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Dorzolamide Hydrochloride
prophylaxis of elevated intraocular pressure, neodynium yttrium aluminum garnet laser posterior capsulotomy, Increased Intra Ocular Pressure (IOP) + 3 more
Treatment
4 FDA approvals
20 Active Studies for Dorzolamide Hydrochloride
What is Dorzolamide Hydrochloride
DorzolamideThe Generic name of this drug
Treatment SummaryDorzolamide is a medication used to treat high pressure in the eyes caused by open-angle glaucoma and ocular hypertension. It works by blocking an enzyme in the eye that helps control fluid pressure. It has minimal side effects compared to other medications and was first introduced in 1995 under the brand name Trusopt or Cosopt PF.
Trusoptis the brand name
Dorzolamide Hydrochloride Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Trusopt
Dorzolamide
1994
62
Approved as Treatment by the FDA
Dorzolamide, also known as Trusopt, is approved by the FDA for 4 uses such as insufficient response to beta-blockers and Open Angle Glaucoma .insufficient response to beta-blockers
Used to treat insufficient response to beta-blockers in combination with Timolol
Open Angle Glaucoma
Used to treat Open Angle Glaucoma (OAG) in combination with Timolol
Increased Intra Ocular Pressure (IOP)
Used to treat Increased Intra Ocular Pressure (IOP) in combination with Timolol
Ocular Hypertension
Used to treat Ocular Hypertension in combination with Timolol
Effectiveness
How Dorzolamide Hydrochloride Affects PatientsDorzolamide is a medication that helps to lower high eye pressure caused by open-angle glaucoma or ocular hypertension. It can be used with other medications, like beta-blockers, to further reduce eye pressure. The effects of this drug usually peak after two hours after it is given.
How Dorzolamide Hydrochloride works in the bodyDorzolamide is used to treat ocular hypertension and open-angle glaucoma, which cause increased pressure in the eye. This increased pressure can lead to damage of the optic nerve, resulting in vision loss. Dorzolamide works by decreasing aqueous humour (fluid) production in the eye and reducing pressure. It does this by targeting an enzyme called carbonic anhydrase (CA), which helps regulate fluid production. Dorzolamide specifically targets CA-II, an enzyme found in red blood cells, and blocks its effects. This reduces the formation of bicarbonate ions and decreases sodium and fluid
When to interrupt dosage
The indicated dose of Dorzolamide Hydrochloride is reliant upon the determined situation, for example neodynium yttrium aluminum garnet laser posterior capsulotomy, Ocular Hypertension and Increased Intra Ocular Pressure (IOP). The quantity of dosage is contingent upon the administration approach (e.g. Solution - Ophthalmic or Solution / drops) stated in the table beneath.Condition
Dosage
Administration
Ocular Hypertension
20.0 mg/mL, , 22.3 mg/mL, 2.0 %
, Ophthalmic, Solution, Solution - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic
Open Angle Glaucoma
20.0 mg/mL, , 22.3 mg/mL, 2.0 %
, Ophthalmic, Solution, Solution - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic
Increased Intra Ocular Pressure (IOP)
20.0 mg/mL, , 22.3 mg/mL, 2.0 %
, Ophthalmic, Solution, Solution - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic
neodynium yttrium aluminum garnet laser posterior capsulotomy
20.0 mg/mL, , 22.3 mg/mL, 2.0 %
, Ophthalmic, Solution, Solution - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic
prophylaxis of elevated intraocular pressure
20.0 mg/mL, , 22.3 mg/mL, 2.0 %
, Ophthalmic, Solution, Solution - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic
insufficient response to beta-blockers
20.0 mg/mL, , 22.3 mg/mL, 2.0 %
, Ophthalmic, Solution, Solution - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic
Warnings
Dorzolamide Hydrochloride ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Dorzolamide may interact with Pulse Frequency
Common Dorzolamide Hydrochloride Drug Interactions
Drug Name
Risk Level
Description
Acebutolol
Minor
Dorzolamide may increase the hypotensive activities of Acebutolol.
Acetylsalicylic acid
Minor
The risk or severity of metabolic acidosis can be increased when Dorzolamide is combined with Acetylsalicylic acid.
Aliskiren
Minor
Dorzolamide may increase the hypotensive activities of Aliskiren.
Aloxiprin
Minor
The risk or severity of metabolic acidosis can be increased when Dorzolamide is combined with Aloxiprin.
Ambrisentan
Minor
Dorzolamide may increase the hypotensive activities of Ambrisentan.
Dorzolamide Hydrochloride Toxicity & Overdose RiskThe toxic dose of dorzolamide in rats is 1927 mg/kg and 1320 mg/kg in mice. If someone takes too much, they may have an electrolyte imbalance, acidosis, or effects on their central nervous system. If this happens, electrolyte levels and blood pH should be monitored and appropriate supportive treatment should be given.
Dorzolamide Hydrochloride Novel Uses: Which Conditions Have a Clinical Trial Featuring Dorzolamide Hydrochloride?
34 active trials are currently evaluating the efficacy of Dorzolamide Hydrochloride in treating Ocular Hypertension, Increased Intra Ocular Pressure (IOP) and Open Angle Glaucoma.Condition
Clinical Trials
Trial Phases
Increased Intra Ocular Pressure (IOP)
0 Actively Recruiting
prophylaxis of elevated intraocular pressure
0 Actively Recruiting
insufficient response to beta-blockers
0 Actively Recruiting
Open Angle Glaucoma
12 Actively Recruiting
Not Applicable, Phase 3, Phase 2
Ocular Hypertension
22 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 3, Phase 4
neodynium yttrium aluminum garnet laser posterior capsulotomy
0 Actively Recruiting
Dorzolamide Hydrochloride Reviews: What are patients saying about Dorzolamide Hydrochloride?
5Patient Review
3/14/2018 My vision improved significantly and immediately.
4.7Patient Review
6/23/2010 I've used this for years and it has saved my vision.
4.3Patient Review
6/30/2011 Though this product has improved the pressure in my eye, I am now constantly tired which I believe is a side effect. As I am already blind in that eye, I am discussing with my doctor whether to stop taking it or decrease my dosage.
3.7Patient Review
9/27/2009 Along with two other treatments, I use this for my glaucoma. Though it was effective in reducing pressure in the eye, I found that it caused hoarseness and weakness in my vocals. Additionally, I often experienced achy pain in the treated eye.
3Patient Review
2/8/2014 I find this drug makes me incredibly tired, to the point where I have almost fallen asleep at the wheel. I also get more headaches and my sinuses are always bothering me since using it. The nasel secretions are very thick and sticky-stringy like paste. I get severe eye pain that is only relieved with a narcotic! & it barely reduces the interoccular pressure.
Patient Q&A Section about dorzolamide hydrochloride
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.When should dorzolamide be taken?
"For adults, use one drop in the affected eye two times a day. For children 2 years of age or older, the dose must be determined by a doctor."
Answered by AI
What are the side effects for dorzolamide?
"You may experience some temporary side effects such as blurred vision, burning or stinging sensations in the eyes, watery eyes, dry eyes, increased sensitivity to light, a bitter taste, or a headache."
Answered by AI
How long can I use dorzolamide eye drops?
"You should only use eye drops that have been opened for four weeks or less to help prevent the risk of eye infections. Single-dose units should be used immediately after they are opened."
Answered by AI
What is Dorzolamide Hydrochloride used for?
"Dorzolamide ophthalmic drops are used to treat increased pressure in the eye caused by open-angle glaucoma or hypertension of the eye. Both conditions are caused by high pressure in your eye and can lead to pain and eventual harm to your vision."
Answered by AI