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What is Cozaar
LosartanThe Generic name of this drug
Treatment SummaryLosartan is a blood pressure medication that works by blocking the action of angiotensin II, a hormone that causes blood vessels to narrow. It is usually prescribed as an alternative to ACE inhibitors, a different type of blood pressure medication, in patients who experience coughing as a side effect of the ACE inhibitors. Losartan can be taken as a standalone tablet, or combined with hydrochlorothiazide, and it is important for patients to have their kidney function and potassium levels checked regularly when taking the drug. Losartan was officially approved by the FDA in 1995.
Cozaaris the brand name
Cozaar Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Cozaar
Losartan
1995
813
Effectiveness
How Cozaar Affects PatientsLosartan is a drug that helps lower blood pressure, and is used to treat diabetes-related kidney disease and reduce the risk of stroke. It is generally taken once a day and can have a long-lasting effect. People taking losartan should be monitored for low blood pressure, kidney function, and potassium levels.
How Cozaar works in the bodyLosartan blocks angiotensin II from binding to AT1 receptors, which are found in the walls of blood vessels and the adrenal gland. This prevents angiotensin II from tightening the blood vessels and raising blood pressure. Losartan is more effective than its active metabolite at blocking these receptors, allowing for a more relaxed blood vessel and lower blood pressure.
When to interrupt dosage
The quantity of Cozaar is contingent upon the determined condition, such as Hypertensive disease, Diabetic Nephropathy and Type 2 Diabetes. The amount of dosage depends on the method of delivery (e.g. Oral or Tablet - Oral) as illustrated in the table beneath.Condition
Dosage
Administration
increased serum creatinine
50.0 mg, , 100.0 mg, 25.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Diabetic Nephropathy
50.0 mg, , 100.0 mg, 25.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Type 2 Diabetes
50.0 mg, , 100.0 mg, 25.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Marfan Syndrome
50.0 mg, , 100.0 mg, 25.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Left Ventricular Hypertrophy
50.0 mg, , 100.0 mg, 25.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Hypertensive disease
50.0 mg, , 100.0 mg, 25.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Ischemic Stroke
50.0 mg, , 100.0 mg, 25.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Ventricular Dysfunction
50.0 mg, , 100.0 mg, 25.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Proteinuria
50.0 mg, , 100.0 mg, 25.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Warnings
Cozaar has two known contraindications, thus its use should be avoided when you have any of the conditions listed in the table below.Cozaar ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Losartan may interact with Pulse Frequency
Common Cozaar Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Losartan.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Losartan.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Losartan.
Amifostine
Major
Losartan may increase the hypotensive activities of Amifostine.
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Losartan.
Cozaar Toxicity & Overdose RiskThe lowest toxic dose of losartan in mice has been found to be 1000mg/kg and 2000mg/kg in rats. In humans, the lowest toxic dose is 10mg/kg/2W for men and 1mg/kg/1D for women. Symptoms of an overdose may include low blood pressure, increased heart rate, or slowed heart rate due to stimulation of the vagus nerve. Treatment for losartan overdose includes supportive care for low blood pressure, but dialysis will not remove losartan from the bloodstream since it is highly protein bound.
Cozaar Novel Uses: Which Conditions Have a Clinical Trial Featuring Cozaar?
219 active studies are currently examining the potential of Cozaar to mitigate increased serum creatinine, Diabetic Nephropathy and Marfan Syndrome.Condition
Clinical Trials
Trial Phases
Type 2 Diabetes
192 Actively Recruiting
Phase 2, Not Applicable, Early Phase 1, Phase 1, Phase 4, Phase 3
Proteinuria
5 Actively Recruiting
Phase 2, Phase 3, Phase 4
Ischemic Stroke
1 Actively Recruiting
Not Applicable
Diabetic Nephropathy
1 Actively Recruiting
Phase 4
Marfan Syndrome
3 Actively Recruiting
Not Applicable
increased serum creatinine
0 Actively Recruiting
Ventricular Dysfunction
14 Actively Recruiting
Not Applicable, Phase 2, Phase 4, Phase 1, Early Phase 1
Hypertensive disease
19 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Left Ventricular Hypertrophy
3 Actively Recruiting
Not Applicable, Phase 4
Cozaar Reviews: What are patients saying about Cozaar?
