Elidel

Vitiligo, Psoriasis, Dermatitis, Atopic + 2 more
Treatment
5 FDA approvals
7 Active Studies for Elidel

What is Elidel

PimecrolimusThe Generic name of this drug
Treatment SummaryPimecrolimus cream is a medication used to treat atopic dermatitis, also known as eczema. It reduces inflammation and helps to control the itching and redness caused by the condition. Pimecrolimus is marketed by Galderma under the trade name Elidel.
Elidelis the brand name
image of different drug pills on a surface
Elidel Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Elidel
Pimecrolimus
2001
12

Approved as Treatment by the FDA

Pimecrolimus, otherwise known as Elidel, is approved by the FDA for 5 uses including moderate Atopic dermatitis and mild Atopic dermatitis .
moderate Atopic dermatitis
Helps manage moderate Atopic dermatitis
mild Atopic dermatitis
Helps manage mild Atopic dermatitis
Dermatitis, Atopic
Helps manage moderate Atopic dermatitis
Second Line Treatment
Helps manage Second Line Treatment
Dermatitis, Atopic
Helps manage mild Atopic dermatitis

Effectiveness

How Elidel Affects PatientsPimecrolimus is used to treat atopic dermatitis (eczema), which is a skin condition that causes redness, itching, scaling, and inflammation. The exact cause of atopic dermatitis is unknown, but it is thought to be triggered by the immune system. Pimecrolimus helps reduce the symptoms of atopic dermatitis by blocking the action of T-cells and mast cells, which are part of the immune system. It does this by preventing the release of chemicals (cytokines) that stimulate T-cells, and by reducing the ability of mast cells to release chemicals that cause inflammation.
How Elidel works in the bodyPimecrolimus binds to and blocks an enzyme called calcineurin. This enzyme is involved in activating T cells, which can cause inflammation. Pimecrolimus blocks the production of certain cytokines, which are proteins released by T cells that cause inflammation. It also stops mast cells from releasing inflammatory substances when they are stimulated.

When to interrupt dosage

The suggested dose of Elidel is contingent upon the identified issue, for example Second Line Treatment, Vitiligo and non-immunocompromised. The dosage can be found in the table below, depending on the technique of delivery (e.g. Cream - Topical or Topical).
Condition
Dosage
Administration
Psoriasis
, 0.01 mg/mg, 1.0 %
, Topical, Cream, Cream - Topical
Second Line Treatment
, 0.01 mg/mg, 1.0 %
, Topical, Cream, Cream - Topical
Vitiligo
, 0.01 mg/mg, 1.0 %
, Topical, Cream, Cream - Topical
Dermatitis, Atopic
, 0.01 mg/mg, 1.0 %
, Topical, Cream, Cream - Topical
Dermatitis, Atopic
, 0.01 mg/mg, 1.0 %
, Topical, Cream, Cream - Topical

Warnings

There are 20 known major drug interactions with Elidel.
Common Elidel Drug Interactions
Drug Name
Risk Level
Description
2-Methoxyethanol
Major
The risk or severity of adverse effects can be increased when Pimecrolimus is combined with 2-Methoxyethanol.
9-(N-methyl-L-isoleucine)-cyclosporin A
Major
The risk or severity of adverse effects can be increased when Pimecrolimus is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
Abatacept
Major
The risk or severity of adverse effects can be increased when Pimecrolimus is combined with Abatacept.
Abetimus
Major
The risk or severity of adverse effects can be increased when Pimecrolimus is combined with Abetimus.
Acteoside
Major
The risk or severity of adverse effects can be increased when Pimecrolimus is combined with Acteoside.
Elidel Toxicity & Overdose RiskApplying too much of this drug can cause burning, itching, redness, and skin infections at the site of application.
image of a doctor in a lab doing drug, clinical research

Elidel Novel Uses: Which Conditions Have a Clinical Trial Featuring Elidel?

