Dantrolene Sodium

Malignant Hyperthermia, Spasticity, prophylaxis of Malignant hyperthermia + 4 more
Treatment
20 Active Studies for Dantrolene Sodium

What is Dantrolene Sodium

DantroleneThe Generic name of this drug
Treatment SummaryDantrolene is a drug that is chemically similar to other medications used to treat epilepsy, but it does not have the same antiepileptic effects.
Dantrolene Sodiumis the brand name
image of different drug pills on a surface
Dantrolene Sodium Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Dantrolene Sodium
Dantrolene
2005
36

Effectiveness

How Dantrolene Sodium Affects PatientsDantrolene is a drug that helps relax muscle contractions. It is the only known effective treatment for malignant hyperthermia, a condition caused by an abnormal reaction to certain drugs or anesthesia. In the body, it works by blocking the release of calcium from the muscles, which helps reduce muscle contractions. It is believed that this drug helps restore calcium levels in the body, which can help reduce the symptoms of malignant hyperthermia.
How Dantrolene Sodium works in the bodyDantrolene reduces the strength of muscle contractions by blocking a receptor in the muscles that helps control calcium levels. This reduces the amount of calcium available to help with muscle contraction, weakening the contraction overall.

When to interrupt dosage

The proposed dosage of Dantrolene Sodium is contingent upon the diagnosed condition, for instance Stroke, Spasticity and Spinal Cord Injury. The measure of dosage fluctuates in relation to the method of delivery (e.g. Capsule - Oral or Injection, solution - Intravenous) detailed in the table underneath.
Condition
Dosage
Administration
prophylaxis of Malignant hyperthermia
, 25.0 mg, 50.0 mg, 100.0 mg, 2.0 mg/mL, 250.0 mg/mL, 20.0 mg
, Oral, Capsule, Capsule - Oral, Intravenous, Injection, Injection - Intravenous, Injection, suspension, Injection, suspension - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, for solution - Intravenous, Injection, powder, for solution, Injection, solution, Injection, solution - Intravenous
Cerebral Palsy
, 25.0 mg, 50.0 mg, 100.0 mg, 2.0 mg/mL, 250.0 mg/mL, 20.0 mg
, Oral, Capsule, Capsule - Oral, Intravenous, Injection, Injection - Intravenous, Injection, suspension, Injection, suspension - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, for solution - Intravenous, Injection, powder, for solution, Injection, solution, Injection, solution - Intravenous
Spasticity
, 25.0 mg, 50.0 mg, 100.0 mg, 2.0 mg/mL, 250.0 mg/mL, 20.0 mg
, Oral, Capsule, Capsule - Oral, Intravenous, Injection, Injection - Intravenous, Injection, suspension, Injection, suspension - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, for solution - Intravenous, Injection, powder, for solution, Injection, solution, Injection, solution - Intravenous
Spinal Cord Injury
, 25.0 mg, 50.0 mg, 100.0 mg, 2.0 mg/mL, 250.0 mg/mL, 20.0 mg
, Oral, Capsule, Capsule - Oral, Intravenous, Injection, Injection - Intravenous, Injection, suspension, Injection, suspension - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, for solution - Intravenous, Injection, powder, for solution, Injection, solution, Injection, solution - Intravenous
Malignant Hyperthermia
, 25.0 mg, 50.0 mg, 100.0 mg, 2.0 mg/mL, 250.0 mg/mL, 20.0 mg
, Oral, Capsule, Capsule - Oral, Intravenous, Injection, Injection - Intravenous, Injection, suspension, Injection, suspension - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, for solution - Intravenous, Injection, powder, for solution, Injection, solution, Injection, solution - Intravenous
Stroke
, 25.0 mg, 50.0 mg, 100.0 mg, 2.0 mg/mL, 250.0 mg/mL, 20.0 mg
, Oral, Capsule, Capsule - Oral, Intravenous, Injection, Injection - Intravenous, Injection, suspension, Injection, suspension - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, for solution - Intravenous, Injection, powder, for solution, Injection, solution, Injection, solution - Intravenous
Multiple Sclerosis
, 25.0 mg, 50.0 mg, 100.0 mg, 2.0 mg/mL, 250.0 mg/mL, 20.0 mg
, Oral, Capsule, Capsule - Oral, Intravenous, Injection, Injection - Intravenous, Injection, suspension, Injection, suspension - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, for solution - Intravenous, Injection, powder, for solution, Injection, solution, Injection, solution - Intravenous

Warnings

Dantrolene Sodium Contraindications
Condition
Risk Level
Notes
Muscle Spasticity
Do Not Combine
Muscle Spasticity
Do Not Combine
Cirrhosis
Do Not Combine
Hepatitis
Do Not Combine
Locomotion
Do Not Combine
active hepatic disease
Do Not Combine
There are 20 known major drug interactions with Dantrolene Sodium.
Common Dantrolene Sodium Drug Interactions
Drug Name
Risk Level
Description
Agmatine
Major
The risk or severity of hyperkalemia can be increased when Dantrolene is combined with Agmatine.
Amiodarone
Major
The risk or severity of hyperkalemia can be increased when Dantrolene is combined with Amiodarone.
Amlodipine
Major
The risk or severity of hyperkalemia can be increased when Dantrolene is combined with Amlodipine.
Aranidipine
Major
The risk or severity of hyperkalemia can be increased when Dantrolene is combined with Aranidipine.
Azelastine
Major
Dantrolene may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Dantrolene Sodium Toxicity & Overdose RiskThe most toxic dose of this medication for rats has been found to be 7400mg/kg. Signs of an overdose may include muscle weakness, changes in alertness or consciousness (such as fatigue or a coma), vomiting, diarrhea, and the presence of crystals in the urine.
image of a doctor in a lab doing drug, clinical research

Dantrolene Sodium Novel Uses: Which Conditions Have a Clinical Trial Featuring Dantrolene Sodium?

