Your session is about to expire
What is Drospirenone
DrospirenoneThe Generic name of this drug
Treatment SummaryDrospirenone is a synthetic hormone found in oral contraceptives such as Yaz. It is used to prevent pregnancy and also to treat acne and premenstrual dysphoric disorder (PMDD) when used in combination with estrogen. There has been some concern that drospirenone may increase the risk of venous thromboembolism, however the FDA concluded that this risk is unclear and may be lower than the risk during pregnancy or after birth.
Yasminis the brand name
Drospirenone Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Yasmin
Drospirenone
2001
64
Effectiveness
How Drospirenone Affects PatientsDrospirenone works by stopping the ovaries from releasing eggs, preventing pregnancy. It can also improve acne and hirsutism by blocking the effects of certain hormones. Taking drospirenone combined with ethinyl estradiol has been found to have beneficial effects on cholesterol levels. As it is similar to the hormone progesterone, drospirenone is believed to cause fewer side effects related to progesterone, such as breast tenderness and mood changes. However, drospirenone may increase the risk of blood clots and cardiovascular issues, especially in smokers and women aged 35 and older. Additionally, this drug may
How Drospirenone works in the bodyDrospirenone and ethinyl estradiol work together to prevent pregnancy. They do this by stopping the release of hormones that trigger ovulation and by altering the consistency of the cervical mucus to block sperm movement. Drospirenone also has anti-mineralocorticoid activity, which helps reduce the effects of naturally occurring androgens. This helps treat acne and hirsutism, as well as reducing the levels of edema in sebaceous follicles.
When to interrupt dosage
The prescribed measure of Drospirenone is contingent upon the diagnosed state, including moderate to severe signs, Menopause and Post-Menarche. The dosage can be found in the table below, varying with the mode of administration (e.g. Tablet, film coated - Oral or Oral).Condition
Dosage
Administration
moderate to severe symptoms
, 0.25 mg, 0.5 mg, 3.0 mg, 1.0 mg, 4.0 mg
, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Kit - Oral, Tablet - Oral, Tablet
Atrophic
, 0.25 mg, 0.5 mg, 3.0 mg, 1.0 mg, 4.0 mg
, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Kit - Oral, Tablet - Oral, Tablet
N-Cadherins
, 0.25 mg, 0.5 mg, 3.0 mg, 1.0 mg, 4.0 mg
, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Kit - Oral, Tablet - Oral, Tablet
Atrophy of vulva
, 0.25 mg, 0.5 mg, 3.0 mg, 1.0 mg, 4.0 mg
, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Kit - Oral, Tablet - Oral, Tablet
Hormonal Contraception
, 0.25 mg, 0.5 mg, 3.0 mg, 1.0 mg, 4.0 mg
, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Kit - Oral, Tablet - Oral, Tablet
Birth Control
, 0.25 mg, 0.5 mg, 3.0 mg, 1.0 mg, 4.0 mg
, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Kit - Oral, Tablet - Oral, Tablet
Acne Vulgaris
, 0.25 mg, 0.5 mg, 3.0 mg, 1.0 mg, 4.0 mg
, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Kit - Oral, Tablet - Oral, Tablet
Folate supplementation therapy
, 0.25 mg, 0.5 mg, 3.0 mg, 1.0 mg, 4.0 mg
, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Kit - Oral, Tablet - Oral, Tablet
Post-Menarche
, 0.25 mg, 0.5 mg, 3.0 mg, 1.0 mg, 4.0 mg
, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Kit - Oral, Tablet - Oral, Tablet
Hot flashes
, 0.25 mg, 0.5 mg, 3.0 mg, 1.0 mg, 4.0 mg
, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Kit - Oral, Tablet - Oral, Tablet
Vasomotor System
, 0.25 mg, 0.5 mg, 3.0 mg, 1.0 mg, 4.0 mg
, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Kit - Oral, Tablet - Oral, Tablet
Adherence to Oral Contraceptive Therapy
, 0.25 mg, 0.5 mg, 3.0 mg, 1.0 mg, 4.0 mg
, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Kit - Oral, Tablet - Oral, Tablet
Warnings
Drospirenone ContraindicationsCondition
Risk Level
Notes
Chronic Kidney Disease
