Duloxetine Hydrochloride

Osteoarthritis of the Knee, Musculoskeletal System, Generalized Anxiety Disorder + 6 more
Treatment
20 Active Studies for Duloxetine Hydrochloride

What is Duloxetine Hydrochloride

DuloxetineThe Generic name of this drug
Treatment SummaryDuloxetine is a medication used to treat depression, anxiety, nerve pain, osteoarthritis, and stress incontinence. It works by increasing levels of serotonin and norepinephrine in the brain, two chemicals that help regulate mood. The drug was developed by Eli Lilly and Company and approved by the FDA in 2004 under the brand name Cymbalta. It is currently being studied for its potential to treat pain associated with cancer and surgery.
Cymbaltais the brand name
image of different drug pills on a surface
Duloxetine Hydrochloride Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Cymbalta
Duloxetine
2004
394

Effectiveness

How Duloxetine Hydrochloride Affects PatientsDuloxetine helps treat stress urinary incontinence by increasing the strength of the muscles that control urine release. It has been shown to improve patient ratings on improvement and quality of life, and to reduce the number of incontinence episodes. It also works to reduce pain from conditions such as diabetic peripheral neuropathy and fibromyalgia by strengthening the pathways that carry pain signals from the body to the brain, making it harder for these signals to be sent. While Duloxetine is used to treat mood disorders, it is still not known exactly how it affects mood regulation. Common side effects include increased blood pressure due to increased nore
How Duloxetine Hydrochloride works in the bodyDuloxetine affects the brain in several ways. It prevents serotonin and norepinephrine from leaving the neuron, which leads to increased activation of certain receptors. These receptors then cause changes in the cell that result in increased electrical activity and inhibition of pain signals. It also affects the limbic system, which is involved in emotional modulation, though it's unsure how this contributes to its uses in depression and anxiety. Duloxetine also causes vasoconstriction by increasing the availability of norepinephrine, which activates adrenergic receptors on the vascular endothelium and causes calcium release from the sarcoplasmic reticulum.

When to interrupt dosage

The proposed dosage of Duloxetine Hydrochloride is reliant upon the discerned condition, such as Low Back Pain, Fibromyalgia and Prostatectomy. The measure of dosage varies, depending on the technique of delivery (e.g. Oral or Capsule, delayed release pellets - Oral) set out in the table beneath.
Condition
Dosage
Administration
Depression
, 20.0 mg, 30.0 mg, 60.0 mg, 40.0 mg
, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Kit - Oral; Topical, Oral; Topical
Diabetic Neuralgia
, 20.0 mg, 30.0 mg, 60.0 mg, 40.0 mg
, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Kit - Oral; Topical, Oral; Topical
Chronic Lower Back Pain
, 20.0 mg, 30.0 mg, 60.0 mg, 40.0 mg
, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Kit - Oral; Topical, Oral; Topical
Prostatectomy
, 20.0 mg, 30.0 mg, 60.0 mg, 40.0 mg
, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Kit - Oral; Topical, Oral; Topical
Musculoskeletal System
, 20.0 mg, 30.0 mg, 60.0 mg, 40.0 mg
, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Kit - Oral; Topical, Oral; Topical
Osteoarthritis of the Knee
, 20.0 mg, 30.0 mg, 60.0 mg, 40.0 mg
, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Kit - Oral; Topical, Oral; Topical
Generalized Anxiety Disorder
, 20.0 mg, 30.0 mg, 60.0 mg, 40.0 mg
, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Kit - Oral; Topical, Oral; Topical
Fibromyalgia
, 20.0 mg, 30.0 mg, 60.0 mg, 40.0 mg
, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Kit - Oral; Topical, Oral; Topical
Stress Urinary Incontinence
, 20.0 mg, 30.0 mg, 60.0 mg, 40.0 mg
, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Kit - Oral; Topical, Oral; Topical

