Deoxycholic Acid

obese experiencing rapid weight loss, Cholelithiasis, Primary Biliary Cholangitis
Treatment
2 FDA approvals
13 Active Studies for Deoxycholic Acid

What is Deoxycholic Acid

Ursodeoxycholic acidThe Generic name of this drug
Treatment SummaryTauroursodeoxycholic acid is a type of bile acid found naturally in bears. It has been used for centuries as a natural remedy in some Asian countries and is approved in Italy and Turkey to treat cholesterol gallstones. It is being studied as a potential treatment for several diseases, including Primary Biliary Cirrhosis (PBC), insulin resistance, amyloidosis, Cystic Fibrosis, Cholestasis, and Amyotrophic Lateral Sclerosis. A phase III clinical trial is currently underway to compare tauroursodeoxycholic acid and ursofalk in adult PBC patients, but the
Actigallis the brand name
image of different drug pills on a surface
Deoxycholic Acid Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Actigall
Ursodeoxycholic acid
1987
100

Approved as Treatment by the FDA

Ursodeoxycholic acid, otherwise known as Actigall, is approved by the FDA for 2 uses which include Cholelithiasis and obese experiencing rapid weight loss .
Cholelithiasis
obese experiencing rapid weight loss

Effectiveness

How Deoxycholic Acid Affects PatientsTauroursodeoxycholic acid is used to lower cholesterol and bile acid levels in order to prevent the formation of gallstones. It also has anti-inflammatory and anti-apoptotic properties, which makes it a potential treatment for neurodegenerative diseases like Alzheimer's and Parkinson's. Furthermore, it can promote angiogenesis and suppress adipogenesis, as well as enhance the production of bone tissue.
How Deoxycholic Acid works in the bodyTauroursodeoxycholic acid is used to reduce and prevent gallstone formation, which is usually caused by high cholesterol. It does this in a few ways. First, it reduces cholesterol absorption from the gut and lowers cholesterol levels in the liver. This increases the solubility of cholesterol in bile and reduces bile cholesterol saturation in the gallbladder. Second, it helps maintain a healthy gut microbiome that promotes bile acid synthesis and reduces liver inflammation. Third, it prevents cell death by disrupting the mitochondrial pathway and inhibiting oxygen-radical production, endoplasmic reticulum stress, and other apoptotic processes.

When to interrupt dosage

The proposed dose of Deoxycholic Acid is contingent upon the diagnosed condition. The amount of dosage is contingent upon the mode of delivery (e.g. Powder, for suspension - Oral or Powder, for suspension) featured in the table below.
Condition
Dosage
Administration
obese experiencing rapid weight loss
, 300.0 mg, 250.0 mg, 500.0 mg, 0.0002 mg/mg, 10.0 mg, 200.0 mg, 400.0 mg
, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Dental, Paste, Paste - Dental
Cholelithiasis
, 300.0 mg, 250.0 mg, 500.0 mg, 0.0002 mg/mg, 10.0 mg, 200.0 mg, 400.0 mg
, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Dental, Paste, Paste - Dental
Primary Biliary Cholangitis
, 300.0 mg, 250.0 mg, 500.0 mg, 0.0002 mg/mg, 10.0 mg, 200.0 mg, 400.0 mg
, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Dental, Paste, Paste - Dental

Warnings

Deoxycholic Acid has twelve contraindications and should not be imbibed in the presence of any of the conditions below.Deoxycholic Acid Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Ursodeoxycholic Acid may interact with Pulse Frequency
Cholangitis
Do Not Combine
Pancreatitis
Do Not Combine
biliary gastrointestinal fistula
Do Not Combine
Calcinosis
Do Not Combine
Bile duct structure
Do Not Combine
radiopaque stones
Do Not Combine
radiolucent bile pigment stones
Do Not Combine
Cholecystitis
Do Not Combine
There are 20 known major drug interactions with Deoxycholic Acid.
Common Deoxycholic Acid Drug Interactions
Drug Name
Risk Level
Description
Capmatinib
Major
The serum concentration of Capmatinib can be decreased when it is combined with Ursodeoxycholic acid.
Rimegepant
Major
The metabolism of Rimegepant can be increased when combined with Ursodeoxycholic acid.
Astemizole
Moderate
Ursodeoxycholic acid may decrease the excretion rate of Astemizole which could result in a higher serum level.
Atazanavir
Moderate
Ursodeoxycholic acid may decrease the excretion rate of Atazanavir which could result in a higher serum level.
Atenolol
Moderate
Ursodeoxycholic acid may decrease the excretion rate of Atenolol which could result in a higher serum level.
Deoxycholic Acid Toxicity & Overdose RiskIt is not known how much tauroursodeoxycholic acid is toxic or what the effects of an overdose are.
image of a doctor in a lab doing drug, clinical research

Deoxycholic Acid Novel Uses: Which Conditions Have a Clinical Trial Featuring Deoxycholic Acid?

Two ongoing trials are assessing the potential of Deoxycholic Acid to ameliorate Cholelithiasis.
Condition
Clinical Trials
Trial Phases
Primary Biliary Cholangitis
13 Actively Recruiting
Phase 3, Phase 1, Phase 2, Not Applicable
Cholelithiasis
0 Actively Recruiting
obese experiencing rapid weight loss
0 Actively Recruiting

Patient Q&A Section about deoxycholic acid

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What does deoxycholic acid do to fat cells?

"Deoxycholic acid is a synthetic form of a substance that your body produces to aid in the absorption of fats. By destroying fat cells, deoxycholic acid helps to lessen the appearance of a double chin."

Answered by AI

What are the side effects of deoxycholic acid?

"If you have any of the following side effects, please contact your doctor immediately: difficulty swallowing, weak facial muscles, a crooked smile, open sores or drainage around the treated area, or pain/burning/irritation/skin changes at the injection site."

Answered by AI

What is deoxycholic acid used for?

"Deoxycholic acid is injected into the submental area in order to improve the appearance of moderate to severe fat accumulation ('double chin'). Deoxycholic acid is a medication that falls into the category of cytolytic drugs. These drugs work by breaking down cells in fatty tissue."

Answered by AI

Is deoxycholic acid injection safe?

"Injecting deoxycholic acid outside of the submental area can cause surrounding tissue damage. Injecting deoxycholic acid into the dermis may cause skin ulceration. If injected into or in close proximity to the facial nerve, it may cause an asymmetrical smile or facial muscle weakness."

Answered by AI

Clinical Trials for Deoxycholic Acid

Have you considered Deoxycholic Acid clinical trials? We made a collection of clinical trials featuring Deoxycholic Acid, we think they might fit your search criteria.
Have you considered Deoxycholic Acid clinical trials? We made a collection of clinical trials featuring Deoxycholic Acid, we think they might fit your search criteria.