Fat Cell Injection for Knee Osteoarthritis
(SVF Trial)
Trial Summary
Will I have to stop taking my current medications?
You will need to stop taking any prescription or over-the-counter pain and anti-inflammatory medications for 7 days before any visit. If you are on anticoagulation therapy, it must be stopped before the injection.
What data supports the effectiveness of the treatment Adipose Derived (AD) Stromal Vascular Fraction (SVF) for knee osteoarthritis?
Is fat cell injection for knee osteoarthritis safe?
How is the treatment Adipose Derived Stromal Vascular Fraction (SVF) unique for knee osteoarthritis?
This treatment is unique because it involves injecting a patient's own fat cells, specifically the stromal vascular fraction (SVF), directly into the knee joint. This approach is thought to provide mechanical support, reduce inflammation, and promote tissue repair, which is different from traditional treatments that mainly focus on pain relief and inflammation control.23489
What is the purpose of this trial?
This is a prospective, non-randomized, interventional, dual site, before-after clinical trial to determine feasibility and safety of a single injection of autologous Adipose Derived (AD) Stromal Vascular Fraction (SVF) for the treatment of knee Post Traumatic Osteoarthritis (PTOA).
Research Team
Claude T Moorman, MD
Principal Investigator
Wake Forest University Health Sciences
Eligibility Criteria
This trial is for adults aged 18-45 who've had significant knee trauma or surgery between 1 and 20 years ago, leading to Post-Trauma Osteoarthritis (PTOA). They should have ongoing knee pain despite trying at least two treatments like medication or physical therapy. Participants need a BMI under 35, speak English, and be able to attend follow-up visits. Pregnant women, tobacco users, those with recent knee injections or certain medical conditions are excluded.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
A single injection of autologous Adipose Derived (AD) Stromal Vascular Fraction (SVF) for the treatment of knee Post Traumatic Osteoarthritis (PTOA)
Follow-up
Participants are monitored for safety and effectiveness after treatment, with assessments at multiple time points
Treatment Details
Interventions
- Adipose Derived (AD) Stromal Vascular Fraction (SVF)
Find a Clinic Near You
Who Is Running the Clinical Trial?
Wake Forest University Health Sciences
Lead Sponsor