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What is Exemestane
ExemestaneThe Generic name of this drug
Treatment SummaryExemestane is a pill taken by postmenopausal women with hormone-receptor-positive breast cancer. It is an aromatase inhibitor, meaning that it permanently binds to enzymes and stops them from producing hormones that can fuel the growth of cancer cells.
Aromasinis the brand name
Exemestane Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Aromasin
Exemestane
1999
18
Approved as Treatment by the FDA
Exemestane, also known as Aromasin, is approved by the FDA for 4 uses which include Advance Directives and Postmenopause .Advance Directives
Postmenopause
Breast
2-3 years of tamoxifen therapy
Effectiveness
How Exemestane Affects PatientsAromatase is an enzyme that turns hormones into estrogen in the adrenal glands. Aromatase inhibitors (AIs) are drugs that lower the amount of estrogen in the body by blocking aromatase in the adrenal glands. Selective AIs (SAIs) decrease levels of estrogen without touching other steroid hormones made by the adrenal gland. Examples of SAIs include anastrozole, letrozole, and exemestane.
How Exemestane works in the bodyExemestane is a drug used to treat breast cancer in post-menopausal women. It works by blocking the aromatase enzyme, which converts androgens to estrogens. This reduces the amount of estrogen in the body, which can slow or even stop the growth of certain types of breast cancer. Exemestane binds to the aromatase enzyme and permanently stops it from working, meaning new enzymatic function must be created to replace it. Exemestane does not affect other enzymes in the process of hormone production, and it has no effect on corticosteroids or aldosterone. By reducing estrogen levels
When to interrupt dosage
The recommended amount of Exemestane is contingent upon the recognized situation, such as 2-3 years of tamoxifen treatment, Advance Directives and Breast. The dosage fluctuates, in relation to the technique of delivery (e.g. Tablet - Oral or Tablet, film coated) featured in the table beneath.Condition
Dosage
Administration
Postmenopause
, 25.0 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral
2-3 years of tamoxifen therapy
, 25.0 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral
Advance Directives
, 25.0 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral
Breast
, 25.0 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral
Warnings
There are 3 known major drug interactions with Exemestane.Common Exemestane Drug Interactions
Drug Name
Risk Level
Description
Haloperidol
Moderate
The serum concentration of Haloperidol can be increased when it is combined with Exemestane.
Methadone
Moderate
The serum concentration of Methadone can be increased when it is combined with Exemestane.
Tucatinib
Moderate
The metabolism of Tucatinib can be decreased when combined with Exemestane.
Exemestane Toxicity & Overdose RiskSeizures
Exemestane Novel Uses: Which Conditions Have a Clinical Trial Featuring Exemestane?
A total of 20 clinical trials are underway to examine the potential of Exemestane in providing Advance Directives, 2-3 years of Tamoxifen therapy and Postmenopausal relief.Condition
Clinical Trials
Trial Phases
2-3 years of tamoxifen therapy
0 Actively Recruiting
Advance Directives
0 Actively Recruiting
Postmenopause
5 Actively Recruiting
Phase 2, Not Applicable
Breast
12 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 3
Exemestane Reviews: What are patients saying about Exemestane?
5Patient Review
2/10/2019 I don't experience many negative side effects from this medication, which is great. The only downside is that sometimes I feel tired and have hot flashes.
4.3Patient Review
3/19/2022 I've been on this medication for seven years now, and I haven't missed a dose yet! I'm hoping to be able to stop taking it this fall. It hasn't been easy, but I don't want the cancer to come back either. The side effects did get better the longer I was on it, but they never totally went away. I just hope that when I stop taking it, I feel better!
3.7Patient Review
11/3/2019 I've been on this blocker for a little over year now. I have experienced some joint pain and fatigue, but it's manageable. My mood is also significantly better than when I was taking Letrozol.
3.3Patient Review
1/29/2021 I've been taking this treatment for a while now and have experienced some very unpleasant side effects, including hot flashes, joint pain, muscle pain, weight gain, and fatigue.
3Patient Review
5/16/2018 While this medication has kept me cancer-free for two years, the side effects are becoming increasingly difficult to manage. I wake up every morning with a new pain, and it seems like all of my joints are affected. Depression and fatigue are also regular problems.
2.3Patient Review
10/23/2017 I've been sweating excessively since being on this medication, and have also put on some weight. Not sure if those side effects are from the drug or just a result of my cancer treatment/fatigue in general, but I'm grateful that the drug is available nonetheless.
2.3Patient Review
12/12/2019 I am 77 and have been on Exemestane for two years now. I tried other hormone inhibitors and they have all had the same side effects for me, the worst being joint pain. Even worse is now I have osteoporosis. My bones were fine before. It appears there is something wrong with a heart valve and I am having a nuclear stress test in a month.
2.3Patient Review
5/12/2019 I've been on this medication for two years now and I'm starting to experience some serious side effects. My muscles ache, my bones feel like they could misalign, and my fingers get stiff. I worry about how it's impacting my organs - kidneys, liver, lungs. I'll be calling my doctor in the morning to see if there are any other options.
2Patient Review
2/15/2019 Unfortunately, this medication caused me to lose hair and feel fatigued. Additionally, it was quite expensive.
1.7Patient Review
9/20/2022 I didn't have a good experience with this medication. It made all of my joints hurt and I had nonstop hot flashes throughout the day.
Patient Q&A Section about exemestane
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What kind of steroid is exemestane?
"Exemestane is a new type of steroidal drug that inhibits the aromatase enzyme. It is marketed under the name Aromasin."
Answered by AI
What are the side effects of exemestane?
"Hot flashes, sweating, muscle or joint pain, tiredness, headache, dizziness, feeling worried or anxious, depression."
Answered by AI
Is exemestane a chemotherapy drug?
"Aromasin is a drug used to treat breast cancer in postmenopausal women. It is often given to women whose cancer has progressed even after taking tamoxifen for 2 to 3 years."
Answered by AI
Is weight gain a side effect of exemestane?
"It is possible that you may gain weight while taking Aromasin, however this side effect has only been reported by people who are taking the drug for advanced breast cancer. The weight gain is not common and is not extreme."
Answered by AI