Endometrin

Amenorrhea, hormonal imbalance, prophylaxis of recurrent spontaneous preterm birth + 9 more

Treatment

20 Active Studies for Endometrin

What is Endometrin

Progesterone

The Generic name of this drug

Treatment Summary

Progesterone is a naturally occurring hormone in women that helps with fertility, implantation of the embryo, and maintaining a successful pregnancy. Low progesterone levels or an insufficient response to progesterone can cause infertility and pregnancy loss. Progesterone is also used in various contraceptive preparations to prevent ovulation and fertilization as well as other formulations to support pregnancy. The pharmaceutical form of progesterone is a chemically identical copy of the human ovarian form and is available in various forms like capsules, gel, tablets, inserts, and injections.

Progesterone

is the brand name

image of different drug pills on a surface

Endometrin Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Progesterone

Progesterone

1978

124

Effectiveness

How Endometrin Affects Patients

Progesterone is a hormone that can have different effects depending on concentration and how it is taken. In general, it helps the uterus prepare for pregnancy and prevents ovulation. Progesterone is taken orally as a capsule, applied as a gel or insert vaginally, injected intramuscularly, or taken as a contraceptive tablet. When taken as a capsule, it opposes the effects of estrogen, decreases and thickens cervical mucous, and helps the endometrium become more suitable for a growing embryo. When applied vaginally, it mimics the effects of naturally occurring progesterone and helps develop decidual tissue

How Endometrin works in the body

Progesterone binds to its own special receptor inside cells. This receptor helps signals to maintain the endometrium, or the lining of the uterus. Progesterone also changes the cervical mucus, making it hard for sperm to swim through. It also stops follicle-stimulating hormone, which can cause ovulation. When used perfectly, it has a 0.5% failure rate at preventing pregnancy. If used normally, the failure rate is estimated to be 5%.

When to interrupt dosage

The measure of Endometrin is contingent upon the established disorder, including hormonal discrepancy, Female Infertility and Postmenopause. The amount of dosage is subject to the technique of delivery, as specified in the table beneath.

Condition

Dosage

Administration

recurrent spontaneous preterm birth

50.0 mg, , 50.0 mg/mL, 100.0 mg, 200.0 mg, 0.09 mg/mg, 0.045 mg/mg, 8.0 %, 10.0 mg/mL, 17.0 mg/mL, 0.001 mg/mg, 1.1 mg/hour, 25.0 mg/mL, 1.0 mg/mg, 0.0025 mg/mg

Injection - Intramuscular, Injection, , Intramuscular, Injection, solution, Injection, solution - Intramuscular, Capsule - Oral, Capsule, Oral, Gel, Vaginal, Gel - Vaginal, Insert - Vaginal, Insert, Liquid - Intramuscular, Liquid, Solution - Intramuscular, Solution, Oral; Transdermal, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule - Vaginal, Cream - Vaginal, Cream, Cream - Topical, Topical, Solution - Topical, Ring - Vaginal, Ring, Capsule; Spray, metered - Oral; Transdermal, Capsule; Spray, metered, Subcutaneous, Solution - Subcutaneous, Cream - Transdermal, Transdermal

Reproductive Technology

50.0 mg, , 50.0 mg/mL, 100.0 mg, 200.0 mg, 0.09 mg/mg, 0.045 mg/mg, 8.0 %, 10.0 mg/mL, 17.0 mg/mL, 0.001 mg/mg, 1.1 mg/hour, 25.0 mg/mL, 1.0 mg/mg, 0.0025 mg/mg

Injection - Intramuscular, Injection, , Intramuscular, Injection, solution, Injection, solution - Intramuscular, Capsule - Oral, Capsule, Oral, Gel, Vaginal, Gel - Vaginal, Insert - Vaginal, Insert, Liquid - Intramuscular, Liquid, Solution - Intramuscular, Solution, Oral; Transdermal, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule - Vaginal, Cream - Vaginal, Cream, Cream - Topical, Topical, Solution - Topical, Ring - Vaginal, Ring, Capsule; Spray, metered - Oral; Transdermal, Capsule; Spray, metered, Subcutaneous, Solution - Subcutaneous, Cream - Transdermal, Transdermal

