Exemestane

Advance Directives, Postmenopause, Breast + 1 more

Treatment

5 FDA approvals

15 Active Studies for Exemestane

What is Exemestane

Exemestane

The Generic name of this drug

Treatment Summary

Exemestane is a pill taken by postmenopausal women with hormone-receptor-positive breast cancer. It is an aromatase inhibitor, meaning that it permanently binds to enzymes and stops them from producing hormones that can fuel the growth of cancer cells.

Aromasin

is the brand name

image of different drug pills on a surface

Exemestane Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Aromasin

Exemestane

1999

18

Approved as Treatment by the FDA

Exemestane, also known as Aromasin, is approved by the FDA for 5 uses which include Early Breast Cancer and 2-3 years of tamoxifen therapy .

Early Breast Cancer

2-3 years of tamoxifen therapy

Postmenopause

Breast

Advance Directives

Effectiveness

How Exemestane Affects Patients

Aromatase is an enzyme that turns hormones into estrogen in the adrenal glands. Aromatase inhibitors (AIs) are drugs that lower the amount of estrogen in the body by blocking aromatase in the adrenal glands. Selective AIs (SAIs) decrease levels of estrogen without touching other steroid hormones made by the adrenal gland. Examples of SAIs include anastrozole, letrozole, and exemestane.

How Exemestane works in the body

Exemestane is a drug used to treat breast cancer in post-menopausal women. It works by blocking the aromatase enzyme, which converts androgens to estrogens. This reduces the amount of estrogen in the body, which can slow or even stop the growth of certain types of breast cancer. Exemestane binds to the aromatase enzyme and permanently stops it from working, meaning new enzymatic function must be created to replace it. Exemestane does not affect other enzymes in the process of hormone production, and it has no effect on corticosteroids or aldosterone. By reducing estrogen levels

When to interrupt dosage

The recommended amount of Exemestane is contingent upon the recognized situation, such as 2-3 years of tamoxifen treatment, Advance Directives and Breast. The dosage fluctuates, in relation to the technique of delivery (e.g. Tablet - Oral or Tablet, film coated) featured in the table beneath.

Condition

Dosage

Administration

Advance Directives

, 25.0 mg

, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral

Postmenopause

, 25.0 mg

, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral

Breast

, 25.0 mg

, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral

2-3 years of tamoxifen therapy

, 25.0 mg

, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral

Warnings

There are 3 known major drug interactions with Exemestane.

Common Exemestane Drug Interactions

Drug Name

Risk Level

Description

Haloperidol

Moderate

The serum concentration of Haloperidol can be increased when it is combined with Exemestane.

Methadone

Moderate

The serum concentration of Methadone can be increased when it is combined with Exemestane.

Tucatinib

Moderate

The metabolism of Tucatinib can be decreased when combined with Exemestane.

Exemestane Toxicity & Overdose Risk

Seizures

image of a doctor in a lab doing drug, clinical research

Exemestane Novel Uses: Which Conditions Have a Clinical Trial Featuring Exemestane?

A total of 20 clinical trials are underway to examine the potential of Exemestane in providing Advance Directives, 2-3 years of Tamoxifen therapy and Postmenopausal relief.

Condition

Clinical Trials

Trial Phases

Advance Directives

0 Actively Recruiting

2-3 years of tamoxifen therapy

0 Actively Recruiting

Breast

10 Actively Recruiting

Phase 2, Not Applicable, Phase 3, Phase 4

Postmenopause

5 Actively Recruiting

Phase 2, Not Applicable

Exemestane Reviews: What are patients saying about Exemestane?

5

Patient Review

2/10/2019

Exemestane for Advanced Breast Cancer Progression Post-Antiestrogen Therapy

I don't experience many negative side effects from this medication, which is great. The only downside is that sometimes I feel tired and have hot flashes.

4.3

Patient Review

3/19/2022

Exemestane for Hormone Receptor Positive Postmenopausal Early Breast Cancer After Adjuvant Tamoxifen

I've been on this medication for seven years now, and I haven't missed a dose yet! I'm hoping to be able to stop taking it this fall. It hasn't been easy, but I don't want the cancer to come back either. The side effects did get better the longer I was on it, but they never totally went away. I just hope that when I stop taking it, I feel better!

3.7

Patient Review

11/3/2019

Exemestane for Hormone Receptor Positive Postmenopausal Early Breast Cancer After Adjuvant Tamoxifen

I've been on this blocker for a little over year now. I have experienced some joint pain and fatigue, but it's manageable. My mood is also significantly better than when I was taking Letrozol.

3.3

Patient Review

1/29/2021

Exemestane for Hormone Receptor Positive Postmenopausal Early Breast Cancer After Adjuvant Tamoxifen

I've been taking this treatment for a while now and have experienced some very unpleasant side effects, including hot flashes, joint pain, muscle pain, weight gain, and fatigue.

3

Patient Review

5/16/2018

Exemestane for Hormone Receptor Positive Postmenopausal Early Breast Cancer After Adjuvant Tamoxifen

While this medication has kept me cancer-free for two years, the side effects are becoming increasingly difficult to manage. I wake up every morning with a new pain, and it seems like all of my joints are affected. Depression and fatigue are also regular problems.

2.3

Patient Review

10/23/2017

Exemestane for Breast Cancer that has Spread to Another Part of the Body

I've been sweating excessively since being on this medication, and have also put on some weight. Not sure if those side effects are from the drug or just a result of my cancer treatment/fatigue in general, but I'm grateful that the drug is available nonetheless.