Warnings

Duloxetine Hydrochloride Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Hypertensive disease
Do Not Combine
Pulse Frequency
Do Not Combine
Liver Disease
Do Not Combine
Pulse Frequency
Do Not Combine
uncontrolled narrow-angle glaucoma
Do Not Combine
There are 20 known major drug interactions with Duloxetine Hydrochloride.
Common Duloxetine Hydrochloride Drug Interactions
Drug Name
Risk Level
Description
Azelastine
Major
Duloxetine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Ethanol
Major
Duloxetine may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Iobenguane
Major
Duloxetine may decrease effectiveness of Iobenguane as a diagnostic agent.
Methylene blue
Major
Duloxetine may increase the serotonergic activities of Methylene blue.
Mirtazapine
Major
Duloxetine may increase the serotonergic activities of Mirtazapine.
Duloxetine Hydrochloride Toxicity & Overdose RiskOverdosing on duloxetine can be fatal and may cause symptoms such as sleepiness, coma, confusion, seizures, fainting, low or high blood pressure, rapid heartbeat, and vomiting. There is no antidote for an overdose and it can't be removed from the body with dialysis. Treatment for an overdose includes supportive care, activated charcoal, and gastric lavage to reduce absorption. If serotonin syndrome occurs, steps may be taken to reduce body temperature or administer cyproheptadine. Long-term use of duloxetine may lead to increased risk of liver cancer in female
image of a doctor in a lab doing drug, clinical research

Duloxetine Hydrochloride Novel Uses: Which Conditions Have a Clinical Trial Featuring Duloxetine Hydrochloride?

387 active trials are studying the potential of Duloxetine Hydrochloride to relieve Musculoskeletal System, Post-Prostatectomy and Chemotherapy Induced Peripheral Neuropathy (CIPN) symptoms.
Condition
Clinical Trials
Trial Phases
Stress Urinary Incontinence
30 Actively Recruiting
Phase 3, Not Applicable, Phase 4, Phase 2
Generalized Anxiety Disorder
33 Actively Recruiting
Not Applicable, Phase 2, Phase 3, Phase 1, Phase 4
Depression
202 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Phase 4, Early Phase 1
Osteoarthritis of the Knee
102 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4, Early Phase 1
Chronic Lower Back Pain
42 Actively Recruiting
Not Applicable, Phase 2, Early Phase 1, Phase 3, Phase 4, Phase 1
Prostatectomy
1 Actively Recruiting
Not Applicable
Musculoskeletal System
2 Actively Recruiting
Not Applicable
Fibromyalgia
0 Actively Recruiting
Diabetic Neuralgia
2 Actively Recruiting
Phase 2

Duloxetine Hydrochloride Reviews: What are patients saying about Duloxetine Hydrochloride?