Endometrial Hyperplasia

50.0 mg, , 50.0 mg/mL, 100.0 mg, 200.0 mg, 0.09 mg/mg, 0.045 mg/mg, 8.0 %, 10.0 mg/mL, 17.0 mg/mL, 0.001 mg/mg, 1.1 mg/hour, 25.0 mg/mL, 1.0 mg/mg, 0.0025 mg/mg

Injection - Intramuscular, Injection, , Intramuscular, Injection, solution, Injection, solution - Intramuscular, Capsule - Oral, Capsule, Oral, Gel, Vaginal, Gel - Vaginal, Insert - Vaginal, Insert, Liquid - Intramuscular, Liquid, Solution - Intramuscular, Solution, Oral; Transdermal, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule - Vaginal, Cream - Vaginal, Cream, Cream - Topical, Topical, Solution - Topical, Ring - Vaginal, Ring, Capsule; Spray, metered - Oral; Transdermal, Capsule; Spray, metered, Subcutaneous, Solution - Subcutaneous, Cream - Transdermal, Transdermal

Amenorrhea

50.0 mg, , 50.0 mg/mL, 100.0 mg, 200.0 mg, 0.09 mg/mg, 0.045 mg/mg, 8.0 %, 10.0 mg/mL, 17.0 mg/mL, 0.001 mg/mg, 1.1 mg/hour, 25.0 mg/mL, 1.0 mg/mg, 0.0025 mg/mg

Injection - Intramuscular, Injection, , Intramuscular, Injection, solution, Injection, solution - Intramuscular, Capsule - Oral, Capsule, Oral, Gel, Vaginal, Gel - Vaginal, Insert - Vaginal, Insert, Liquid - Intramuscular, Liquid, Solution - Intramuscular, Solution, Oral; Transdermal, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule - Vaginal, Cream - Vaginal, Cream, Cream - Topical, Topical, Solution - Topical, Ring - Vaginal, Ring, Capsule; Spray, metered - Oral; Transdermal, Capsule; Spray, metered, Subcutaneous, Solution - Subcutaneous, Cream - Transdermal, Transdermal

hormonal imbalance

50.0 mg, , 50.0 mg/mL, 100.0 mg, 200.0 mg, 0.09 mg/mg, 0.045 mg/mg, 8.0 %, 10.0 mg/mL, 17.0 mg/mL, 0.001 mg/mg, 1.1 mg/hour, 25.0 mg/mL, 1.0 mg/mg, 0.0025 mg/mg

Injection - Intramuscular, Injection, , Intramuscular, Injection, solution, Injection, solution - Intramuscular, Capsule - Oral, Capsule, Oral, Gel, Vaginal, Gel - Vaginal, Insert - Vaginal, Insert, Liquid - Intramuscular, Liquid, Solution - Intramuscular, Solution, Oral; Transdermal, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule - Vaginal, Cream - Vaginal, Cream, Cream - Topical, Topical, Solution - Topical, Ring - Vaginal, Ring, Capsule; Spray, metered - Oral; Transdermal, Capsule; Spray, metered, Subcutaneous, Solution - Subcutaneous, Cream - Transdermal, Transdermal

Postmenopause

50.0 mg, , 50.0 mg/mL, 100.0 mg, 200.0 mg, 0.09 mg/mg, 0.045 mg/mg, 8.0 %, 10.0 mg/mL, 17.0 mg/mL, 0.001 mg/mg, 1.1 mg/hour, 25.0 mg/mL, 1.0 mg/mg, 0.0025 mg/mg

