Danazol

Endometriosis, Thrombocytopenia, Breast + 1 more
Treatment
6 FDA approvals
20 Active Studies for Danazol

What is Danazol

DanazolThe Generic name of this drug
Treatment SummaryDanazol is a man-made steroid that suppresses the hormones released from the pituitary gland. It has some androgenic properties and is used to treat endometriosis and certain types of breast conditions. Danazol works by inhibiting the release of gonadotropins, which are hormones responsible for regulating reproductive functions.
Danocrineis the brand name
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Danazol Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Danocrine
Danazol
1976
22

Approved as Treatment by the FDA

Danazol, also known as Danocrine, is approved by the FDA for 6 uses which include Fibrocystic Disease of Breast and Hereditary Angioedema (HAE) .
Fibrocystic Disease of Breast
Hereditary Angioedema (HAE)
Helps manage Hereditary Angioedema (HAE)
Endometriosis
Angioedemas, Hereditary
Helps manage Hereditary Angioedema (HAE)
Breast
Endometriosis

Effectiveness

How Danazol Affects PatientsDanazol is a synthetic steroid derived from testosterone. It was the first drug approved by the FDA to specifically treat endometriosis, but is now largely replaced by GnRH agonists. Danazol works by stopping the pituitary gland from producing gonadotropins, and has some androgenic properties.
How Danazol works in the bodyDanazol works to suppress the activity of hormones related to the pituitary-ovarian axis. It also limits the production of estrogens in the ovaries, and binds to hormone receptors. In the treatment of endometriosis, it causes normal and ectopic endometrial tissues to become inactive and atrophic. For fibrocystic breast disease, the effect is thought to be related to suppressed estrogenic stimulation. Lastly, it increases the level of a key protein in hereditary angioedema, C1 esterase inhibitor, which helps to control the C4 component of the complement system.

When to interrupt dosage

The suggested measure of Danazol is dependent on the determined condition, such as Thrombocytopenia, Endometriosis and Angioedemas, Hereditary. The amount of dosage changes, as per the procedure of delivery (e.g. Capsule or Oral) indicated in the following table.
Condition
Dosage
Administration
Endometriosis
, 100.0 mg, 200.0 mg, 50.0 mg
, Oral, Capsule, Capsule - Oral
Thrombocytopenia
, 100.0 mg, 200.0 mg, 50.0 mg
, Oral, Capsule, Capsule - Oral
Breast
, 100.0 mg, 200.0 mg, 50.0 mg
, Oral, Capsule, Capsule - Oral
Angioedemas, Hereditary
, 100.0 mg, 200.0 mg, 50.0 mg
, Oral, Capsule, Capsule - Oral

Warnings

Danazol Contraindications
Condition
Risk Level
Notes
androgen-dependent tumor
Do Not Combine
Thrombosis
Do Not Combine
potential for pregnancy
Do Not Combine
undiagnosed abnormal genital bleeding
Do Not Combine
Kidney
Do Not Combine
Thromboembolism
Do Not Combine
Porphyrias
Do Not Combine
There are 20 known major drug interactions with Danazol.
Common Danazol Drug Interactions
Drug Name
Risk Level
Description
(R)-warfarin
Major
The metabolism of (R)-warfarin can be decreased when combined with Danazol.
(S)-Warfarin
Major
The metabolism of (S)-Warfarin can be decreased when combined with Danazol.
1,2-Benzodiazepine
Major
The metabolism of 1,2-Benzodiazepine can be decreased when combined with Danazol.
3,5-diiodothyropropionic acid
Major
The metabolism of 3,5-diiodothyropropionic acid can be decreased when combined with Danazol.
5-androstenedione
Major
The metabolism of 5-androstenedione can be decreased when combined with Danazol.
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Danazol Novel Uses: Which Conditions Have a Clinical Trial Featuring Danazol?

43 active clinical trials are currently being conducted to analyze the potential of Danazol in managing Thrombocytopenia, Endometriosis and Breast Symptoms.
Condition
Clinical Trials
Trial Phases
Endometriosis
29 Actively Recruiting
Early Phase 1, Phase 2, Phase 3, Not Applicable, Phase 4
Breast
0 Actively Recruiting
Thrombocytopenia
0 Actively Recruiting
Angioedemas, Hereditary
13 Actively Recruiting
Phase 3, Phase 2, Phase 1, Phase 4

Danazol Reviews: What are patients saying about Danazol?

5Patient Review
9/11/2009
Danazol for Cystic Disease of the Breast
I felt drowsy, moody, and unbalanced after taking this medication. I also felt a bit heaty and had headaches. The worst part was that I gained weight easily, even while dieting.
5Patient Review
12/13/2009
Danazol for Prevention of Angioedema Attacks in Patient with Hereditary Angioedema
I've been on Danazol for 28 years and it's definitely been worth the side effects. I'm pain- and swelling-free, thanks to this medication.
5Patient Review
12/22/2009
Danazol for Prevention of Angioedema Attacks in Patient with Hereditary Angioedema
I've used this drug for 15 years to great effect; it's really helped me control my migraines.
4.7Patient Review
6/23/2009
Danazol for Prevention of Angioedema Attacks in Patient with Hereditary Angioedema
4.3Patient Review
10/22/2010
Danazol for Prevention of Angioedema Attacks in Patient with Hereditary Angioedema
I've been on this medication for two years now. My dosage has increased to 100mg twice daily, and I no longer experience any breast pain. The only side effects I've noticed are slight weight gain and flushing, but nothing too severe.
View All Reviews
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Patient Q&A Section about danazol

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What kind of steroid is danazol?

"Danocrine is a synthetic steroid that causes multiple, diverse biological effects by binding to different types of steroid transport proteins. These include proteins in the circulation as well as specific receptors in target tissues. Danazol also inhibits gonadotropins in the central nervous system, which suppresses gametogenesis and steroidogenesis."

Answered by AI

What is danazol used for in males?

"The present invention involves the use of danazol in the manufacture of a medicament for the treatment of hypogonadism in males. The medicament may be used to treat hypogonadism resulting from any biological or physical cause."

Answered by AI

What are side effects of danazol?

"The following side effects may occur: weight gain, acne, flushing, sweating, voice changes (hoarseness, change in pitch), abnormal growth of body hair (in women), vaginal dryness/irritation, or decreased breast size. If you experience any of these side effects, tell your doctor or pharmacist."

Answered by AI

What is the mechanism of action of danazol?

"Danazol suppresses the pituitary gland's output of gonadotropins, which in turn inhibits fertility. It also has some androgenic properties, meaning it can promote the development of male sex characteristics. Danazol is converted into ethisterone and 17-hydroxymethylethisterone by the liver."

Answered by AI

Clinical Trials for Danazol

Have you considered Danazol clinical trials? We made a collection of clinical trials featuring Danazol, we think they might fit your search criteria.
Have you considered Danazol clinical trials? We made a collection of clinical trials featuring Danazol, we think they might fit your search criteria.
Have you considered Danazol clinical trials? We made a collection of clinical trials featuring Danazol, we think they might fit your search criteria.
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