Felodipine

Hypertensive disease, previous failed monotherapy
Treatment
1 FDA approval
20 Active Studies for Felodipine

What is Felodipine

FelodipineThe Generic name of this drug
Treatment SummaryFelodipine is a type of medication used to treat high blood pressure. It works by blocking calcium influx into the cells of the smooth muscle in the walls of the blood vessels, which helps relax the vessel and lower blood pressure. Felodipine is unique in that it binds to various calcium-binding proteins, competes with mineralcorticoid receptors, and blocks calcium influx through voltage-gated T-type calcium channels. This makes it the most potent calcium channel blocker currently available.
Plendilis the brand name
image of different drug pills on a surface
Felodipine Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Plendil
Felodipine
1991
128

Approved as Treatment by the FDA

Felodipine, also known as Plendil, is approved by the FDA for 1 uses including Hypertensive disease .
Hypertensive disease
Helps manage High Blood Pressure (Hypertension)

Effectiveness

How Felodipine Affects PatientsFelodipine is a type of calcium channel blocker, which are drugs used to reduce blood pressure. It works by blocking the activity of certain types of calcium channels, and may also interfere with other proteins involved in muscle contraction, cell excitability and hormone regulation. Though it binds to many different molecules, it is believed that its main effects come from blocking the voltage-gated L-type calcium channels, which are more abundant in artery cells than in heart cells. This makes it more effective at reducing blood pressure in the arteries than in the heart.
How Felodipine works in the bodyFelodipine works to reduce blood pressure by decreasing the amount of calcium that enters cells in your arteries. Normally, when calcium binds to a protein called calmodulin, it triggers a reaction that causes your arteries to contract. Felodipine prevents this reaction from happening, so your arteries stay relaxed and your blood pressure goes down. This makes felodipine an effective treatment for mild to moderate high blood pressure.

When to interrupt dosage

The dosage of Felodipine is contingent upon the diagnosed condition. The measure of dosage is also dependent upon the technique of delivery listed in the table below.
Condition
Dosage
Administration
Hypertensive disease
2.5 mg, , 10.0 mg, 5.0 mg
, Tablet, extended release, Tablet, extended release - Oral, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
previous failed monotherapy
2.5 mg, , 10.0 mg, 5.0 mg
, Tablet, extended release, Tablet, extended release - Oral, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral

Warnings

There are 20 known major drug interactions with Felodipine.
Common Felodipine Drug Interactions
Drug Name
Risk Level
Description
(R)-warfarin
Major
The metabolism of (R)-warfarin can be decreased when combined with Felodipine.
(S)-Warfarin
Major
The metabolism of (S)-Warfarin can be decreased when combined with Felodipine.
Acenocoumarol
Major
The metabolism of Acenocoumarol can be decreased when combined with Felodipine.
Almotriptan
Major
The metabolism of Almotriptan can be decreased when combined with Felodipine.
Amifostine
Major
Felodipine may increase the hypotensive activities of Amifostine.
Felodipine Toxicity & Overdose RiskOverdosing on propranolol can lead to excessive widening of blood vessels, causing a significant drop in blood pressure and a slow heart rate. The lowest toxic dose of propranolol in rats has been found to be 1050mg/kg.
image of a doctor in a lab doing drug, clinical research

Felodipine Novel Uses: Which Conditions Have a Clinical Trial Featuring Felodipine?

Currently, 18 active studies are investigating the potential of Felodipine to address therapeutic failure in previous monotherapy interventions.
Condition
Clinical Trials
Trial Phases
previous failed monotherapy
0 Actively Recruiting
Hypertensive disease
27 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3

Felodipine Reviews: What are patients saying about Felodipine?