Injection - Intramuscular, Injection, , Intramuscular, Injection, solution, Injection, solution - Intramuscular, Capsule - Oral, Capsule, Oral, Gel, Vaginal, Gel - Vaginal, Insert - Vaginal, Insert, Liquid - Intramuscular, Liquid, Solution - Intramuscular, Solution, Oral; Transdermal, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule - Vaginal, Cream - Vaginal, Cream, Cream - Topical, Topical, Solution - Topical, Ring - Vaginal, Ring, Capsule; Spray, metered - Oral; Transdermal, Capsule; Spray, metered, Subcutaneous, Solution - Subcutaneous, Cream - Transdermal, Transdermal

Hysterectomy

50.0 mg, , 50.0 mg/mL, 100.0 mg, 200.0 mg, 0.09 mg/mg, 0.045 mg/mg, 8.0 %, 10.0 mg/mL, 17.0 mg/mL, 0.001 mg/mg, 1.1 mg/hour, 25.0 mg/mL, 1.0 mg/mg, 0.0025 mg/mg

Injection - Intramuscular, Injection, , Intramuscular, Injection, solution, Injection, solution - Intramuscular, Capsule - Oral, Capsule, Oral, Gel, Vaginal, Gel - Vaginal, Insert - Vaginal, Insert, Liquid - Intramuscular, Liquid, Solution - Intramuscular, Solution, Oral; Transdermal, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule - Vaginal, Cream - Vaginal, Cream, Cream - Topical, Topical, Solution - Topical, Ring - Vaginal, Ring, Capsule; Spray, metered - Oral; Transdermal, Capsule; Spray, metered, Subcutaneous, Solution - Subcutaneous, Cream - Transdermal, Transdermal

Amenorrhea

50.0 mg, , 50.0 mg/mL, 100.0 mg, 200.0 mg, 0.09 mg/mg, 0.045 mg/mg, 8.0 %, 10.0 mg/mL, 17.0 mg/mL, 0.001 mg/mg, 1.1 mg/hour, 25.0 mg/mL, 1.0 mg/mg, 0.0025 mg/mg

Injection - Intramuscular, Injection, , Intramuscular, Injection, solution, Injection, solution - Intramuscular, Capsule - Oral, Capsule, Oral, Gel, Vaginal, Gel - Vaginal, Insert - Vaginal, Insert, Liquid - Intramuscular, Liquid, Solution - Intramuscular, Solution, Oral; Transdermal, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule - Vaginal, Cream - Vaginal, Cream, Cream - Topical, Topical, Solution - Topical, Ring - Vaginal, Ring, Capsule; Spray, metered - Oral; Transdermal, Capsule; Spray, metered, Subcutaneous, Solution - Subcutaneous, Cream - Transdermal, Transdermal

Uterine hemorrhage

50.0 mg, , 50.0 mg/mL, 100.0 mg, 200.0 mg, 0.09 mg/mg, 0.045 mg/mg, 8.0 %, 10.0 mg/mL, 17.0 mg/mL, 0.001 mg/mg, 1.1 mg/hour, 25.0 mg/mL, 1.0 mg/mg, 0.0025 mg/mg

Injection - Intramuscular, Injection, , Intramuscular, Injection, solution, Injection, solution - Intramuscular, Capsule - Oral, Capsule, Oral, Gel, Vaginal, Gel - Vaginal, Insert - Vaginal, Insert, Liquid - Intramuscular, Liquid, Solution - Intramuscular, Solution, Oral; Transdermal, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule - Vaginal, Cream - Vaginal, Cream, Cream - Topical, Topical, Solution - Topical, Ring - Vaginal, Ring, Capsule; Spray, metered - Oral; Transdermal, Capsule; Spray, metered, Subcutaneous, Solution - Subcutaneous, Cream - Transdermal, Transdermal

Vasomotor System

50.0 mg, , 50.0 mg/mL, 100.0 mg, 200.0 mg, 0.09 mg/mg, 0.045 mg/mg, 8.0 %, 10.0 mg/mL, 17.0 mg/mL, 0.001 mg/mg, 1.1 mg/hour, 25.0 mg/mL, 1.0 mg/mg, 0.0025 mg/mg

