Coumadin

Atrial Fibrillation, cardiac valve replacement, mechanical heart valve + 10 more

Treatment

14 FDA approvals

20 Active Studies for Coumadin

Treatment for

Atrial Fibrillation

What is Coumadin

WarfarinThe Generic name of this drug

Treatment SummaryWarfarin is a blood-thinning drug used to stop the formation and movement of blood clots. It was originally designed as a pesticide, but is now the most commonly prescribed oral anticoagulant in North America. Warfarin can cross the placenta during pregnancy which can lead to fetal bleeding, miscarriage, premature birth, stillbirth, or death of the baby. Other potential side effects include necrosis, purple toe syndrome, osteoporosis, calcification of valves and arteries, and drug interactions. Warfarin does not change the viscosity of blood, but it blocks the body’s

Coumadinis the brand name

image of different drug pills on a surface

Coumadin Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Coumadin

Warfarin

1995

557

Approved as Treatment by the FDA

Warfarin, otherwise known as Coumadin, is approved by the FDA for 14 uses which include Atrial Fibrillation and history of myocardial infarction .

Atrial Fibrillation

history of myocardial infarction

Venous Thrombosis (Disorder)

Deep Vein Thrombosis (DVT)

cardiac valve replacement

Atrial Fibrillation

Systemic Embolism

prophylaxis of Venous thrombosis

Disease

Pulmonary Embolism

prophylaxis of Thromboembolic event

Stroke

Heart Attack

Effectiveness

How Coumadin Affects PatientsWarfarin is a blood thinning drug used to prevent dangerous blood clots. It is commonly prescribed to people with deep vein thrombosis or atrial fibrillation, as well as those with cardiac valve disease or valve replacements. The main goal of warfarin therapy is to keep potentially dangerous clots from forming and travelling to the lungs, heart, or brain. However, warfarin can also cause negative side effects, such as cholesterol microemboli leading to visual disturbances, acute kidney injury, central nervous system ischemia, and purple or blue toe syndrome. In some cases, it can also cause warfar

How Coumadin works in the bodyWarfarin is a drug that stops the production of vitamin K in the body. Vitamin K helps create proteins in the blood that are responsible for clotting. Without these proteins, the blood cannot clot, and you may experience excessive bleeding. Warfarin binds to vitamin K epoxide reductase and prevents the recycling of vitamin K, creating an anticoagulation effect. To reverse this effect, you need to take more vitamin K, either through supplements or by removing the inhibition of the enzyme. It takes about 2 days for new clotting proteins to be made in the liver. Taking antibiotics can also reduce the amount of vitamin K

When to interrupt dosage

The measure of Coumadin is contingent upon the identified condition, including Pulmonary Embolism, Atrial Fibrillation and Heart Attack. The portion of dosage fluctuates as per the method of delivery specified in the table below.

Condition

Dosage

Administration

prophylaxis of Thromboembolic event