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Low Dose CT Scans for Lung Cancer Detection in Firefighters

N/A
Recruiting
Led By Lecia V Sequist, MD
Research Sponsored by Massachusetts General Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Willing and able to receive LDCT screening at MGH or who have been screened via LDCT within the past year at MGH or another institution, and are willing to release their images to the study
40-80 years of age or with 10 years of firefighting experience
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 12 months
Awards & highlights

Study Summary

This trial will compare CT scan findings of firefighters to a control group, and see if there is a relationship between work exposure and findings. They will also test a method to better identify high-risk patients.

Who is the study for?
This trial is for current or retired firefighters aged 40-80, or those with at least 10 years of firefighting experience. Participants must be willing to undergo LDCT lung screening and have no personal history of lung cancer. Active cancer patients are excluded.Check my eligibility
What is being tested?
The study is testing if Low Dose CT (LDCT) scans show different results in firefighters compared to non-firefighters, how job exposures affect scan findings, and if a proteomics assay can help assess the risk of detected lung nodules.See study design
What are the potential side effects?
Low Dose CT scans are generally safe but may include exposure to low levels of radiation which carries a small risk of potentially harmful effects like cancer development over time.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am willing to undergo or have had a low-dose CT scan within the last year and can share the images.
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I am between 40 and 80 years old or have been a firefighter for 10 years.
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I have never had lung cancer before.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~12 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 12 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
High-risk nodule detection rate
Nodule detection rate
Secondary outcome measures
Coronary artery calcification (CAC) ordinal scores
Interstitial lung disease detection rate

Trial Design

1Treatment groups
Experimental Treatment
Group I: Low-Dose CTExperimental Treatment1 Intervention
Low Dose CT Scan of the Chest

Find a Location

Who is running the clinical trial?

Massachusetts General HospitalLead Sponsor
2,924 Previous Clinical Trials
13,192,573 Total Patients Enrolled
Lecia V Sequist, MDPrincipal InvestigatorMassachusetts General Hospital
Erica T Warner, ScDPrincipal InvestigatorMassachusetts General Hospital

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is there an age restriction for enrolment in this medical experiment?

"Adhering to the requirements of this research, participants must be aged between 40 and 80 years old."

Answered by AI

Is admission to this experiment open at present?

"Affirmative. Clinicaltrials.gov data indicates that this research project, which was originally posted on March 2nd 2021, is actively recruiting patients at the moment. 850 participants are needed from a single clinical trial location."

Answered by AI

Does this investigation invite participation from the public?

"The current research project is looking to enrol 850 individuals between the ages of 40 and 80 that suffer from a respiratory malady. In order to qualify, participants should be firefighters or former firefighters in the Boston region, with no personal experience of lung cancer. Additionally they need to accept an LDCT screening at MGH or supply evidence of recent LDCT results carried out elsewhere, alongside being willing to provide images for study use. Lastly, candidates must have either attained their fortieth year or completed ten years as fire personnel before participation can begin."

Answered by AI

What is the cap on patient participation for this clinical experiment?

"Correct. According to the clinicaltrials.gov website, this medical trial is actively searching for participants after having been posted in March of 2021 and updated most recently in November 2022. 850 patients are being recruited from a single location."

Answered by AI
~65 spots leftby Jun 2024