What is Enalaprilat
EnalaprilatThe Generic name of this drug
Treatment SummaryEnalaprilat is a medication used to treat high blood pressure. It works by preventing an enzyme called Angiotensin Converting Enzyme (ACE) from turning angiotensin I into angiotensin II, which can cause vasoconstriction and sodium reabsorption in the kidneys. Enalaprilat was developed to reduce side effects and the metallic taste that some patients experienced with captopril, the first ACE inhibitor. The active ingredient in enalaprilat is not easily absorbed through the digestive system, so it is only available as an intravenous injection.
Enalaprilatis the brand name
Enalaprilat Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Enalaprilat
Enalaprilat
2000
12
Effectiveness
How Enalaprilat Affects PatientsEnalaprilat injection quickly reduces both systolic and diastolic blood pressure, usually without causing lightheadedness. The effects usually start within 15 minutes, with the maximum effect occurring between 1-4 hours after administration. The effects usually last around 6 hours, but this may vary depending on the dose given. Enalapril also increases blood flow to the kidneys, but usually does not change the rate of filtration. This is also the case in patients with high blood pressure caused by kidney problems.
How Enalaprilat works in the bodyEnalaprilat is a medicine used to treat high blood pressure. It works by blocking an enzyme called Angiotensin Converting Enzyme (ACE). This enzyme is responsible for making a protein called angiotensin II, which narrows your blood vessels and causes the body to keep more salt. By blocking ACE, enalaprilat reduces the amount of angiotensin II in your body, which helps lower your blood pressure and reduce the amount of fluid in your blood.
When to interrupt dosage
The sum of Enalaprilat depends on the diagnosed condition, including Left Ventricular Dysfunction, Diabetic Nephropathy and Hypertensive disease. The amount of dosage is contingent upon the technique of delivery outlined in the table below.Condition
Dosage
Administration
Left Ventricular Dysfunction
, 2.5 mg/mL, 1.25 mg/mL
Injection, solution - Intravenous, , Injection, Injection - Intravenous, Solution, Intravenous, Injection, solution, Solution - Intravenous
Diabetic Nephropathy
, 2.5 mg/mL, 1.25 mg/mL
Injection, solution - Intravenous, , Injection, Injection - Intravenous, Solution, Intravenous, Injection, solution, Solution - Intravenous
Hypertensive disease
, 2.5 mg/mL, 1.25 mg/mL
Injection, solution - Intravenous, , Injection, Injection - Intravenous, Solution, Intravenous, Injection, solution, Solution - Intravenous
Congestive Heart Failure
, 2.5 mg/mL, 1.25 mg/mL
Injection, solution - Intravenous, , Injection, Injection - Intravenous, Solution, Intravenous, Injection, solution, Solution - Intravenous
Warnings
Enalaprilat has three contraindications and should not be taken when facing any of the issues outlined in the table below.Enalaprilat ContraindicationsCondition
Risk Level
Notes
Angioedema
Do Not Combine
Angioedema
Do Not Combine
Angioedema
Do Not Combine
Common Enalaprilat Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Enalaprilat may increase the hypotensive activities of Amifostine.
Azathioprine
Major
The risk or severity of myelosuppression, anemia, and severe leukopenia can be increased when Enalaprilat is combined with Azathioprine.
Sacubitril
Major
The risk or severity of angioedema can be increased when Enalaprilat is combined with Sacubitril.
Sodium aurothiomalate
Major
The risk or severity of hypotension, nitritoid reactions, facial flushing, nausea, and vomiting can be increased when Enalaprilat is combined with Sodium aurothiomalate.
Acrivastine
Minor
Enalaprilat may decrease the excretion rate of Acrivastine which could result in a higher serum level.
Enalaprilat Toxicity & Overdose RiskTaking enalaprilat may cause side effects such as heart attack, tiredness, dizziness, fever, rash, and constipation. It can also lead to a more serious issue called angioedema (swelling of the face, lips, tongue, throat, etc.) which can be fatal. Other rarer side effects include anaphylaxis, low blood pressure, low white blood cells, liver failure, high potassium levels, and persistent coughing. Enalaprilat should not be taken during pregnancy as it can cause injury or death to the fetus or newborn.
Enalaprilat Novel Uses: Which Conditions Have a Clinical Trial Featuring Enalaprilat?
