancer survivors who have had chemotherapy improve their memory and attention. The therapy involves learning new thinking and behavior strategies to manage cognitive problems better.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It might be best to discuss this with the trial coordinators or your doctor.
Is Memory and Attention Adaptation Training (MAAT) safe for humans?
How is the treatment MAAT different from other treatments for chemotherapy-related cognitive impairment?
What data supports the effectiveness of the treatment Memory and Attention Adaptation Training (MAAT) for chemotherapy-related cognitive impairment?
Research shows that MAAT, a type of cognitive-behavioral therapy, helps improve memory and attention in breast cancer survivors who have undergone chemotherapy. Participants in studies reported better cognitive function and quality of life after receiving MAAT, and they found it helpful in managing memory problems.12347
Who Is on the Research Team?
Robert J Ferguson, PhD
Principal Investigator
St. Jude Children's Research Hospital
Donna Posluszny, PhD
Principal Investigator
University of Pittsburgh
Are You a Good Fit for This Trial?
This trial is for breast cancer survivors who've had chemotherapy, are currently disease-free, and experiencing memory or concentration issues. They must be 1-5 years post-treatment, over 18, speak English, and willing to use videoconferencing. Exclusions include severe memory disorders, previous CNS treatments unrelated to their cancer, other mental health conditions that could affect cognition.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive either Memory and Attention Adaptation Training (MAAT) or Supportive Therapy (ST) for 8 weeks via videoconferencing
Post-Treatment Assessment
Participants undergo post-treatment assessments including cognitive function tests and optional fMRI
Follow-up
Participants are monitored for safety and effectiveness after treatment, with assessments at 6-month follow-up
What Are the Treatments Tested in This Trial?
Interventions
- Memory and Attention Adaptation Training (MAAT)
- Supportive Therapy (ST)
Memory and Attention Adaptation Training (MAAT) is already approved in United States for the following indications:
- Chemotherapy-related cognitive dysfunction in breast cancer survivors
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Pittsburgh
Lead Sponsor
National Institutes of Health (NIH)
Collaborator
National Cancer Institute (NCI)
Collaborator