Do Not Combine
high risk of venous thrombotic disease
Do Not Combine
Neoplasms, Hormone-Dependent
Do Not Combine
Migraine, Classic
Do Not Combine
Porphyria
Do Not Combine
Breast
Do Not Combine
suspected pregnancy
Do Not Combine
Breast Milk Production
Do Not Combine
Metrorrhagia
Do Not Combine
Hypersensitivity
Do Not Combine
acute liver disease
Do Not Combine
Renal Insufficiency, Acute
Do Not Combine
Deep Vein Thrombosis (DVT)
Do Not Combine
Vision Loss
Do Not Combine
untreated endometrial hyperplasia
Do Not Combine
Tobacco Use
Do Not Combine
Liver Function Tests
Do Not Combine
Thrombophilia
Do Not Combine
Thromboembolism
Do Not Combine
high risk of arterial thrombotic disease
Do Not Combine
estrogen-dependent neoplasia
Do Not Combine
Neoplasms, Hepatic
Do Not Combine
Adrenal Insufficiency
Do Not Combine
recent thromboembolic event
Do Not Combine
Breast
Do Not Combine
estrogen-dependent neoplasia
Do Not Combine
Common Drospirenone Drug Interactions
Drug Name
Risk Level
Description
Tranexamic acid
Major
Drospirenone may increase the thrombogenic activities of Tranexamic acid.
Acetohexamide
Minor
The therapeutic efficacy of Acetohexamide can be decreased when used in combination with Drospirenone.
Agmatine
Minor
The risk or severity of hyperkalemia can be increased when Drospirenone is combined with Agmatine.
Aliskiren
Minor
The risk or severity of hyperkalemia can be increased when Drospirenone is combined with Aliskiren.
Anisodamine
Minor
The risk or severity of hyperkalemia can be increased when Drospirenone is combined with Anisodamine.
Drospirenone Toxicity & Overdose RiskThe lowest toxic dose of drospirenone in rats is greater than 2000mg/kg. Signs of an overdose include nausea and abnormal bleeding. It may also cause changes in the levels of sodium and potassium in the blood, as well as a buildup of acid in the blood and high levels of potassium. These should be monitored closely if an overdose occurs.
Drospirenone Novel Uses: Which Conditions Have a Clinical Trial Featuring Drospirenone?
104 active clinical trials are assessing the potential of Drospirenone for Acne Vulgaris, Post-Menarche and N-Cadherins treatment.Condition
Clinical Trials
Trial Phases
Atrophic
5 Actively Recruiting
Phase 2, Phase 4, Not Applicable
Birth Control
31 Actively Recruiting
Not Applicable, Phase 3, Phase 4, Early Phase 1
Hot flashes
22 Actively Recruiting
Phase 2, Not Applicable, Phase 1, Phase 4, Early Phase 1
Folate supplementation therapy
0 Actively Recruiting
moderate to severe symptoms
0 Actively Recruiting
N-Cadherins
1 Actively Recruiting
Phase 1
Hormonal Contraception
0 Actively Recruiting
Atrophy of vulva
1 Actively Recruiting
Not Applicable
Post-Menarche
0 Actively Recruiting
Acne Vulgaris
0 Actively Recruiting
Adherence to Oral Contraceptive Therapy
0 Actively Recruiting
Vasomotor System
0 Actively Recruiting
Patient Q&A Section about drospirenone
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is Yaz the same as drospirenone?
"The drugs Yaz and Yasmin are birth control pills that contain the combination of two hormones, drospirenone and ethinyl estradiol. These drugs are used to prevent pregnancy by stopping the ovaries from releasing eggs."
Answered by AI
Does drospirenone cause weight gain?
"Drospirenone/ethinyl estradiol birth control may cause weight gain in some women due to water retention and changes to your appetite. This weight gain is usually the result of water retention and often reverses when you discontinue the medication."
Answered by AI
What does drospirenone do to the body?
"Progestin-only oral contraceptives are used to prevent pregnancy. Progestin is a female hormone that works by preventing the release of eggs from the ovaries (ovulation) and changing the cervical mucus and the lining of the uterus."
Answered by AI
What hormone is drospirenone?
"Drospirenone is a progestin that is used in birth control pills, which are a combination of synthetic female hormones progesterone and estrogen."
Answered by AI