Estradiol Valerate

Low Testosterone, hypoestrogenism, Fracture + 25 more
Treatment
3 FDA approvals
20 Active Studies for Estradiol Valerate

What is Estradiol Valerate

Estradiol valerateThe Generic name of this drug
Treatment SummaryEstradiol Valerate (E2V) is a modified form of the hormone estradiol, which is found naturally in the human body. It is used to treat menopausal symptoms such as hot flashes, vaginal dryness, mood changes, irregular menses, chills, and sleeping problems. It is also used to treat some types of prostate cancer and can be found in combination with progestin as Natazia to prevent pregnancy and treat heavy menstrual bleeding. Estradiol Valerate is available as an injection called Delestrogen and is more potent than other forms of estrogen.
Delestrogenis the brand name
image of different drug pills on a surface
Estradiol Valerate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Delestrogen
Estradiol valerate
1954
22

Approved as Treatment by the FDA

Estradiol valerate, also called Delestrogen, is approved by the FDA for 3 uses like Heavy Menstrual Bleeding and Oral Contraceptives .
Heavy Menstrual Bleeding
Used to treat Heavy Menstrual Bleeding in combination with Dienogest
Oral Contraceptives
Used to treat Oral Contraceptives in combination with Dienogest
Menorrhagia
Used to treat Heavy Menstrual Bleeding in combination with Dienogest

Effectiveness

How Estradiol Valerate Affects PatientsEstrogen is a hormone that acts on different areas of the body. It binds to two types of receptors: Estrogen Receptor Alpha and Estrogen Receptor Beta. It also activates the G Protein-coupled Estrogen Receptor, which is responsible for its effects in the body.
How Estradiol Valerate works in the bodyEstradiol is a hormone that enters many cells in the body, including organs, breasts and the brain. When it binds to its target receptor, it can direct the cell to make proteins that express the effects of estradiol. These proteins can help to increase the production of other hormones, and reduce symptoms related to a lack of estradiol, like those experienced during menopause.