Injection - Intramuscular, Injection, , Intramuscular, Injection, solution, Injection, solution - Intramuscular, Capsule - Oral, Capsule, Oral, Gel, Vaginal, Gel - Vaginal, Insert - Vaginal, Insert, Liquid - Intramuscular, Liquid, Solution - Intramuscular, Solution, Oral; Transdermal, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule - Vaginal, Cream - Vaginal, Cream, Cream - Topical, Topical, Solution - Topical, Ring - Vaginal, Ring, Capsule; Spray, metered - Oral; Transdermal, Capsule; Spray, metered, Subcutaneous, Solution - Subcutaneous, Cream - Transdermal, Transdermal

Hot flashes

50.0 mg, , 50.0 mg/mL, 100.0 mg, 200.0 mg, 0.09 mg/mg, 0.045 mg/mg, 8.0 %, 10.0 mg/mL, 17.0 mg/mL, 0.001 mg/mg, 1.1 mg/hour, 25.0 mg/mL, 1.0 mg/mg, 0.0025 mg/mg

Injection - Intramuscular, Injection, , Intramuscular, Injection, solution, Injection, solution - Intramuscular, Capsule - Oral, Capsule, Oral, Gel, Vaginal, Gel - Vaginal, Insert - Vaginal, Insert, Liquid - Intramuscular, Liquid, Solution - Intramuscular, Solution, Oral; Transdermal, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule - Vaginal, Cream - Vaginal, Cream, Cream - Topical, Topical, Solution - Topical, Ring - Vaginal, Ring, Capsule; Spray, metered - Oral; Transdermal, Capsule; Spray, metered, Subcutaneous, Solution - Subcutaneous, Cream - Transdermal, Transdermal

prophylaxis of recurrent spontaneous preterm birth

50.0 mg, , 50.0 mg/mL, 100.0 mg, 200.0 mg, 0.09 mg/mg, 0.045 mg/mg, 8.0 %, 10.0 mg/mL, 17.0 mg/mL, 0.001 mg/mg, 1.1 mg/hour, 25.0 mg/mL, 1.0 mg/mg, 0.0025 mg/mg

Injection - Intramuscular, Injection, , Intramuscular, Injection, solution, Injection, solution - Intramuscular, Capsule - Oral, Capsule, Oral, Gel, Vaginal, Gel - Vaginal, Insert - Vaginal, Insert, Liquid - Intramuscular, Liquid, Solution - Intramuscular, Solution, Oral; Transdermal, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule - Vaginal, Cream - Vaginal, Cream, Cream - Topical, Topical, Solution - Topical, Ring - Vaginal, Ring, Capsule; Spray, metered - Oral; Transdermal, Capsule; Spray, metered, Subcutaneous, Solution - Subcutaneous, Cream - Transdermal, Transdermal

Warnings

Endometrin Contraindications

Condition

Risk Level

Notes

Liver Diseases

Do Not Combine

Thromboembolism

Do Not Combine

suspected pregnancy

Do Not Combine

Pulmonary Embolism

Do Not Combine

Stroke

Do Not Combine

Cerebrovascular accident

Do Not Combine

Thrombophlebitis

Do Not Combine

Breast

Do Not Combine

Deep Vein Thrombosis

Do Not Combine

Pulmonary Embolism

Do Not Combine

Pulmonary Embolism

Do Not Combine

Breast Cancer

Do Not Combine

Deep Vein Thrombosis

Do Not Combine

Breast

Do Not Combine

Breast

Do Not Combine

undiagnosed abnormal genital bleeding

Do Not Combine

suspected pregnancy

Do Not Combine

Thromboembolism

Do Not Combine

Malignant Neoplasms

Do Not Combine

Stroke

Do Not Combine

undiagnosed vaginal bleeding

Do Not Combine

Abortion, Spontaneous

Do Not Combine

Venous Thrombosis

Do Not Combine

Thrombophlebitis

Do Not Combine

Stroke

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Progesterone may interact with Pulse Frequency

Severe Hypersensitivity Reactions

Do Not Combine

Progesterone may interact with Pulse Frequency

There are 20 known major drug interactions with Endometrin.

