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Aerobic Exercise for Cancer

N/A

Recruiting

Led By Lee Jones, PhD

Research Sponsored by Memorial Sloan Kettering Cancer Center

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Age ≥ 18 yrs

- Prior treatment with chemotherapy

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 2 years

Awards & highlights

Study Summary

This trial will look at whether aerobic exercise can change blood biomarkers related to disease.

Who is the study for?

This trial is for adults who have had or are having androgen deprivation therapy, breast cancer with stable disease or no evidence of disease, high risk of cardiovascular disease, stage III colorectal or breast cancer post-therapy, localized prostate cancer under active surveillance, Lynch syndrome without intense exercise habits. Exclusions include severe heart/lung conditions, mental impairment affecting cooperation, other conflicting trials.Check my eligibility

What is being tested?

The study investigates if aerobic exercise like walking can alter blood biomarkers in patients with various cancers. Participants will engage in structured exercises and provide blood samples to track changes.See study design

What are the potential side effects?

While the trial involves low-risk activities such as walking and blood draws which typically have minimal side effects like bruising from needle insertion or muscle soreness from exercise; risks specific to participants' health conditions will be monitored.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am 18 years old or older.

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I have previously undergone chemotherapy.

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I am 60 years old or older.

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I have had radiation therapy on the left side of my chest or breast.

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I have been diagnosed with Lynch Syndrome.

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I am currently on or have had hormone therapy for cancer.

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I have finished all my cancer treatments.

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I have had a bone marrow transplant in the past.

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I am 18 years old or older.

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Part of my lower colon is intact for biopsy.

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I have a solid tumor.

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I am a man with early-stage prostate cancer and am being closely monitored.

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I have a genetic form of colorectal cancer known as Lynch syndrome.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 2 years

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~2 years

This trial's timeline: 3 weeks for screening, Varies for treatment, and 2 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

changes in residual tumor burden (Solid tumor group)

number of patients with variant allele frequency (VAF)

Trial Design

4Treatment groups

Experimental Treatment

Group I: post treatment patients with breast or colorectal cancerExperimental Treatment3 Interventions

Exercise treatment will consist of individualized walking delivered up to 5 times weekly. Patients in all cohorts will receive one dose of exercise (i.e., ~300 mins/wk following a non-linear dosing schedule) in both cohorts. Patients will have the option to receive exercise treatment at MSK or at their residence. Home-based exercise will be implemented and monitored using a telemedicine approach (i.e.,TeleEx) established in the Exercise-Oncology (ExOnc) Service

Group II: patients with clonal hematopoiesisExperimental Treatment2 Interventions

Group III: men with localized prostate cancer undergoing active surveillanceExperimental Treatment3 Interventions

Group IV: Individuals with Lynch SyndromeExperimental Treatment3 Interventions

0 / 13Eligibility criteria met

Find a Location

Who is running the clinical trial?

Memorial Sloan Kettering Cancer CenterLead Sponsor

1,936 Previous Clinical Trials

588,849 Total Patients Enrolled

Lee Jones, PhDPrincipal InvestigatorMemorial Sloan Kettering Cancer Center

7 Previous Clinical Trials

5,481 Total Patients Enrolled

Media Library

Exercise Clinical Trial Eligibility Overview. Trial Name: NCT03996239 — N/A

Cancer Research Study Groups: Individuals with Lynch Syndrome, post treatment patients with breast or colorectal cancer, men with localized prostate cancer undergoing active surveillance, patients with clonal hematopoiesis

Cancer Clinical Trial 2023: Exercise Highlights & Side Effects. Trial Name: NCT03996239 — N/A

Exercise 2023 Treatment Timeline for Medical Study. Trial Name: NCT03996239 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the aggregate figure of participants involved in this clinical trial?

"To meet the requirements of this trial, 40 individuals that fulfill the set inclusion criteria are needed to take part. Two locations providing assistance for those participating in this study include Duke University Medical Center (Data or Specimen Analysis Only) found in Durham, North carolina and SOMALOGIC (Data or Specimen Analysis Only) located in Boulder, Colorado."

Answered by AI

Does this experiment still have open slots for participants?

"The current status of the trial, according to clinicaltrials.gov records, is actively recruiting participants. The first posting date was June 20th 2019 and there has been recent activity on October 26th 2022."

Answered by AI

Are there numerous locales conducting this research inside the state?

"The current trial is being conducted in 3 locations, Duke University Medical Center (Data or Specimen Analysis Only) located in Durham, North carolina; SOMALOGIC (Data or Specimen Analysis Only) situated in Boulder Colorado; and Memorial Sloan Kettering Bergen based out of Montvale New york. Additionally there are 10 other sites where data collection is taking place simultaneously."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Researching the Effect of Aerobic Exercise on Cancer

2019. "Researching the Effect of Aerobic Exercise on Cancer". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03996239.