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What is Felodipine
FelodipineThe Generic name of this drug
Treatment SummaryFelodipine is a type of medication used to treat high blood pressure. It works by blocking calcium influx into the cells of the smooth muscle in the walls of the blood vessels, which helps relax the vessel and lower blood pressure. Felodipine is unique in that it binds to various calcium-binding proteins, competes with mineralcorticoid receptors, and blocks calcium influx through voltage-gated T-type calcium channels. This makes it the most potent calcium channel blocker currently available.
Plendilis the brand name
Felodipine Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Plendil
Felodipine
1991
128
Approved as Treatment by the FDA
Felodipine, also known as Plendil, is approved by the FDA for 1 uses including Hypertensive disease .Hypertensive disease
Helps manage High Blood Pressure (Hypertension)
Effectiveness
How Felodipine Affects PatientsFelodipine is a type of calcium channel blocker, which are drugs used to reduce blood pressure. It works by blocking the activity of certain types of calcium channels, and may also interfere with other proteins involved in muscle contraction, cell excitability and hormone regulation. Though it binds to many different molecules, it is believed that its main effects come from blocking the voltage-gated L-type calcium channels, which are more abundant in artery cells than in heart cells. This makes it more effective at reducing blood pressure in the arteries than in the heart.
How Felodipine works in the bodyFelodipine works to reduce blood pressure by decreasing the amount of calcium that enters cells in your arteries. Normally, when calcium binds to a protein called calmodulin, it triggers a reaction that causes your arteries to contract. Felodipine prevents this reaction from happening, so your arteries stay relaxed and your blood pressure goes down. This makes felodipine an effective treatment for mild to moderate high blood pressure.
When to interrupt dosage
The dosage of Felodipine is contingent upon the diagnosed condition. The measure of dosage is also dependent upon the technique of delivery listed in the table below.Condition
Dosage
Administration
previous failed monotherapy
2.5 mg, , 10.0 mg, 5.0 mg
, Tablet, extended release, Tablet, extended release - Oral, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Hypertensive disease
2.5 mg, , 10.0 mg, 5.0 mg
, Tablet, extended release, Tablet, extended release - Oral, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Warnings
There are 20 known major drug interactions with Felodipine.Common Felodipine Drug Interactions
Drug Name
Risk Level
Description
(R)-warfarin
Major
The metabolism of (R)-warfarin can be decreased when combined with Felodipine.
(S)-Warfarin
Major
The metabolism of (S)-Warfarin can be decreased when combined with Felodipine.
Acenocoumarol
Major
The metabolism of Acenocoumarol can be decreased when combined with Felodipine.
Almotriptan
Major
The metabolism of Almotriptan can be decreased when combined with Felodipine.
Amifostine
Major
Felodipine may increase the hypotensive activities of Amifostine.
Felodipine Toxicity & Overdose RiskOverdosing on propranolol can lead to excessive widening of blood vessels, causing a significant drop in blood pressure and a slow heart rate. The lowest toxic dose of propranolol in rats has been found to be 1050mg/kg.
Felodipine Novel Uses: Which Conditions Have a Clinical Trial Featuring Felodipine?
Currently, 18 active studies are investigating the potential of Felodipine to address therapeutic failure in previous monotherapy interventions.Condition
Clinical Trials
Trial Phases
previous failed monotherapy
0 Actively Recruiting
Hypertensive disease
19 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Felodipine Reviews: What are patients saying about Felodipine?
5Patient Review
8/3/2018 I started having problems when I increased my dosage to 2.5 twice a day like the doctor recommended. I felt tired, foggy-eyed, and off balance all the time. Yesterday I stopped taking the drug altogether to see if that would help, and so far I'm feeling better.
5Patient Review
11/11/2014 Initially, this worked well to reduce my high blood pressure. However, after some time my doctor prescribed calcium with vitamin D, and that caused me a lot of pain in my chest. I now have to avoid calcium supplements and soy entirely.
5Patient Review
4/26/2012 When I first started taking this medication, I experienced an itchy rash on my arms and neck. Additionally, I had problems with erectile dysfunction (although I'm not sure if the two were related). Luckily, Levitra corrected the issue.
4.3Patient Review
8/5/2013 This has been helping me a lot with my chronic back pain.
4.3Patient Review
2/2/20114Patient Review
5/27/2016 I've been using this medication for a little while now and it's been mostly effective. However, I have noticed more tingling in my feet recently and I'm pretty sure it's because of the meds.
4Patient Review
11/30/20113.3Patient Review
12/21/2013 This treatment has helped lower my blood pressure, but I still need a diuretic for swelling and have developed a rash.
3.3Patient Review
11/20/2012 This medication didn't do much for my constipation.
3Patient Review
8/2/2022 Since starting felodopine 2 months ago, I have developed really bad pains at the back of both legs. My GP checked me for blood clots and said I was all clear. I was told that if it was the felodopine, I would have swollen legs and feet, but I don't. This has made my life miserable as I can't do any of the things I enjoy anymore.
3Patient Review
4/11/2021 I stopped taking this medication because my left leg was swelling and it felt like I had sciatica. The swelling has gone down, but the pain is still there.
3Patient Review
5/20/20112.7Patient Review
12/30/2012 I've been on this medication for a few years now, and my doctor is upping the dosage because my blood pressure is still high (145/75) and my glucose levels are also elevated. All of my other labwork came back normal.
2.3Patient Review
1/2/2014 My blood pressure readings have remained elevated since starting this medication.
2Patient Review
1/16/2019 I developed a cough and some difficulty breathing after starting this medication. Has anyone else had similar problems?
2Patient Review
7/2/2012 I've been feeling dizzy since starting this medication.
1Patient Review
10/4/2015 I started taking this medication, and it has caused my joints to become incredibly painful. I can hardly get out of bed in the morning, and feel like I need a wheelchair. These drugs are not right for me.
Patient Q&A Section about felodipine
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is the difference between felodipine and amlodipine?
"The text is saying that Amlodipine is more effective than Felodipine, likely because Amlodipine stays in the system for a longer time."
Answered by AI
What is the side effect of felodipine?
"If you experience bloating or swelling of the face, arms, hands, lower legs, or feet; tingling of the hands or feet; or unusual weight gain or weight loss, tell your doctor right away. You may also experience redness, swelling, or bleeding of the gums while taking this medicine."
Answered by AI
Is felodipine a good blood pressure tablet?
"Felodipine is used to treat high blood pressure. This medication relaxes and widens blood vessels so blood can flow more easily, which helps prevent strokes, heart attacks, and kidney problems."
Answered by AI
What is the drug felodipine used for?
"Felodipine is a medication used to treat high blood pressure that works by blocking calcium channels."
Answered by AI