Common Endometrin Drug Interactions

Drug Name

Risk Level

Description

Amitriptyline

Major

The metabolism of Amitriptyline can be decreased when combined with Progesterone.

Amoxapine

Major

The metabolism of Amoxapine can be decreased when combined with Progesterone.

Astemizole

Major

The metabolism of Astemizole can be decreased when combined with Progesterone.

Axitinib

Major

The metabolism of Axitinib can be decreased when combined with Progesterone.

Cabazitaxel

Major

The metabolism of Cabazitaxel can be decreased when combined with Progesterone.

Endometrin Toxicity & Overdose Risk

The toxic dose of progesterone for rats is 327 mg/kg. While some forms of progesterone can be used during pregnancy, high doses can affect fertility and cause tumors in animals. Some studies have suggested that using combined oral contraceptives may increase the risk of breast cancer, but no clear evidence has been found for progestin-only contraceptives. Progesterone can be found in breast milk, but it does not appear to negatively affect babies. However, there have been isolated cases of decreased milk production reported.

image of a doctor in a lab doing drug, clinical research

Endometrin Novel Uses: Which Conditions Have a Clinical Trial Featuring Endometrin?

Currently, there are 56 active studies assessing the potential of Endometrin in Gel formation, Assisted Reproductive Techniques (ART) and other Reproductive Technologies.

Condition

Clinical Trials

Trial Phases

Endometrial Hyperplasia

0 Actively Recruiting

Postmenopause

5 Actively Recruiting

Phase 2, Not Applicable

recurrent spontaneous preterm birth

0 Actively Recruiting

Uterine hemorrhage

0 Actively Recruiting

hormonal imbalance

0 Actively Recruiting

Vasomotor System

0 Actively Recruiting

Amenorrhea

0 Actively Recruiting

Hot flashes

19 Actively Recruiting

Not Applicable, Phase 4, Phase 2, Early Phase 1, Phase 3

Reproductive Technology

2 Actively Recruiting

Not Applicable

Amenorrhea

0 Actively Recruiting

prophylaxis of recurrent spontaneous preterm birth

0 Actively Recruiting

Hysterectomy

3 Actively Recruiting

Phase 3, Not Applicable

Endometrin Reviews: What are patients saying about Endometrin?

4.3

Patient Review

9/5/2009

Endometrin for Infertility caused by Deficiency of a Hormone-Progesterone

I followed the instructions and took this medicine twice daily, once in the morning and once at night. My progesterone levels were good at 15. However, I still miscarried. Additionally, I experienced bleeding while taking this medication which was inconvenient.

4.3

Patient Review

5/5/2011

Endometrin for Infertility caused by Deficiency of a Hormone-Progesterone

I started taking this medication after my pregnancy test, which was on Monday. I'm really hoping it will be effective for me.

4

Patient Review

4/28/2009

Endometrin for Infertility caused by Deficiency of a Hormone-Progesterone

I've been on this progesterone regimen for a little over a week now, taking it four times daily. The spotting has been the most uncomfortable side effect, but I am hopeful that it means the medication is working.

3.7

Patient Review

10/25/2015

Endometrin for Infertility caused by Deficiency of a Hormone-Progesterone

The main downside to this drug is that it gives you a really dry vagina. It's not the progesterone, it's the pill itself. I literally feel like my vag is full of plaster. But other than that, it's been fine.

Patient Q&A Section about endometrin

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does Endometrin help you stay pregnant?

"This medication contains a female hormone called progesterone. Progesterone and other hormones help you become and stay pregnant. This medication is used to increase the level of progesterone in women taking fertility treatments because these treatments tend to decrease progesterone levels."

Answered by AI

How far do you insert Endometrin?

"Wash your hands before and after you insert the Endometrin (progesterone). Take the applicator out of the packaging, and put the insert into the space on the thin end of the applicator. Put the applicator into your vagina as far as you can comfortably, and press the plunger to release the insert. Get rid of the applicator after each use."