16 active trials are being conducted to examine the utility of Elidel in providing relief from Atopic Dermatitis and Second Line Treatment of Dermatitis.
Condition
Clinical Trials
Trial Phases
Dermatitis, Atopic
0 Actively Recruiting
Vitiligo
7 Actively Recruiting
Phase 2, Phase 3, Phase 1
Dermatitis, Atopic
0 Actively Recruiting
Psoriasis
0 Actively Recruiting
Second Line Treatment
0 Actively Recruiting

Elidel Reviews: What are patients saying about Elidel?

5Patient Review
3/11/2018
Elidel for Eczema Skin Condition Resisting Treatment
Elidel was a game-changer for me. I had atopic dermatitis on my face, ears and chin area that was uncontrolled and nothing worked; but after using this twice a day for six weeks as directed, there was drastic improvement. My skin is now soft with no itching or redness.
5Patient Review
12/8/2016
Elidel for Eczema Skin Condition Resisting Treatment
This cream has been amazing, quickly and significantly clearing up my facial eczema, mild rosacea, and atopic dermatitis.
5Patient Review
12/21/2020
Elidel for Eczema Skin Condition Resisting Treatment
After years of my regular doctor failing to properly diagnose my scaly, red, patchy skin, I went to a dermatologist that a friend recommended. They took one look at my skin and said "eczema," and then prescribed Elidel. At first I was hesitant because of the price tag; however, it truly is worth it if the medication works like it did for me. After only a couple applications, the puffiness, redness, and scaliness around my eyes were gone.
4.3Patient Review
4/10/2016
Elidel for Atopic Dermatitis
Elidel is extremely effective. However, I would caution against using it for more than a few days at a time as the side effects can be bothersome if it's overused.
2.3Patient Review
7/22/2017
Elidel for Eczema Skin Condition Resisting Treatment
I was instructed to use this on my eyelids, eyebrows, and upper cheeks. However, it only made my eyelids more red and created pimple-like eruptions. It's very difficult to apply without getting near your eyes.
2Patient Review
8/7/2018
Elidel for Atopic Dermatitis
My dermatologist prescribed Elidel with confidence. She first gave me a sample to try, and later I'd have to buy it. She was extremely sure of the expected result; however, the medicine didn't work for me at all. I used it just as she advised but there was absolutely no improvement. Not only that, but it's prohibitively expensive.
1.7Patient Review
8/12/2017
Elidel for Eczema Skin Condition Resisting Treatment
I've had eczema for as long as I can remember, and was recently prescribed Elidel. It's been around four days, and I've only noticed a change in the texture of my skin; however, the redness and irritation are still very bad.
1.3Patient Review
6/17/2016
Elidel for Atopic Dermatitis
This treatment is way too harsh. It burns constantly, and you can't even get near the sun without feeling more burning. Plus, if it gets near your eyes it gives you a stye! Avoid this product.
1Patient Review
3/14/2019
Elidel for Atopic Dermatitis
Elidel not only failed to help with my dry patches, but it also gave me two cold sores! I would rather live with the dry patches than deal with that again.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about elidel

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What Elidel cream is used for?

"Elidel is a topical cream prescribed for the treatment of mild to moderate eczema in adults and children over the age of two. It is not for use in patients with a weakened immune system."

Answered by AI

Is Elidel a steroid cream?

"Elidel cream is a non-steroidal cream that helps to diminish the redness and itchiness often associated with eczema by targeting the specific cells that cause inflammation."

Answered by AI

What are the side effects of Elidel cream?

"Some mild side effects of this treatment include a burning or warm feeling of the treated skin, a headache, cold symptoms like a stuffy nose or sneezing, and swollen hair follicles. You might also experience some acne or warts, and the treated skin may feel burning, stinging, tingling, or sore. Some other side effects can include an upset stomach and muscle pain."

Answered by AI

Is Elidel good for face?

"You can apply Elidel to your face, and you may be able to use a moisturizer in combination with the drug. When you apply Elidel to your face (or the rest of your body), put the medication only on areas of skin that have eczema. You should avoid getting Elidel cream in your eyes, mouth, and nose."

