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What is Enalaprilat
EnalaprilatThe Generic name of this drug
Treatment SummaryEnalaprilat is a medication used to treat high blood pressure. It works by preventing an enzyme called Angiotensin Converting Enzyme (ACE) from turning angiotensin I into angiotensin II, which can cause vasoconstriction and sodium reabsorption in the kidneys. Enalaprilat was developed to reduce side effects and the metallic taste that some patients experienced with captopril, the first ACE inhibitor. The active ingredient in enalaprilat is not easily absorbed through the digestive system, so it is only available as an intravenous injection.
Enalaprilatis the brand name
Enalaprilat Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Enalaprilat
Enalaprilat
2000
12
Effectiveness
How Enalaprilat Affects PatientsEnalaprilat injection quickly reduces both systolic and diastolic blood pressure, usually without causing lightheadedness. The effects usually start within 15 minutes, with the maximum effect occurring between 1-4 hours after administration. The effects usually last around 6 hours, but this may vary depending on the dose given. Enalapril also increases blood flow to the kidneys, but usually does not change the rate of filtration. This is also the case in patients with high blood pressure caused by kidney problems.
How Enalaprilat works in the bodyEnalaprilat is a medicine used to treat high blood pressure. It works by blocking an enzyme called Angiotensin Converting Enzyme (ACE). This enzyme is responsible for making a protein called angiotensin II, which narrows your blood vessels and causes the body to keep more salt. By blocking ACE, enalaprilat reduces the amount of angiotensin II in your body, which helps lower your blood pressure and reduce the amount of fluid in your blood.
When to interrupt dosage
The sum of Enalaprilat depends on the diagnosed condition, including Left Ventricular Dysfunction, Diabetic Nephropathy and Hypertensive disease. The amount of dosage is contingent upon the technique of delivery outlined in the table below.Condition
Dosage
Administration
Congestive Heart Failure
, 2.5 mg/mL, 1.25 mg/mL
, Intravenous, Injection, Injection - Intravenous, Injection, solution, Injection, solution - Intravenous, Solution - Intravenous, Solution
Diabetic Nephropathies
, 2.5 mg/mL, 1.25 mg/mL
, Intravenous, Injection, Injection - Intravenous, Injection, solution, Injection, solution - Intravenous, Solution - Intravenous, Solution
Ventricular Dysfunction, Left
, 2.5 mg/mL, 1.25 mg/mL
, Intravenous, Injection, Injection - Intravenous, Injection, solution, Injection, solution - Intravenous, Solution - Intravenous, Solution
Hypertensive disease
, 2.5 mg/mL, 1.25 mg/mL
, Intravenous, Injection, Injection - Intravenous, Injection, solution, Injection, solution - Intravenous, Solution - Intravenous, Solution
Warnings
Enalaprilat has three contraindications and should not be taken when facing any of the issues outlined in the table below.Enalaprilat ContraindicationsCondition
Risk Level
Notes
Angioedema
Do Not Combine
Angioedema
Do Not Combine
Angioedema
Do Not Combine
Common Enalaprilat Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Enalaprilat may increase the hypotensive activities of Amifostine.
Azathioprine
Major
The risk or severity of myelosuppression, anemia, and severe leukopenia can be increased when Enalaprilat is combined with Azathioprine.
Sacubitril
Major
The risk or severity of angioedema can be increased when Enalaprilat is combined with Sacubitril.
Sodium aurothiomalate
Major
The risk or severity of hypotension, nitritoid reactions, facial flushing, nausea, and vomiting can be increased when Enalaprilat is combined with Sodium aurothiomalate.
Acrivastine
Minor
Enalaprilat may decrease the excretion rate of Acrivastine which could result in a higher serum level.
Enalaprilat Toxicity & Overdose RiskTaking enalaprilat may cause side effects such as heart attack, tiredness, dizziness, fever, rash, and constipation. It can also lead to a more serious issue called angioedema (swelling of the face, lips, tongue, throat, etc.) which can be fatal. Other rarer side effects include anaphylaxis, low blood pressure, low white blood cells, liver failure, high potassium levels, and persistent coughing. Enalaprilat should not be taken during pregnancy as it can cause injury or death to the fetus or newborn.
Enalaprilat Novel Uses: Which Conditions Have a Clinical Trial Featuring Enalaprilat?
331 active studies are currently analyzing the potential of Enalaprilat to alleviate Diabetic Nephropathy, Congestive Heart Failure and Hypertensive diseases.Condition
Clinical Trials
Trial Phases
Hypertensive disease
23 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Diabetic Nephropathies
0 Actively Recruiting
Ventricular Dysfunction, Left
0 Actively Recruiting
Congestive Heart Failure
176 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 4, Phase 3, Early Phase 1
Enalaprilat Reviews: What are patients saying about Enalaprilat?
5Patient Review
1/12/2016 I've been taking this medication for three years and, while it has helped regulate my blood pressure, I have started to experience a number of unpleasant side effects. These include sweating, fatigue, coughing, low sex drive, and general feelings of malaise.
5Patient Review
2/23/2015 I discontinued using this medication after it made me cough a lot and I ended up in bed.
5Patient Review
10/24/2018 I've been on Enalapril for over a decade now, and it's done wonders for my blood pressure. I started out taking just 10 mg once per day, but found that by evening my BP had gone up again. So, I changed the dosage to 10mg twice a day and later increased it to 15mg twice a day. This has worked very well for me with no negative side effects whatsoever.
5Patient Review
12/18/2014 I sometimes experience severe dizziness after taking this medication, but it does go away quickly.
5Patient Review
5/15/2014Patient Q&A Section about enalaprilat
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is enalaprilat the same as enalapril?
"The drug enalaprilat is the active form of the medication enalapril, which is taken orally. Enalapril is used to treat hypertension, and works by preventing the enzyme ACE from turning angiotensin I into angiotensin II."
Answered by AI
How do you give an enalaprilat injection?
"The administration of enalaprilat injection should be done slowly through an IV, as indicated above. It can be administered directly, or diluted with a compatible diluent up to 50 mL."
Answered by AI
When do you use enalaprilat?
"This medication is used to treat high blood pressure. By lowering your blood pressure, it helps reduce your risk of developing heart disease, stroke, or kidney problems."
Answered by AI
Is enalaprilat an ACE inhibitor?
"Fosinopril (Monopril) Lisinopril (Priopril)
There are several types of ACE inhibitors, including Benazepril, Captopril, Enalapril, Fosinopril, and Lisinopril."
Answered by AI
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