5Patient Review
8/3/2018
Felodipine for High Blood Pressure
I started having problems when I increased my dosage to 2.5 twice a day like the doctor recommended. I felt tired, foggy-eyed, and off balance all the time. Yesterday I stopped taking the drug altogether to see if that would help, and so far I'm feeling better.
5Patient Review
11/11/2014
Felodipine for High Blood Pressure
Initially, this worked well to reduce my high blood pressure. However, after some time my doctor prescribed calcium with vitamin D, and that caused me a lot of pain in my chest. I now have to avoid calcium supplements and soy entirely.
5Patient Review
4/26/2012
Felodipine for High Blood Pressure
When I first started taking this medication, I experienced an itchy rash on my arms and neck. Additionally, I had problems with erectile dysfunction (although I'm not sure if the two were related). Luckily, Levitra corrected the issue.
4.3Patient Review
8/5/2013
Felodipine for High Blood Pressure
This has been helping me a lot with my chronic back pain.
4.3Patient Review
2/2/2011
Felodipine for High Blood Pressure
4Patient Review
5/27/2016
Felodipine for High Blood Pressure
I've been using this medication for a little while now and it's been mostly effective. However, I have noticed more tingling in my feet recently and I'm pretty sure it's because of the meds.
4Patient Review
11/30/2011
Felodipine for High Blood Pressure
3.3Patient Review
12/21/2013
Felodipine for High Blood Pressure
This treatment has helped lower my blood pressure, but I still need a diuretic for swelling and have developed a rash.
3.3Patient Review
11/20/2012
Felodipine for High Blood Pressure
This medication didn't do much for my constipation.
3Patient Review
8/2/2022
Felodipine for High Blood Pressure
Since starting felodopine 2 months ago, I have developed really bad pains at the back of both legs. My GP checked me for blood clots and said I was all clear. I was told that if it was the felodopine, I would have swollen legs and feet, but I don't. This has made my life miserable as I can't do any of the things I enjoy anymore.
3Patient Review
4/11/2021
Felodipine for High Blood Pressure
I stopped taking this medication because my left leg was swelling and it felt like I had sciatica. The swelling has gone down, but the pain is still there.
3Patient Review
5/20/2011
Felodipine for Occasional Numbness, Prickling, or Tingling of Fingers and Toes
2.7Patient Review
12/30/2012
Felodipine for High Blood Pressure
I've been on this medication for a few years now, and my doctor is upping the dosage because my blood pressure is still high (145/75) and my glucose levels are also elevated. All of my other labwork came back normal.
2.3Patient Review
1/2/2014
Felodipine for High Blood Pressure
My blood pressure readings have remained elevated since starting this medication.
2Patient Review
1/16/2019
Felodipine for High Blood Pressure
I developed a cough and some difficulty breathing after starting this medication. Has anyone else had similar problems?
2Patient Review
7/2/2012
Felodipine for High Blood Pressure
I've been feeling dizzy since starting this medication.
1Patient Review
10/4/2015
Felodipine for High Blood Pressure
I started taking this medication, and it has caused my joints to become incredibly painful. I can hardly get out of bed in the morning, and feel like I need a wheelchair. These drugs are not right for me.
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Patient Q&A Section about felodipine

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the difference between felodipine and amlodipine?

"The text is saying that Amlodipine is more effective than Felodipine, likely because Amlodipine stays in the system for a longer time."

Answered by AI

What is the side effect of felodipine?

"If you experience bloating or swelling of the face, arms, hands, lower legs, or feet; tingling of the hands or feet; or unusual weight gain or weight loss, tell your doctor right away. You may also experience redness, swelling, or bleeding of the gums while taking this medicine."

Answered by AI

Is felodipine a good blood pressure tablet?

"Felodipine is used to treat high blood pressure. This medication relaxes and widens blood vessels so blood can flow more easily, which helps prevent strokes, heart attacks, and kidney problems."

Answered by AI

What is the drug felodipine used for?

"Felodipine is a medication used to treat high blood pressure that works by blocking calcium channels."

Answered by AI

Clinical Trials for Felodipine

Image of University of Alabama at Birmingham in Birmingham, United States.

Dietary Interventions for Hypertension

18+
All Sexes
Birmingham, AL
Natriuretic peptides (NPs) are hormones produced by the heart and play an important role in maintaining cardiovascular health and have favorable metabolic benefits. Low NP levels are associated with an increased likelihood of the development of cardiometabolic diseases like diabetes and hypertension. NP levels are known to be highly heritable, with up to half of the differences in NP levels being explained by genetics. The investigators aim to describe the genetic architecture of NPs by examining the genetic variants associated with NPs, and generate and validate a polygenic score (PGS) for NPs. The investigators will use this NP PGS to examine the association of genetically determined NP levels with cardiometabolic and cardiovascular outcomes. The investigators will conduct a genotype-guided physiological clinical trial that aims to assess the genetic factors affecting NP levels and their impact on blood pressure and NP response to saline infusion, high-salt diet, and low-salt diet. These findings will help support personal medicine approaches to lower the increasing burden of hypertension in the United States.
Waitlist Available
Has No Placebo
University of Alabama at BirminghamPankaj Arora, MD, FAHA
Have you considered Felodipine clinical trials? We made a collection of clinical trials featuring Felodipine, we think they might fit your search criteria.Go to Trials
Image of Wayne Health Mobile Units in Detroit, United States.