2.3

Patient Review

12/12/2019

Exemestane for Hormone Receptor Positive Postmenopausal Early Breast Cancer After Adjuvant Tamoxifen

I am 77 and have been on Exemestane for two years now. I tried other hormone inhibitors and they have all had the same side effects for me, the worst being joint pain. Even worse is now I have osteoporosis. My bones were fine before. It appears there is something wrong with a heart valve and I am having a nuclear stress test in a month.

2.3

Patient Review

5/12/2019

Exemestane for Hormone Receptor Positive Postmenopausal Early Breast Cancer After Adjuvant Tamoxifen

I've been on this medication for two years now and I'm starting to experience some serious side effects. My muscles ache, my bones feel like they could misalign, and my fingers get stiff. I worry about how it's impacting my organs - kidneys, liver, lungs. I'll be calling my doctor in the morning to see if there are any other options.

2

Patient Review

2/15/2019

Exemestane for Prevention of Breast Cancer

Unfortunately, this medication caused me to lose hair and feel fatigued. Additionally, it was quite expensive.

1.7

Patient Review

9/20/2022

Exemestane for Hormone Receptor Positive Postmenopausal Early Breast Cancer After Adjuvant Tamoxifen

I didn't have a good experience with this medication. It made all of my joints hurt and I had nonstop hot flashes throughout the day.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about exemestane

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What kind of steroid is exemestane?

"Exemestane is a new type of steroidal drug that inhibits the aromatase enzyme. It is marketed under the name Aromasin."

Answered by AI

What are the side effects of exemestane?

"Hot flashes, sweating, muscle or joint pain, tiredness, headache, dizziness, feeling worried or anxious, depression."

Answered by AI

Is exemestane a chemotherapy drug?

"Aromasin is a drug used to treat breast cancer in postmenopausal women. It is often given to women whose cancer has progressed even after taking tamoxifen for 2 to 3 years."

Answered by AI

Is weight gain a side effect of exemestane?

"It is possible that you may gain weight while taking Aromasin, however this side effect has only been reported by people who are taking the drug for advanced breast cancer. The weight gain is not common and is not extreme."

Answered by AI

Clinical Trials for Exemestane

Image of Karmanos Cancer Institute in Detroit, United States.

Magic Ink for Breast Cancer

18+
Female
Detroit, MI

The goal of this clinical trial is to learn if tattoos applied with Magic Ink is as safe as commercially available standard tattoo ink for the purpose of radiation in women with breast cancer undergoing radiation treatment. The main questions are: * Is the Magic Ink as safe as standard tattoo ink * Does Magic Ink continue to function and remain visible for radiation therapists during the treatment Participants will be consented and given a skin assessment. Once enrolled participants will be administered the Magic Ink tattoo instead of the standard tattoo ink in preparation for their radiation treatment. Participants will also complete a survey regarding body image. Skin assessment will occur again after the first week of radiation and at 3 months later. Throughout the radiation therapy the medical physicist will complete surveys about ease of set-up of the equipment.

Recruiting
Has No Placebo

Karmanos Cancer Institute

Michael Dominello, DO

Image of Don tyson Center for Agricultural Sciencers in Fayetteville, United States.

Protein and Exercise for Postmenopausal Women

Any Age
Female
Fayetteville, AR

The goal of this clinical trial is to learn if consuming a higher protein diet that includes one serving of beef each day, in combination with resistance exercise, improves wellbeing in postmenopausal women. It will also tell us about how higher protein intake changes body composition and blood values related to health. The main questions it aims to answer are: * Does higher protein intake combined with resistance training improve mood and sleep in postmenopausal women? * What other health benefits to postmenopausal women experience when the follow a higher protein diet and participate in resistance exercise? Researchers will compare three groups 1) postmenopausal women living their daily lives as usual, 2) postmenopausal women consuming a higher protein diet, and 2) postmenopausal women consuming a higher protein diet and participating in resistance training. Participants will: * Consume a higher protein diet for 16 weeks * Participate in an at-home resistance training for 16 weeks * Keep a diary of their food intake, sleep habits, and mood * Have health assessments every 4 weeks

Recruiting
Has No Placebo

Don tyson Center for Agricultural Sciencers (+1 Sites)

Jamie Baum

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Image of Natera, Inc. (Data or Specimen Analysis Only) in San Carlos, United States.

Exercise for Cancer

18+
All Sexes
San Carlos, CA

Researchers think that exercise may be able to prevent cancer from coming back by lowering ctDNA levels. The purpose of this study is to explore how aerobic exercise (exercise that stimulates and strengthens the heart and lungs and improves the body's use of oxygen) can reduce the level of ctDNA found in the blood. During the study, the highest level of exercise that is practical, is safe, and has positive effects on the body that may prevent the return of cancer (including a decrease in ctDNA levels) will be found. Each level of exercise tested will be a certain number of minutes each week. Once the best level of exercise is found, it will be tested further in a new group of participants. All participants in this study will have been previously treated for breast, prostate, or colorectal cancer.

Waitlist Available
Has No Placebo

Natera, Inc. (Data or Specimen Analysis Only) (+10 Sites)

Jessica Scott, PhD

Have you considered Exemestane clinical trials?

We made a collection of clinical trials featuring Exemestane, we think they might fit your search criteria.
Go to Trials