This is a single-center, parallel-arm, blind, sham-controlled, feasibility randomized controlled trial (RCT) to be conducted in healthy cesarean-born infants. Eligible infants will be randomized 1:1 to have their nose swabbed with either maternal vaginal secretions or a sterile swab (intervention vs. control group, respectively) following birth by cesarean section (C-section). The main hypothesis is that conducting an RCT assessing the utility of vaginal seeding in modifying the early-life upper respiratory tract (URT) microbiome of infants born by C-section is feasible and that the intervention is safe.
2 Primary · 3 Secondary · Reporting Duration: One year following randomization
40 Total Participants · 2 Treatment Groups
Primary Treatment: Intervention Group · Has Placebo Group · N/A
Age 18 - 40 · Female Participants · 9 Total Inclusion CriteriaMark “Yes” if the following statements are true for you: