Drospirenone

Birth Control, Acne Vulgaris, Folate supplementation therapy + 9 more
Treatment
20 Active Studies for Drospirenone

What is Drospirenone

DrospirenoneThe Generic name of this drug
Treatment SummaryDrospirenone is a synthetic hormone found in oral contraceptives such as Yaz. It is used to prevent pregnancy and also to treat acne and premenstrual dysphoric disorder (PMDD) when used in combination with estrogen. There has been some concern that drospirenone may increase the risk of venous thromboembolism, however the FDA concluded that this risk is unclear and may be lower than the risk during pregnancy or after birth.
Yasminis the brand name
image of different drug pills on a surface
Drospirenone Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Yasmin
Drospirenone
2001
64

Effectiveness

How Drospirenone Affects PatientsDrospirenone works by stopping the ovaries from releasing eggs, preventing pregnancy. It can also improve acne and hirsutism by blocking the effects of certain hormones. Taking drospirenone combined with ethinyl estradiol has been found to have beneficial effects on cholesterol levels. As it is similar to the hormone progesterone, drospirenone is believed to cause fewer side effects related to progesterone, such as breast tenderness and mood changes. However, drospirenone may increase the risk of blood clots and cardiovascular issues, especially in smokers and women aged 35 and older. Additionally, this drug may
How Drospirenone works in the bodyDrospirenone and ethinyl estradiol work together to prevent pregnancy. They do this by stopping the release of hormones that trigger ovulation and by altering the consistency of the cervical mucus to block sperm movement. Drospirenone also has anti-mineralocorticoid activity, which helps reduce the effects of naturally occurring androgens. This helps treat acne and hirsutism, as well as reducing the levels of edema in sebaceous follicles.

When to interrupt dosage

The prescribed measure of Drospirenone is contingent upon the diagnosed state, including moderate to severe signs, Menopause and Post-Menarche. The dosage can be found in the table below, varying with the mode of administration (e.g. Tablet, film coated - Oral or Oral).
Condition
Dosage
Administration
Birth Control
, 0.25 mg, 0.5 mg, 3.0 mg, 1.0 mg, 4.0 mg
, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Kit - Oral, Tablet - Oral, Tablet
moderate to severe symptoms
, 0.25 mg, 0.5 mg, 3.0 mg, 1.0 mg, 4.0 mg
, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Kit - Oral, Tablet - Oral, Tablet
N-Cadherins
, 0.25 mg, 0.5 mg, 3.0 mg, 1.0 mg, 4.0 mg
, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Kit - Oral, Tablet - Oral, Tablet
Hormonal Contraception
, 0.25 mg, 0.5 mg, 3.0 mg, 1.0 mg, 4.0 mg
, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Kit - Oral, Tablet - Oral, Tablet
Vasomotor System
, 0.25 mg, 0.5 mg, 3.0 mg, 1.0 mg, 4.0 mg
, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Kit - Oral, Tablet - Oral, Tablet
Acne Vulgaris
, 0.25 mg, 0.5 mg, 3.0 mg, 1.0 mg, 4.0 mg
, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Kit - Oral, Tablet - Oral, Tablet
Adherence to Oral Contraceptive Therapy
, 0.25 mg, 0.5 mg, 3.0 mg, 1.0 mg, 4.0 mg
, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Kit - Oral, Tablet - Oral, Tablet
Atrophic
, 0.25 mg, 0.5 mg, 3.0 mg, 1.0 mg, 4.0 mg
, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Kit - Oral, Tablet - Oral, Tablet
Post-Menarche
, 0.25 mg, 0.5 mg, 3.0 mg, 1.0 mg, 4.0 mg
, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Kit - Oral, Tablet - Oral, Tablet
Atrophy of vulva
, 0.25 mg, 0.5 mg, 3.0 mg, 1.0 mg, 4.0 mg
, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Kit - Oral, Tablet - Oral, Tablet
Folate supplementation therapy
, 0.25 mg, 0.5 mg, 3.0 mg, 1.0 mg, 4.0 mg
, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Kit - Oral, Tablet - Oral, Tablet
Hot flashes
, 0.25 mg, 0.5 mg, 3.0 mg, 1.0 mg, 4.0 mg
, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Kit - Oral, Tablet - Oral, Tablet