331 active studies are currently analyzing the potential of Enalaprilat to alleviate Diabetic Nephropathy, Congestive Heart Failure and Hypertensive diseases.Condition
Clinical Trials
Trial Phases
Diabetic Nephropathy
1 Actively Recruiting
Phase 4
Congestive Heart Failure
317 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Early Phase 1, Phase 4
Hypertensive disease
19 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4
Left Ventricular Dysfunction
8 Actively Recruiting
Not Applicable, Phase 4
Enalaprilat Reviews: What are patients saying about Enalaprilat?
5Patient Review
1/12/2016 I've been taking this medication for three years and, while it has helped regulate my blood pressure, I have started to experience a number of unpleasant side effects. These include sweating, fatigue, coughing, low sex drive, and general feelings of malaise.
5Patient Review
2/23/2015 I discontinued using this medication after it made me cough a lot and I ended up in bed.
5Patient Review
10/24/2018 I've been on Enalapril for over a decade now, and it's done wonders for my blood pressure. I started out taking just 10 mg once per day, but found that by evening my BP had gone up again. So, I changed the dosage to 10mg twice a day and later increased it to 15mg twice a day. This has worked very well for me with no negative side effects whatsoever.
5Patient Review
12/18/2014 I sometimes experience severe dizziness after taking this medication, but it does go away quickly.
5Patient Review
5/15/20145Patient Review
5/22/2017 So I switched from hydrochlorothiazide to enalapril 2.5 mg a week ago because the former was giving me hives, numbness in my arms and hands, knee pain, and severe headaches. So far the results have been great—my blood pressure has gone down from 150/96 to 106/76.
5Patient Review
10/24/2018 I've been taking Enalapril for over a decade now, and it's been great. I originally started on 10 mg once per day, but found that my blood pressure would go up by evening. So, I changed the dosage to 10mg twice a day and later increased it to 15 mg twice a day. It works really well for me with no negative side effects whatsoever.
5Patient Review
5/15/20145Patient Review
12/18/2014 I sometimes experience severe dizziness after taking this medication, but it does go away quickly.
5Patient Review
2/23/2015 I used this medication in conjunction with another, but it made me so cough badly that I had to discontinue both. Now I'm thinking I might just need to use the enalapril 5 mg tablet as prescribed halve tab twice daily.
5Patient Review
1/12/2016 I've been taking this treatment for three years and it has effectively kept my blood pressure in check. However, I am starting to experience some unpleasant side effects, such as sweating, fatigue, low sex drive, and shortness of breath.
5Patient Review
5/22/2017 I switched from hydrochlorothiazide to enalapril 2.5 mg a week ago because the former was giving me hives, numbness in both arms and hands, knee pain, and severe headaches. So far the results have been great; my blood pressure has gone from 150/96 to 106/76.
4.7Patient Review
7/12/2014 This medication has improved my dog's quality of life immensely. He's a senior dog with an enlarged heart, and this medication has made it much easier for him to breathe.
4.7Patient Review
7/12/2014 This medication has helped my dog "Ted" a lot. He's a senior dog with an enlarged heart, and this med helps him breathe easier. It's made his life (and mine) much nicer.
4Patient Review
5/23/2020 I've been taking this medication for over 15 years to help control my blood pressure. It's not perfect, but when combined with another high blood pressure medication, it's been very effective for me with few side effects.
4Patient Review
5/23/2020 I've been on this medication for over 15 years. It's not perfect, but adding it to another high blood pressure medication has allowed me to control my blood pressure without the horrible side-effects I've experienced with other medications.
3.7Patient Review
7/26/2014 I was taking this medication and it led to some really severe coughing fits. It got to the point where my chest and stomach would hurt from all the hacking. Once I looked up the side effects and saw that this was a common one, I stopped taking it and haven't had any issues since.
3.7Patient Review
7/26/2014 This medication gave me really severe coughing fits. Once I did some research and found out that this was a common side effect, I stopped taking it and haven't had any issues since.
3.3Patient Review
3/21/2017 This medication does a great job of lowering my blood pressure. I was struggling to keep it normal with other medications, but this one has really helped me out.
3.3Patient Review
4/15/2015 I didn't see the results I was hoping for when taking this drug in combination with Atenolol. My blood pressure remained unchanged.
3.3Patient Review
4/15/2015 I didn't see the results I was hoping for when taking this drug in combination with Atenolol.