258 active clinical trials are being conducted to examine the potential of Dantrolene Sodium to manage Multiple Sclerosis, Spinal Cord Injury and Spasticity.
Condition
Clinical Trials
Trial Phases
Cerebral Palsy
1 Actively Recruiting
Not Applicable
Multiple Sclerosis
197 Actively Recruiting
Phase 3, Not Applicable, Phase 2, Phase 1, Phase 4, Early Phase 1
Spasticity
5 Actively Recruiting
Not Applicable, Phase 2, Phase 3, Phase 1
Spinal Cord Injury
44 Actively Recruiting
Not Applicable, Phase 1, Phase 4, Phase 2, Early Phase 1, Phase 3
prophylaxis of Malignant hyperthermia
0 Actively Recruiting
Malignant Hyperthermia
0 Actively Recruiting
Stroke
11 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3

Dantrolene Sodium Reviews: What are patients saying about Dantrolene Sodium?

5Patient Review
10/27/2010
Dantrolene Sodium for Muscle Spasms due to a Brain Disease
Though my neurologist said this medication is quite old, it works much better for me than a newer one I tried. I have MS and first started taking this in 2002; however, I began to experience more pain recently. Therefore, my doctor switched me to a different medication. After only one week on the new med, I changed back to Dantrolene because of the fatigue and pain it caused me. In comparison, Dantrolene allows me to function normally despite the minor pain it doesn't completely relieve.
5Patient Review
7/2/2012
Dantrolene Sodium for Muscle Spasm
Dantrolene has been an absolute lifesaver for me. I have MS, and while baclofen works sometimes, it's not always reliable. This drug has helped me get my life back on track; even though it made me drowsy at first, that effect went away after a little while and I felt like myself again. Just be sure to get regular liver tests done by your doctor.
4.3Patient Review
6/1/2009
Dantrolene Sodium for Muscle Spasms due to a Brain Disease
Dantrolene sodium has been quite effective in reducing the muscle spasms I experience as a result of my Multiple Sclerosis.
4Patient Review
12/16/2008
Dantrolene Sodium for Muscle Spasms due to a Brain Disease
This drug has helped me a lot in the three weeks that I've been using it. Before, I was having spasms after my severe stroke which made it difficult to do simple things like moving my limbs. This medication relaxes my muscles so I can slowly but surely regain movement and function. Although there's no guarantee, I'm hopeful that within a year of continued use I'll be back to about 95% of what I was before the stroke happened.
3Patient Review
11/5/2013
Dantrolene Sodium for Muscle Spasms caused by a Spinal Disease
I take one 20mg capsule of this medication to help with muscle spasms from my multiple sclerosis. It's been helpful in reducing the involuntary spasms, but now my left foot seems swollen and it hasn't gone away.
2.3Patient Review
8/26/2022
Dantrolene Sodium for Muscle Spasms caused by a Spinal Disease
Unfortunately, this medication did not help with my spasticity and made my IBD much worse.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about dantrolene sodium

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What kind of drug is dantrolene?

"Dantrolene is used to prevent, treat, or reduce the risk of malignant hyperthermia, which is a disorder that causes a fast rise in body temperature and muscle contractions. Dantrolene is a medication that belongs to a class of drugs called skeletal muscle relaxants."

Answered by AI

What is dantrolene sodium used for?

"Dantrolene is used to help relax certain muscles in your body that are causing spasms, cramping, or tightness. This can be due to medical problems such as multiple sclerosis (MS), cerebral palsy, stroke, or injury to the spine."

Answered by AI

What is dantrolene an antidote for?

"There are a few different antidotes for cyanide poisoning. One is to give the person activated charcoal, which will absorb the poison. Another is to give them an injection of a thiosulfate solution, which will help to detoxify the poison. You can also give them oxygen to help them breathe and to prevent further damage to the cells.

There are a few different antidotes that can be administered to someone who has been poisoned by cyanide. One is to give the person activated charcoal, which will absorb the poison. Another is to give them an injection of a thiosulfate solution, which will help to detoxify the poison. You can also give them oxygen to help them breathe and to prevent further damage to the cells."

Answered by AI

Which of the following is a side effect of dantrolene sodium?

"The following effects may occur as your body adjusts to this medication, but they should lessen after several days. These include: drowsiness, dizziness, weakness, tiredness, nausea and diarrhea. Headache, constipation, trouble speaking and drooling may also occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly."

Answered by AI

Clinical Trials for Dantrolene Sodium

Have you considered Dantrolene Sodium clinical trials? We made a collection of clinical trials featuring Dantrolene Sodium, we think they might fit your search criteria.
Have you considered Dantrolene Sodium clinical trials? We made a collection of clinical trials featuring Dantrolene Sodium, we think they might fit your search criteria.
Have you considered Dantrolene Sodium clinical trials? We made a collection of clinical trials featuring Dantrolene Sodium, we think they might fit your search criteria.