Text Message Reminders for High Blood Pressure

18+
All Sexes
Detroit, MI
This project is part of the ACHIEVE GREATER (Addressing Cardiometabolic Health In Populations Through Early PreVEntion in the GREAT LakEs Region) Center (IRB# 100221MP2A), the purpose of which is to improve cardiometabolic health in two uniquely comparable cities: Detroit, Michigan, and Cleveland, Ohio. The ACHIEVE GREATER Center involves separate but related projects that aim to improve cardiometabolic health outcomes through better risk factor control for three chronic conditions that are of tremendous public health importance, (hypertension (HTN), heart failure, and coronary heart disease), all of which contribute significantly to premature death in Detroit and Cleveland. The present study is the prospective observational cohort component of ACHIEVE P1- EPI (Project 1) of the ACHIEVE GREATER Center and serves to characterize the population of patients with blood pressure (BP) levels above normal attending The Wayne Health Mobile Health Unit (MHU) events to better understand key factors (e.g., social determinants of health) that convey information about baseline BP levels and related clinical outcomes (e.g., follow-up clinic visits, BP control, and cardiovascular events).
Recruiting
Has No Placebo
Wayne Health Mobile UnitsSteven J Korzeniewski, PhD
Have you considered Felodipine clinical trials? We made a collection of clinical trials featuring Felodipine, we think they might fit your search criteria.Go to Trials
Image of Northern Arizona University in Flagstaff, United States.

CardioCare Quest for High Blood Pressure

18+
All Sexes
Flagstaff, AZ
This project aims to address healthcare disparities among Navaho people diagnosed with hypertension or prehypertension through three main objectives. Firstly, it identifies and shares insights on healthcare access disparities affecting Navaho individuals experiencing nonadherence to hypertension treatment. Secondly, the proposal develops a telehealth solution based on factors identified as knowledge gaps caused by healthcare access disparities in hypertension management; we will use the factors to design a series of engaging minigames that can be incorporated into the larger CardioCare Quest. These minigames will be co-designed with end users and clinicians. Finally, the proposal conducts comprehensive qualitative and quantitative assessments of user experiences, perceptions, and challenges with CardioCare Quest.
Recruiting
Has No Placebo
Northern Arizona University (+1 Sites)Tochukwu Ikwunne, PhD
Image of Tufts University in Boston, United States.

Food as Medicine for Cardiometabolic Health

18+
All Sexes
Boston, MA
Though the Mississippi Delta has a rich agricultural history and some of the nation's most fertile soil, residents have experienced the legacy of slavery and economic exploitation through food insecurity and poverty for generations. This project focuses on Bolivar, Washington, and Sunflower, contiguous counties in the Delta that are designated as health disparity populations. Over 65% of the 100,000 residents are Black/African American and \~30% live at or below the poverty level. Obesity rates are high and the rate of diabetes is almost double the national average. Tufts University received a grant from the National Institute of Minority Health and Health Disparities to develop, test, and evaluate a Food is Medicine program in Mississippi. The Delta Growing a Resilient, Enriching, Equitable, Nourishing food System (GREENS) Food is Medicine (FIM) Project, is a collaborative project in Bolivar, Washington, and Sunflower counties in Mississippi. The intervention involves regularly distributed fruit and vegetable produce boxes as well as nutrition education materials to the intervention group. The control group will receive produce boxes later, after they complete study activities. The project's primary goal is to improve health outcomes by creating a FIM intervention. The Delta GREENS FIM Project aims to become a model for promoting nutrition security and management of chronic conditions in varied communities nationwide.
Recruiting
Has No Placebo
Tufts UniversityChristina D Economos, PhD
Image of Providence College in Providence, United States.

Heat Therapy for High Blood Pressure

18 - 50
All Sexes
Providence, RI
The goal of this clinical trial is to test whether putting a participant's legs in a hot bath after exercise improves blood pressure in people with higher blood pressure. . The main questions it aims to answer are: * Whether exercise alone, hot water leg bath alone, or both treatments together cause blood pressure to be lower during sleep. * If there are any changes in heart rhythm or blood vessel health after exercise, hot water leg bath, or the two treatments together that relate to changes in blood pressure. Participants will complete four different trials: * 30 minutes of walking with a 45-minute lukewarm leg bath after * 30 minutes of walking with a 45-minute hot leg bath after * 45 minutes of a hot leg bath with no exercise * A day with no exercise or leg bath Researchers will look at heart rhythm, blood vessels, and blood pressure after each of these trials to see if there are differences, and if exercise and heat together can improve heart health more than exercise or heat alone.
Recruiting
Has No Placebo
Providence CollegeBrett R Ely, PhD
Have you considered Felodipine clinical trials? We made a collection of clinical trials featuring Felodipine, we think they might fit your search criteria.Go to Trials
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