5Patient Review
2/6/2016 I've been using this treatment for years and it's always worked great for me. The only downside is that my insurance company doesn't cover it because the generic version doesn't work for me. I've tried two different manufacturers, but the generic just doesn't cut it. So now I'm stuck paying $90 out of pocket every month.
4.3Patient Review
3/16/2014 I have experienced significant hair loss since starting this medication. I have spoken with other females who report the same side effect. Has anyone else, esp. females, had this issue? The drug has been effective for treating hypertension, otherwise.
4.3Patient Review
3/2/20144Patient Review
3/24/2014 I was recently diagnosed with stage three kidney failure and, needless to say, I was shocked. I'm currently waiting on more lab results to come back before making any decisions about treatment; however, I have been off Losartan for a week now and will wait another week to see how my body responds.
3.7Patient Review
5/24/2014 I took one 25mg pill along with 10mg coreg and BP went up to 150. It is usually 130.
3.3Patient Review
8/5/2014 The pill is very bitter when split, and it seems to cause indigestion and slight ear ringing.
3.3Patient Review
12/7/2015 I experienced numbness on one side of my face and head, plus a lot of ringing in my ears. The dizziness was also really bad. I did see a small drop in blood pressure, but not enough to justify the other symptoms.
3Patient Review
12/6/2018 My blood pressure was only slightly reduced after taking this medication.
3Patient Review
1/31/2015 I had trouble sleeping and my back hurt before starting this treatment, but I saw no change in blood pressure.
3Patient Review
6/20/2014 I developed neuropathy after just four months of use.
2.7Patient Review
5/18/2015 I occasionally felt dizzy, and constantly had a metal taste in my mouth and suffered from dry mouth.
2.3Patient Review
1/20/2016 Switched to this medication from Metoprolol per my doctor's recommendation. Stayed on it for one week before noticing that my blood pressure increased and heart rate was much higher than normal. This medicine seemed to have the opposite effect of what it was supposed to do.
2.3Patient Review
3/30/2014 I'm cautiously optimistic.
2Patient Review
6/30/2020 I began to perspire excessively while on this medication, and even years after discontinuing use. I never had a problem with sweating before, but now it's an ongoing issue. Additionally, I became very dizzy one time while out shopping; thankfully my husband was there to help me. In light of these experiences, I would not consider this medication to be safe. Why don't doctors warn patients about potential side effects?
2Patient Review
3/31/2017 I've been on this pill for over ten years. I recently switched to the generic brand, and I feel like it's not working as well. Is that possible?
2Patient Review
9/18/2014 The cough medication I was prescribed left me with a really dry mouth and an irritated throat.
1.7Patient Review
10/13/2015 After taking this medication for a week, I experienced some pretty unpleasant side effects. These included a cough, stuffy nose, hoarseness, tiredness, and horrible sore throat. Additionally, I had leg cramps at night and numbness in my left cheek and right arm.
1.7Patient Review
9/19/2017 The generic form of this medication did not work at all. I ended up in the ER with tachardia.
1Patient Review
12/22/2015 I had an extreme reaction to this medication the first time I took it. I went into anaphylactic shock and ended up in the ER getting IV treatment with four different medications.
Patient Q&A Section about cozaar
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Are losartan and Cozaar the same?
"Losartan potassium is the generic name of a prescription medication that is sold under the brand name Cozaar."
Answered by AI
Is Cozaar a beta blocker?
"Cozaar and atenolol are two different types of drugs. Cozaar is an angiotensin receptor blocker (ARB) while atenolol is a beta-blocker. The brand name for atenolol is Tenormin."
Answered by AI
What is the medicine Cozaar used for?
"Losartan is a medication used to manage high blood pressure. It can also help protect kidneys from damage caused by diabetes and lower the risk of strokes for patients with high blood pressure or an enlarged heart. Reducing high blood pressure helps prevent strokes, heart attacks, and kidney problems."
Answered by AI