5Patient Review
6/21/2022
Duloxetine Hydrochloride for Neuropathic Pain
This medication has had a profound and transformative effect on my life. It is by far the most effective treatment I've ever received in terms of reducing pain and improving my overall feeling of well-being.
5Patient Review
6/7/2022
Duloxetine Hydrochloride for Chronic Muscle or Bone Pain
This medicine has been hugely beneficial for me. It's significantly reduced the pain I experience from fibromyalgia, as well as my anxiety levels. Overall, it's made a profound difference in my day-to-day life.
5Patient Review
7/23/2022
Duloxetine Hydrochloride for Neuropathic Pain
I had a spinal fusion a few years ago which led to unbearable nerve pain and damage in my right leg. I've been taking 120mg of this medication for almost two years now and it's really helped me get by.
5Patient Review
11/1/2022
Duloxetine Hydrochloride for Major Depressive Disorder
I'm so glad I found out about duloxetine. It's really helped me to feel calmer and more content. The intrusive thoughts and suicidal ideation have completely stopped since starting this medication, and I've generally been in a much better mood.
3.7Patient Review
9/28/2022
Duloxetine Hydrochloride for Anxiousness associated with Depression
I'm not sure if it's the medicine or not, but I've been feeling sick lately. Has anyone else had this side effect?
2.3Patient Review
5/30/2022
Duloxetine Hydrochloride for Chronic Muscle or Bone Pain
This medication was given to me after I mentioned suicidal ideation in relation to my back pain. While it did help to level out my mood, it completely killed my appetite. I went from 230 pounds to 170 in just a few months because I had no desire whatsoever to eat anything. My sex drive also took a huge dive while on this medication; I didn't even think about sex at all. Once I stopped taking the medication, my appetite and sex drive both returned to normal.
2.3Patient Review
8/9/2022
Duloxetine Hydrochloride for Neuropathic Pain
I was originally prescribed Duloxetine 20mg for neuropathic nerve pain, and it worked well for the first few months. However, my mPCP suggested I up the dosage to 30mg. Unfortunately, this caused complete digestive shutdown and chronic constipation. In addition, I had to urinate excessively at night and my skin felt incredibly dry and rough. As a result, I stopped taking the medication.
1.7Patient Review
7/17/2022
Duloxetine Hydrochloride for Major Depressive Disorder
After six years of taking sertraline, I haven't found it to be helpful at all. If anything, it's made me more paranoid and emotional. I'm also dealing with PTSD and sleep problems. It's difficult to find a way to cope that doesn't put my life at risk.
1.7Patient Review
7/10/2022
Duloxetine Hydrochloride for Neuropathic Pain
Duloxetine was a terrible experience for me. First, I lost a lot of hair, and then I broke out in hives and welts all over my body. The itching was unbearable. Never taking that again.
1.7Patient Review
6/24/2022
Duloxetine Hydrochloride for Major Depressive Disorder
This medication made me feel more depressed and even suicidal.
1.3Patient Review
10/10/2022
Duloxetine Hydrochloride for Anxiousness associated with Depression
DON'T TAKE THIS DRUG! The withdrawal effects are really scary and intense. I would never want to experience that again.
1Patient Review
8/2/2022
Duloxetine Hydrochloride for Neuropathic Pain
This medication is really difficult to stop taking. I've tried tapering down a few times, and each time I experience horrible withdrawal symptoms like brain zaps. It also seems to interact negatively with a lot of other medications, and I think it might have made my hypertension worse.
1Patient Review
10/14/2022
Duloxetine Hydrochloride for Chronic Muscle or Bone Pain
I was prescribed this for pain related to muscle necrosis, but it did nothing for me. If anything, it made my symptoms worse. I felt nauseous all the time, could barely eat, and had severe diarrhea. On top of that, I was constantly sweating and shaking. My doctor wanted to increase the dose, but there's no way I'm taking more of this stuff. It's awful.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about duloxetine hydrochloride

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is duloxetine Hydrochloride used for?

"This medication is used to treat depression, anxiety, and nerve pain caused by diabetes. It is also used to treat muscle pain and stiffness associated with fibromyalgia."

Answered by AI

What are the side effects with duloxetine?

"...

If you're struggling to sleep, taking duloxetine first thing in the morning may help. If you're getting headaches, make sure to rest and drink plenty of fluids. If you're feeling dizzy, blurred vision, constipation, diarrhoea, nausea, or vomiting, dry mouth, these may be side effects of the medication."

Answered by AI

Is duloxetine hydrochloride a narcotic?

"Duloxetine belongs to a group of drugs known as selective norepinephrine reuptake inhibitors (SNRIs). Duloxetine is not a selective serotonin reuptake inhibitor (SSRI) or a narcotic."

Answered by AI

Is duloxetine a strong painkiller?

"The research reported in this document demonstrates that duloxetine is an effective way to treat chronic pain, as it significantly improves pain intensity, physical functioning, and overall patient improvement ratings."

Answered by AI

Clinical Trials for Duloxetine Hydrochloride

Have you considered Duloxetine Hydrochloride clinical trials? We made a collection of clinical trials featuring Duloxetine Hydrochloride, we think they might fit your search criteria.
Have you considered Duloxetine Hydrochloride clinical trials? We made a collection of clinical trials featuring Duloxetine Hydrochloride, we think they might fit your search criteria.
Have you considered Duloxetine Hydrochloride clinical trials? We made a collection of clinical trials featuring Duloxetine Hydrochloride, we think they might fit your search criteria.