Answered by AI

What does Endometrin do for pregnancy?

"ENDOMETRIN is a medication that helps support embryo implantation and early pregnancy. It is given as part of an Assisted Reproductive Technology (ART) treatment program for infertile women."

Answered by AI

What happens when you insert Endometrin?

"To insert the Endometrin tablet, open the individually wrapped packaging and remove the tablet. With the tablet placed on the applicator, insert it into the vagina as far as it will comfortably go and press the plunger to release the tablet. Endometrin is available in three different doses, 100 mg, 200 mg, and 300 mg.

Once the tablet is inserted into the vagina, it quickly dissolves and is available to be absorbed into the circulation to be taken to the uterus. Each Endometrin insert and applicator come individually wrapped within the Endometrin box.

To insert the Endometrin tablet, open the individually wrapped packaging and remove the tablet. With the tablet placed on the applicator, insert it into the vagina as far as it will comfortably go and press the plunger to release the tablet. Endometrin is available in three different doses: 100 mg, 200 mg, and 300 mg."

Answered by AI

Clinical Trials for Endometrin

Image of VA Greater Los Angeles Healthcare System, West Los Angeles, CA in West Los Angeles, United States.

Treatment for Obesity

Any Age
All Sexes
West Los Angeles, CA

Women Veterans are the fastest growing segment of VA users, with most users in midlife. This dramatic growth has created challenges for VA to ensure that appropriate services are available to meet women Veterans' needs, and that they will want and be able to use those services. Furthermore, few VA improvement efforts have focused on women Veterans' health and health care in midlife. The EMPOWER QUERI 3.0 Program is a cluster randomized type 3 hybrid implementation-effectiveness trial testing two strategies designed to support implementation and sustainment of evidence-based practices for women Veterans in at least 18 VA facilities from 4 regions.

Waitlist Available
Has No Placebo

VA Greater Los Angeles Healthcare System, West Los Angeles, CA

Alison B Hamilton, PhD MPH

Image of Erevna Innovations Inc. in Montreal, Canada.

Sculptra + Restylane for Post-Menopausal Skin Concerns

40 - 65
Female
Montreal, Canada

The post-menopausal state is marked by a sharp decline in estrogen, leading to significant structural and functional changes in the skin, including collagen loss, dryness, thinning, and reduced elasticity. To address these concerns, aesthetic injectables products such as Sculptra® Aesthetic (poly-L-lactic-acid \[PLLA- SCA\]) and Restylane Skinboosters®\[HASBV\] (small-particle hyaluronic acid - SP-HA) can be used. PLLA-SCA stimulates collagen production via cellular activation (biostimulator), gradually improving dermal structure. HASBV enhances hydration, elasticity, and skin texture when injected under the skin. Considering that hydration and laxity represent the primary aesthetic concerns in this patient population. Targeted treatment with SP-HA (HASBV) to improve hydration and PLLA-SCA to address laxity have been shown to produce significant clinical outcomes by directly addressing these key dermal deficiencies. This approach forms the basis of the current study.

Phase 4
Recruiting

Erevna Innovations Inc.

Andreas Nikolis, MD, PhD

Image of Shady Grove Fertility Rockville in Rockville, United States.

ICSI vs IVF for Female Infertility

Any Age
Female
Rockville, MD

The goal of this clinical trial is to learn whether two different methods of helping eggs and sperm join-intracytoplasmic sperm injection (ICSI) and conventional in vitro fertilization (IVF)-lead to better embryo development when using frozen donor sperm in people who do not have male fertility problems. The main questions it aims to answer are: Does one method create more usable embryos (blastocysts) than the other? Is there a difference in how often fertilization does not happen at all? Do either of the methods lead to better embryo quality or early pregnancy? Participants will: Have their eggs divided into two groups. One group will be fertilized using ICSI (where a sperm is injected directly into an egg), and the other using conventional IVF (where eggs are mixed with sperm in a dish). The fertilization method for each egg will be randomly assigned, with a random process also used to determine the assignment of any extra egg when an odd number is collected. Continue regular fertility treatment while the study team compares the results of each fertilization method. This study includes people with non-male factor infertility and uses frozen donor sperm. It hopes to learn whether ICSI, which is often used even when it may not be needed, truly helps improve outcomes compared to conventional IVF in these cases.