When to interrupt dosage

The recommended measure of Estradiol Valerate is contingent upon the diagnosed condition, including severe menopausal vulvovaginal atrophy, Menopausal Symptoms and Menorrhagia. The amount of dosage also depends on the method of administration featured in the table beneath.
Condition
Dosage
Administration
Menopausal Symptoms
10.0 mg/mL, 20.0 mg/mL, 40.0 mg/mL, , 3.0 mg, 1.0 mg, 2.0 mg, 8.0 mg, 6.5 mg/mL
, Injection, Intramuscular, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Tablet - Oral, Liquid, Liquid - Intramuscular, Solution, Solution - Intramuscular, Kit, Oral, Tablet
Low Testosterone
10.0 mg/mL, 20.0 mg/mL, 40.0 mg/mL, , 3.0 mg, 1.0 mg, 2.0 mg, 8.0 mg, 6.5 mg/mL
, Injection, Intramuscular, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Tablet - Oral, Liquid, Liquid - Intramuscular, Solution, Solution - Intramuscular, Kit, Oral, Tablet
Fracture
10.0 mg/mL, 20.0 mg/mL, 40.0 mg/mL, , 3.0 mg, 1.0 mg, 2.0 mg, 8.0 mg, 6.5 mg/mL
, Injection, Intramuscular, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Tablet - Oral, Liquid, Liquid - Intramuscular, Solution, Solution - Intramuscular, Kit, Oral, Tablet
severe menopausal vulvovaginal atrophy
10.0 mg/mL, 20.0 mg/mL, 40.0 mg/mL, , 3.0 mg, 1.0 mg, 2.0 mg, 8.0 mg, 6.5 mg/mL
, Injection, Intramuscular, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Tablet - Oral, Liquid, Liquid - Intramuscular, Solution, Solution - Intramuscular, Kit, Oral, Tablet
Ovarian Resection
10.0 mg/mL, 20.0 mg/mL, 40.0 mg/mL, , 3.0 mg, 1.0 mg, 2.0 mg, 8.0 mg, 6.5 mg/mL
, Injection, Intramuscular, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Tablet - Oral, Liquid, Liquid - Intramuscular, Solution, Solution - Intramuscular, Kit, Oral, Tablet
Irregular Menstruation
10.0 mg/mL, 20.0 mg/mL, 40.0 mg/mL, , 3.0 mg, 1.0 mg, 2.0 mg, 8.0 mg, 6.5 mg/mL
, Injection, Intramuscular, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Tablet - Oral, Liquid, Liquid - Intramuscular, Solution, Solution - Intramuscular, Kit, Oral, Tablet
Oral Contraceptives
10.0 mg/mL, 20.0 mg/mL, 40.0 mg/mL, , 3.0 mg, 1.0 mg, 2.0 mg, 8.0 mg, 6.5 mg/mL
, Injection, Intramuscular, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Tablet - Oral, Liquid, Liquid - Intramuscular, Solution, Solution - Intramuscular, Kit, Oral, Tablet
Uterus
10.0 mg/mL, 20.0 mg/mL, 40.0 mg/mL, , 3.0 mg, 1.0 mg, 2.0 mg, 8.0 mg, 6.5 mg/mL
, Injection, Intramuscular, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Tablet - Oral, Liquid, Liquid - Intramuscular, Solution, Solution - Intramuscular, Kit, Oral, Tablet
Pharmaceutical Preparations
10.0 mg/mL, 20.0 mg/mL, 40.0 mg/mL, , 3.0 mg, 1.0 mg, 2.0 mg, 8.0 mg, 6.5 mg/mL
, Injection, Intramuscular, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Tablet - Oral, Liquid, Liquid - Intramuscular, Solution, Solution - Intramuscular, Kit, Oral, Tablet
Malignant neoplasm of prostate
10.0 mg/mL, 20.0 mg/mL, 40.0 mg/mL, , 3.0 mg, 1.0 mg, 2.0 mg, 8.0 mg, 6.5 mg/mL
, Injection, Intramuscular, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Tablet - Oral, Liquid, Liquid - Intramuscular, Solution, Solution - Intramuscular, Kit, Oral, Tablet
moderate menopausal vulvovaginal atrophy
10.0 mg/mL, 20.0 mg/mL, 40.0 mg/mL, , 3.0 mg, 1.0 mg, 2.0 mg, 8.0 mg, 6.5 mg/mL
, Injection, Intramuscular, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Tablet - Oral, Liquid, Liquid - Intramuscular, Solution, Solution - Intramuscular, Kit, Oral, Tablet
Primary Ovarian Insufficiency
10.0 mg/mL, 20.0 mg/mL, 40.0 mg/mL, , 3.0 mg, 1.0 mg, 2.0 mg, 8.0 mg, 6.5 mg/mL
, Injection, Intramuscular, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Tablet - Oral, Liquid, Liquid - Intramuscular, Solution, Solution - Intramuscular, Kit, Oral, Tablet
Primary Amenorrhoea
10.0 mg/mL, 20.0 mg/mL, 40.0 mg/mL, , 3.0 mg, 1.0 mg, 2.0 mg, 8.0 mg, 6.5 mg/mL
, Injection, Intramuscular, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Tablet - Oral, Liquid, Liquid - Intramuscular, Solution, Solution - Intramuscular, Kit, Oral, Tablet
Hot flashes
10.0 mg/mL, 20.0 mg/mL, 40.0 mg/mL, , 3.0 mg, 1.0 mg, 2.0 mg, 8.0 mg, 6.5 mg/mL
, Injection, Intramuscular, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Tablet - Oral, Liquid, Liquid - Intramuscular, Solution, Solution - Intramuscular, Kit, Oral, Tablet
hypoestrogenism
10.0 mg/mL, 20.0 mg/mL, 40.0 mg/mL, , 3.0 mg, 1.0 mg, 2.0 mg, 8.0 mg, 6.5 mg/mL
, Injection, Intramuscular, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Tablet - Oral, Liquid, Liquid - Intramuscular, Solution, Solution - Intramuscular, Kit, Oral, Tablet
moderate Menopausal Vasomotor Symptoms
10.0 mg/mL, 20.0 mg/mL, 40.0 mg/mL, , 3.0 mg, 1.0 mg, 2.0 mg, 8.0 mg, 6.5 mg/mL
, Injection, Intramuscular, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Tablet - Oral, Liquid, Liquid - Intramuscular, Solution, Solution - Intramuscular, Kit, Oral, Tablet
Hormone Replacement Therapy
10.0 mg/mL, 20.0 mg/mL, 40.0 mg/mL, , 3.0 mg, 1.0 mg, 2.0 mg, 8.0 mg, 6.5 mg/mL
, Injection, Intramuscular, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Tablet - Oral, Liquid, Liquid - Intramuscular, Solution, Solution - Intramuscular, Kit, Oral, Tablet
Premature Menopause
10.0 mg/mL, 20.0 mg/mL, 40.0 mg/mL, , 3.0 mg, 1.0 mg, 2.0 mg, 8.0 mg, 6.5 mg/mL
, Injection, Intramuscular, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Tablet - Oral, Liquid, Liquid - Intramuscular, Solution, Solution - Intramuscular, Kit, Oral, Tablet
Menstruation Disturbances
10.0 mg/mL, 20.0 mg/mL, 40.0 mg/mL, , 3.0 mg, 1.0 mg, 2.0 mg, 8.0 mg, 6.5 mg/mL
, Injection, Intramuscular, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Tablet - Oral, Liquid, Liquid - Intramuscular, Solution, Solution - Intramuscular, Kit, Oral, Tablet
Osteoporosis, Postmenopausal
10.0 mg/mL, 20.0 mg/mL, 40.0 mg/mL, , 3.0 mg, 1.0 mg, 2.0 mg, 8.0 mg, 6.5 mg/mL
, Injection, Intramuscular, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Tablet - Oral, Liquid, Liquid - Intramuscular, Solution, Solution - Intramuscular, Kit, Oral, Tablet