Warnings

Drospirenone Contraindications
Condition
Risk Level
Notes
Chronic Kidney Disease
Do Not Combine
Venous Thrombosis
Do Not Combine
Neoplasms, Hormone-Dependent
Do Not Combine
Migraine with Aura
Do Not Combine
Porphyrias
Do Not Combine
Breast
Do Not Combine
suspected pregnancy
Do Not Combine
Breast Milk Production
Do Not Combine
Metrorrhagia
Do Not Combine
Hypersensitivity
Do Not Combine
Liver Failure, Acute
Do Not Combine
Acute Kidney Injury
Do Not Combine
Deep Vein Thrombosis (DVT)
Do Not Combine
Vision Loss
Do Not Combine
Endometrial Hyperplasia
Do Not Combine
Tobacco Use
Do Not Combine
Liver Function Tests
Do Not Combine
Thrombophilia
Do Not Combine
Thromboembolism
Do Not Combine
high risk of arterial thrombotic disease
Do Not Combine
estrogen-dependent neoplasia
Do Not Combine
Liver Neoplasms
Do Not Combine
Adrenal Insufficiency
Do Not Combine
Thrombosis
Do Not Combine
Breast
Do Not Combine
estrogen-dependent neoplasia
Do Not Combine
There are 20 known major drug interactions with Drospirenone.
Common Drospirenone Drug Interactions
Drug Name
Risk Level
Description
Tranexamic acid
Major
Drospirenone may increase the thrombogenic activities of Tranexamic acid.
Acetohexamide
Minor
The therapeutic efficacy of Acetohexamide can be decreased when used in combination with Drospirenone.
Agmatine
Minor
The risk or severity of hyperkalemia can be increased when Drospirenone is combined with Agmatine.
Aliskiren
Minor
The risk or severity of hyperkalemia can be increased when Drospirenone is combined with Aliskiren.
Anisodamine
Minor
The risk or severity of hyperkalemia can be increased when Drospirenone is combined with Anisodamine.
Drospirenone Toxicity & Overdose RiskThe lowest toxic dose of drospirenone in rats is greater than 2000mg/kg. Signs of an overdose include nausea and abnormal bleeding. It may also cause changes in the levels of sodium and potassium in the blood, as well as a buildup of acid in the blood and high levels of potassium. These should be monitored closely if an overdose occurs.
image of a doctor in a lab doing drug, clinical research

Drospirenone Novel Uses: Which Conditions Have a Clinical Trial Featuring Drospirenone?

104 active clinical trials are assessing the potential of Drospirenone for Acne Vulgaris, Post-Menarche and N-Cadherins treatment.
Condition
Clinical Trials
Trial Phases
N-Cadherins
0 Actively Recruiting
moderate to severe symptoms
0 Actively Recruiting
Folate supplementation therapy
0 Actively Recruiting
Acne Vulgaris
0 Actively Recruiting
Atrophy of vulva
1 Actively Recruiting
Not Applicable
Hormonal Contraception
0 Actively Recruiting
Hot flashes
19 Actively Recruiting
Not Applicable, Phase 4, Phase 2, Early Phase 1, Phase 3
Post-Menarche
0 Actively Recruiting
Adherence to Oral Contraceptive Therapy
0 Actively Recruiting
Birth Control
22 Actively Recruiting
Not Applicable, Phase 3, Phase 4, Early Phase 1, Phase 2
Atrophic
4 Actively Recruiting
Phase 4, Not Applicable
Vasomotor System
0 Actively Recruiting

Patient Q&A Section about drospirenone

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Yaz the same as drospirenone?

"The drugs Yaz and Yasmin are birth control pills that contain the combination of two hormones, drospirenone and ethinyl estradiol. These drugs are used to prevent pregnancy by stopping the ovaries from releasing eggs."

Answered by AI

Does drospirenone cause weight gain?

"Drospirenone/ethinyl estradiol birth control may cause weight gain in some women due to water retention and changes to your appetite. This weight gain is usually the result of water retention and often reverses when you discontinue the medication."

Answered by AI

What does drospirenone do to the body?

"Progestin-only oral contraceptives are used to prevent pregnancy. Progestin is a female hormone that works by preventing the release of eggs from the ovaries (ovulation) and changing the cervical mucus and the lining of the uterus."

Answered by AI

What hormone is drospirenone?

"Drospirenone is a progestin that is used in birth control pills, which are a combination of synthetic female hormones progesterone and estrogen."