Recruiting
Has No Placebo

Shady Grove Fertility Rockville

Kate Devine, MD

Have you considered Endometrin clinical trials?

We made a collection of clinical trials featuring Endometrin, we think they might fit your search criteria.
Go to Trials

Have you considered Endometrin clinical trials?

We made a collection of clinical trials featuring Endometrin, we think they might fit your search criteria.
Go to Trials
Image of Don tyson Center for Agricultural Sciencers in Fayetteville, United States.

Protein and Exercise for Postmenopausal Women

Any Age
Female
Fayetteville, AR

The goal of this clinical trial is to learn if consuming a higher protein diet that includes one serving of beef each day, in combination with resistance exercise, improves wellbeing in postmenopausal women. It will also tell us about how higher protein intake changes body composition and blood values related to health. The main questions it aims to answer are: * Does higher protein intake combined with resistance training improve mood and sleep in postmenopausal women? * What other health benefits to postmenopausal women experience when the follow a higher protein diet and participate in resistance exercise? Researchers will compare three groups 1) postmenopausal women living their daily lives as usual, 2) postmenopausal women consuming a higher protein diet, and 2) postmenopausal women consuming a higher protein diet and participating in resistance training. Participants will: * Consume a higher protein diet for 16 weeks * Participate in an at-home resistance training for 16 weeks * Keep a diary of their food intake, sleep habits, and mood * Have health assessments every 4 weeks

Recruiting
Has No Placebo

Don tyson Center for Agricultural Sciencers (+1 Sites)

Jamie Baum

Image of The Buck Institute for Research on Aging in Novato, United States.

GLYLO Supplement for Postmenopausal Aging

45 - 65
Female
Novato, CA

The aim of this study is to assess the effectiveness of GLYLO, a dietary supplement, in postmenopausal women aged 45 to 65 who are overweight or obese and have elevated HbA1c levels. Specifically, the study seeks to evaluate whether GLYLO can reduce advanced glycation end products (AGEs) levels, which are harmful compounds formed when sugar attaches to proteins or fats in the body and can contribute to aging and disease. The primary outcome of the study is to determine if GLYLO reduces AGEs, enhances metabolic and hormonal health, and mitigates age-related functional decline. This study includes one screening visit and three testing visits over a 6-month period. After eligibility is confirmed, participants will be randomly assigned to one of two groups to take either GLYLO (two capsules daily) or a placebo at home for 24 weeks. Participants will provide blood samples at every visit. During the three testing visits, they will complete physical performance and cognitive function tests, provide both blood and urine samples, and fill out quality of life and 24-hour dietary intake questionnaires. The dietary intake questionnaires will be completed only twice i.e. at the baseline visit and again at the final 6-month visit.

Recruiting
Advanced

The Buck Institute for Research on Aging

Image of Noll Laboratory in University Park, United States.

Estradiol and Elagolix for Menopause

42 - 64
Female
University Park, PA

The frequency and severity of heat waves has increased in the last decades. Older adults (over 65 years) have impaired responses to heat stress making them at increased risk for adverse events. Previous heat waves report that women over 65 experience worse health outcomes than any other age group and age matched men. Aging and reproductive hormones, specifically estrogen, independently alter responses to heat stress. However, the combined effects of low estrogen following menopause and aging on the response to heat stress are unknown. In this study, the investigators will identify the role of estrogen in pre and post menopausal women on thermoregulatory responses to heat stress.

Phase 4
Recruiting

Noll Laboratory

W. Larry Kenney, Ph.D.

Have you considered Endometrin clinical trials?

We made a collection of clinical trials featuring Endometrin, we think they might fit your search criteria.
Go to Trials