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What is Doxylamine Succinate
DoxylamineThe Generic name of this drug
Treatment SummaryPyridoxine is a form of Vitamin B6, a water-soluble vitamin that is found naturally in many foods. It is an essential nutrient that helps the body function properly. Animals must get pyridoxine through their diet since plants and microorganisms can make their own. Once in the body, pyridoxine is converted to pyridoxal 5-phosphate, which helps create amino acids, neurotransmitters, sphingolipids, and aminolevulinic acid. It is used to treat Vitamin B6 deficiency, prevent isoniazid-induced peripheral neuropathy
Unisom SleepTabsis the brand name
Doxylamine Succinate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Unisom SleepTabs
Doxylamine
1978
82
Approved as Treatment by the FDA
Doxylamine, also known as Unisom SleepTabs, is approved by the FDA for 4 uses like Gastrointestinal distress and Catarrh .Gastrointestinal distress
Used to treat Nausea in combination with Pyridoxine
Catarrh
Used in combination with Doxylamine for Common Cold
Nausea and Vomiting
Used to treat Vomiting in combination with Pyridoxine
Symptoms Flu
Used in combination with Doxylamine for Symptoms Flu
Effectiveness
How Doxylamine Succinate Affects PatientsVitamin B6 (pyridoxine) is a water-soluble vitamin used to prevent and treat deficiencies and peripheral neuropathy in those taking isoniazid. In a small group of people, it has been shown to lower blood pressure, reduce platelet aggregation, lower total cholesterol, and increase good cholesterol levels. It has also been found to protect vascular endothelial cells from injury by activated platelets. Studies have also shown that vitamin B6 deficiency can have a negative impact on the immune system, leading to reduced delayed-type hypersensitivity (DTH) responses and decreased interleukin-2 production.
How Doxylamine Succinate works in the bodyVitamin B6 is a group of three related compounds that help the body in many ways. The most common type is pyridoxine. It helps with metabolism, the making of certain molecules, and the production of neurotransmitters like serotonin, dopamine, norepinephrine, and GABA.
When to interrupt dosage
The extent of Doxylamine Succinate is contingent upon the identified disorder, including Arteriosclerosis, Metabolic Acidosis and Toxinfectious state. The magnitude of dosage fluctuates according to the administration method delineated in the table below.Condition
Dosage
Administration
Mild Allergic Rhinitis
, 1.25 mg/mL, 6.25 mg, 25.0 mg, 0.625 mg/mL, 12.5 mg, 7.5 mg, 6.25 mg/mL, 3.125 mg/mL, 9.75 mg/mL, 5.0 mg, 10.0 mg, 0.0125 mg/mg, 12.5 mg/mL, 1.0 mg/mL, 20.0 mg, 0.75 mg/mL, 135.0 mg/mL, 10.5 mg, 9.78 mg/mL, 0.4167 mg/mL, 6.5 mg, 7.5 mg/mL, 1.2 mg/mL, 6.0 mg/mL
, Oral, Liquid, Liquid - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Tablet, effervescent, Tablet, effervescent - Oral, Powder, for solution, Powder, for solution - Oral, Kit, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Syrup - Oral, Syrup, Kit - Oral, Kit; Tablet, Kit; Tablet - Oral, Capsule; Kit, Capsule; Kit - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, chewable, Tablet, chewable - Oral, Powder - Oral, Powder
Insomnia
, 1.25 mg/mL, 6.25 mg, 25.0 mg, 0.625 mg/mL, 12.5 mg, 7.5 mg, 6.25 mg/mL, 3.125 mg/mL, 9.75 mg/mL, 5.0 mg, 10.0 mg, 0.0125 mg/mg, 12.5 mg/mL, 1.0 mg/mL, 20.0 mg, 0.75 mg/mL, 135.0 mg/mL, 10.5 mg, 9.78 mg/mL, 0.4167 mg/mL, 6.5 mg, 7.5 mg/mL, 1.2 mg/mL, 6.0 mg/mL
, Oral, Liquid, Liquid - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Tablet, effervescent, Tablet, effervescent - Oral, Powder, for solution, Powder, for solution - Oral, Kit, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Syrup - Oral, Syrup, Kit - Oral, Kit; Tablet, Kit; Tablet - Oral, Capsule; Kit, Capsule; Kit - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, chewable, Tablet, chewable - Oral, Powder - Oral, Powder
Catarrh