Answered by AI

Clinical Trials for Drospirenone

Image of Erevna Innovations Inc. in Montreal, Canada.

Sculptra + Restylane for Post-Menopausal Skin Concerns

40 - 65
Female
Montreal, Canada
The post-menopausal state is marked by a sharp decline in estrogen, leading to significant structural and functional changes in the skin, including collagen loss, dryness, thinning, and reduced elasticity. To address these concerns, aesthetic injectables products such as Sculptra® Aesthetic (poly-L-lactic-acid \[PLLA- SCA\]) and Restylane Skinboosters®\[HASBV\] (small-particle hyaluronic acid - SP-HA) can be used. PLLA-SCA stimulates collagen production via cellular activation (biostimulator), gradually improving dermal structure. HASBV enhances hydration, elasticity, and skin texture when injected under the skin. Considering that hydration and laxity represent the primary aesthetic concerns in this patient population. Targeted treatment with SP-HA (HASBV) to improve hydration and PLLA-SCA to address laxity have been shown to produce significant clinical outcomes by directly addressing these key dermal deficiencies. This approach forms the basis of the current study.
Phase 4
Recruiting
Erevna Innovations Inc.Andreas Nikolis, MD, PhD
Have you considered Drospirenone clinical trials? We made a collection of clinical trials featuring Drospirenone, we think they might fit your search criteria.Go to Trials
Image of University of California, San Diego in La Jolla, United States.

Lidocaine for Pain Control in Birth Control

18 - 50
Female
La Jolla, CA
The goal of this research study is to learn more about how different uses of a numbing medication might affect pain levels while getting an IUD placed. The investigators are also studying participants opinions of their clinicians' empathy. The investigators are inviting patients who arrive at their clinic visit seeking an IUD. Usually, at University of California, San Diego (UCSD), for patients who have never delivered a baby, clinicians use a buffered paracervical block for before IUD placement. The purpose of this research study is to investigate whether a "buffered" (2 cc of sodium bicarbonate, 18 cc of 1% lidocaine) paracervical block (numbing medication given on both sides of the cervix) is effective in reducing pain during IUD placement in individuals with prior C-sections, the difference between buffered and unbuffered for nulliparous patients, and whether a medicated gel reduces pain with the paracervical block.
Recruiting
Paid Trial
University of California, San DiegoSheila K Mody, MD, MPH
Have you considered Drospirenone clinical trials? We made a collection of clinical trials featuring Drospirenone, we think they might fit your search criteria.Go to Trials
Image of Calabasas Pharmacy in Calabasas, United States.

Electronic Health Record Platform for Birth Control

18 - 51
Female
Calabasas, CA
Hormonal contraceptives are medications that require a prescription, traditionally from a physician or advanced practice provider. Over the past decade, pharmacists have gained the authority to prescribe contraceptives in many states, allowing patients to access these medications directly in pharmacies without first seeing another healthcare provider. The Pharmacist Resource to Implement Services as Modules (PRISM) is an Electronic Health Record platform designed to streamline workflows and provide clinical decision support, making it easier and safer to deliver clinical services in community pharmacies. This pilot study will evaluate patient-reported outcomes for women receiving contraceptive services from pharmacists using the PRISM platform at five community pharmacies across the United States over a 12-week period. The study will assess the quality of care, contraception continuation and failure rates, side effect rates, preventative healthcare utilization, and overall patient experience with pharmacy contraceptive services.
Waitlist Available
Has No Placebo
Calabasas Pharmacy (+4 Sites)OvaryIt, LLC
Image of Noll Laboratory in University Park, United States.

Estradiol and Elagolix for Menopause

42 - 64
Female
University Park, PA
The frequency and severity of heat waves has increased in the last decades. Older adults (over 65 years) have impaired responses to heat stress making them at increased risk for adverse events. Previous heat waves report that women over 65 experience worse health outcomes than any other age group and age matched men. Aging and reproductive hormones, specifically estrogen, independently alter responses to heat stress. However, the combined effects of low estrogen following menopause and aging on the response to heat stress are unknown. In this study, the investigators will identify the role of estrogen in pre and post menopausal women on thermoregulatory responses to heat stress.
Phase 4
Recruiting
Noll LaboratoryW. Larry Kenney, Ph.D.
Have you considered Drospirenone clinical trials? We made a collection of clinical trials featuring Drospirenone, we think they might fit your search criteria.Go to Trials
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