Answered by AI

Clinical Trials for Elidel

Image of Marvel Clinical Research in Huntington Beach, United States.

Ritlecitinib for Vitiligo

Any Age
All Sexes
Huntington Beach, CA
This study is to evaluate how safe and effective ritlecitinib is in participants with non-segmental vitiligo (NSV). Ritlecitinib is studied in patients with non-segmental vitiligo. Vitiligo is a chronic acquired depigmentation disorder characterized by well-defined pale white patches of skin. Non-segmental vitiligo is an autoimmune disorder and is the focus of this study. The study will show: * if the repigmentation (the recovery of pigmentation) achieved in study B7981040 (also called the "parent study") will stay the same or will further increase if you keep receiving the same study medicine (ritlecitinib 50 milligrams or placebo) * Or if more repigmentation can be achieved if you start receiving ritlecitinib 100 milligrams in this study * Or how long the repigmentation achieved during the parent study lasts if you start receiving placebo in this study. This study is seeking for participants who: * have non-segmental vitiligo (either active or stable) and * received ritlecitinib or placebo for 52 weeks in the parent study. A placebo looks exactly like the study capsule but does not contain any medicine in it. All participants in this study will receive the study medicine or placebo. The study medicine (ritlecitinib 50 milligrams or 100 milligrams) or placebo are capsules that are taken by mouth at home every day. On study visit days, you must take the medication at the study site, and not at home. Participants may receive the study medicine or placebo for up to 52 weeks. The study will look at the experiences of people receiving the study medicine. This will help see if ritlecitinib is better for treating vitiligo. Participants will be involved in this study for a maximum of 60 weeks. During this time, they will have 9 study visits during the study. Ritlecitinib 50 mg is an approved drug for the treatment of severe Alopecia Areata (a disease with similar abnormal changes in the body functions like vitiligo) in the US, EU and Japan. China, Great Britain and other market applications are pending.
Phase 3
Recruiting
Marvel Clinical Research (+34 Sites)Pfizer CT.gov Call CenterPfizer
Image of Michigan Center for Research Company /ID# 260069 in Clarkston, United States.

Upadacitinib for Vitiligo

Any Age
All Sexes
Clarkston, MI
Vitiligo is a common chronic autoimmune disease that causes the body's immune system to attack its own pigment producing skin cells. This study is to evaluate how safe and effective upadacitinib is in participants with non-segmental vitiligo (NSV). Adverse effects and change in disease activity will be assessed. Upadacitinib is an approved drug for various immune-mediated inflammatory diseases and is currently being investigated for the treatment of NSV. There will be 2 replicate studies running at the same time (Study 1 and Study 2 with periods A and B) and an optional exploratory Narrow-Band Ultraviolet B (NB-UVB) phototherapy study (Study 3). In Period A, participants are placed in 1 of 2 groups called treatment arms. Each group receives a different treatment. There is a 1 in 3 chance that participants will receive placebo and 2 in 3 chance participants will receive upadacitinib. In Period B, all participants will receive upadacitinib. Approximately 270 adult and adolescent participants with NSV will be enrolled in each main study ((Study 1 and Study 2, 540 subjects total) at approximately 90 sites worldwide with an option for adult participants who completed Period A of either study and did not achieve T-VASI 90 at week 48 while on study drug, to enter Study 3. In Studies 1 and 2: Period A, participants will receive oral tablets of upadacitinib or placebo once a day for 48 weeks. In Period B, participants will receive oral tablets of upadacitinib 15 mg once a day for 112 weeks. Participants will be followed up for 30 days. Study 3 participants will receive upadacitinib monotherapy or upadacitinib with NB-UBV phototherapy for at least 24 weeks followed by upadacitinib alone. There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at a hospital or clinic. The effect of the treatment will be checked by medical assessments, blood tests, checking for side effects and completing questionnaires.
Phase 3
Waitlist Available
Quick Reply
Michigan Center for Research Company /ID# 260069 (+65 Sites)ABBVIE INC.AbbVie
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