, 1.25 mg/mL, 6.25 mg, 25.0 mg, 0.625 mg/mL, 12.5 mg, 7.5 mg, 6.25 mg/mL, 3.125 mg/mL, 9.75 mg/mL, 5.0 mg, 10.0 mg, 0.0125 mg/mg, 12.5 mg/mL, 1.0 mg/mL, 20.0 mg, 0.75 mg/mL, 135.0 mg/mL, 10.5 mg, 9.78 mg/mL, 0.4167 mg/mL, 6.5 mg, 7.5 mg/mL, 1.2 mg/mL, 6.0 mg/mL
, Oral, Liquid, Liquid - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Tablet, effervescent, Tablet, effervescent - Oral, Powder, for solution, Powder, for solution - Oral, Kit, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Syrup - Oral, Syrup, Kit - Oral, Kit; Tablet, Kit; Tablet - Oral, Capsule; Kit, Capsule; Kit - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, chewable, Tablet, chewable - Oral, Powder - Oral, Powder
Nausea and Vomiting
, 1.25 mg/mL, 6.25 mg, 25.0 mg, 0.625 mg/mL, 12.5 mg, 7.5 mg, 6.25 mg/mL, 3.125 mg/mL, 9.75 mg/mL, 5.0 mg, 10.0 mg, 0.0125 mg/mg, 12.5 mg/mL, 1.0 mg/mL, 20.0 mg, 0.75 mg/mL, 135.0 mg/mL, 10.5 mg, 9.78 mg/mL, 0.4167 mg/mL, 6.5 mg, 7.5 mg/mL, 1.2 mg/mL, 6.0 mg/mL
, Oral, Liquid, Liquid - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Tablet, effervescent, Tablet, effervescent - Oral, Powder, for solution, Powder, for solution - Oral, Kit, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Syrup - Oral, Syrup, Kit - Oral, Kit; Tablet, Kit; Tablet - Oral, Capsule; Kit, Capsule; Kit - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, chewable, Tablet, chewable - Oral, Powder - Oral, Powder
Symptoms Flu
, 1.25 mg/mL, 6.25 mg, 25.0 mg, 0.625 mg/mL, 12.5 mg, 7.5 mg, 6.25 mg/mL, 3.125 mg/mL, 9.75 mg/mL, 5.0 mg, 10.0 mg, 0.0125 mg/mg, 12.5 mg/mL, 1.0 mg/mL, 20.0 mg, 0.75 mg/mL, 135.0 mg/mL, 10.5 mg, 9.78 mg/mL, 0.4167 mg/mL, 6.5 mg, 7.5 mg/mL, 1.2 mg/mL, 6.0 mg/mL
, Oral, Liquid, Liquid - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Tablet, effervescent, Tablet, effervescent - Oral, Powder, for solution, Powder, for solution - Oral, Kit, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Syrup - Oral, Syrup, Kit - Oral, Kit; Tablet, Kit; Tablet - Oral, Capsule; Kit, Capsule; Kit - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, chewable, Tablet, chewable - Oral, Powder - Oral, Powder
Gastrointestinal distress
, 1.25 mg/mL, 6.25 mg, 25.0 mg, 0.625 mg/mL, 12.5 mg, 7.5 mg, 6.25 mg/mL, 3.125 mg/mL, 9.75 mg/mL, 5.0 mg, 10.0 mg, 0.0125 mg/mg, 12.5 mg/mL, 1.0 mg/mL, 20.0 mg, 0.75 mg/mL, 135.0 mg/mL, 10.5 mg, 9.78 mg/mL, 0.4167 mg/mL, 6.5 mg, 7.5 mg/mL, 1.2 mg/mL, 6.0 mg/mL
, Oral, Liquid, Liquid - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Tablet, effervescent, Tablet, effervescent - Oral, Powder, for solution, Powder, for solution - Oral, Kit, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Syrup - Oral, Syrup, Kit - Oral, Kit; Tablet, Kit; Tablet - Oral, Capsule; Kit, Capsule; Kit - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, chewable, Tablet, chewable - Oral, Powder - Oral, Powder
Warnings
Doxylamine Succinate has one contraindication, so it should not be implemented in cases of the situations set out in the following table.There are 20 known major drug interactions with Doxylamine Succinate.Common Doxylamine Succinate Drug Interactions
Drug Name
Risk Level
Description
Aclidinium
Major
The risk or severity of adverse effects can be increased when Doxylamine is combined with Aclidinium.
Azelastine
Major
Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Cimetropium
Major
The risk or severity of adverse effects can be increased when Doxylamine is combined with Cimetropium.
Eluxadoline
Major
The risk or severity of constipation can be increased when Doxylamine is combined with Eluxadoline.
Glycopyrronium
Major
The risk or severity of adverse effects can be increased when Doxylamine is combined with Glycopyrronium.
Doxylamine Succinate Toxicity & Overdose RiskThe toxic dose of this drug for a rat is 4 gm/kg, and symptoms of overdose may include seizures, difficulty breathing, excessive movement, diarrhea, lack of coordination, and weak muscles.