Warnings

Estradiol Valerate has eleven contraindications, so it should not be taken in combination with the conditions described in the table below.Estradiol Valerate Contraindications
Condition
Risk Level
Notes
Thromboembolism
Do Not Combine
Venous Thrombosis
Do Not Combine
estrogen-dependent neoplasia
Do Not Combine
Pulmonary Embolism
Do Not Combine
Pulmonary Embolism
Do Not Combine
Thromboembolism
Do Not Combine
Metrorrhagia
Do Not Combine
Breast Cancer
Do Not Combine
Breast
Do Not Combine
Deep Vein Thrombosis
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Estradiol Valerate may interact with Pulse Frequency
There are 20 known major drug interactions with Estradiol Valerate.
Common Estradiol Valerate Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be increased when combined with Estradiol valerate.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be increased when combined with Estradiol valerate.
Alectinib
Major
The metabolism of Alectinib can be increased when combined with Estradiol valerate.
Aminophylline
Major
The metabolism of Aminophylline can be increased when combined with Estradiol valerate.
Anagrelide
Major
The metabolism of Anagrelide can be decreased when combined with Estradiol valerate.
image of a doctor in a lab doing drug, clinical research

Estradiol Valerate Novel Uses: Which Conditions Have a Clinical Trial Featuring Estradiol Valerate?

27 active clinical trials are currently examining the potential of Estradiol Valerate in ameliorating Irregular Menstruation, diminished reproductive organ function and female Castration.
Condition
Clinical Trials
Trial Phases
Low Testosterone
5 Actively Recruiting
Phase 4, Phase 2, Phase 1
Menopausal Symptoms
1 Actively Recruiting
Not Applicable
hypoestrogenism
2 Actively Recruiting
Phase 4
Hormone Replacement Therapy
0 Actively Recruiting
Fracture
0 Actively Recruiting
Primary Ovarian Insufficiency
0 Actively Recruiting
Osteoporosis, Postmenopausal
0 Actively Recruiting
Menorrhagia
0 Actively Recruiting
Irregular Menstruation
5 Actively Recruiting
Phase 4, Not Applicable, Phase 2
Primary Amenorrhoea
0 Actively Recruiting
Ovarian Resection
0 Actively Recruiting
Menopause
0 Actively Recruiting
severe menopausal vulvovaginal atrophy
0 Actively Recruiting
Pharmaceutical Preparations
0 Actively Recruiting
female castration
0 Actively Recruiting
Uterus
0 Actively Recruiting
Malignant neoplasm of prostate
0 Actively Recruiting
Hot flashes
18 Actively Recruiting
Phase 1, Phase 4, Not Applicable, Early Phase 1, Phase 2, Phase 3
Menstruation Disturbances
2 Actively Recruiting
Phase 4, Not Applicable
Amenorrhea
0 Actively Recruiting

Estradiol Valerate Reviews: What are patients saying about Estradiol Valerate?

5Patient Review
10/17/2013
Estradiol Valerate for Low Estrogen After Operation to Remove Ovaries
I've used this treatment regularly for 52 years and it has kept me feeling healthy and alert. It also prevents the terrible headaches I used to get!
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about estradiol valerate

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What does estradiol valerate do to males?

"Estradiol valerate is sometimes used to treat advanced prostate cancer in men. The usual dosage is 30 mg or more every 1 to 2 weeks, given by intramuscular injection."

Answered by AI

Is estradiol valerate safe?

"However, it is one of the safest and most effective ways to treat symptoms of menopause.

Delestrogen (estradiol valerate injection) is safe to take; however, it may raise your risk of some serious medical problems when used for long periods of time. These problems include breast cancer and blood clots. Despite this, it is one of the safest and most effective ways to treat symptoms of menopause."

Answered by AI

What does estradiol valerate do in the body?

"This medication is designed to treat symptoms in women caused by a reduction of estrogen in the body. These symptoms include hot flashes and vaginal dryness, and are common during menopause. The medication works by replacing the estrogen in the body, and thus alleviating these symptoms."

Answered by AI

What is the difference between estradiol and estradiol valerate?

"Estradiol Valerate (also known as E2V) is a pro-drug ester of Estradiol. Estradiol is a naturally occurring hormone that circulates within the human body and is the most potent form of all estrogenic steroids. Estradiol acts as the major female sex hormone."

Answered by AI

Clinical Trials for Estradiol Valerate

Have you considered Estradiol Valerate clinical trials? We made a collection of clinical trials featuring Estradiol Valerate, we think they might fit your search criteria.
Have you considered Estradiol Valerate clinical trials? We made a collection of clinical trials featuring Estradiol Valerate, we think they might fit your search criteria.
Have you considered Estradiol Valerate clinical trials? We made a collection of clinical trials featuring Estradiol Valerate, we think they might fit your search criteria.
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