3.3Patient Review
3/21/2017 This medication is much better at regulating my blood pressure. I was taking labetalol and amlodipine before this, but even with those it was difficult to maintain a normal blood pressure. With this medication, though, I'm able to have a more normal range.
3Patient Review
5/24/20143Patient Review
5/24/20142.7Patient Review
4/22/2017 I started taking enalapril because I had a bad experience with amlodipine. At first, this drug was great. My blood pressure was normal and I didn't have any side effects. But after a couple of weeks, I developed a dry cough that kept me up at night. It got worse and worse until I couldn't take it anymore and stopped taking the drug after 5 months.
2.7Patient Review
6/21/20142.7Patient Review
6/21/20142.7Patient Review
4/22/2017 I had to switch to enalapril from amlodipine because of how terrible the latter was. At first, this new drug was great! My blood pressure lowered and I experienced no adverse effects. However, after a few weeks I developed a dry cough that made it impossible for me to sleep. This continued to worsen until I just couldn't take it anymore and stopped taking the medication altogether.
2.3Patient Review
6/3/2018 I didn't have a good experience with this medication. I felt very out of it and exhausted while taking it, and it made me feel like I was drunk all the time. My blood pressure did stay low, but the side effects weren't worth it for me.
2.3Patient Review
7/16/2018 I've been on this medication for a few months now. It caused me to cough a little bit at first, but that went away relatively quickly. My main worry now is the significant increase in my waist size; even though I haven't gained any weight, my pants are much tighter than before. Has anyone else experienced this side effect?
2.3Patient Review
3/23/2015 This medication helps to control my blood pressure.
2.3Patient Review
3/23/2015 Helps to manage my blood pressure.
2.3Patient Review
6/3/2018 I found that the mental fogginess and fatigue were too much for me to handle after only taking this drug for a short while. It did keep my blood pressure low, but I stopped taking it because I didn't feel like it was worth the side effects.
2.3Patient Review
7/16/2018 I've been on this medication for a while now, and at first it caused me to cough a bit. However, my bigger worry is that I seem to be gaining inches around my waistline, even though I haven't gained any weight. Has anyone else experienced this side effect?
1.7Patient Review
10/18/2018 I took this medication for two months and experienced a range of negative side effects, including a bad cough, dizziness, headaches, insomnia, and extreme dry mouth. While it did lower my blood pressure as intended, the side effects were not worth it in my opinion.
1.7Patient Review
10/18/2018 I took this medication for two months and experienced a whole host of negative side-effects, like a bad cough, dizziness when standing up, headaches, insomnia, and extreme dry mouth. It did lower my blood pressure as intended but the trade-off wasn't worth it for me.
1Patient Review
4/7/2020 I had such bad heart palpitations that I couldn't sleep, and it also resulted in asthma. This treatment did nothing to help my blood pressure, but luckily I found some relief from natural B vitamins and regular exercise. Even though those things helped, I still have asthma; thanks doc!
1Patient Review
5/14/20141Patient Review
5/14/20141Patient Review
4/7/2020 I had such severe heart palpitations that it resulted in asthma and breathing problems. This treatment did little to relieve my blood pressure. However, I take NATURAL B vitamins and exercise regularly, which has helped me get my blood pressure back to normal.
Patient Q&A Section about enalaprilat
Is enalaprilat the same as enalapril?
"The drug enalaprilat is the active form of the medication enalapril, which is taken orally. Enalapril is used to treat hypertension, and works by preventing the enzyme ACE from turning angiotensin I into angiotensin II." - Anonymous Online Contributor
Unverified Answer
How do you give an enalaprilat injection?
"The administration of enalaprilat injection should be done slowly through an IV, as indicated above. It can be administered directly, or diluted with a compatible diluent up to 50 mL." - Anonymous Online Contributor
Unverified Answer
When do you use enalaprilat?
"This medication is used to treat high blood pressure. By lowering your blood pressure, it helps reduce your risk of developing heart disease, stroke, or kidney problems." - Anonymous Online Contributor
Unverified Answer
Is enalaprilat an ACE inhibitor?
"Fosinopril (Monopril) Lisinopril (Priopril)
There are several types of ACE inhibitors, including Benazepril, Captopril, Enalapril, Fosinopril, and Lisinopril." - Anonymous Online Contributor
Unverified Answer