Doxylamine Succinate Novel Uses: Which Conditions Have a Clinical Trial Featuring Doxylamine Succinate?
Currently, 170 active studies are assessing the potential of Doxylamine Succinate to alleviate Nausea, Vitamin B6 Deficiency and Muscle Pain.Condition
Clinical Trials
Trial Phases
Insomnia
93 Actively Recruiting
Phase 4, Not Applicable, Phase 2, Phase 3, Phase 1, Early Phase 1
Symptoms Flu
0 Actively Recruiting
Mild Allergic Rhinitis
0 Actively Recruiting
Gastrointestinal distress
20 Actively Recruiting
Not Applicable, Phase 2, Phase 4, Phase 1, Phase 3, Early Phase 1
Nausea and Vomiting
23 Actively Recruiting
Not Applicable, Phase 3, Phase 2, Phase 4
Catarrh
2 Actively Recruiting
Phase 2, Not Applicable
Doxylamine Succinate Reviews: What are patients saying about Doxylamine Succinate?
5Patient Review
7/20/2019 I had really bad anxiety after taking this. My heart rate was through the roof and I felt itchy and on fire. I'm pregnant and was recommended this by my doctor, but I'll never take it again after what happened.
5Patient Review
9/5/2019 I have difficulty falling asleep and often wake up after just a few hours, so I decided to give this sleep-aid a try. One half of a pill was enough to help me sleep through the night, which is great. However, I am now worried about becoming reliant on it.
5Patient Review
1/13/2021 Though it makes me sleepy, I often wake up feeling depressed. This morning depression really affects my daily thoughts and activities.
5Patient Review
1/12/2022 I initially loved this treatment, but after doing some research, I'm scared that prolonged use could lead to dementia or Alzheimer's.
4.3Patient Review
1/26/2022 I've taken one pill a night with a tiny amount of melatonin for years and always have the best sleep. However now I wake with terrible anxiety, lethargy and depression. It doesn’t go for a couple of hours then I am fine. It's really affecting my life so I think I may try melatonin only.
4Patient Review
8/8/2021 I started with a whole pill (25mg) but found that it made me too drowsy the next day, so now I stick to half a pill. It's just effective enough for me - I sleep through the night and don't feel groggy in the morning.
4Patient Review
6/13/2020 I got a great high from this product.
4Patient Review
1/9/2022 This product has helped me a lot. I take it every night and have no trouble falling asleep or staying asleep.
3.7Patient Review
11/29/2020 I had a severe allergic reaction to this medication which caused dizziness. I only realized this after consulting the box, which I had thrown away. Make sure you read the side effects before taking this drug!
3Patient Review
11/16/2020 I have no recollection of taking this sleep aid, or of what happened in the intervening time. I woke up on the bathroom floor with no idea how I got there. This product is not ideal for people who want to improve their sleep and memory.
2.7Patient Review
8/2/2022 I took a smaller dosage because other sleep medications have made me incredibly drowsy in the past. With this one, I felt lightheaded and woke up every hour. The dreams I had were also very strange. This medication did not help me fall asleep like it said it would.
2.3Patient Review
3/2/2022 I was disappointed with this product. I follow the recommended dosage and still felt wide awake.
2Patient Review
4/19/2022 My doctor recommended this to me when I stopped taking Mirtazapine because of weight gain. They told me to take half a tablet to avoid drowsiness the next day, but unfortunately I only got around four hours of broken sleep and woke up feeling like a zombie. It kept me awake all night and I'm exhausted today. Won't be using it again.
1.7Patient Review
5/28/2022 I've had terrible insomnia for years, and the pharmacist recommended Restavit. I took 1/4 tablet as directed, but unfortunately felt no effects whatsoever.
1Patient Review
4/6/2021 Insomnia has been a real issue for me, and I had high hopes that this drug would be the answer. Unfortunately, even taking three pills didn't help me get to sleep at all.
Patient Q&A Section about doxylamine succinate
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Does doxylamine succinate make you sleepy?
"The reason why antihistamines make you sleepy is because they cross the blood-brain barrier which mimics a natural function."
Answered by AI
Is doxylamine succinate a good sleep aid?
"There are other options that are better than doxylamine if you are considering taking sleeping pills. Doxylamine does not promote sleep in the same way as prescription sleep medications, such as benzodiazepine and non-benzodiazepine medications."
Answered by AI
What are the side effects of taking doxylamine succinate?
"Dry mouth, nose, and throat, drowsiness, nausea, increased chest congestion, headache, excitement, and nervousness are all common side effects of antihistamines."
Answered by AI