Cozaar

Marfan Syndrome, Proteinuria, Hypertrophy, Left Ventricular + 6 more
Treatment
20 Active Studies for Cozaar

What is Cozaar

LosartanThe Generic name of this drug
Treatment SummaryLosartan is a blood pressure medication that works by blocking the action of angiotensin II, a hormone that causes blood vessels to narrow. It is usually prescribed as an alternative to ACE inhibitors, a different type of blood pressure medication, in patients who experience coughing as a side effect of the ACE inhibitors. Losartan can be taken as a standalone tablet, or combined with hydrochlorothiazide, and it is important for patients to have their kidney function and potassium levels checked regularly when taking the drug. Losartan was officially approved by the FDA in 1995.
Cozaaris the brand name
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Cozaar Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Cozaar
Losartan
1995
813

Effectiveness

How Cozaar Affects PatientsLosartan is a drug that helps lower blood pressure, and is used to treat diabetes-related kidney disease and reduce the risk of stroke. It is generally taken once a day and can have a long-lasting effect. People taking losartan should be monitored for low blood pressure, kidney function, and potassium levels.
How Cozaar works in the bodyLosartan blocks angiotensin II from binding to AT1 receptors, which are found in the walls of blood vessels and the adrenal gland. This prevents angiotensin II from tightening the blood vessels and raising blood pressure. Losartan is more effective than its active metabolite at blocking these receptors, allowing for a more relaxed blood vessel and lower blood pressure.

When to interrupt dosage

The quantity of Cozaar is contingent upon the determined condition, such as Hypertensive disease, Diabetic Nephropathy and Type 2 Diabetes. The amount of dosage depends on the method of delivery (e.g. Oral or Tablet - Oral) as illustrated in the table beneath.
Condition
Dosage
Administration
Type 2 Diabetes
50.0 mg, , 100.0 mg, 25.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Ischemic Stroke
50.0 mg, , 100.0 mg, 25.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Marfan Syndrome
50.0 mg, , 100.0 mg, 25.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Ventricular Dysfunction
50.0 mg, , 100.0 mg, 25.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Proteinuria
50.0 mg, , 100.0 mg, 25.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Hypertrophy, Left Ventricular
50.0 mg, , 100.0 mg, 25.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Diabetic Nephropathies
50.0 mg, , 100.0 mg, 25.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Hypertensive disease
50.0 mg, , 100.0 mg, 25.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
increased serum creatinine
50.0 mg, , 100.0 mg, 25.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral

Warnings

Cozaar has two known contraindications, thus its use should be avoided when you have any of the conditions listed in the table below.Cozaar Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Losartan may interact with Pulse Frequency
Pulse Frequency
Do Not Combine
There are 20 known major drug interactions with Cozaar.
Common Cozaar Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Losartan.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Losartan.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Losartan.
Amifostine
Major
Losartan may increase the hypotensive activities of Amifostine.
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Losartan.
Cozaar Toxicity & Overdose RiskThe lowest toxic dose of losartan in mice has been found to be 1000mg/kg and 2000mg/kg in rats. In humans, the lowest toxic dose is 10mg/kg/2W for men and 1mg/kg/1D for women. Symptoms of an overdose may include low blood pressure, increased heart rate, or slowed heart rate due to stimulation of the vagus nerve. Treatment for losartan overdose includes supportive care for low blood pressure, but dialysis will not remove losartan from the bloodstream since it is highly protein bound.
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Cozaar Novel Uses: Which Conditions Have a Clinical Trial Featuring Cozaar?

219 active studies are currently examining the potential of Cozaar to mitigate increased serum creatinine, Diabetic Nephropathy and Marfan Syndrome.
Condition
Clinical Trials
Trial Phases
Type 2 Diabetes
177 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4, Early Phase 1
Marfan Syndrome
2 Actively Recruiting
Not Applicable
increased serum creatinine
0 Actively Recruiting
Ventricular Dysfunction
0 Actively Recruiting
Ischemic Stroke
0 Actively Recruiting
Hypertensive disease
23 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Proteinuria
3 Actively Recruiting
Phase 2, Phase 3
Hypertrophy, Left Ventricular
0 Actively Recruiting
Diabetic Nephropathies
0 Actively Recruiting

Cozaar Reviews: What are patients saying about Cozaar?

5Patient Review
2/6/2016
Cozaar for High Blood Pressure
I've been using this treatment for years and it's always worked great for me. The only downside is that my insurance company doesn't cover it because the generic version doesn't work for me. I've tried two different manufacturers, but the generic just doesn't cut it. So now I'm stuck paying $90 out of pocket every month.
4.3Patient Review
3/16/2014
Cozaar for High Blood Pressure
I have experienced significant hair loss since starting this medication. I have spoken with other females who report the same side effect. Has anyone else, esp. females, had this issue? The drug has been effective for treating hypertension, otherwise.
4.3Patient Review
3/2/2014
Cozaar for High Blood Pressure
4Patient Review
3/24/2014
Cozaar for High Blood Pressure
I was recently diagnosed with stage three kidney failure and, needless to say, I was shocked. I'm currently waiting on more lab results to come back before making any decisions about treatment; however, I have been off Losartan for a week now and will wait another week to see how my body responds.
3.7Patient Review
5/24/2014
Cozaar for High Blood Pressure
I took one 25mg pill along with 10mg coreg and BP went up to 150. It is usually 130.
View All Reviews
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Patient Q&A Section about cozaar

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are some of the side effects of Cozaar?

"The symptoms of the flu include: diarrhea, stomach pain, muscle cramps, leg or back pain, dizziness, headache, sleep problems (insomnia), tiredness, and more."

Answered by AI

Are losartan and Cozaar the same?

"Losartan potassium is the generic name of a prescription medication that is sold under the brand name Cozaar."

Answered by AI

Is Cozaar a beta blocker?

"Cozaar and atenolol are two different types of drugs. Cozaar is an angiotensin receptor blocker (ARB) while atenolol is a beta-blocker. The brand name for atenolol is Tenormin."

Answered by AI

What is the medicine Cozaar used for?

"Losartan is a medication used to manage high blood pressure. It can also help protect kidneys from damage caused by diabetes and lower the risk of strokes for patients with high blood pressure or an enlarged heart. Reducing high blood pressure helps prevent strokes, heart attacks, and kidney problems."

Answered by AI

Clinical Trials for Cozaar

Have you considered Cozaar clinical trials? We made a collection of clinical trials featuring Cozaar, we think they might fit your search criteria.
Have you considered Cozaar clinical trials? We made a collection of clinical trials featuring Cozaar, we think they might fit your search criteria.
Have you considered Cozaar clinical trials? We made a collection of clinical trials featuring Cozaar, we think they might fit your search criteria.
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